The Experts below are selected from a list of 90 Experts worldwide ranked by ideXlab platform
Haruki Yamaya - One of the best experts on this subject based on the ideXlab platform.
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alcohol high blood pressure and serum gamma glutamyl Transpeptidase level
Hypertension, 1991Co-Authors: Yuichi Yamada, Masao Ishizaki, Teruhiko Kido, Ryumon Honda, Ikiko Tsuritani, Eriko Ikai, Haruki YamayaAbstract:The influence of the level of serum Gamma-Glutamyl Transpeptidase, a biological marker of alcohol consumption, on elevations of blood pressure and on the development of hypertension related to increases in alcohol consumption was determined in a cross-sectional study of 1,492 middle-aged male workers and in a subsequent 5-year follow-up study of 1,393 workers. Blood pressure levels, as well as the prevalence and incidence of hypertension, were higher in the subjects with serum Gamma-Glutamyl Transpeptidase levels above 50 units/l than in those with normal levels. These differences were more marked in drinkers who consumed 30 ml or more of alcohol per day. Thus, elevated serum Gamma-Glutamyl Transpeptidase activity may identify drinkers at higher risk for the development of alcohol-related hypertension.
Yannick Laperche - One of the best experts on this subject based on the ideXlab platform.
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Tissue-specific expression of multiple Gamma-Glutamyl Transpeptidase mRNAs in rat epithelia.
American Journal of Physiology-Cell Physiology, 1991Co-Authors: M Darbouy, M.n. Chobert, Olivier Lahuna, T Okamoto, Jean-pierre Bonvalet, Nicolette Farman, Yannick LapercheAbstract:Gamma-Glutamyl Transpeptidase (GGT) is an enzyme that plays a key role in interorgan glutathione transport. Three mRNAs (mRNAI, mRNAII, and mRNAIII) are known to encode the GGT precursor; they are ...
Hans Weiher - One of the best experts on this subject based on the ideXlab platform.
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Enhanced Gamma-Glutamyl Transpeptidase expression and superoxide production in Mpv17-/- glomerulosclerosis mice.
Biological chemistry, 2001Co-Authors: Gunter Wagner, Alexander Reuter, Eva Maria Wagner, Kurt Stettmaier, Wolf Bors, Helmut Sies, Hans WeiherAbstract:Recently, Gamma-Glutamyl Transpeptidase, which initiates cleavage of extracellular glutathione, has been shown to promote oxidative damage to cells. Here we examined a murine disease model of glomerulosclerosis, involving loss of the Mpv17 gene coding for a peroxisomal protein. In Mpv17-/- cells, enzyme activity and mRNA expression (examined by quantitative RT-PCR) of membrane-bound Gamma-Glutamyl Transpeptidase were increased, while plasma glutathione peroxidase and superoxide dismutase levels were lowered. Superoxide anion production in these cells was increased as documented by electron spin resonance spectroscopy. In the presence of Mn(III)tetrakis(4-benzoic acid)porphyrin, the activities of Gamma-Glutamyl Transpeptidase and plasma glutathione peroxidase were unchanged, suggesting a relationship between enzyme expression and the amount of reactive oxygen species. Inhibition of Gamma-Glutamyl Transpeptidase by acivicin reverted the lowered plasma glutathione peroxidase and superoxide dismutase activities, indicating reciprocal control of gene expression for these enzymes.
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enhanced gamma glutamyl Transpeptidase expression and superoxide production in mpv17 glomerulosclerosis mice
Biological Chemistry, 2001Co-Authors: Gunter Wagner, Alexander Reuter, Eva Maria Wagner, Kurt Stettmaier, Wolf Bors, Helmut Sies, Hans WeiherAbstract:Recently, Gamma-Glutamyl Transpeptidase, which initiates cleavage of extracellular glutathione, has been shown to promote oxidative damage to cells. Here we examined a murine disease model of glomerulosclerosis, involving loss of the Mpv17 gene coding for a peroxisomal protein. In Mpv17-/- cells, enzyme activity and mRNA expression (examined by quantitative RT-PCR) of membrane-bound Gamma-Glutamyl Transpeptidase were increased, while plasma glutathione peroxidase and superoxide dismutase levels were lowered. Superoxide anion production in these cells was increased as documented by electron spin resonance spectroscopy. In the presence of Mn(III)tetrakis(4-benzoic acid)porphyrin, the activities of Gamma-Glutamyl Transpeptidase and plasma glutathione peroxidase were unchanged, suggesting a relationship between enzyme expression and the amount of reactive oxygen species. Inhibition of Gamma-Glutamyl Transpeptidase by acivicin reverted the lowered plasma glutathione peroxidase and superoxide dismutase activities, indicating reciprocal control of gene expression for these enzymes.
Yuichi Yamada - One of the best experts on this subject based on the ideXlab platform.
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alcohol high blood pressure and serum gamma glutamyl Transpeptidase level
Hypertension, 1991Co-Authors: Yuichi Yamada, Masao Ishizaki, Teruhiko Kido, Ryumon Honda, Ikiko Tsuritani, Eriko Ikai, Haruki YamayaAbstract:The influence of the level of serum Gamma-Glutamyl Transpeptidase, a biological marker of alcohol consumption, on elevations of blood pressure and on the development of hypertension related to increases in alcohol consumption was determined in a cross-sectional study of 1,492 middle-aged male workers and in a subsequent 5-year follow-up study of 1,393 workers. Blood pressure levels, as well as the prevalence and incidence of hypertension, were higher in the subjects with serum Gamma-Glutamyl Transpeptidase levels above 50 units/l than in those with normal levels. These differences were more marked in drinkers who consumed 30 ml or more of alcohol per day. Thus, elevated serum Gamma-Glutamyl Transpeptidase activity may identify drinkers at higher risk for the development of alcohol-related hypertension.
M Darbouy - One of the best experts on this subject based on the ideXlab platform.
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Tissue-specific expression of multiple Gamma-Glutamyl Transpeptidase mRNAs in rat epithelia.
American Journal of Physiology-Cell Physiology, 1991Co-Authors: M Darbouy, M.n. Chobert, Olivier Lahuna, T Okamoto, Jean-pierre Bonvalet, Nicolette Farman, Yannick LapercheAbstract:Gamma-Glutamyl Transpeptidase (GGT) is an enzyme that plays a key role in interorgan glutathione transport. Three mRNAs (mRNAI, mRNAII, and mRNAIII) are known to encode the GGT precursor; they are ...
