The Experts below are selected from a list of 252210 Experts worldwide ranked by ideXlab platform
Takashi Uno - One of the best experts on this subject based on the ideXlab platform.
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mr imaging of the superior cervical Ganglion and inferior Ganglion of the vagus nerve structures that can mimic pathologic retropharyngeal lymph nodes
American Journal of Neuroradiology, 2018Co-Authors: Hajime Yokota, Hiroki Mukai, Shinya Hattori, Kei Yamada, Yoshimi Anzai, Takashi UnoAbstract:BACKGROUND AND PURPOSE: The superior cervical Ganglion and inferior Ganglion of the vagus nerve can mimic pathologic retropharyngeal lymph nodes. We studied the cross-sectional anatomy of the superior cervical Ganglion and inferior Ganglion of the vagus nerve to evaluate how they can be differentiated from the retropharyngeal lymph nodes. MATERIALS AND METHODS: This retrospective study consists of 2 parts. Cohort 1 concerned the signal intensity of routine neck MR imaging with 2D sequences, apparent diffusion coefficient, and contrast enhancement of the superior cervical Ganglion compared with lymph nodes with or without metastasis in 30 patients. Cohort 2 used 3D neurography to assess the morphology and spatial relationships of the superior cervical Ganglion, inferior Ganglion of the vagus nerve, and the retropharyngeal lymph nodes in 50 other patients. RESULTS: All superior cervical Ganglions had homogeneously greater enhancement and lower signal on diffusion-weighted imaging than lymph nodes. Apparent diffusion coefficient values of the superior cervical Ganglion (1.80 ± 0.28 × 10 −3 mm 2 /s) were significantly higher than normal and metastatic lymph nodes (0.86 ± 0.10 × 10 −3 mm 2 /s, P −3 mm 2 /s, P P P = .004). The highest at vertebral level was the retropharyngeal lymph nodes, followed, in order, by the inferior Ganglion of the vagus nerve and the superior cervical Ganglion ( P P = .001). The retropharyngeal lymph node, superior cervical Ganglion, and inferior Ganglion of the vagus nerve formed a line from anteromedial to posterolateral. CONCLUSIONS: The superior cervical Ganglion and the inferior Ganglion of the vagus nerve can be almost always differentiated from retropharyngeal lymph nodes on MR imaging by evaluating the signal, size, and position.
Olle Lindvall - One of the best experts on this subject based on the ideXlab platform.
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cometin is a novel neurotrophic factor that promotes neurite outgrowth and neuroblast migration in vitro and supports survival of spiral Ganglion neurons in vivo
Experimental Neurology, 2012Co-Authors: Jesper Roland Jorgensen, Anette Fransson, Lone Fjordlarsen, Lachlan H Thompson, Jeffrey P Houchins, Nuno Miguel Gomes Andrade, Malene Torp, Nisse Kalkkinen, Elisabet Andersson, Olle LindvallAbstract:Neurotrophic factors are secreted proteins responsible for migration, growth and survival of neurons during development, and for maintenance and plasticity of adult neurons. Here we present a novel secreted protein named Cometin which together with Meteorin defines a new evolutionary conserved protein family. During early mouse development, Cometin is found exclusively in the floor plate and from E13.5 also in dorsal root Ganglions and inner ear but apparently not in the adult nervous system. In vitro, Cometin promotes neurite outgrowth from dorsal root Ganglion cells which can be blocked by inhibition of the Janus or MEK kinases. In this assay, additive effects of Cometin and Meteorin are observed indicating separate receptors. Furthermore, Cometin supports migration of neuroblasts from subventricular zone explants to the same extend as stromal cell derived factor la. Given the neurotrophic properties in vitro, combined with the restricted inner ear expression during development, we further investigated Cometin in relation to deafness. In neomycin deafened guinea pigs, two weeks intracochlear infusion of recombinant Cometin supports spiral Ganglion neuron survival and function. In contrast to the control group receiving artificial perilymph, Cometin treated animals retain normal electrically-evoked brainstem response which is maintained several weeks after treatment cessation. Neuroprotection is also evident from stereological analysis of the spiral Ganglion. Altogether, these studies show that Cometin is a potent new neurotrophic factor with therapeutic potential. (C) 2011 Elsevier Inc. All rights reserved. (Less)
Hajime Yokota - One of the best experts on this subject based on the ideXlab platform.
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mr imaging of the superior cervical Ganglion and inferior Ganglion of the vagus nerve structures that can mimic pathologic retropharyngeal lymph nodes
American Journal of Neuroradiology, 2018Co-Authors: Hajime Yokota, Hiroki Mukai, Shinya Hattori, Kei Yamada, Yoshimi Anzai, Takashi UnoAbstract:BACKGROUND AND PURPOSE: The superior cervical Ganglion and inferior Ganglion of the vagus nerve can mimic pathologic retropharyngeal lymph nodes. We studied the cross-sectional anatomy of the superior cervical Ganglion and inferior Ganglion of the vagus nerve to evaluate how they can be differentiated from the retropharyngeal lymph nodes. MATERIALS AND METHODS: This retrospective study consists of 2 parts. Cohort 1 concerned the signal intensity of routine neck MR imaging with 2D sequences, apparent diffusion coefficient, and contrast enhancement of the superior cervical Ganglion compared with lymph nodes with or without metastasis in 30 patients. Cohort 2 used 3D neurography to assess the morphology and spatial relationships of the superior cervical Ganglion, inferior Ganglion of the vagus nerve, and the retropharyngeal lymph nodes in 50 other patients. RESULTS: All superior cervical Ganglions had homogeneously greater enhancement and lower signal on diffusion-weighted imaging than lymph nodes. Apparent diffusion coefficient values of the superior cervical Ganglion (1.80 ± 0.28 × 10 −3 mm 2 /s) were significantly higher than normal and metastatic lymph nodes (0.86 ± 0.10 × 10 −3 mm 2 /s, P −3 mm 2 /s, P P P = .004). The highest at vertebral level was the retropharyngeal lymph nodes, followed, in order, by the inferior Ganglion of the vagus nerve and the superior cervical Ganglion ( P P = .001). The retropharyngeal lymph node, superior cervical Ganglion, and inferior Ganglion of the vagus nerve formed a line from anteromedial to posterolateral. CONCLUSIONS: The superior cervical Ganglion and the inferior Ganglion of the vagus nerve can be almost always differentiated from retropharyngeal lymph nodes on MR imaging by evaluating the signal, size, and position.
Weihua Ding - One of the best experts on this subject based on the ideXlab platform.
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increased hcn channel activity in the gasserian Ganglion contributes to trigeminal neuropathic pain
The Journal of Pain, 2018Co-Authors: Jason T Doheny, Shiqian Shen, Weihua Ding, Jinsheng Yang, Yi Zhang, Lucy ChenAbstract:Abstract Orofacial neuropathic pain caused by trigeminal nerve injury is a debilitating condition with limited therapeutic options. Hyperpolarization-activated cyclic nucleotide-gated (HCN) channels regulate neuronal excitability and are involved in the development and maintenance of chronic pain. However, the effect of HCN channel activity in the Gasserian Ganglion on trigeminal neuropathic pain has not been examined. We evaluated nociceptive behaviors after microinjection of the HCN channel blockers ZD7288 or ivabradine into the Gasserian Ganglion in rats with trigeminal nerve injury. Both blockers dose-dependently ameliorated evoked and spontaneous nociceptive behavior in rats with trigeminal neuropathic pain. Moreover, the clinically available HCN channel blocker ivabradine showed a prolonged antinociceptive effect. In the Gasserian Ganglion, HCN1 and HCN2 are major HCN isoforms. After trigeminal nerve injury, the counts of HCN1 as well as HCN2 immuno-positive punctae were increased in the ipsilateral Gasserian Ganglions. These results indicate that the increased HCN channel activity in the Gasserian Ganglion directly contributes to neuropathic pain resulting from trigeminal nerve injury. Perspective Trigeminal nerve damage-induced orofacial pain is severe and more resistant to standard pharmacological treatment than other types of neuropathic pain. Our study suggests that targeting HCN channel activities in the Gasserian Ganglion may provide an alternative treatment of trigeminal neuropathy including trigeminal neuralgia.
Jesper Roland Jorgensen - One of the best experts on this subject based on the ideXlab platform.
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cometin is a novel neurotrophic factor that promotes neurite outgrowth and neuroblast migration in vitro and supports survival of spiral Ganglion neurons in vivo
Experimental Neurology, 2012Co-Authors: Jesper Roland Jorgensen, Anette Fransson, Lone Fjordlarsen, Lachlan H Thompson, Jeffrey P Houchins, Nuno Miguel Gomes Andrade, Malene Torp, Nisse Kalkkinen, Elisabet Andersson, Olle LindvallAbstract:Neurotrophic factors are secreted proteins responsible for migration, growth and survival of neurons during development, and for maintenance and plasticity of adult neurons. Here we present a novel secreted protein named Cometin which together with Meteorin defines a new evolutionary conserved protein family. During early mouse development, Cometin is found exclusively in the floor plate and from E13.5 also in dorsal root Ganglions and inner ear but apparently not in the adult nervous system. In vitro, Cometin promotes neurite outgrowth from dorsal root Ganglion cells which can be blocked by inhibition of the Janus or MEK kinases. In this assay, additive effects of Cometin and Meteorin are observed indicating separate receptors. Furthermore, Cometin supports migration of neuroblasts from subventricular zone explants to the same extend as stromal cell derived factor la. Given the neurotrophic properties in vitro, combined with the restricted inner ear expression during development, we further investigated Cometin in relation to deafness. In neomycin deafened guinea pigs, two weeks intracochlear infusion of recombinant Cometin supports spiral Ganglion neuron survival and function. In contrast to the control group receiving artificial perilymph, Cometin treated animals retain normal electrically-evoked brainstem response which is maintained several weeks after treatment cessation. Neuroprotection is also evident from stereological analysis of the spiral Ganglion. Altogether, these studies show that Cometin is a potent new neurotrophic factor with therapeutic potential. (C) 2011 Elsevier Inc. All rights reserved. (Less)
