Ganoderma lucidum

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Yan Ping Pang - One of the best experts on this subject based on the ideXlab platform.

Daniel Sliva - One of the best experts on this subject based on the ideXlab platform.

  • Ganoderma lucidum(Reishi) in Cancer Treatment
    Integrative cancer therapies, 2003
    Co-Authors: Daniel Sliva
    Abstract:

    The popular edible mushroom Ganoderma lucidum (Reishi) has been widely used for the general promotion of health and longevity in Asian countries. The dried powder of Ganoderma lucidum was popular as a cancer chemotherapy agent in ancient China. The authors recently demonstrated that Ganoderma lucidum inhibits constitutively active transcription factors nuclear factor kappa B (NF-kappaB) and AP-1, which resulted in the inhibition of expression of urokinase-type plasminogen activator (uPA) and its receptor uPAR. Ganoderma lucidum also suppressed cell adhesion and cell migration of highly invasive breast and prostate cancer cells, suggesting its potency to reduce tumor invasiveness. Thus, Ganoderma lucidum clearly demonstrates anticancer activity in experiments with cancer cells and has possible therapeutic potential as a dietary supplement for an alternative therapy for breast and prostate cancer. However, because of the availability of Ganoderma lucidum from different sources, it is advisable to test its biologic activity.

Li Ya Xia - One of the best experts on this subject based on the ideXlab platform.

Dean Guo - One of the best experts on this subject based on the ideXlab platform.

  • cytotoxic triterpenoids from Ganoderma lucidum
    Phytochemistry, 2010
    Co-Authors: Chunru Cheng, Qingxi Yue, Xiaoyi Song, Sijia Tao, Xuan Liu, Shuhong Guan, Dean Guo
    Abstract:

    A systematic study of the metabolites in Ganoderma lucidum led to isolation of 43 triterpenoids, six of them (1-6) are hitherto unknown. The structures of the latter were elucidated on the basis of spectroscopic studies and comparison with the known related compounds. All of the compounds were assayed for their inhibitory activities against human HeLa cervical cancer cell lines. Some compounds exhibit significant cytotoxicity, and their structure-activity relationships are discussed.

Gao Jian - One of the best experts on this subject based on the ideXlab platform.