The Experts below are selected from a list of 2043 Experts worldwide ranked by ideXlab platform
Lisa Schmölz - One of the best experts on this subject based on the ideXlab platform.
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The vitamin E derivative garcinoic acid from Garcinia Kola nut seeds attenuates the inflammatory response.
Redox biology, 2019Co-Authors: Maria Wallert, Julia Bauer, Stefan Kluge, Lisa Schmölz, Yung-chih Chen, Melanie Ziegler, Amy Kate Searle, Alexander Maxones, Martin Schubert, Maria ThürmerAbstract:The plant Garcinia Kola is used in African ethno-medicine to treat various oxidation- and inflammation-related diseases but its bioactive compounds are not well characterized. Garcinoic acid (GA) is one of the few phytochemicals that have been isolated from Garcinia Kola. We investigated the anti-inflammatory potential of the methanol extract of Garcinia Kola seeds (NE) and purified GA, as a major phytochemical in these seeds, in lipopolysaccharide (LPS)-activated mouse RAW264.7 macrophages and its anti-atherosclerotic potential in high fat diet fed ApoE-/- mice. This study outlines an optimized procedure for the extraction and purification of GA from Garcinia Kola seeds with an increased yield and a purity of >99%. We found that LPS-induced upregulation of iNos and Cox2 expression, and the formation of the respective signaling molecules nitric oxide and prostanoids, were significantly diminished by both the NE and GA. In addition, GA treatment in mice decreased intra-plaque inflammation by attenuating nitrotyrosinylation. Further, modulation of lymphocyte sub-populations in blood and spleen have been detected, showing immune regulative properties of GA. Our study provides molecular insights into the anti-inflammatory activities of Garcinia Kola and reveals GA as promising natural lead for the development of multi-target drugs to treat inflammation-driven diseases.
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Garcinia Kola african ethno medication with anti atherosclerotic effects
Free Radical Biology and Medicine, 2017Co-Authors: Maria Wallert, Stefan Kluge, Lisa Schmölz, Yung-chih Chen, Julia HeiseAbstract:The plant Garcinia Kola is used in African ethno medicine to treat various diseases. Anti-inflammatory effects are one of the several beneficial properties described for this plant. We hypothesized that garcinoic acid (GA), as one of the phytochemicals isolated from Garcinia Kola, is responsible for these effects. Therefore, we investigated the capacity of GA to block the inflammatory response in LPS-activated murine macrophages and the inflammatory disease atherosclerosis. We found that the LPS-induced upregulation of the expression of iNos and Cox2 and the formation of respective signaling molecules nitric oxide, thromboxanes and prostaglandins was significantly diminished by GA. Further, application of GA (1 mg/kg, i.p.) affected the composition, but not the size of developed atherosclerotic plaques in aortic roots of ApoE-/-mice fed with high-fat Western-type diet. In brief, stability of the plaques was improved by increased collagen content and smaller necrotic core size under GA treatment. Based on these data we predict that GA blocks inflammatory response and plays a pivotal role in the formation of atherosclerotic plaques, in particular, affecting the degree of stability. If the proposed anti-atherosclerotic properties of GA are supported by further studies, this compound is a promising new therapeutic lead molecule against atherosclerosis and its complications.
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Garcinia Kola – African ethno medication with anti-atherosclerotic effects?
Free Radical Biology and Medicine, 2017Co-Authors: Maria Wallert, Stefan Kluge, Lisa Schmölz, Yung-chih Chen, Amy Kate Searle, Martin Schubert, Julia Heise, Andreas Koeberle, Francesco Galli, Oliver WerzAbstract:The plant Garcinia Kola is used in African ethno medicine to treat various diseases. Anti-inflammatory effects are one of the several beneficial properties described for this plant. We hypothesized that garcinoic acid (GA), as one of the phytochemicals isolated from Garcinia Kola, is responsible for these effects. Therefore, we investigated the capacity of GA to block the inflammatory response in LPS-activated murine macrophages and the inflammatory disease atherosclerosis. We found that the LPS-induced upregulation of the expression of iNos and Cox2 and the formation of respective signaling molecules nitric oxide, thromboxanes and prostaglandins was significantly diminished by GA. Further, application of GA (1 mg/kg, i.p.) affected the composition, but not the size of developed atherosclerotic plaques in aortic roots of ApoE-/-mice fed with high-fat Western-type diet. In brief, stability of the plaques was improved by increased collagen content and smaller necrotic core size under GA treatment. Based on these data we predict that GA blocks inflammatory response and plays a pivotal role in the formation of atherosclerotic plaques, in particular, affecting the degree of stability. If the proposed anti-atherosclerotic properties of GA are supported by further studies, this compound is a promising new therapeutic lead molecule against atherosclerosis and its complications.
Maria Wallert - One of the best experts on this subject based on the ideXlab platform.
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The vitamin E derivative garcinoic acid from Garcinia Kola nut seeds attenuates the inflammatory response.
Redox biology, 2019Co-Authors: Maria Wallert, Julia Bauer, Stefan Kluge, Lisa Schmölz, Yung-chih Chen, Melanie Ziegler, Amy Kate Searle, Alexander Maxones, Martin Schubert, Maria ThürmerAbstract:The plant Garcinia Kola is used in African ethno-medicine to treat various oxidation- and inflammation-related diseases but its bioactive compounds are not well characterized. Garcinoic acid (GA) is one of the few phytochemicals that have been isolated from Garcinia Kola. We investigated the anti-inflammatory potential of the methanol extract of Garcinia Kola seeds (NE) and purified GA, as a major phytochemical in these seeds, in lipopolysaccharide (LPS)-activated mouse RAW264.7 macrophages and its anti-atherosclerotic potential in high fat diet fed ApoE-/- mice. This study outlines an optimized procedure for the extraction and purification of GA from Garcinia Kola seeds with an increased yield and a purity of >99%. We found that LPS-induced upregulation of iNos and Cox2 expression, and the formation of the respective signaling molecules nitric oxide and prostanoids, were significantly diminished by both the NE and GA. In addition, GA treatment in mice decreased intra-plaque inflammation by attenuating nitrotyrosinylation. Further, modulation of lymphocyte sub-populations in blood and spleen have been detected, showing immune regulative properties of GA. Our study provides molecular insights into the anti-inflammatory activities of Garcinia Kola and reveals GA as promising natural lead for the development of multi-target drugs to treat inflammation-driven diseases.
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Garcinia Kola african ethno medication with anti atherosclerotic effects
Free Radical Biology and Medicine, 2017Co-Authors: Maria Wallert, Stefan Kluge, Lisa Schmölz, Yung-chih Chen, Julia HeiseAbstract:The plant Garcinia Kola is used in African ethno medicine to treat various diseases. Anti-inflammatory effects are one of the several beneficial properties described for this plant. We hypothesized that garcinoic acid (GA), as one of the phytochemicals isolated from Garcinia Kola, is responsible for these effects. Therefore, we investigated the capacity of GA to block the inflammatory response in LPS-activated murine macrophages and the inflammatory disease atherosclerosis. We found that the LPS-induced upregulation of the expression of iNos and Cox2 and the formation of respective signaling molecules nitric oxide, thromboxanes and prostaglandins was significantly diminished by GA. Further, application of GA (1 mg/kg, i.p.) affected the composition, but not the size of developed atherosclerotic plaques in aortic roots of ApoE-/-mice fed with high-fat Western-type diet. In brief, stability of the plaques was improved by increased collagen content and smaller necrotic core size under GA treatment. Based on these data we predict that GA blocks inflammatory response and plays a pivotal role in the formation of atherosclerotic plaques, in particular, affecting the degree of stability. If the proposed anti-atherosclerotic properties of GA are supported by further studies, this compound is a promising new therapeutic lead molecule against atherosclerosis and its complications.
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Garcinia Kola – African ethno medication with anti-atherosclerotic effects?
Free Radical Biology and Medicine, 2017Co-Authors: Maria Wallert, Stefan Kluge, Lisa Schmölz, Yung-chih Chen, Amy Kate Searle, Martin Schubert, Julia Heise, Andreas Koeberle, Francesco Galli, Oliver WerzAbstract:The plant Garcinia Kola is used in African ethno medicine to treat various diseases. Anti-inflammatory effects are one of the several beneficial properties described for this plant. We hypothesized that garcinoic acid (GA), as one of the phytochemicals isolated from Garcinia Kola, is responsible for these effects. Therefore, we investigated the capacity of GA to block the inflammatory response in LPS-activated murine macrophages and the inflammatory disease atherosclerosis. We found that the LPS-induced upregulation of the expression of iNos and Cox2 and the formation of respective signaling molecules nitric oxide, thromboxanes and prostaglandins was significantly diminished by GA. Further, application of GA (1 mg/kg, i.p.) affected the composition, but not the size of developed atherosclerotic plaques in aortic roots of ApoE-/-mice fed with high-fat Western-type diet. In brief, stability of the plaques was improved by increased collagen content and smaller necrotic core size under GA treatment. Based on these data we predict that GA blocks inflammatory response and plays a pivotal role in the formation of atherosclerotic plaques, in particular, affecting the degree of stability. If the proposed anti-atherosclerotic properties of GA are supported by further studies, this compound is a promising new therapeutic lead molecule against atherosclerosis and its complications.
Uche Samuel Ndidi - One of the best experts on this subject based on the ideXlab platform.
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effects of Garcinia Kola biflavonoid fractions on serum lipid profile and kidney function parameters in hyperlipidemic rats
Clinical Phytoscience, 2017Co-Authors: Ene Blessing Adejor, D A Ameh, Dorcas Bolanle James, Olumuyiwa A Owolabi, Uche Samuel NdidiAbstract:Garcinia Kola is used in traditional medicine in various parts of Africa including Nigeria for the amelioration of hypertension, cough, diabetes, sickle cell anemia, bacterial and fungal infections amongst others. The prophylactic and therapeutic efficacy of Garcinia Kola biflavonoid fractions (GKBF); root bark (RBBF), stem bark (SBBF) and seed (SBF)) on the lipid profile and kidney function of Poloxamer 407 (P407) induced hyperlipidemic rats were determined. Hyperlipidemia was induced by a single intraperitoneal dose of P407 after 19 days in the prophylactic group and after every 48 h in therapeutic group for 21 days. Atorvastatin (standard drug) and the GKBF were administered to different subgroups before induction in Prophylactic group and after induction in therapeutic group. Experimental animals were euthanized after day 21 of the study and blood samples collected for the evaluation of lipid levels and kidney function. All Prophylactic and therapeutic group treated sub-groups had significantly (p 0.05) change in urea and creatinine concentrations. This study shows that Garcinia Kola biflavonoid fraction has potential prophylactic and therapeutic efficacy in the management of hyperlipidemia.
U. Akpamu - One of the best experts on this subject based on the ideXlab platform.
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Some Haematological Parameters in Rabbits Treated With Methanolic Extract of Garcinia Kola
African Journal of Biomedical Research, 2013Co-Authors: U C Osifo, M. O. Ozor, U. Akpamu, I C IdehenAbstract:This study investigates the effect of methanolic extract of Garcinia Kola on some haematological parameters of adult male rabbits. The rabbits (1.55kg) were assigned into two groups; A (control, n = 10) and B (experimental, n = 10). In addition to water and feed given ad libitum , the experimental group received 100mg/day of methanolic extract of Garcinia Kola for 4weeks. At the end of the experiment, blood was obtained for assessment of the data herein presented. Results (paired sample t-test) as judge against with the control values presented significant reduction (p
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The effect of chronic ingestion of crude Garcinia Kola on the histology of the liver
European Journal of Experimental Biology, 2012Co-Authors: Charity U Osifo, U. Akpamu, Charlse I Idehen, Williams A Adisa, Kerry E AzekeAbstract:Different quantities of Garcinia Kola in form of determined doses in mg/kg body weight was given to different groups of rabbits daily for a period of six weeks, to assess possible adverse effects of chronic administration on the histology of the liver. 1200mg/kg, 1500mg/kg and 1800mg/kg of the reconstituted powdered Garcinia Kola were administered to the rabbits in the test groups B, C and D respectively while A (control) received normal saline. Slide photomicrographs of the control (group A) shows normal histological hepatocytes. Although photomicrographs of the tests groups (B, C and D) presented mild cellular edema, this was not of any pathological significant because it was also observed in the control (group A). The elicitation of no observable histo-pathological effects by Garcinia Kola on the histology of the liver is a reflection of its hepatic safety in healthy condition. However, it toxic dose requires investigation and thus the needs for further studies.
Ene Blessing Adejor - One of the best experts on this subject based on the ideXlab platform.
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effects of Garcinia Kola biflavonoid fractions on serum lipid profile and kidney function parameters in hyperlipidemic rats
Clinical Phytoscience, 2017Co-Authors: Ene Blessing Adejor, D A Ameh, Dorcas Bolanle James, Olumuyiwa A Owolabi, Uche Samuel NdidiAbstract:Garcinia Kola is used in traditional medicine in various parts of Africa including Nigeria for the amelioration of hypertension, cough, diabetes, sickle cell anemia, bacterial and fungal infections amongst others. The prophylactic and therapeutic efficacy of Garcinia Kola biflavonoid fractions (GKBF); root bark (RBBF), stem bark (SBBF) and seed (SBF)) on the lipid profile and kidney function of Poloxamer 407 (P407) induced hyperlipidemic rats were determined. Hyperlipidemia was induced by a single intraperitoneal dose of P407 after 19 days in the prophylactic group and after every 48 h in therapeutic group for 21 days. Atorvastatin (standard drug) and the GKBF were administered to different subgroups before induction in Prophylactic group and after induction in therapeutic group. Experimental animals were euthanized after day 21 of the study and blood samples collected for the evaluation of lipid levels and kidney function. All Prophylactic and therapeutic group treated sub-groups had significantly (p 0.05) change in urea and creatinine concentrations. This study shows that Garcinia Kola biflavonoid fraction has potential prophylactic and therapeutic efficacy in the management of hyperlipidemia.
