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Hua Hui-ming - One of the best experts on this subject based on the ideXlab platform.
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Studies on the chemical constituents of the barks of Garcinia xanthochymus
Chinese Journal of Medicinal Chemistry, 2012Co-Authors: Hua Hui-mingAbstract:Garcinia xanthochymus is a traditional Dai medicine native to the south and southwest of Yunnan Province of China.The medicinal plants of the genus Garcinia are well-known as rich sources of xanthones,benzophenones.These phenolic constituents have been reported to possess a wide range of biological and pharmacological properties,such as antibacterial,antimalarial,and cytotoxic activities.In the course of our search for anticaner agents from the genus Garcinia,we investigated the chemical constituents of the 95% EtOH extract of the barks of Garcinia xanthochymus.Ten compounds were isolated by various kinds of column chromatography on silica gel,Sephadex LH-20 and ODS.Their structures were identified as 1,2,5-trihydroxyxanthone(1),1,4,5-trihydroxyxanthone(2),1,6-dihydroxy-4,5-dimethoxyxanthone(3),1,5-dihydroxy-3-methoxyxanthone(4),1,4-dihydroxy-5-methoxy-6,6′-dimethylpyrano(2′,3′:6,7)xanthone(5),luteolin(6),quercetin(7),kaempferol(8),tirucallane-7,24-dien-3-ol(9) and morolic acid acetate(10),respectively.Compounds 6,9,10 are isolated from Garcinia xanthochymus for the first time.
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Progress in Caged Polyprenylated Xanthones of Garcinia genus
Natural Product Research and Development, 2011Co-Authors: Hua Hui-mingAbstract:On the basis of the research on caged polyprenylated xanthones isolated from the resin of Garcinia hanburyi and the related literatures,an overview on the structures,spectral characteristics,biosynthesis pathway and biological activities of caged polyprenylated xanthones from Garcinia genus was taken.
James T Lyles - One of the best experts on this subject based on the ideXlab platform.
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in vitro antiplasmodial activity of benzophenones and xanthones from edible fruits of Garcinia species
Planta Medica, 2014Co-Authors: James T Lyles, Adam Negrin, Shabana I Khan, Edward J KennellyAbstract:Species of Garcinia have been used to combat malaria in traditional African and Asian medicines, including Ayurveda. In the current study, we have identified antiplasmodial benzophenone and xanthone compounds from edible Garcinia species by testing for in vitro inhibitory activity against Plasmodium falciparum. Whole fruits of Garcinia xanthochymus, G. mangostana, G. spicata, and G. livingstonei were extracted and tested for antiplasmodial activity. Garcinia xanthochymus was subjected to bioactivity-guided fractionation to identify active partitions. Purified benzophenones (1-9) and xanthones (10-18) were then screened in the plasmodial lactate dehydrogenase assay and tested for cytotoxicity against mammalian (Vero) cells. The benzophenones guttiferone E (4), isoxanthochymol (5), and guttiferone H (6), isolated from G. xanthochymus, and the xanthones α-mangostin (15), β-mangostin (16), and 3-isomangostin (17), known from G. mangostana, showed antiplasmodial activity with IC50 values in the range of 4.71-11.40 µM. Artemisinin and chloroquine were used as positive controls and exhibited IC50 values in the range of 0.01-0.24 µM. The identification of antiplasmodial benzophenone and xanthone compounds from G. xanthochymus and G. mangostana provides evidence for the antiplasmodial activity of Garcinia species and warrants further investigation of these fruits as dietary sources of chemopreventive compounds.
Edward J Kennelly - One of the best experts on this subject based on the ideXlab platform.
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UPLC-QTOFMS(E)-Guided Dereplication of the Endangered Chinese Species Garcinia paucinervis to Identify Additional Benzophenone Derivatives.
Journal of natural products, 2016Co-Authors: Harini Anandhi Senthilkumar, Edward J Kennelly, Mario Figueroa, Jimmie E. Fata, Chunlin LongAbstract:A number of Garcinia species accumulate benzophenone derivatives that may be useful for the treatment of breast cancer. The dereplication of new benzophenone derivatives from Garcinia species is challenging due to the occurrence of multiple isomers and the known compounds found in their extracts. In the current study, a strategy is described using the UPLC-QTOFMS(E) technique to identify tentatively the known and uncharacterized benzophenones of interest based upon the characteristic fragmentation ions. Several UPLC-QTOFMS peaks (a-ee) appeared to contain benzophenone derivatives, and 12 of these peaks contained compounds with MS ionization profiles not consistent with previously identified compounds from the seeds of Garcinia paucinervis, an endangered Chinese species. The targeted isolation of unidentified compounds of interest afforded five new benzophenones, paucinones E-I (1-5), which were determined by MS and NMR analysis and ECD spectroscopy. These compounds were evaluated for cytotoxicity against three breast cancer cell lines inclusive of MDA-MB-231, SKBR3, and MCF-7. These results indicate that the UPLC-QTOFMS(E)-guided isolation procedure is an efficient strategy for isolating new benzophenones from Garcinia species.
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in vitro antiplasmodial activity of benzophenones and xanthones from edible fruits of Garcinia species
Planta Medica, 2014Co-Authors: James T Lyles, Adam Negrin, Shabana I Khan, Edward J KennellyAbstract:Species of Garcinia have been used to combat malaria in traditional African and Asian medicines, including Ayurveda. In the current study, we have identified antiplasmodial benzophenone and xanthone compounds from edible Garcinia species by testing for in vitro inhibitory activity against Plasmodium falciparum. Whole fruits of Garcinia xanthochymus, G. mangostana, G. spicata, and G. livingstonei were extracted and tested for antiplasmodial activity. Garcinia xanthochymus was subjected to bioactivity-guided fractionation to identify active partitions. Purified benzophenones (1-9) and xanthones (10-18) were then screened in the plasmodial lactate dehydrogenase assay and tested for cytotoxicity against mammalian (Vero) cells. The benzophenones guttiferone E (4), isoxanthochymol (5), and guttiferone H (6), isolated from G. xanthochymus, and the xanthones α-mangostin (15), β-mangostin (16), and 3-isomangostin (17), known from G. mangostana, showed antiplasmodial activity with IC50 values in the range of 4.71-11.40 µM. Artemisinin and chloroquine were used as positive controls and exhibited IC50 values in the range of 0.01-0.24 µM. The identification of antiplasmodial benzophenone and xanthone compounds from G. xanthochymus and G. mangostana provides evidence for the antiplasmodial activity of Garcinia species and warrants further investigation of these fruits as dietary sources of chemopreventive compounds.
Achmad Ilham Rizwani - One of the best experts on this subject based on the ideXlab platform.
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Therapeutic Potency of Mangosteen (Garcinia mangostana) Peel Extract For Shigella dysenteriae Infected Mice’s Colon Mucosal Destruction
JUXTA: Jurnal Ilmiah Mahasiswa Kedokteran Universitas Airlangga, 2019Co-Authors: Achmad Ilham Rizwani, Arifa Mustika, Lindawati AlimsardjonoAbstract:Introduction : Antibiotics treatment for bacillary dysentery due to Shigella dysenteriae infection have shown resistancy. Mangosteen ( Garcinia maangostana) peel have a therapy potency for Shigella dysenteriae infection due to its antibacterial and antiinflamation activity. Methods : This research was an experimental research, 30 mice was used which divided to 5 groups. The mice was infected with Shigella dysenteriae intraperitoneally, then azithromycin, aquadest, and 3 different doses of mangosteen (Garcinia mangostana ) peel was given for each group for 5 days, which then the mice’s colon was collected and made into histopathology slide and its mucosal destruction was observed in 3 fields of view in each slide, 1 – 4 score was given acording to its mucosal destruction. Kruskal-Wallis test is used to analyze the data and then Mann Whitney test also used for further analysis. Result : there was a healing effect obeserved when mangosteen ( Garcinia mangostana ) peel extract was given to the mice’s colon mucosal, 100 mg/Kg body mass dose of mangosteen ( Garcinia mangostana ) peel extract already given a positive effect on mice’s mucosal colon histopathological appearance, no difference observed between 3 dose given. Conclusion : Mangosteen ( Garcinia mangostana ) peel extract consumption gave healing appearance to destruction of colon mucosal wall of mice with Shigella dysenteriae infection at 100 mg/Kg body mass.
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POTENSI TERAPI EKSTRAK KULIT MANGGIS (Garcinia mangostana) TERHADAP KERUSAKAN MUKOSA KOLON PADA MODEL HEWAN COBA MENCIT INFEKSI Shigella dysenteriae
2018Co-Authors: Achmad Ilham RizwaniAbstract:Background : Antibiotics treatment for bacillary dysentery due to Shigella dysenteriae infection have shown resistency. Mangosteen (Garcinia maangostana) rind have a therapy potency for Shigella dysenteriae infection due to its antibacterial, antiinflamation, and antioxidant activity. Objectives : Studying the potency of therapy with mangosteen (Garcinia mangostana) rind to mice’s colon mucose with Shigella dysenteriae infection. Methods : This research was an experimintal research, 30 mices was used which divided to 5 groups. The mices was infected with Shigella dysenteriae intraperitoneally, then azithromycin, aquadest, and 3 different doses of mangosteen (Garcinia mangostana) rind was given for each group for 5 days, which then the mice’s colon was collected and made into histopathology slide and its mucosal destruction was observed in 3 fields of view in each slide, 1 – 4 score was given acording to its mucosal destruction. Kruskal-Wallis test is used to analyzed the data and then Mann Whitney test also used for further analyze. Result : there was a healing effect obeserved when mangosteen (Garcinia mangostana) rind extract was given to the mice’s colon mucosal, 100 mg/Kg body mass dose of mangosteen (Garcinia mangostana) rind extract already given a positive effect on mice’s mucosal colon histopathological appearance, no difference observed between 3 dose given. Conclusion : Mangosteen (Garcinia mangostana) rind extract consumption gave healing appearance to destruction of colon mucosal wall of mices with Shigella dysenteriae infection at 100 mg/Kg body mass. Keyword : Mangosteen rind extract, Shigella dysenteriae, bacillary dysenteriae, Mice’s colon mucosal
K. A. Anu Appaiah - One of the best experts on this subject based on the ideXlab platform.
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Application of native yeast from Garcinia (Garcinia xanthochumus) for the preparation of fermented beverage: Changes in biochemical and antioxidant properties
Food Bioscience, 2014Co-Authors: Amit Kumar Rai, K. A. Anu AppaiahAbstract:Abstract Garcinia beverage was prepared by fermentation of ameliorated must of Garcinia xanthochymus using native yeast isolated from naturally fermented Garcinia must. The native yeast was identified as Hanseniaspora sp. (Accession no. U826968 ) based on biochemical and molecular tests. Low alcoholic Garcinia beverages were prepared at four different must concentration (5%, 10%, 20%, and 30% w/v). Fermentation using Hansiniaspora sp. was carried out for 28 days and the fermented must were analyzed for changes in physical, biochemical and sensory characteristics. The present study mainly focused on changes in organic acid profile during fermentation, in particular, degradation of oxalic acid and antioxidant properties of the fermented beverage. Results showed utilization of citric acid and 100% degradation of oxalic acid (antinutritional factor) with the synthesis of aspartic acid. Antioxidant activity (DPPH radical scavenging activity) was significantly higher in beverage with higher must concentration along with dose dependency. Upon sensory analysis, the beverage prepared with 5% and 10% must were the only acceptable ones.
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Production of Garcinia wine: changes in biochemical parameters, organic acids and free sugars during fermentation of Garcinia must.
International Journal of Food Science & Technology, 2010Co-Authors: Amit Kumar Rai, Maya Prakash, K. A. Anu AppaiahAbstract:Garcinia wine was prepared by fermentation of ameliorated must of Garcinia xanthochymus using Saccharomyces cerevisiae. The present studies focused on changes in biochemical parameters (brix, pH, aldehydes, esters and alcohols), organic acids (reduction of oxalic acid), free sugars and antioxidant activities on fermentation of Garcinia must. The wine had higher amount of residual sugars contributing to the calorific value. The aldehydes and esters content in the final wine were 0.034% and 0.26%, respectively. There was reduction of citric acid and oxalic acid (antinutritional factor) and synthesis of aspartic acid and glutamic acid. Garcinia beverage was accepted on sensory analysis with high score for desirable attributes and overall quality with alcohol content of 6.1%. There was increase in total phenolics (0.039% gallic acid equivalent) and reducing power on fermentation but decrease in 2,2-diphenyl-1-picrylhydrazyl radical scavenging activity.
