The Experts below are selected from a list of 204 Experts worldwide ranked by ideXlab platform
G N J Tytgat - One of the best experts on this subject based on the ideXlab platform.
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acute upper gi Bleeding did anything change time trend analysis of incidence and outcome of acute upper gi Bleeding between 1993 1994 and 2000
The American Journal of Gastroenterology, 2003Co-Authors: M E Van Leerdam, E M Vreeburg, E A J Rauws, A A M Geraedts, Jan G P Tijssen, Johannes B Reitsma, G N J TytgatAbstract:Abstract Objectives The aim of this study was to examine recent time trends in incidence and outcome of upper GI Bleeding. Methods Prospective data collection on all patients presenting with acute upper GI Bleeding from a defined geographical area in the period 1993/1994 and 2000. Results Incidence decreased from 61.7/100,000 in 1993/94 to 47.7/100,000 persons annually in 2000, corresponding to a 23% decrease in incidence after age adjustment (95% CI = 15–30%). The incidence was higher among patients of more advanced age. ReBleeding (16% vs 15%) and mortality (14% vs 13%) did not differ between the two time periods. Ulcer Bleeding was the most frequent cause of Bleeding, at 40% (1993/94) and 46% (2000). Incidence remained stable for both duodenal and Gastric Ulcer Bleeding. Almost one half of all patients with peptic Ulcer Bleeding were using nonsteroidal anti-inflammatory drugs or aspirin. Also, among patients with Ulcer Bleeding, reBleeding (22% vs 20%) and mortality (15% vs 14%) did not differ between the two time periods. Increasing age, presence of severe and life-threatening comorbidity, and reBleeding were associated with higher mortality. Conclusions Between 1993/1994 and 2000, among patients with acute upper GI Bleeding, the incidence rate of upper GI Bleeding significantly decreased, but no improvement was seen in the risk of reBleeding or mortality in these patients. The incidence rate of Ulcer Bleeding remained stable. Prevention of Ulcer Bleeding is important.
Bor-shyang Sheu - One of the best experts on this subject based on the ideXlab platform.
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Weak up-regulation of serum response factor in Gastric Ulcers in patients with co-morbidities is associated with increased risk of recurrent Bleeding
BMC Gastroenterology, 2011Co-Authors: Hsiu-chi Cheng, Hsiao-bai Yang, Wei-lun Chang, Yi-chun Yeh, Yu-ching Tsai, Bor-shyang SheuAbstract:Background Serum response factor (SRF) is crucial for Gastric Ulcer healing process. The study determined if Gastric Ulcer tissues up-regulate SRF and if such up-regulation correlated with co-morbidities and the risk of recurrent Bleeding. Methods Ulcer and non-Ulcer tissues were obtained from 142 patients with active Gastric Ulcers for SRF expression assessed by immunohistochemistry. Based on the degree of SRF expression between these two tissue types, SRF up-regulation was classified as strong, intermediate, and weak patterns. The patients were followed-up to determine if SRF up-regulation correlated to recurrent Bleeding. Results Gastric Ulcer tissues had higher SRF expression than non-Ulcer tissues ( p < 0.05). Patients with strong SRF up-regulation had lower rates of stigmata of recent hemorrhage (SRH) on the Ulcer base than the others ( p < 0.05). Multivariate logistic regression confirmed that co-morbidities and weak SRF up-regulation were two independent factors of recurrent Gastric Ulcer Bleeding ( p < 0.05). Combining both factors, there was an 8.29-fold (95% CI, 1.31~52.62; p = 0.03) higher risk of recurrent Gastric Ulcer Bleeding. Conclusions SRF expression is higher in Gastric Ulcer tissues than in non-Ulcer tissues. Weak SRF up-regulation, combined with the presence of co-morbidities, increase the risk of the recurrent Gastric Ulcer Bleeding.
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Weak up-regulation of serum response factor in Gastric Ulcers in patients with co-morbidities is associated with increased risk of recurrent Bleeding.
BMC gastroenterology, 2011Co-Authors: Hsiu-chi Cheng, Hsiao-bai Yang, Wei-lun Chang, Yi-chun Yeh, Yu-ching Tsai, Bor-shyang SheuAbstract:Serum response factor (SRF) is crucial for Gastric Ulcer healing process. The study determined if Gastric Ulcer tissues up-regulate SRF and if such up-regulation correlated with co-morbidities and the risk of recurrent Bleeding. Ulcer and non-Ulcer tissues were obtained from 142 patients with active Gastric Ulcers for SRF expression assessed by immunohistochemistry. Based on the degree of SRF expression between these two tissue types, SRF up-regulation was classified as strong, intermediate, and weak patterns. The patients were followed-up to determine if SRF up-regulation correlated to recurrent Bleeding. Gastric Ulcer tissues had higher SRF expression than non-Ulcer tissues (p < 0.05). Patients with strong SRF up-regulation had lower rates of stigmata of recent hemorrhage (SRH) on the Ulcer base than the others (p < 0.05). Multivariate logistic regression confirmed that co-morbidities and weak SRF up-regulation were two independent factors of recurrent Gastric Ulcer Bleeding (p < 0.05). Combining both factors, there was an 8.29-fold (95% CI, 1.31~52.62; p = 0.03) higher risk of recurrent Gastric Ulcer Bleeding. SRF expression is higher in Gastric Ulcer tissues than in non-Ulcer tissues. Weak SRF up-regulation, combined with the presence of co-morbidities, increase the risk of the recurrent Gastric Ulcer Bleeding.
Shih-chung Hsieh - One of the best experts on this subject based on the ideXlab platform.
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Acute thrombosis of a transplanted renal artery after Gastric Ulcer Bleeding in a patient with a long-term well-functioning renal allograft: A case report and literature review.
Medicine, 2016Co-Authors: Jyh-gang Leu, Cheng-chun Wei, Shih-chung HsiehAbstract:Background Acute thrombosis of a transplanted renal artery is a serious vascular complication following renal allograft transplantation, which usually occurs within the first month after transplantation and often results in graft loss. It rarely occurs beyond the first month, except in a rejected kidney or in a kidney with high-grade transplant renal artery stenosis. Result A 65-year-old male with a history of type 2 diabetes mellitus, hypertension, pulmonary tuberculosis, and end-stage renal disease was previously treated with hemodialysis (HD). He received a kidney transplant and had a well-functioning graft for 2 years. He presented to our emergency department with Gastric Ulcer Bleeding and received treatment involving an endoscopic submucosal epinephrine injection, a proton pump inhibitor, and blood transfusions. Nine days later, he complained of sudden lower abdominal pain and had acute anuric kidney failure. Renal ultrasonography revealed an absence of blood flow to the allograft kidney. Renal artery angiogram demonstrated complete occlusion of the transplanted renal artery. After thrombectomy and percutaneous transluminal angioplasty (PTA) with stent placement, 60% stenosis of the proximal renal artery with distal perfusion was noted. However, his graft function did not improve, and he received HD again. Histopathology of the transplanted kidney revealed ischemic tubular nephropathy with focal infarction without rejection. Conclusion This is the first case of acute thrombosis of the transplanted renal artery following Gastric Ulcer Bleeding in a patient with a long-term well-functioning graft kidney.
M E Van Leerdam - One of the best experts on this subject based on the ideXlab platform.
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acute upper gi Bleeding did anything change time trend analysis of incidence and outcome of acute upper gi Bleeding between 1993 1994 and 2000
The American Journal of Gastroenterology, 2003Co-Authors: M E Van Leerdam, E M Vreeburg, E A J Rauws, A A M Geraedts, Jan G P Tijssen, Johannes B Reitsma, G N J TytgatAbstract:Abstract Objectives The aim of this study was to examine recent time trends in incidence and outcome of upper GI Bleeding. Methods Prospective data collection on all patients presenting with acute upper GI Bleeding from a defined geographical area in the period 1993/1994 and 2000. Results Incidence decreased from 61.7/100,000 in 1993/94 to 47.7/100,000 persons annually in 2000, corresponding to a 23% decrease in incidence after age adjustment (95% CI = 15–30%). The incidence was higher among patients of more advanced age. ReBleeding (16% vs 15%) and mortality (14% vs 13%) did not differ between the two time periods. Ulcer Bleeding was the most frequent cause of Bleeding, at 40% (1993/94) and 46% (2000). Incidence remained stable for both duodenal and Gastric Ulcer Bleeding. Almost one half of all patients with peptic Ulcer Bleeding were using nonsteroidal anti-inflammatory drugs or aspirin. Also, among patients with Ulcer Bleeding, reBleeding (22% vs 20%) and mortality (15% vs 14%) did not differ between the two time periods. Increasing age, presence of severe and life-threatening comorbidity, and reBleeding were associated with higher mortality. Conclusions Between 1993/1994 and 2000, among patients with acute upper GI Bleeding, the incidence rate of upper GI Bleeding significantly decreased, but no improvement was seen in the risk of reBleeding or mortality in these patients. The incidence rate of Ulcer Bleeding remained stable. Prevention of Ulcer Bleeding is important.
Hsiu-chi Cheng - One of the best experts on this subject based on the ideXlab platform.
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Weak up-regulation of serum response factor in Gastric Ulcers in patients with co-morbidities is associated with increased risk of recurrent Bleeding
BMC Gastroenterology, 2011Co-Authors: Hsiu-chi Cheng, Hsiao-bai Yang, Wei-lun Chang, Yi-chun Yeh, Yu-ching Tsai, Bor-shyang SheuAbstract:Background Serum response factor (SRF) is crucial for Gastric Ulcer healing process. The study determined if Gastric Ulcer tissues up-regulate SRF and if such up-regulation correlated with co-morbidities and the risk of recurrent Bleeding. Methods Ulcer and non-Ulcer tissues were obtained from 142 patients with active Gastric Ulcers for SRF expression assessed by immunohistochemistry. Based on the degree of SRF expression between these two tissue types, SRF up-regulation was classified as strong, intermediate, and weak patterns. The patients were followed-up to determine if SRF up-regulation correlated to recurrent Bleeding. Results Gastric Ulcer tissues had higher SRF expression than non-Ulcer tissues ( p < 0.05). Patients with strong SRF up-regulation had lower rates of stigmata of recent hemorrhage (SRH) on the Ulcer base than the others ( p < 0.05). Multivariate logistic regression confirmed that co-morbidities and weak SRF up-regulation were two independent factors of recurrent Gastric Ulcer Bleeding ( p < 0.05). Combining both factors, there was an 8.29-fold (95% CI, 1.31~52.62; p = 0.03) higher risk of recurrent Gastric Ulcer Bleeding. Conclusions SRF expression is higher in Gastric Ulcer tissues than in non-Ulcer tissues. Weak SRF up-regulation, combined with the presence of co-morbidities, increase the risk of the recurrent Gastric Ulcer Bleeding.
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Weak up-regulation of serum response factor in Gastric Ulcers in patients with co-morbidities is associated with increased risk of recurrent Bleeding.
BMC gastroenterology, 2011Co-Authors: Hsiu-chi Cheng, Hsiao-bai Yang, Wei-lun Chang, Yi-chun Yeh, Yu-ching Tsai, Bor-shyang SheuAbstract:Serum response factor (SRF) is crucial for Gastric Ulcer healing process. The study determined if Gastric Ulcer tissues up-regulate SRF and if such up-regulation correlated with co-morbidities and the risk of recurrent Bleeding. Ulcer and non-Ulcer tissues were obtained from 142 patients with active Gastric Ulcers for SRF expression assessed by immunohistochemistry. Based on the degree of SRF expression between these two tissue types, SRF up-regulation was classified as strong, intermediate, and weak patterns. The patients were followed-up to determine if SRF up-regulation correlated to recurrent Bleeding. Gastric Ulcer tissues had higher SRF expression than non-Ulcer tissues (p < 0.05). Patients with strong SRF up-regulation had lower rates of stigmata of recent hemorrhage (SRH) on the Ulcer base than the others (p < 0.05). Multivariate logistic regression confirmed that co-morbidities and weak SRF up-regulation were two independent factors of recurrent Gastric Ulcer Bleeding (p < 0.05). Combining both factors, there was an 8.29-fold (95% CI, 1.31~52.62; p = 0.03) higher risk of recurrent Gastric Ulcer Bleeding. SRF expression is higher in Gastric Ulcer tissues than in non-Ulcer tissues. Weak SRF up-regulation, combined with the presence of co-morbidities, increase the risk of the recurrent Gastric Ulcer Bleeding.
