The Experts below are selected from a list of 7074 Experts worldwide ranked by ideXlab platform
Michael Horowitz - One of the best experts on this subject based on the ideXlab platform.
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load dependent effects of duodenal glucose on glycemia Gastrointestinal Hormones antropyloroduodenal motility and energy intake in healthy men
2007Co-Authors: Amelia N Pilichiewicz, Michael Horowitz, André J. P. M. Smout, Judith M. Wishart, Reawika Chaikomin, Ixchel M Brennan, Christopher K Rayner, Karen L Jones, Christine FeinlebissetAbstract:Gastric emptying is a major determinant of glycemia, Gastrointestinal Hormone release, and appetite. We determined the effects of different intraduodenal glucose loads on glycemia, insulinemia, glu...
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modulation by high fat diets of Gastrointestinal function and Hormones associated with the regulation of energy intake implications for the pathophysiology of obesity
2007Co-Authors: Tanya J Little, Michael Horowitz, Christine FeinlebissetAbstract:The presence of fat in the small intestine slows gastric emptying, stimulates the release of many Gastrointestinal Hormones, and suppresses appetite and energy intake as a result of the digestion of fats into free fatty acids; the effects of free fatty acids are, in turn, dependent on their chain length. Given these effects of fat, it is paradoxical that high dietary fat intakes have been linked to increased energy intake and body weight and are considered to play a significant role in the pathogenesis of obesity. However, increasing evidence indicates that a chronic increase in dietary fat is associated with an attenuation of the feedback signals arising from the small intestine induced by fat, with a consequent relative acceleration of gastric emptying, modulation of Gastrointestinal Hormone secretion, and attenuation of the suppression of energy intake. This review addresses the Gastrointestinal factors involved in the regulation of appetite and energy intake, with a particular focus on 1) the Gastrointestinal mechanisms triggered by small intestinal fat that modulate energy intake, 2) the potential role of a high dietary fat intake in the development of obesity, and 3) implications for the prevention and management of obesity.
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dose related effects of lauric acid on antropyloroduodenal motility Gastrointestinal Hormone release appetite and energy intake in healthy men
2005Co-Authors: Tanya J Little, Michael Horowitz, André J. P. M. Smout, Judith M. Wishart, Amelia N Pilichiewicz, Kate L Feltrin, Thomas Rades, James H Meyer, Christine FeinlebissetAbstract:We recently reported that intraduodenal infusion of lauric acid (C12) (0.375 kcal/min, 106 mM) stimulates isolated pyloric pressure waves (IPPWs), inhibits antral and duodenal pressure waves (PWs),...
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Original contributionEffect of small intestinal nutrient infusion on appetite, Gastrointestinal Hormone release, and gastric myoelectrical activity in young and older men
2001Co-Authors: Caroline G. Macintosh, Michael Horowitz, Marc A.m.t. Verhagen, André J. P. M. Smout, Judith M. Wishart, Howard A. Morris, Elizabeth A. Goble, John E. Morley, Ian ChapmanAbstract:OBJECTIVE: The mechanisms responsible for the reduction in appetite and slowing of gastric emptying in older persons are poorly understood. The aim of this study was to evaluate the effects of aging on small intestinal regulation of appetite, GI Hormone release, and gastric myoelectrical activity. METHODS: Thirteen older (65–84 yr) and 13 young (18–32 yr) healthy men received isovolumetric, intraduodenal (ID) infusions of saline (control), lipid, and glucose for 120 min, on separate days. The energy content of the lipid and glucose infusions was identical at 2.86 kcal/min. Immediately after the ID infusions, each subject was offered a buffet meal, and ad libitum food intake was quantified. Blood glucose and plasma insulin, glucagon-like peptide 1, and glucose-dependent insulinotropic peptide were measured. Gastric myoelectrical activity was measured by surface electrogastrography (EGG). RESULTS: ID lipid suppressed food intake in both the young and older men (p < 0.05), whereas ID glucose suppressed food intake only in the older men (p < 0.05). The blood glucose (p < 0.01) and insulin (p < 0.05) responses to ID glucose were greater in older than young men. However, there were no differences in glucagon-like peptide 1 or glucose-dependent insulinotropic peptide responses to any of the infusions. There was a greater increase in the EGG power ratio both during and after ID glucose infusion in the young (p < 0.05) than the older men, and an attenuation of EGG frequency by nutrient infusions in older, but not young, men. CONCLUSIONS: Our findings indicate that aging is associated with nutrient-specific changes in appetite, hormonal, and gastric myoelectrical (EGG) responses to ID nutrients. An enhanced satiating effect of small intestinal carbohydrates may potentially contribute to the anorexia of aging.
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effect of small intestinal nutrient infusion on appetite Gastrointestinal Hormone release and gastric myoelectrical activity in young and older men
2001Co-Authors: Caroline G. Macintosh, Michael Horowitz, Marc A.m.t. Verhagen, André J. P. M. Smout, Judith M. Wishart, Howard A. Morris, Elizabeth A. Goble, John E. Morley, Ian T ChapmanAbstract:Effect of small intestinal nutrient infusion on appetite, Gastrointestinal Hormone release, and gastric myoelectrical activity in young and older men
André J. P. M. Smout - One of the best experts on this subject based on the ideXlab platform.
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load dependent effects of duodenal glucose on glycemia Gastrointestinal Hormones antropyloroduodenal motility and energy intake in healthy men
2007Co-Authors: Amelia N Pilichiewicz, Michael Horowitz, André J. P. M. Smout, Judith M. Wishart, Reawika Chaikomin, Ixchel M Brennan, Christopher K Rayner, Karen L Jones, Christine FeinlebissetAbstract:Gastric emptying is a major determinant of glycemia, Gastrointestinal Hormone release, and appetite. We determined the effects of different intraduodenal glucose loads on glycemia, insulinemia, glu...
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dose related effects of lauric acid on antropyloroduodenal motility Gastrointestinal Hormone release appetite and energy intake in healthy men
2005Co-Authors: Tanya J Little, Michael Horowitz, André J. P. M. Smout, Judith M. Wishart, Amelia N Pilichiewicz, Kate L Feltrin, Thomas Rades, James H Meyer, Christine FeinlebissetAbstract:We recently reported that intraduodenal infusion of lauric acid (C12) (0.375 kcal/min, 106 mM) stimulates isolated pyloric pressure waves (IPPWs), inhibits antral and duodenal pressure waves (PWs),...
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Original contributionEffect of small intestinal nutrient infusion on appetite, Gastrointestinal Hormone release, and gastric myoelectrical activity in young and older men
2001Co-Authors: Caroline G. Macintosh, Michael Horowitz, Marc A.m.t. Verhagen, André J. P. M. Smout, Judith M. Wishart, Howard A. Morris, Elizabeth A. Goble, John E. Morley, Ian ChapmanAbstract:OBJECTIVE: The mechanisms responsible for the reduction in appetite and slowing of gastric emptying in older persons are poorly understood. The aim of this study was to evaluate the effects of aging on small intestinal regulation of appetite, GI Hormone release, and gastric myoelectrical activity. METHODS: Thirteen older (65–84 yr) and 13 young (18–32 yr) healthy men received isovolumetric, intraduodenal (ID) infusions of saline (control), lipid, and glucose for 120 min, on separate days. The energy content of the lipid and glucose infusions was identical at 2.86 kcal/min. Immediately after the ID infusions, each subject was offered a buffet meal, and ad libitum food intake was quantified. Blood glucose and plasma insulin, glucagon-like peptide 1, and glucose-dependent insulinotropic peptide were measured. Gastric myoelectrical activity was measured by surface electrogastrography (EGG). RESULTS: ID lipid suppressed food intake in both the young and older men (p < 0.05), whereas ID glucose suppressed food intake only in the older men (p < 0.05). The blood glucose (p < 0.01) and insulin (p < 0.05) responses to ID glucose were greater in older than young men. However, there were no differences in glucagon-like peptide 1 or glucose-dependent insulinotropic peptide responses to any of the infusions. There was a greater increase in the EGG power ratio both during and after ID glucose infusion in the young (p < 0.05) than the older men, and an attenuation of EGG frequency by nutrient infusions in older, but not young, men. CONCLUSIONS: Our findings indicate that aging is associated with nutrient-specific changes in appetite, hormonal, and gastric myoelectrical (EGG) responses to ID nutrients. An enhanced satiating effect of small intestinal carbohydrates may potentially contribute to the anorexia of aging.
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effect of small intestinal nutrient infusion on appetite Gastrointestinal Hormone release and gastric myoelectrical activity in young and older men
2001Co-Authors: Caroline G. Macintosh, Michael Horowitz, Marc A.m.t. Verhagen, André J. P. M. Smout, Judith M. Wishart, Howard A. Morris, Elizabeth A. Goble, John E. Morley, Ian T ChapmanAbstract:Effect of small intestinal nutrient infusion on appetite, Gastrointestinal Hormone release, and gastric myoelectrical activity in young and older men
Judith M. Wishart - One of the best experts on this subject based on the ideXlab platform.
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load dependent effects of duodenal glucose on glycemia Gastrointestinal Hormones antropyloroduodenal motility and energy intake in healthy men
2007Co-Authors: Amelia N Pilichiewicz, Michael Horowitz, André J. P. M. Smout, Judith M. Wishart, Reawika Chaikomin, Ixchel M Brennan, Christopher K Rayner, Karen L Jones, Christine FeinlebissetAbstract:Gastric emptying is a major determinant of glycemia, Gastrointestinal Hormone release, and appetite. We determined the effects of different intraduodenal glucose loads on glycemia, insulinemia, glu...
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dose related effects of lauric acid on antropyloroduodenal motility Gastrointestinal Hormone release appetite and energy intake in healthy men
2005Co-Authors: Tanya J Little, Michael Horowitz, André J. P. M. Smout, Judith M. Wishart, Amelia N Pilichiewicz, Kate L Feltrin, Thomas Rades, James H Meyer, Christine FeinlebissetAbstract:We recently reported that intraduodenal infusion of lauric acid (C12) (0.375 kcal/min, 106 mM) stimulates isolated pyloric pressure waves (IPPWs), inhibits antral and duodenal pressure waves (PWs),...
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Original contributionEffect of small intestinal nutrient infusion on appetite, Gastrointestinal Hormone release, and gastric myoelectrical activity in young and older men
2001Co-Authors: Caroline G. Macintosh, Michael Horowitz, Marc A.m.t. Verhagen, André J. P. M. Smout, Judith M. Wishart, Howard A. Morris, Elizabeth A. Goble, John E. Morley, Ian ChapmanAbstract:OBJECTIVE: The mechanisms responsible for the reduction in appetite and slowing of gastric emptying in older persons are poorly understood. The aim of this study was to evaluate the effects of aging on small intestinal regulation of appetite, GI Hormone release, and gastric myoelectrical activity. METHODS: Thirteen older (65–84 yr) and 13 young (18–32 yr) healthy men received isovolumetric, intraduodenal (ID) infusions of saline (control), lipid, and glucose for 120 min, on separate days. The energy content of the lipid and glucose infusions was identical at 2.86 kcal/min. Immediately after the ID infusions, each subject was offered a buffet meal, and ad libitum food intake was quantified. Blood glucose and plasma insulin, glucagon-like peptide 1, and glucose-dependent insulinotropic peptide were measured. Gastric myoelectrical activity was measured by surface electrogastrography (EGG). RESULTS: ID lipid suppressed food intake in both the young and older men (p < 0.05), whereas ID glucose suppressed food intake only in the older men (p < 0.05). The blood glucose (p < 0.01) and insulin (p < 0.05) responses to ID glucose were greater in older than young men. However, there were no differences in glucagon-like peptide 1 or glucose-dependent insulinotropic peptide responses to any of the infusions. There was a greater increase in the EGG power ratio both during and after ID glucose infusion in the young (p < 0.05) than the older men, and an attenuation of EGG frequency by nutrient infusions in older, but not young, men. CONCLUSIONS: Our findings indicate that aging is associated with nutrient-specific changes in appetite, hormonal, and gastric myoelectrical (EGG) responses to ID nutrients. An enhanced satiating effect of small intestinal carbohydrates may potentially contribute to the anorexia of aging.
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effect of small intestinal nutrient infusion on appetite Gastrointestinal Hormone release and gastric myoelectrical activity in young and older men
2001Co-Authors: Caroline G. Macintosh, Michael Horowitz, Marc A.m.t. Verhagen, André J. P. M. Smout, Judith M. Wishart, Howard A. Morris, Elizabeth A. Goble, John E. Morley, Ian T ChapmanAbstract:Effect of small intestinal nutrient infusion on appetite, Gastrointestinal Hormone release, and gastric myoelectrical activity in young and older men
Caroline G. Macintosh - One of the best experts on this subject based on the ideXlab platform.
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Original contributionEffect of small intestinal nutrient infusion on appetite, Gastrointestinal Hormone release, and gastric myoelectrical activity in young and older men
2001Co-Authors: Caroline G. Macintosh, Michael Horowitz, Marc A.m.t. Verhagen, André J. P. M. Smout, Judith M. Wishart, Howard A. Morris, Elizabeth A. Goble, John E. Morley, Ian ChapmanAbstract:OBJECTIVE: The mechanisms responsible for the reduction in appetite and slowing of gastric emptying in older persons are poorly understood. The aim of this study was to evaluate the effects of aging on small intestinal regulation of appetite, GI Hormone release, and gastric myoelectrical activity. METHODS: Thirteen older (65–84 yr) and 13 young (18–32 yr) healthy men received isovolumetric, intraduodenal (ID) infusions of saline (control), lipid, and glucose for 120 min, on separate days. The energy content of the lipid and glucose infusions was identical at 2.86 kcal/min. Immediately after the ID infusions, each subject was offered a buffet meal, and ad libitum food intake was quantified. Blood glucose and plasma insulin, glucagon-like peptide 1, and glucose-dependent insulinotropic peptide were measured. Gastric myoelectrical activity was measured by surface electrogastrography (EGG). RESULTS: ID lipid suppressed food intake in both the young and older men (p < 0.05), whereas ID glucose suppressed food intake only in the older men (p < 0.05). The blood glucose (p < 0.01) and insulin (p < 0.05) responses to ID glucose were greater in older than young men. However, there were no differences in glucagon-like peptide 1 or glucose-dependent insulinotropic peptide responses to any of the infusions. There was a greater increase in the EGG power ratio both during and after ID glucose infusion in the young (p < 0.05) than the older men, and an attenuation of EGG frequency by nutrient infusions in older, but not young, men. CONCLUSIONS: Our findings indicate that aging is associated with nutrient-specific changes in appetite, hormonal, and gastric myoelectrical (EGG) responses to ID nutrients. An enhanced satiating effect of small intestinal carbohydrates may potentially contribute to the anorexia of aging.
-
effect of small intestinal nutrient infusion on appetite Gastrointestinal Hormone release and gastric myoelectrical activity in young and older men
2001Co-Authors: Caroline G. Macintosh, Michael Horowitz, Marc A.m.t. Verhagen, André J. P. M. Smout, Judith M. Wishart, Howard A. Morris, Elizabeth A. Goble, John E. Morley, Ian T ChapmanAbstract:Effect of small intestinal nutrient infusion on appetite, Gastrointestinal Hormone release, and gastric myoelectrical activity in young and older men
Christine Feinlebisset - One of the best experts on this subject based on the ideXlab platform.
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load dependent effects of duodenal glucose on glycemia Gastrointestinal Hormones antropyloroduodenal motility and energy intake in healthy men
2007Co-Authors: Amelia N Pilichiewicz, Michael Horowitz, André J. P. M. Smout, Judith M. Wishart, Reawika Chaikomin, Ixchel M Brennan, Christopher K Rayner, Karen L Jones, Christine FeinlebissetAbstract:Gastric emptying is a major determinant of glycemia, Gastrointestinal Hormone release, and appetite. We determined the effects of different intraduodenal glucose loads on glycemia, insulinemia, glu...
-
modulation by high fat diets of Gastrointestinal function and Hormones associated with the regulation of energy intake implications for the pathophysiology of obesity
2007Co-Authors: Tanya J Little, Michael Horowitz, Christine FeinlebissetAbstract:The presence of fat in the small intestine slows gastric emptying, stimulates the release of many Gastrointestinal Hormones, and suppresses appetite and energy intake as a result of the digestion of fats into free fatty acids; the effects of free fatty acids are, in turn, dependent on their chain length. Given these effects of fat, it is paradoxical that high dietary fat intakes have been linked to increased energy intake and body weight and are considered to play a significant role in the pathogenesis of obesity. However, increasing evidence indicates that a chronic increase in dietary fat is associated with an attenuation of the feedback signals arising from the small intestine induced by fat, with a consequent relative acceleration of gastric emptying, modulation of Gastrointestinal Hormone secretion, and attenuation of the suppression of energy intake. This review addresses the Gastrointestinal factors involved in the regulation of appetite and energy intake, with a particular focus on 1) the Gastrointestinal mechanisms triggered by small intestinal fat that modulate energy intake, 2) the potential role of a high dietary fat intake in the development of obesity, and 3) implications for the prevention and management of obesity.
-
dose related effects of lauric acid on antropyloroduodenal motility Gastrointestinal Hormone release appetite and energy intake in healthy men
2005Co-Authors: Tanya J Little, Michael Horowitz, André J. P. M. Smout, Judith M. Wishart, Amelia N Pilichiewicz, Kate L Feltrin, Thomas Rades, James H Meyer, Christine FeinlebissetAbstract:We recently reported that intraduodenal infusion of lauric acid (C12) (0.375 kcal/min, 106 mM) stimulates isolated pyloric pressure waves (IPPWs), inhibits antral and duodenal pressure waves (PWs),...
