The Experts below are selected from a list of 5469 Experts worldwide ranked by ideXlab platform
Hong W Zhang - One of the best experts on this subject based on the ideXlab platform.
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melatonin attenuates noise stress induced Gastrointestinal motility disorder and gastric stress ulcer role of Gastrointestinal Hormones and oxidative stress in rats
Journal of Neurogastroenterology and Motility, 2015Co-Authors: Lei Zhang, Ji T Gong, Hu Q Zhang, Quan H Song, Guang H Xu, Xiao D Tang, Hai F Zhang, Hong W ZhangAbstract:BACKGROUND/AIMS: There are increasing evidences for Gastrointestinal motility disorder (GIMD) and gastric stress ulcer induced by noise stress. The present study was to investigate the reversed effect of melatonin on GIMD and gastric stress ulcer induced by noise stress and potential mechanism. METHODS: Noise stress was induced on rats, and melatonin (15 mg/kg) was administered to rats by intraperitoneal injection. Differences were assessed in gastric residual rate (GRR), small intestine propulsion rate (SPR), Guth injury score, cortisol, Gastrointestinal Hormones (calcitonin-gene-related peptide and motilin) and oxidative stress markers (superoxide dismutase and malondialde hyde) in blood plasma as well as gastric mucosa homogenate with or without melatonin. The pathological examination of gastric mucosa was also performed. RESULTS: The GRR and SPR were improved by noise stress compared with control (P < 0.05). The pathological examination and Guth injury score revealed gastric stress ulcer. Moreover, the levels of cortisol, motilin and malondialdehyde in blood plasma and ma-londialdehyde in gastric mucosa homogenate were increased by noise stress (P < 0.05). CGRP and superoxide dismutase activ-ity in both of blood plasma and gastric mucosa homogenate were significantly decreased (P< 0.05). Furthermore, melatonin reversed changes in GRR, SPR, pathological examination, Guth injury score, cortisol, motilin, CGRP, superoxide dismutase activity and malondialdehyde (P < 0.05). CONCLUSIONS: Melatonin is effective in reversing the GIMD and gastric stress ulcer induced by noise stress. The underlying mechanism may be involved in oxidative stress and Gastrointestinal Hormones.
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melatonin attenuates noise stress induced Gastrointestinal motility disorder and gastric stress ulcer role of Gastrointestinal Hormones and oxidative stress in rats
Journal of Neurogastroenterology and Motility, 2015Co-Authors: Lei Zhang, Ji T Gong, Hu Q Zhang, Quan H Song, Guang H Xu, Xiao D Tang, Hai F Zhang, Hong W ZhangAbstract:BACKGROUND/AIMS: There are increasing evidences for Gastrointestinal motility disorder (GIMD) and gastric stress ulcer induced by noise stress. The present study was to investigate the reversed effect of melatonin on GIMD and gastric stress ulcer induced by noise stress and potential mechanism. METHODS: Noise stress was induced on rats, and melatonin (15 mg/kg) was administered to rats by intraperitoneal injection. Differences were assessed in gastric residual rate (GRR), small intestine propulsion rate (SPR), Guth injury score, cortisol, Gastrointestinal Hormones (calcitonin-gene-related peptide and motilin) and oxidative stress markers (superoxide dismutase and malondialde hyde) in blood plasma as well as gastric mucosa homogenate with or without melatonin. The pathological examination of gastric mucosa was also performed. RESULTS: The GRR and SPR were improved by noise stress compared with control (P < 0.05). The pathological examination and Guth injury score revealed gastric stress ulcer. Moreover, the levels of cortisol, motilin and malondialdehyde in blood plasma and ma-londialdehyde in gastric mucosa homogenate were increased by noise stress (P < 0.05). CGRP and superoxide dismutase activ-ity in both of blood plasma and gastric mucosa homogenate were significantly decreased (P< 0.05). Furthermore, melatonin reversed changes in GRR, SPR, pathological examination, Guth injury score, cortisol, motilin, CGRP, superoxide dismutase activity and malondialdehyde (P < 0.05). CONCLUSIONS: Melatonin is effective in reversing the GIMD and gastric stress ulcer induced by noise stress. The underlying mechanism may be involved in oxidative stress and Gastrointestinal Hormones.
Lei Zhang - One of the best experts on this subject based on the ideXlab platform.
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melatonin attenuates noise stress induced Gastrointestinal motility disorder and gastric stress ulcer role of Gastrointestinal Hormones and oxidative stress in rats
Journal of Neurogastroenterology and Motility, 2015Co-Authors: Lei Zhang, Ji T Gong, Hu Q Zhang, Quan H Song, Guang H Xu, Xiao D Tang, Hai F Zhang, Hong W ZhangAbstract:BACKGROUND/AIMS: There are increasing evidences for Gastrointestinal motility disorder (GIMD) and gastric stress ulcer induced by noise stress. The present study was to investigate the reversed effect of melatonin on GIMD and gastric stress ulcer induced by noise stress and potential mechanism. METHODS: Noise stress was induced on rats, and melatonin (15 mg/kg) was administered to rats by intraperitoneal injection. Differences were assessed in gastric residual rate (GRR), small intestine propulsion rate (SPR), Guth injury score, cortisol, Gastrointestinal Hormones (calcitonin-gene-related peptide and motilin) and oxidative stress markers (superoxide dismutase and malondialde hyde) in blood plasma as well as gastric mucosa homogenate with or without melatonin. The pathological examination of gastric mucosa was also performed. RESULTS: The GRR and SPR were improved by noise stress compared with control (P < 0.05). The pathological examination and Guth injury score revealed gastric stress ulcer. Moreover, the levels of cortisol, motilin and malondialdehyde in blood plasma and ma-londialdehyde in gastric mucosa homogenate were increased by noise stress (P < 0.05). CGRP and superoxide dismutase activ-ity in both of blood plasma and gastric mucosa homogenate were significantly decreased (P< 0.05). Furthermore, melatonin reversed changes in GRR, SPR, pathological examination, Guth injury score, cortisol, motilin, CGRP, superoxide dismutase activity and malondialdehyde (P < 0.05). CONCLUSIONS: Melatonin is effective in reversing the GIMD and gastric stress ulcer induced by noise stress. The underlying mechanism may be involved in oxidative stress and Gastrointestinal Hormones.
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melatonin attenuates noise stress induced Gastrointestinal motility disorder and gastric stress ulcer role of Gastrointestinal Hormones and oxidative stress in rats
Journal of Neurogastroenterology and Motility, 2015Co-Authors: Lei Zhang, Ji T Gong, Hu Q Zhang, Quan H Song, Guang H Xu, Xiao D Tang, Hai F Zhang, Hong W ZhangAbstract:BACKGROUND/AIMS: There are increasing evidences for Gastrointestinal motility disorder (GIMD) and gastric stress ulcer induced by noise stress. The present study was to investigate the reversed effect of melatonin on GIMD and gastric stress ulcer induced by noise stress and potential mechanism. METHODS: Noise stress was induced on rats, and melatonin (15 mg/kg) was administered to rats by intraperitoneal injection. Differences were assessed in gastric residual rate (GRR), small intestine propulsion rate (SPR), Guth injury score, cortisol, Gastrointestinal Hormones (calcitonin-gene-related peptide and motilin) and oxidative stress markers (superoxide dismutase and malondialde hyde) in blood plasma as well as gastric mucosa homogenate with or without melatonin. The pathological examination of gastric mucosa was also performed. RESULTS: The GRR and SPR were improved by noise stress compared with control (P < 0.05). The pathological examination and Guth injury score revealed gastric stress ulcer. Moreover, the levels of cortisol, motilin and malondialdehyde in blood plasma and ma-londialdehyde in gastric mucosa homogenate were increased by noise stress (P < 0.05). CGRP and superoxide dismutase activ-ity in both of blood plasma and gastric mucosa homogenate were significantly decreased (P< 0.05). Furthermore, melatonin reversed changes in GRR, SPR, pathological examination, Guth injury score, cortisol, motilin, CGRP, superoxide dismutase activity and malondialdehyde (P < 0.05). CONCLUSIONS: Melatonin is effective in reversing the GIMD and gastric stress ulcer induced by noise stress. The underlying mechanism may be involved in oxidative stress and Gastrointestinal Hormones.
Josep Vidal - One of the best experts on this subject based on the ideXlab platform.
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Gastrointestinal Hormones and weight loss maintenance following roux en y gastric bypass
The Journal of Clinical Endocrinology and Metabolism, 2015Co-Authors: Ana De Hollanda, Gregori Casals, Salvadora Delgado, Amanda Jimenez, Judith Viaplana, Antonio M Lacy, Josep VidalAbstract:Context: Factors underlying variable weight loss (WL) after Roux-en-Y gastric bypass (RYGB) are poorly understood. Objective: Our objective was to gain insight on the role of Gastrointestinal Hormones on poor WL maintenance (P-WLM) following RYGB. Design and Patients: First, glucagon-like peptide-1 (GLP-1), peptide YY (PYY), and ghrelin responses to a standardized mixed liquid meal (SMLM) were compared between subjects with good WL (G-WL, n = 32) or P-WLM (n = 22). Second, we evaluated food intake (FI) following blockade of gut hormonal secretion in G-WL (n = 23) or P-WLM (n = 19) subjects. Finally, the impact of dietary-induced WL on the hormonal response in subjects with P-WLM (n = 14) was assessed. Setting: This study was undertaken in a tertiary hospital. Main Outcome Measures: In studies 1 and 3, the outcomes measures were the areas under the curve of gut Hormones following a SMLM; in study 2, FI following subcutaneous injection of saline or octreotide were evaluated. Results: P-WLM associated a blun...
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Gastrointestinal Hormones and weight loss response after roux en y gastric bypass
Surgery for Obesity and Related Diseases, 2014Co-Authors: Ana De Hollanda, Amanda Jimenez, Antonio M Lacy, Ricard Corcelles, Ioana Patrascioiu, Josep VidalAbstract:Abstract Background Mechanisms underlying variable weight loss (WL) response after Roux-en-Y gastric bypass (RYGB) are poorly understood. The objective of this study was to compare Gastrointestinal hormonal responses to meal intake, and fasting plasma concentrations of surrogate markers of enterocyte mass and bile acid effect between patients with failed (F-WL) or successful WL (S-WL) after RYGB. Methods Cross-sectional study including 30 nondiabetic patients, evaluated at≥24 months after RYGB. Cases (F-WL; n=10) and controls (S-WL; n=20) were selected based on percent of excess WL (%EWL) Results F-WL patients presented lesser suppression of ghrelin (incremental area under the curve [iAUC]: F-WL −12490±6530 versus S-WL −31196±4536 pg×mL -1 ×min; P -1 ×min; P = .02) but not in the PYY and GLP-2, response to meal intake. Citrulline concentrations were significantly correlated with time after surgery (rho = .537; P P Conclusion Although limited by the cross-sectional design, our data suggest a role of some Gastrointestinal Hormones as mediators of successful weight loss but argues against larger enterocyte mass after BS as determinant of failed weight loss after RYGB.
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comparable early changes in Gastrointestinal Hormones after sleeve gastrectomy and roux en y gastric bypass surgery for morbidly obese type 2 diabetic subjects
Surgical Endoscopy and Other Interventional Techniques, 2012Co-Authors: Fabiola Romero, Antonio M Lacy, Joana Nicolau, Lilliam Flores, Roser Casamitjana, Ainitze Ibarzabal, Josep VidalAbstract:Background Sleeve gastrectomy (SG) and Roux-en-Y gastric bypass (RYGBP) are associated with similar type 2 diabetes mellitus (T2DM) resolution rates for morbidly obese subjects. However, the mechanisms underlying the resolution of T2DM after SG have not been clarified to date. This study aimed to compare the early changes in Gastrointestinal Hormones involved in insulin and glucagon secretion in morbidly obese T2DM subjects undergoing SG or RYGBP.
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comparable early changes in Gastrointestinal Hormones after sleeve gastrectomy and roux en y gastric bypass surgery for morbidly obese type 2 diabetic subjects
Surgical Endoscopy and Other Interventional Techniques, 2012Co-Authors: Fabiola Romero, Antonio M Lacy, Joana Nicolau, Lilliam Flores, Roser Casamitjana, Ainitze Ibarzabal, Josep VidalAbstract:Sleeve gastrectomy (SG) and Roux-en-Y gastric bypass (RYGBP) are associated with similar type 2 diabetes mellitus (T2DM) resolution rates for morbidly obese subjects. However, the mechanisms underlying the resolution of T2DM after SG have not been clarified to date. This study aimed to compare the early changes in Gastrointestinal Hormones involved in insulin and glucagon secretion in morbidly obese T2DM subjects undergoing SG or RYGBP. This prospective study investigated 12 subjects with T2DM who had undergone SG (n = 6) or RYGBP (n = 6). Five body mass index (BMI)-matched obese non-diabetic subjects and five BMI-matched obese diabetic subjects served as control subjects. Glucose, insulin, glucagon, glucagon-like peptide 1 (GLP-1), glucose-dependent insulinotropic polypeptide (GIP), and GLP-2 were determined after a standardized mixed liquid meal before surgery and 6 weeks afterward. After 6 weeks, five of the six subjects in each surgical group presented with T2DM remission, although the area under the curve (AUC)0–120 of glucose was greater than that of the non-diabetic control subjects (P < 0.01). Postsurgically, the indices of insulin and glucagon secretion were comparable between the two surgical groups. The AUC0–120 of GLP-1 (P < 0.05) and GLP-2 (P < 0.05) was significantly and comparably enlarged after SG and RYGB. The postsurgical GIP response was significantly associated with the glucagon response throughout the meal test (ρ = 0.747; P < 0.01). The data show that in a cohort of morbidly obese T2DM subjects, SG and RYGBP are associated with an early improvement in glucose tolerance, similar changes in insulin and glucagon secretion, and a similar GLP-1, GIP, and GLP-2 response to a standardized mixed liquid meal.
Ji T Gong - One of the best experts on this subject based on the ideXlab platform.
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melatonin attenuates noise stress induced Gastrointestinal motility disorder and gastric stress ulcer role of Gastrointestinal Hormones and oxidative stress in rats
Journal of Neurogastroenterology and Motility, 2015Co-Authors: Lei Zhang, Ji T Gong, Hu Q Zhang, Quan H Song, Guang H Xu, Xiao D Tang, Hai F Zhang, Hong W ZhangAbstract:BACKGROUND/AIMS: There are increasing evidences for Gastrointestinal motility disorder (GIMD) and gastric stress ulcer induced by noise stress. The present study was to investigate the reversed effect of melatonin on GIMD and gastric stress ulcer induced by noise stress and potential mechanism. METHODS: Noise stress was induced on rats, and melatonin (15 mg/kg) was administered to rats by intraperitoneal injection. Differences were assessed in gastric residual rate (GRR), small intestine propulsion rate (SPR), Guth injury score, cortisol, Gastrointestinal Hormones (calcitonin-gene-related peptide and motilin) and oxidative stress markers (superoxide dismutase and malondialde hyde) in blood plasma as well as gastric mucosa homogenate with or without melatonin. The pathological examination of gastric mucosa was also performed. RESULTS: The GRR and SPR were improved by noise stress compared with control (P < 0.05). The pathological examination and Guth injury score revealed gastric stress ulcer. Moreover, the levels of cortisol, motilin and malondialdehyde in blood plasma and ma-londialdehyde in gastric mucosa homogenate were increased by noise stress (P < 0.05). CGRP and superoxide dismutase activ-ity in both of blood plasma and gastric mucosa homogenate were significantly decreased (P< 0.05). Furthermore, melatonin reversed changes in GRR, SPR, pathological examination, Guth injury score, cortisol, motilin, CGRP, superoxide dismutase activity and malondialdehyde (P < 0.05). CONCLUSIONS: Melatonin is effective in reversing the GIMD and gastric stress ulcer induced by noise stress. The underlying mechanism may be involved in oxidative stress and Gastrointestinal Hormones.
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melatonin attenuates noise stress induced Gastrointestinal motility disorder and gastric stress ulcer role of Gastrointestinal Hormones and oxidative stress in rats
Journal of Neurogastroenterology and Motility, 2015Co-Authors: Lei Zhang, Ji T Gong, Hu Q Zhang, Quan H Song, Guang H Xu, Xiao D Tang, Hai F Zhang, Hong W ZhangAbstract:BACKGROUND/AIMS: There are increasing evidences for Gastrointestinal motility disorder (GIMD) and gastric stress ulcer induced by noise stress. The present study was to investigate the reversed effect of melatonin on GIMD and gastric stress ulcer induced by noise stress and potential mechanism. METHODS: Noise stress was induced on rats, and melatonin (15 mg/kg) was administered to rats by intraperitoneal injection. Differences were assessed in gastric residual rate (GRR), small intestine propulsion rate (SPR), Guth injury score, cortisol, Gastrointestinal Hormones (calcitonin-gene-related peptide and motilin) and oxidative stress markers (superoxide dismutase and malondialde hyde) in blood plasma as well as gastric mucosa homogenate with or without melatonin. The pathological examination of gastric mucosa was also performed. RESULTS: The GRR and SPR were improved by noise stress compared with control (P < 0.05). The pathological examination and Guth injury score revealed gastric stress ulcer. Moreover, the levels of cortisol, motilin and malondialdehyde in blood plasma and ma-londialdehyde in gastric mucosa homogenate were increased by noise stress (P < 0.05). CGRP and superoxide dismutase activ-ity in both of blood plasma and gastric mucosa homogenate were significantly decreased (P< 0.05). Furthermore, melatonin reversed changes in GRR, SPR, pathological examination, Guth injury score, cortisol, motilin, CGRP, superoxide dismutase activity and malondialdehyde (P < 0.05). CONCLUSIONS: Melatonin is effective in reversing the GIMD and gastric stress ulcer induced by noise stress. The underlying mechanism may be involved in oxidative stress and Gastrointestinal Hormones.
Hu Q Zhang - One of the best experts on this subject based on the ideXlab platform.
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melatonin attenuates noise stress induced Gastrointestinal motility disorder and gastric stress ulcer role of Gastrointestinal Hormones and oxidative stress in rats
Journal of Neurogastroenterology and Motility, 2015Co-Authors: Lei Zhang, Ji T Gong, Hu Q Zhang, Quan H Song, Guang H Xu, Xiao D Tang, Hai F Zhang, Hong W ZhangAbstract:BACKGROUND/AIMS: There are increasing evidences for Gastrointestinal motility disorder (GIMD) and gastric stress ulcer induced by noise stress. The present study was to investigate the reversed effect of melatonin on GIMD and gastric stress ulcer induced by noise stress and potential mechanism. METHODS: Noise stress was induced on rats, and melatonin (15 mg/kg) was administered to rats by intraperitoneal injection. Differences were assessed in gastric residual rate (GRR), small intestine propulsion rate (SPR), Guth injury score, cortisol, Gastrointestinal Hormones (calcitonin-gene-related peptide and motilin) and oxidative stress markers (superoxide dismutase and malondialde hyde) in blood plasma as well as gastric mucosa homogenate with or without melatonin. The pathological examination of gastric mucosa was also performed. RESULTS: The GRR and SPR were improved by noise stress compared with control (P < 0.05). The pathological examination and Guth injury score revealed gastric stress ulcer. Moreover, the levels of cortisol, motilin and malondialdehyde in blood plasma and ma-londialdehyde in gastric mucosa homogenate were increased by noise stress (P < 0.05). CGRP and superoxide dismutase activ-ity in both of blood plasma and gastric mucosa homogenate were significantly decreased (P< 0.05). Furthermore, melatonin reversed changes in GRR, SPR, pathological examination, Guth injury score, cortisol, motilin, CGRP, superoxide dismutase activity and malondialdehyde (P < 0.05). CONCLUSIONS: Melatonin is effective in reversing the GIMD and gastric stress ulcer induced by noise stress. The underlying mechanism may be involved in oxidative stress and Gastrointestinal Hormones.
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melatonin attenuates noise stress induced Gastrointestinal motility disorder and gastric stress ulcer role of Gastrointestinal Hormones and oxidative stress in rats
Journal of Neurogastroenterology and Motility, 2015Co-Authors: Lei Zhang, Ji T Gong, Hu Q Zhang, Quan H Song, Guang H Xu, Xiao D Tang, Hai F Zhang, Hong W ZhangAbstract:BACKGROUND/AIMS: There are increasing evidences for Gastrointestinal motility disorder (GIMD) and gastric stress ulcer induced by noise stress. The present study was to investigate the reversed effect of melatonin on GIMD and gastric stress ulcer induced by noise stress and potential mechanism. METHODS: Noise stress was induced on rats, and melatonin (15 mg/kg) was administered to rats by intraperitoneal injection. Differences were assessed in gastric residual rate (GRR), small intestine propulsion rate (SPR), Guth injury score, cortisol, Gastrointestinal Hormones (calcitonin-gene-related peptide and motilin) and oxidative stress markers (superoxide dismutase and malondialde hyde) in blood plasma as well as gastric mucosa homogenate with or without melatonin. The pathological examination of gastric mucosa was also performed. RESULTS: The GRR and SPR were improved by noise stress compared with control (P < 0.05). The pathological examination and Guth injury score revealed gastric stress ulcer. Moreover, the levels of cortisol, motilin and malondialdehyde in blood plasma and ma-londialdehyde in gastric mucosa homogenate were increased by noise stress (P < 0.05). CGRP and superoxide dismutase activ-ity in both of blood plasma and gastric mucosa homogenate were significantly decreased (P< 0.05). Furthermore, melatonin reversed changes in GRR, SPR, pathological examination, Guth injury score, cortisol, motilin, CGRP, superoxide dismutase activity and malondialdehyde (P < 0.05). CONCLUSIONS: Melatonin is effective in reversing the GIMD and gastric stress ulcer induced by noise stress. The underlying mechanism may be involved in oxidative stress and Gastrointestinal Hormones.
