The Experts below are selected from a list of 10920 Experts worldwide ranked by ideXlab platform
Ha Zuilhof - One of the best experts on this subject based on the ideXlab platform.
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engineering the protein corona structure on gold nanoclusters enables red shifted emissions in the second near infrared window for Gastrointestinal Imaging
Angewandte Chemie, 2020Co-Authors: Weili Wang, Yifei Kong, Ha Zuilhof, Meng Gao, Yang Huang, Jun Jiang, Qianqian Xie, Huizhen Zheng, Yanxia PanAbstract:Fluorescence emissions in the second near infrared window (NIR‐II) have shown extraordinary advantages for bio‐Imaging. However, it’s a big challenge to exploit NIR‐II emitters for Gastrointestinal (GI) tract Imaging due to fluorescence quenching in digestive microenvironment. Herein, we made an interesting finding that red‐shifted emissions of Au nanoclusters (AuNCs) into NIR‐II region with improved quantum yields (QY) could be achieved by engineering a corona structure of a ribonuclease‐A (RNase‐A) on particle surfaces. RNase‐A encapsulated AuNCs (RNase‐A@AuNCs) displayed emissions at 1050 nm with a 1.9% QY. Compare to rare earth and silver based NIR‐II emitters, RNase‐A@AuNCs had excellent biocompatibility, showed >50‐fold higher sensitivity in GI tract, and homogeneously migrated during Gastrointestinal peristalsis to allow visualization of the detailed structures of GI tract. Notably, RNase‐A@AuNCs could be exploited to successfully differentiate intestinal tumor mice from the healthy, indicating a potential utility for early diagnosis of intestinal tumors in clinics.
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engineering the protein corona structure on gold nanoclusters enables red shifted emissions in the second near infrared window for Gastrointestinal Imaging
Angewandte Chemie, 2020Co-Authors: Weili Wang, Yifei Kong, Ju Jiang, Qianqia Xie, Huizhe Zheng, Ha Zuilhof, Meng Gao, Yang Huang, Xiaoming CaiAbstract:The application of NIR-II emitters for Gastrointestinal (GI) tract Imaging remains challenging due to fluorescence quenching in the digestive microenvironment. Herein, we report that red-shifting of the fluorescence emission of Au nanoclusters (AuNCs) into NIR-II region with improved quantum yields (QY) could be achieved by engineering a protein corona structure consisting of a ribonuclease-A (RNase-A) on the particle surfaces. RNase-A-encapsulated AuNCs (RNase-A@AuNCs) displayed emissions at 1050 nm with a 1.9 % QY. Compared to rare earth and silver-based NIR-II emitters, RNase-A@AuNCs had excellent biocompatibility, showing >50-fold higher sensitivity in GI tract, and migrated homogenously during Gastrointestinal peristalsis to allow visualization of the detailed structures of the GI tract. RNase-A@AuNCs could successfully examine intestinal tumor mice from healthy mice, indicating a potential utility for early diagnosis of intestinal tumors.
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engineering corona structure on gold nanoclusters for Gastrointestinal Imaging by red shifted emissions in the second near infrared window
Angewandte Chemie, 2020Co-Authors: Weili Wang, Yifei Kong, Xiaoming Cai, Meng Gao, Yang Huang, Jun Jiang, Qianqian Xie, Huizhen Zheng, Yanxia Pan, Ha ZuilhofAbstract:Fluorescence emissions in the second near infrared window (NIR‐II) have shown extraordinary advantages for bio‐Imaging. However, it’s a big challenge to exploit NIR‐II emitters for Gastrointestinal (GI) tract Imaging due to fluorescence quenching in digestive microenvironment. Herein, we made an interesting finding that red‐shifted emissions of Au nanoclusters (AuNCs) into NIR‐II region with improved quantum yields (QY) could be achieved by engineering a corona structure of a ribonuclease‐A (RNase‐A) on particle surfaces. RNase‐A encapsulated AuNCs (RNase‐A@AuNCs) displayed emissions at 1050 nm with a 1.9% QY. Compare to rare earth and silver based NIR‐II emitters, RNase‐A@AuNCs had excellent biocompatibility, showed >50‐fold higher sensitivity in GI tract, and homogeneously migrated during Gastrointestinal peristalsis to allow visualization of the detailed structures of GI tract. Notably, RNase‐A@AuNCs could be exploited to successfully differentiate intestinal tumor mice from the healthy, indicating a potential utility for early diagnosis of intestinal tumors in clinics.
Lawrence A Stein - One of the best experts on this subject based on the ideXlab platform.
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the role of abdominal radiography in the evaluation of the nontrauma emergency patient
Radiology, 2008Co-Authors: Zina S Kellow, Meaghan Macinnes, David Kurzencwyg, Sapna Rawal, Rehana Jaffer, Bojan Kovacina, Lawrence A SteinAbstract:Purpose: To characterize the utility of abdominal radiography for nontrauma emergency patients in a single-institution setting. Materials and Methods: Following approval from the Director of Professional Services, a retrospective review of radiography and of patient records was conducted for patients who presented to a nontrauma emergency department over a period of 6 months and who were imaged by using abdominal radiography. Only the first radiograph per patient was used for analysis. The interpretations were sorted as normal, nonspecific, or abnormal. The patients' medical records were reviewed to determine whether further Imaging was performed (computed tomography, ultrasonography, or upper Gastrointestinal Imaging) and results were compared with abdominal radiography. Chart reviews were conducted to identify patients in whom abdominal radiography alone influenced treatment. Results: In 874 patients, interpretation of abdominal radiography was normal in 34% (n = 300), nonspecific in 46% (n = 406), and ...
Ronald L Eisenberg - One of the best experts on this subject based on the ideXlab platform.
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the role of abdominal radiography in the evaluation of the nontrauma emergency patient new thoughts on an old problem
Radiology, 2008Co-Authors: Ronald L EisenbergAbstract:Ronald L. Eisenberg, MD, JD M ore than one-quarter of a century ago, our group challenged the indiscriminate use of ordinary abdominal radiographs, demonstrating that 53.7% of them could be eliminated without missing any clinically important findings (1). We recommended that abdominal radiography could safely be restricted to those suffering from moderate to severe abdominal tenderness and patients with clinical signs and symptoms highly suggestive of bowel obstruction, ureteral calculi, ischemia, or gallbladder disease. However, our article had little effect on ordering patterns, despite the continuing need to control overuse of Imaging resources and the emergence of newer technologies that may provide more precise and reliable answers to clinical questions. In this issue of Radiology, Kellow et al (2) again address this important and provocative issue. Showing a high incidence of positive computed tomography (CT), ultrasonography (US), or upper Gastrointestinal Imaging findings, even in patients whose abdominal radiograph was interpreted as normal or nonspecific (81% of the total studies), they confirm the frequent futility of conventional Imaging for many abdominal conditions and the continuing overuse of abdominal radiographs 25 years after our article was published. They make the sweeping statement that, “with the exception of localization of catheter placement, there no longer remains a role for abdominal radiography in nontrauma emergency room patients,” arguing that “when Imaging is needed, the emergency physician should be encouraged to immediately request more definitive Imaging modalities [eg, CT and US],” which were not readily available when our article was published. Although I completely agree that abdominal radiography is overused and could be eliminated in many cases, I would suggest that a somewhat more temperate and nuanced approach is needed. Ultimately, it is not sufficient to merely state the futility of abdominal radiography in most clinical settings, but to evaluate the reasons why emergency room physicians order this modality for situations in which no Imaging is required. Unfortunately, Kellow et al (2) performed their study in an institution in which emergency room physicians did not read their own images. Consequently, they were forced to use the official radiology report as a surrogate for the emergency room interpretation. Although I certainly would agree that “one may assume that the radiologists’ report is more often accurate, so use of the official report would overestimate, rather than underestimate, the use of radiography,” this is not the major issue. Rather, it is the lack of information about the interpretation of the emergency room physician that is the problem, as this is critical to further understanding the role of radiography in the emergency department setting. In many cases, if not most, the interpretation of the radiologist has little bearing on health care decisions, since the patient has already been treated on the basis of the referring clinician’s assessment of the images. The major issue, which is impossible to assess in a retrospective study, is the thought process of the ordering physician in the emergency room. Did the doctor in the emergency room expect to discover an abnormality on the abdominal radiograph? Or, was the study ordered merely to placate the patient, to assure someone with a low probability of disease that there was no acute abnormality? Of the patients with abdominal radiographs that were interpreted as normal on review by the radioloPublished online 10.1148/radiol.2483080863
Zina S Kellow - One of the best experts on this subject based on the ideXlab platform.
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the role of abdominal radiography in the evaluation of the nontrauma emergency patient
Radiology, 2008Co-Authors: Zina S Kellow, Meaghan Macinnes, David Kurzencwyg, Sapna Rawal, Rehana Jaffer, Bojan Kovacina, Lawrence A SteinAbstract:Purpose: To characterize the utility of abdominal radiography for nontrauma emergency patients in a single-institution setting. Materials and Methods: Following approval from the Director of Professional Services, a retrospective review of radiography and of patient records was conducted for patients who presented to a nontrauma emergency department over a period of 6 months and who were imaged by using abdominal radiography. Only the first radiograph per patient was used for analysis. The interpretations were sorted as normal, nonspecific, or abnormal. The patients' medical records were reviewed to determine whether further Imaging was performed (computed tomography, ultrasonography, or upper Gastrointestinal Imaging) and results were compared with abdominal radiography. Chart reviews were conducted to identify patients in whom abdominal radiography alone influenced treatment. Results: In 874 patients, interpretation of abdominal radiography was normal in 34% (n = 300), nonspecific in 46% (n = 406), and ...
Weili Wang - One of the best experts on this subject based on the ideXlab platform.
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engineering the protein corona structure on gold nanoclusters enables red shifted emissions in the second near infrared window for Gastrointestinal Imaging
Angewandte Chemie, 2020Co-Authors: Weili Wang, Yifei Kong, Ha Zuilhof, Meng Gao, Yang Huang, Jun Jiang, Qianqian Xie, Huizhen Zheng, Yanxia PanAbstract:Fluorescence emissions in the second near infrared window (NIR‐II) have shown extraordinary advantages for bio‐Imaging. However, it’s a big challenge to exploit NIR‐II emitters for Gastrointestinal (GI) tract Imaging due to fluorescence quenching in digestive microenvironment. Herein, we made an interesting finding that red‐shifted emissions of Au nanoclusters (AuNCs) into NIR‐II region with improved quantum yields (QY) could be achieved by engineering a corona structure of a ribonuclease‐A (RNase‐A) on particle surfaces. RNase‐A encapsulated AuNCs (RNase‐A@AuNCs) displayed emissions at 1050 nm with a 1.9% QY. Compare to rare earth and silver based NIR‐II emitters, RNase‐A@AuNCs had excellent biocompatibility, showed >50‐fold higher sensitivity in GI tract, and homogeneously migrated during Gastrointestinal peristalsis to allow visualization of the detailed structures of GI tract. Notably, RNase‐A@AuNCs could be exploited to successfully differentiate intestinal tumor mice from the healthy, indicating a potential utility for early diagnosis of intestinal tumors in clinics.
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engineering the protein corona structure on gold nanoclusters enables red shifted emissions in the second near infrared window for Gastrointestinal Imaging
Angewandte Chemie, 2020Co-Authors: Weili Wang, Yifei Kong, Ju Jiang, Qianqia Xie, Huizhe Zheng, Ha Zuilhof, Meng Gao, Yang Huang, Xiaoming CaiAbstract:The application of NIR-II emitters for Gastrointestinal (GI) tract Imaging remains challenging due to fluorescence quenching in the digestive microenvironment. Herein, we report that red-shifting of the fluorescence emission of Au nanoclusters (AuNCs) into NIR-II region with improved quantum yields (QY) could be achieved by engineering a protein corona structure consisting of a ribonuclease-A (RNase-A) on the particle surfaces. RNase-A-encapsulated AuNCs (RNase-A@AuNCs) displayed emissions at 1050 nm with a 1.9 % QY. Compared to rare earth and silver-based NIR-II emitters, RNase-A@AuNCs had excellent biocompatibility, showing >50-fold higher sensitivity in GI tract, and migrated homogenously during Gastrointestinal peristalsis to allow visualization of the detailed structures of the GI tract. RNase-A@AuNCs could successfully examine intestinal tumor mice from healthy mice, indicating a potential utility for early diagnosis of intestinal tumors.
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engineering corona structure on gold nanoclusters for Gastrointestinal Imaging by red shifted emissions in the second near infrared window
Angewandte Chemie, 2020Co-Authors: Weili Wang, Yifei Kong, Xiaoming Cai, Meng Gao, Yang Huang, Jun Jiang, Qianqian Xie, Huizhen Zheng, Yanxia Pan, Ha ZuilhofAbstract:Fluorescence emissions in the second near infrared window (NIR‐II) have shown extraordinary advantages for bio‐Imaging. However, it’s a big challenge to exploit NIR‐II emitters for Gastrointestinal (GI) tract Imaging due to fluorescence quenching in digestive microenvironment. Herein, we made an interesting finding that red‐shifted emissions of Au nanoclusters (AuNCs) into NIR‐II region with improved quantum yields (QY) could be achieved by engineering a corona structure of a ribonuclease‐A (RNase‐A) on particle surfaces. RNase‐A encapsulated AuNCs (RNase‐A@AuNCs) displayed emissions at 1050 nm with a 1.9% QY. Compare to rare earth and silver based NIR‐II emitters, RNase‐A@AuNCs had excellent biocompatibility, showed >50‐fold higher sensitivity in GI tract, and homogeneously migrated during Gastrointestinal peristalsis to allow visualization of the detailed structures of GI tract. Notably, RNase‐A@AuNCs could be exploited to successfully differentiate intestinal tumor mice from the healthy, indicating a potential utility for early diagnosis of intestinal tumors in clinics.
