The Experts below are selected from a list of 87 Experts worldwide ranked by ideXlab platform
Roger Bouillon - One of the best experts on this subject based on the ideXlab platform.
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improvement of gastric emptying in diabetic gastroparesis by erythromycin preliminary studies
The New England Journal of Medicine, 1990Co-Authors: Jozef Janssens, Theo Peeters, Gaston Vantrappen, Jan Tack, J L Urbain, M De Roo, Erik Muls, Roger BouillonAbstract:Abstract Erythromycin mimics the effect of the Gastrointestinal Polypeptide motilin on Gastrointestinal motility, probably by binding to motilin receptors and acting as a motilin agonist. Erythromycin may thus have clinical application in patients with disturbances of gastroduodenal motility, such as diabetic gastroparesis. To examine this possibility, we studied the effect of erythromycin on gastric emptying in 10 patients with insulin-dependent diabetes mellitus and gastroparesis. We studied the emptying of liquids and solids simultaneously on separate days after the intravenous administration of erythromycin (200 mg) or placebo, using a double-isotope technique and a double-blind, crossover design. Erythromycin shortened the prolonged gastric-emptying times for both liquids and solids to normal. For example, 120 minutes after the ingestion of a solid meal, mean (±SE) retention was 63±9 percent with placebo and 4±1 percent with erythromycin, as compared with 9±3 percent in 10 healthy subjects. The corre...
Jozef Janssens - One of the best experts on this subject based on the ideXlab platform.
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improvement of gastric emptying in diabetic gastroparesis by erythromycin preliminary studies
The New England Journal of Medicine, 1990Co-Authors: Jozef Janssens, Theo Peeters, Gaston Vantrappen, Jan Tack, J L Urbain, M De Roo, Erik Muls, Roger BouillonAbstract:Abstract Erythromycin mimics the effect of the Gastrointestinal Polypeptide motilin on Gastrointestinal motility, probably by binding to motilin receptors and acting as a motilin agonist. Erythromycin may thus have clinical application in patients with disturbances of gastroduodenal motility, such as diabetic gastroparesis. To examine this possibility, we studied the effect of erythromycin on gastric emptying in 10 patients with insulin-dependent diabetes mellitus and gastroparesis. We studied the emptying of liquids and solids simultaneously on separate days after the intravenous administration of erythromycin (200 mg) or placebo, using a double-isotope technique and a double-blind, crossover design. Erythromycin shortened the prolonged gastric-emptying times for both liquids and solids to normal. For example, 120 minutes after the ingestion of a solid meal, mean (±SE) retention was 63±9 percent with placebo and 4±1 percent with erythromycin, as compared with 9±3 percent in 10 healthy subjects. The corre...
Ming-gao Zhao - One of the best experts on this subject based on the ideXlab platform.
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Anxiolytic Actions of Motilin in the Basolateral Amygdala
Molecular Neurobiology, 2013Co-Authors: Bin Feng, Ken-ichi Ozaki, Yan-yan Guo, Ding-hua Yi, Jin-cheng Liu, Xiao Qiang Li, Jinfeng Zhang, Ming-gao ZhaoAbstract:Motilin is a 22-amino-acid Gastrointestinal Polypeptide that was first isolated from the porcine intestine. We identified that motilin receptor is highly expressed in GABAergic interneurons in the basolateral nucleus (BLA) of the amygdala, the structure of which is closely involved in assigning stress disorder and anxiety. However, little is known about the role of motilin in BLA neuronal circuits and the molecular mechanisms of stress-related anxiety. Whole-cell recordings from amygdala slices showed that motilin depolarized the interneurons and facilitated GABAergic transmission in the BLA, which is mimicked by the motilin receptor agonist, erythromycin. BLA local injection of erythromycin or motilin can reduce the anxiety-like behavior in mice after acute stress. Therefore, motilin is essential in regulating interneuron excitability and GABAergic transmission in BLA. Moreover, the anxiolytic actions of motilin can partly be explained by modulating the BLA neuronal circuits. The present data demonstrate the importance of motilin in anxiety and the development of motilin receptor non-peptide agonist as a clear target for the potential treatment of anxiety disorders.
Theo Peeters - One of the best experts on this subject based on the ideXlab platform.
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improvement of gastric emptying in diabetic gastroparesis by erythromycin preliminary studies
The New England Journal of Medicine, 1990Co-Authors: Jozef Janssens, Theo Peeters, Gaston Vantrappen, Jan Tack, J L Urbain, M De Roo, Erik Muls, Roger BouillonAbstract:Abstract Erythromycin mimics the effect of the Gastrointestinal Polypeptide motilin on Gastrointestinal motility, probably by binding to motilin receptors and acting as a motilin agonist. Erythromycin may thus have clinical application in patients with disturbances of gastroduodenal motility, such as diabetic gastroparesis. To examine this possibility, we studied the effect of erythromycin on gastric emptying in 10 patients with insulin-dependent diabetes mellitus and gastroparesis. We studied the emptying of liquids and solids simultaneously on separate days after the intravenous administration of erythromycin (200 mg) or placebo, using a double-isotope technique and a double-blind, crossover design. Erythromycin shortened the prolonged gastric-emptying times for both liquids and solids to normal. For example, 120 minutes after the ingestion of a solid meal, mean (±SE) retention was 63±9 percent with placebo and 4±1 percent with erythromycin, as compared with 9±3 percent in 10 healthy subjects. The corre...
Jan Tack - One of the best experts on this subject based on the ideXlab platform.
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improvement of gastric emptying in diabetic gastroparesis by erythromycin preliminary studies
The New England Journal of Medicine, 1990Co-Authors: Jozef Janssens, Theo Peeters, Gaston Vantrappen, Jan Tack, J L Urbain, M De Roo, Erik Muls, Roger BouillonAbstract:Abstract Erythromycin mimics the effect of the Gastrointestinal Polypeptide motilin on Gastrointestinal motility, probably by binding to motilin receptors and acting as a motilin agonist. Erythromycin may thus have clinical application in patients with disturbances of gastroduodenal motility, such as diabetic gastroparesis. To examine this possibility, we studied the effect of erythromycin on gastric emptying in 10 patients with insulin-dependent diabetes mellitus and gastroparesis. We studied the emptying of liquids and solids simultaneously on separate days after the intravenous administration of erythromycin (200 mg) or placebo, using a double-isotope technique and a double-blind, crossover design. Erythromycin shortened the prolonged gastric-emptying times for both liquids and solids to normal. For example, 120 minutes after the ingestion of a solid meal, mean (±SE) retention was 63±9 percent with placebo and 4±1 percent with erythromycin, as compared with 9±3 percent in 10 healthy subjects. The corre...
