The Experts below are selected from a list of 228 Experts worldwide ranked by ideXlab platform
Oliver E Blacque - One of the best experts on this subject based on the ideXlab platform.
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mks and nphp modules cooperate to establish basal body transition zone membrane associations and ciliary Gate Function during ciliogenesis
Journal of Cell Biology, 2011Co-Authors: Corey L Williams, Chunmei Li, Katarzyna Kida, Peter N Inglis, Swetha Mohan, Lucie Semenec, Nathan J Bialas, Rachel M Stupay, Nansheng Chen, Oliver E BlacqueAbstract:Meckel-Gruber syndrome (MKS), nephronophthisis (NPHP), and related ciliopathies present with overlapping phenotypes and display considerable allelism between at least twelve different genes of largely unexplained Function. We demonstrate that the conserved C. elegans B9 domain (MKS-1, MKSR-1, and MKSR-2), MKS-3/TMEM67, MKS-5/RPGRIP1L, MKS-6/CC2D2A, NPHP-1, and NPHP-4 proteins exhibit essential, collective Functions at the transition zone (TZ), an underappreciated region at the base of all cilia characterized by Y-shaped assemblages that link axoneme microtubules to surrounding membrane. These TZ proteins Functionally interact as members of two distinct modules, which together contribute to an early ciliogenic event. Specifically, MKS/MKSR/NPHP proteins establish basal body/TZ membrane attachments before or coinciding with intraflagellar transport–dependent axoneme extension and subsequently restrict accumulation of nonciliary components within the ciliary compartment. Together, our findings uncover a unified role for eight TZ-localized proteins in basal body anchoring and establishing a ciliary Gate during ciliogenesis, and suggest that disrupting ciliary Gate Function contributes to phenotypic features of the MKS/NPHP disease spectrum.
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MKS and NPHP modules cooperate to establish basal body/transition zone membrane associations and ciliary Gate Function during ciliogenesis
Journal of Cell Biology, 2011Co-Authors: Corey L Williams, Chunmei Li, Katarzyna Kida, Peter N Inglis, Swetha Mohan, Lucie Semenec, Nathan J Bialas, Rachel M Stupay, Nansheng Chen, Oliver E BlacqueAbstract:Meckel-Gruber syndrome (MKS), nephronophthisis (NPHP), and related ciliopathies present with overlapping phenotypes and display considerable allelism between at least twelve different genes of largely unexplained Function. We demonstrate that the conserved C. elegans B9 domain (MKS-1, MKSR-1, and MKSR-2), MKS-3/TMEM67, MKS-5/RPGRIP1L, MKS-6/CC2D2A, NPHP-1, and NPHP-4 proteins exhibit essential, collective Functions at the transition zone (TZ), an underappreciated region at the base of all cilia characterized by Y-shaped assemblages that link axoneme microtubules to surrounding membrane. These TZ proteins Functionally interact as members of two distinct modules, which together contribute to an early ciliogenic event. Specifically, MKS/MKSR/NPHP proteins establish basal body/TZ membrane attachments before or coinciding with intraflagellar transport–dependent axoneme extension and subsequently restrict accumulation of nonciliary components within the ciliary compartment. Together, our findings uncover a unified role for eight TZ-localized proteins in basal body anchoring and establishing a ciliary Gate during ciliogenesis, and suggest that disrupting ciliary Gate Function contributes to phenotypic features of the MKS/NPHP disease spectrum.
Chun Yuan - One of the best experts on this subject based on the ideXlab platform.
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Gate Function based structure-aware convolution for scene semantic segmentation
2017 IEEE International Conference on Multimedia and Expo (ICME), 2017Co-Authors: Zhou Cheng, Jiancheng Li, Chun YuanAbstract:The aim of scene semantic segmentation is to label each pixel with a class which it belongs to in high level cognition. State-of-art works mainly adapt convolutional neural networks originally designed for image classification to make dense prediction. However the inner structure of scene itself and its stuff is more flexible and variable, which is distinct from the objects in image classification task. Therefore we propose a Gate Function based structure-aware convolution for deep neural networks with the ability of modeling inner variance in scene. The Gate Function is a RNN-based learnable Function or a handcrafted one, which is applied to distinguish efficient activations from convolution area. It is proved that dilated convolution is a subclass of Gate Function. As shown in our experiments on scene datasets, the proposed convolution method efficiently improves the accuracy of current semantic segmentation systems by partly replacing original networks' convolution layers with ours.
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ICME - Gate Function based structure-aware convolution for scene semantic segmentation
2017 IEEE International Conference on Multimedia and Expo (ICME), 2017Co-Authors: Zhou Cheng, Jiancheng Li, Chun YuanAbstract:The aim of scene semantic segmentation is to label each pixel with a class which it belongs to in high level cognition. State-of-art works mainly adapt convolutional neural networks originally designed for image classification to make dense prediction. However the inner structure of scene itself and its stuff is more flexible and variable, which is distinct from the objects in image classification task. Therefore we propose a Gate Function based structure-aware convolution for deep neural networks with the ability of modeling inner variance in scene. The Gate Function is a RNN-based learnable Function or a handcrafted one, which is applied to distinguish efficient activations from convolution area. It is proved that dilated convolution is a subclass of Gate Function. As shown in our experiments on scene datasets, the proposed convolution method efficiently improves the accuracy of current semantic segmentation systems by partly replacing original networks' convolution layers with ours.
Corey L Williams - One of the best experts on this subject based on the ideXlab platform.
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mks and nphp modules cooperate to establish basal body transition zone membrane associations and ciliary Gate Function during ciliogenesis
Journal of Cell Biology, 2011Co-Authors: Corey L Williams, Chunmei Li, Katarzyna Kida, Peter N Inglis, Swetha Mohan, Lucie Semenec, Nathan J Bialas, Rachel M Stupay, Nansheng Chen, Oliver E BlacqueAbstract:Meckel-Gruber syndrome (MKS), nephronophthisis (NPHP), and related ciliopathies present with overlapping phenotypes and display considerable allelism between at least twelve different genes of largely unexplained Function. We demonstrate that the conserved C. elegans B9 domain (MKS-1, MKSR-1, and MKSR-2), MKS-3/TMEM67, MKS-5/RPGRIP1L, MKS-6/CC2D2A, NPHP-1, and NPHP-4 proteins exhibit essential, collective Functions at the transition zone (TZ), an underappreciated region at the base of all cilia characterized by Y-shaped assemblages that link axoneme microtubules to surrounding membrane. These TZ proteins Functionally interact as members of two distinct modules, which together contribute to an early ciliogenic event. Specifically, MKS/MKSR/NPHP proteins establish basal body/TZ membrane attachments before or coinciding with intraflagellar transport–dependent axoneme extension and subsequently restrict accumulation of nonciliary components within the ciliary compartment. Together, our findings uncover a unified role for eight TZ-localized proteins in basal body anchoring and establishing a ciliary Gate during ciliogenesis, and suggest that disrupting ciliary Gate Function contributes to phenotypic features of the MKS/NPHP disease spectrum.
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MKS and NPHP modules cooperate to establish basal body/transition zone membrane associations and ciliary Gate Function during ciliogenesis
Journal of Cell Biology, 2011Co-Authors: Corey L Williams, Chunmei Li, Katarzyna Kida, Peter N Inglis, Swetha Mohan, Lucie Semenec, Nathan J Bialas, Rachel M Stupay, Nansheng Chen, Oliver E BlacqueAbstract:Meckel-Gruber syndrome (MKS), nephronophthisis (NPHP), and related ciliopathies present with overlapping phenotypes and display considerable allelism between at least twelve different genes of largely unexplained Function. We demonstrate that the conserved C. elegans B9 domain (MKS-1, MKSR-1, and MKSR-2), MKS-3/TMEM67, MKS-5/RPGRIP1L, MKS-6/CC2D2A, NPHP-1, and NPHP-4 proteins exhibit essential, collective Functions at the transition zone (TZ), an underappreciated region at the base of all cilia characterized by Y-shaped assemblages that link axoneme microtubules to surrounding membrane. These TZ proteins Functionally interact as members of two distinct modules, which together contribute to an early ciliogenic event. Specifically, MKS/MKSR/NPHP proteins establish basal body/TZ membrane attachments before or coinciding with intraflagellar transport–dependent axoneme extension and subsequently restrict accumulation of nonciliary components within the ciliary compartment. Together, our findings uncover a unified role for eight TZ-localized proteins in basal body anchoring and establishing a ciliary Gate during ciliogenesis, and suggest that disrupting ciliary Gate Function contributes to phenotypic features of the MKS/NPHP disease spectrum.
Zhou Cheng - One of the best experts on this subject based on the ideXlab platform.
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Gate Function based structure-aware convolution for scene semantic segmentation
2017 IEEE International Conference on Multimedia and Expo (ICME), 2017Co-Authors: Zhou Cheng, Jiancheng Li, Chun YuanAbstract:The aim of scene semantic segmentation is to label each pixel with a class which it belongs to in high level cognition. State-of-art works mainly adapt convolutional neural networks originally designed for image classification to make dense prediction. However the inner structure of scene itself and its stuff is more flexible and variable, which is distinct from the objects in image classification task. Therefore we propose a Gate Function based structure-aware convolution for deep neural networks with the ability of modeling inner variance in scene. The Gate Function is a RNN-based learnable Function or a handcrafted one, which is applied to distinguish efficient activations from convolution area. It is proved that dilated convolution is a subclass of Gate Function. As shown in our experiments on scene datasets, the proposed convolution method efficiently improves the accuracy of current semantic segmentation systems by partly replacing original networks' convolution layers with ours.
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ICME - Gate Function based structure-aware convolution for scene semantic segmentation
2017 IEEE International Conference on Multimedia and Expo (ICME), 2017Co-Authors: Zhou Cheng, Jiancheng Li, Chun YuanAbstract:The aim of scene semantic segmentation is to label each pixel with a class which it belongs to in high level cognition. State-of-art works mainly adapt convolutional neural networks originally designed for image classification to make dense prediction. However the inner structure of scene itself and its stuff is more flexible and variable, which is distinct from the objects in image classification task. Therefore we propose a Gate Function based structure-aware convolution for deep neural networks with the ability of modeling inner variance in scene. The Gate Function is a RNN-based learnable Function or a handcrafted one, which is applied to distinguish efficient activations from convolution area. It is proved that dilated convolution is a subclass of Gate Function. As shown in our experiments on scene datasets, the proposed convolution method efficiently improves the accuracy of current semantic segmentation systems by partly replacing original networks' convolution layers with ours.
Nansheng Chen - One of the best experts on this subject based on the ideXlab platform.
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mks and nphp modules cooperate to establish basal body transition zone membrane associations and ciliary Gate Function during ciliogenesis
Journal of Cell Biology, 2011Co-Authors: Corey L Williams, Chunmei Li, Katarzyna Kida, Peter N Inglis, Swetha Mohan, Lucie Semenec, Nathan J Bialas, Rachel M Stupay, Nansheng Chen, Oliver E BlacqueAbstract:Meckel-Gruber syndrome (MKS), nephronophthisis (NPHP), and related ciliopathies present with overlapping phenotypes and display considerable allelism between at least twelve different genes of largely unexplained Function. We demonstrate that the conserved C. elegans B9 domain (MKS-1, MKSR-1, and MKSR-2), MKS-3/TMEM67, MKS-5/RPGRIP1L, MKS-6/CC2D2A, NPHP-1, and NPHP-4 proteins exhibit essential, collective Functions at the transition zone (TZ), an underappreciated region at the base of all cilia characterized by Y-shaped assemblages that link axoneme microtubules to surrounding membrane. These TZ proteins Functionally interact as members of two distinct modules, which together contribute to an early ciliogenic event. Specifically, MKS/MKSR/NPHP proteins establish basal body/TZ membrane attachments before or coinciding with intraflagellar transport–dependent axoneme extension and subsequently restrict accumulation of nonciliary components within the ciliary compartment. Together, our findings uncover a unified role for eight TZ-localized proteins in basal body anchoring and establishing a ciliary Gate during ciliogenesis, and suggest that disrupting ciliary Gate Function contributes to phenotypic features of the MKS/NPHP disease spectrum.
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MKS and NPHP modules cooperate to establish basal body/transition zone membrane associations and ciliary Gate Function during ciliogenesis
Journal of Cell Biology, 2011Co-Authors: Corey L Williams, Chunmei Li, Katarzyna Kida, Peter N Inglis, Swetha Mohan, Lucie Semenec, Nathan J Bialas, Rachel M Stupay, Nansheng Chen, Oliver E BlacqueAbstract:Meckel-Gruber syndrome (MKS), nephronophthisis (NPHP), and related ciliopathies present with overlapping phenotypes and display considerable allelism between at least twelve different genes of largely unexplained Function. We demonstrate that the conserved C. elegans B9 domain (MKS-1, MKSR-1, and MKSR-2), MKS-3/TMEM67, MKS-5/RPGRIP1L, MKS-6/CC2D2A, NPHP-1, and NPHP-4 proteins exhibit essential, collective Functions at the transition zone (TZ), an underappreciated region at the base of all cilia characterized by Y-shaped assemblages that link axoneme microtubules to surrounding membrane. These TZ proteins Functionally interact as members of two distinct modules, which together contribute to an early ciliogenic event. Specifically, MKS/MKSR/NPHP proteins establish basal body/TZ membrane attachments before or coinciding with intraflagellar transport–dependent axoneme extension and subsequently restrict accumulation of nonciliary components within the ciliary compartment. Together, our findings uncover a unified role for eight TZ-localized proteins in basal body anchoring and establishing a ciliary Gate during ciliogenesis, and suggest that disrupting ciliary Gate Function contributes to phenotypic features of the MKS/NPHP disease spectrum.