The Experts below are selected from a list of 324 Experts worldwide ranked by ideXlab platform
Thomas A Farrell - One of the best experts on this subject based on the ideXlab platform.
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long term results of transrenal ureteral occlusion with use of gianturco coils and Gelatin Sponge pledgets
Journal of Vascular and Interventional Radiology, 1997Co-Authors: Michael J Wallace, Thomas A Farrell, Marshall E. HicksAbstract:Purpose To evaluate transrenal ureteral occlusion with Gianturco coils and Gelatin Sponge pledgets. Materials and Methods The authors reviewed 34 ureteral occlusions in 22 patients during a 4-year period. The indications for this procedure included vesicovaginal fistula in 11 patients and urinary incontinence in three patients. All patients except one had a history of pelvic malignancy and previous radiation therapy. Pre-existing percutaneous nephrostomy tubes were in place in 20 ureters to be embolized. Distal ureteral occlusion was achieved by placement of Gianturco coils alone or in combination with Gelatin Sponge pledgets. A percutaneous nephrostomy catheter was then placed to provide permanent external diversion. Follow-up ranged from 2 weeks to 29 months (mean, 6.2 months). Results Occlusion was technically successful in all embolized ureters. All patients experienced prompt resolution of symptoms as indicated by complete or near complete perineal dryness within 72 hours. Complications were limited to coil migration into the renal pelvis in two patients and nephrostomy catheter occlusion requiring replacement in another three patients. Conclusion Ureteral occlusion with Gianturco coils and Gelatin Sponge is a safe and reliable method of achieving permanent supravesical urinary diversion in the management of chronic lower urinary tract fistulas.
Marshall E. Hicks - One of the best experts on this subject based on the ideXlab platform.
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long term results of transrenal ureteral occlusion with use of gianturco coils and Gelatin Sponge pledgets
Journal of Vascular and Interventional Radiology, 1997Co-Authors: Michael J Wallace, Thomas A Farrell, Marshall E. HicksAbstract:Purpose To evaluate transrenal ureteral occlusion with Gianturco coils and Gelatin Sponge pledgets. Materials and Methods The authors reviewed 34 ureteral occlusions in 22 patients during a 4-year period. The indications for this procedure included vesicovaginal fistula in 11 patients and urinary incontinence in three patients. All patients except one had a history of pelvic malignancy and previous radiation therapy. Pre-existing percutaneous nephrostomy tubes were in place in 20 ureters to be embolized. Distal ureteral occlusion was achieved by placement of Gianturco coils alone or in combination with Gelatin Sponge pledgets. A percutaneous nephrostomy catheter was then placed to provide permanent external diversion. Follow-up ranged from 2 weeks to 29 months (mean, 6.2 months). Results Occlusion was technically successful in all embolized ureters. All patients experienced prompt resolution of symptoms as indicated by complete or near complete perineal dryness within 72 hours. Complications were limited to coil migration into the renal pelvis in two patients and nephrostomy catheter occlusion requiring replacement in another three patients. Conclusion Ureteral occlusion with Gianturco coils and Gelatin Sponge is a safe and reliable method of achieving permanent supravesical urinary diversion in the management of chronic lower urinary tract fistulas.
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Percutaneous Ureteral Occlusion with Use of Gianturco Coils and Gelatin Sponge. Part I. Swine Model
Journal of Vascular and Interventional Radiology, 1992Co-Authors: Kenneth T. Bing, Marshall E. Hicks, Robert S. Figenshau, Mark R. Wick, Daniel Picus, Michael D. Darcy, Ralph V. ClaymanAbstract:An animal model was developed to study ureteral occlusion produced by steel coils and Gelatin Sponge. A coil nest was formed in the ureter, and in all but one pig, Gelatin Sponge pledgets were incorporated in the coil nest. Animals were killed at 2 hours, 1 week, 1 month, and 2 months. High-grade obstruction was present immediately following the procedure in all animals and was documented to be persistent by means of antegrade nephrostograms obtained just prior to death. At gross examination after death, ureteral thickening and strictures were evident. Histologic studies helped confirm the presence of acute and chronic inflammatory changes. In the in vivo model, Gelatin Sponge was not found necessary for acute ureteral occlusion. However, in an ancillary in vitro study in which a rigid plastic tube was used, Gelatin Sponge was necessary in addition to coil occlusion to provide acute total obstruction. The authors’ findings suggest that in a compliant ureter, coil occlusion alone produces sufficient mechanical occlusion. Long-term obstruction is probably due to mechanical obstruction and stricture formation.
Hiroyasu Yokomise - One of the best experts on this subject based on the ideXlab platform.
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regeneration of canine tracheal cartilage by slow release of basic fibroblast growth factor from Gelatin Sponge
Asaio Journal, 2006Co-Authors: Hitoshi Igai, Taku Okamoto, Yasumichi Yamamoto, Masashi Gotoh, Yasuhiko Tabata, Sung Soo Chang, Noriyuki Misaki, Masaya Yamamoto, Hiroyasu YokomiseAbstract:: We investigated the efficiency of basic fibroblast growth factor (b-FGF) released from a Gelatin Sponge in the regeneration of tracheal cartilage. A 1-cm gap was made in the midventral portion of each of 10 consecutive cervical tracheal cartilages (rings 4 to 13) in 15 experimental dogs. In the control group (n = 5), the resulting gap was left blank. In the Gelatin group (n = 5), a Gelatin Sponge alone was implanted in the gap. In the b-FGF group (n = 5), a Gelatin Sponge containing 100 mug b-FGF solution was implanted in the gap. We euthanatized one of the five dogs in each group at 1 month after implantation and one at 3 months and examined the implant sites macroscopically and microscopically. In the control and Gelatin groups, no regenerated cartilage was observed in the tracheal cartilage gap at 1 or 3 months. The distances between the cartilage stumps had shrunk. In the b-FGF group, fibrous cartilage had started to regenerate from both host cartilage stumps at 1 month. At 3 months, regenerated fibrous cartilage filled the gap and had connected each of the stumps. The regenerated cartilage was covered with regenerated perichondrium originating from the host perichondrium. Shrinkage of the distance between the host cartilage stumps was not observed in the b-FGF group. We succeeded in inducing cartilage regeneration in the gaps in canine tracheal cartilage rings by using the slow release of b-FGF from a Gelatin Sponge. The regenerated cartilage induced by b-FGF was fibrous cartilage.
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slow release of bone morphogenetic protein 2 from a Gelatin Sponge to promote regeneration of tracheal cartilage in a canine model
The Journal of Thoracic and Cardiovascular Surgery, 2004Co-Authors: Taku Okamoto, Yasumichi Yamamoto, Masashi Gotoh, Chenglong Huang, Tatsuo Nakamura, Yasuhiko Shimizu, Yasuhiko Tabata, Hiroyasu YokomiseAbstract:Abstract Objectives We investigated whether bone morphogenetic protein 2, released slowly from a Gelatin Sponge, could induce cartilage regeneration in a canine model of tracheomalacia and evaluated the long-term results. Methods A 1 × 5-cm gap was made in the anterior cervical trachea by removing 5-cm long strips of 10 sequential cartilagines. In the control group (n = 5), the gaps were left untreated. In the Gelatin Sponge group (n = 5), a Gelatin Sponge soaked in a buffer solution was implanted in each defect. In the bone morphogenetic protein group (n = 5), a Gelatin Sponge soaked in a buffer solution containing 12 μg bone morphogenetic protein 2 was implanted in each defect. Results Tracheomalacia was observed in the control and Gelatin Sponge groups but not in the bone morphogenetic protein group. No regenerated cartilage was detected in the control or Gelatin Sponge groups, even 6 months after surgery. In contrast, regenerated cartilage, which had developed from the host perichondrium, was observed around the stumps of the resected cartilagines in the bone morphogenetic protein group. This regenerated cartilage maintained the integrity of the internal lumen for longer than 6 months. A compressive fracture test revealed that the tracheal cartilage in the bone morphogenetic protein group was significantly more stable than that in the Gelatin Sponge and control groups ( P = .0015 and P = .0001, respectively). Conclusions In this canine model of tracheomalacia, cartilage regeneration was induced around the stumps of tracheal cartilagines by bone morphogenetic protein 2 released slowly from a Gelatin Sponge. This regenerated cartilage was not reabsorbed for longer than 6 months and was strong enough to maintain the integrity of the internal lumen of the trachea.
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cartilage regeneration using slow release of bone morphogenetic protein 2 from a Gelatin Sponge to treat experimental canine tracheomalacia a preliminary report
Asaio Journal, 2003Co-Authors: Taku Okamoto, Yasumichi Yamamoto, Masashi Gotoh, Chenglong Huang, Minoru Kihara, Kotaro Kameyama, Eiichi Hayashi, Kenji Nakamura, Akira Yamauchi, Hiroyasu YokomiseAbstract:: We investigated whether saber sheath-type tracheomalacia could be treated by the slow release of bone morphogenetic protein (BMP)-2 from a Gelatin Sponge. A 1 cm gap was made in the middle portion of each of 10 consecutive tracheal cartilage rings in the canine cervix (control group, n = 3), then a Gelatin Sponge containing 12 microg of BMP-2 solution was implanted in the gap (12 microg group, n = 3). In another group (120 microg + P group, n = 3), the implanted Gelatin Sponge contained 120 microg of BMP-2 solution, and the gap was covered with periosteum. All of the control dogs developed saber sheath-type tracheomalacia, whereas tracheomalacia was not observed in the 12 microg and 120 microg + P groups. In the 12 microg group, fibrous cartilage was observed at the ends of the cartilage stumps. In the 120 microg + P group, newly formed bone and cartilage were observed to form a bridge between the cartilage stumps. The regeneration of cartilage or bone induced by the slow release of BMP-2 from a Gelatin Sponge might be useful for treatment of tracheomalacia.
Michael J Wallace - One of the best experts on this subject based on the ideXlab platform.
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long term results of transrenal ureteral occlusion with use of gianturco coils and Gelatin Sponge pledgets
Journal of Vascular and Interventional Radiology, 1997Co-Authors: Michael J Wallace, Thomas A Farrell, Marshall E. HicksAbstract:Purpose To evaluate transrenal ureteral occlusion with Gianturco coils and Gelatin Sponge pledgets. Materials and Methods The authors reviewed 34 ureteral occlusions in 22 patients during a 4-year period. The indications for this procedure included vesicovaginal fistula in 11 patients and urinary incontinence in three patients. All patients except one had a history of pelvic malignancy and previous radiation therapy. Pre-existing percutaneous nephrostomy tubes were in place in 20 ureters to be embolized. Distal ureteral occlusion was achieved by placement of Gianturco coils alone or in combination with Gelatin Sponge pledgets. A percutaneous nephrostomy catheter was then placed to provide permanent external diversion. Follow-up ranged from 2 weeks to 29 months (mean, 6.2 months). Results Occlusion was technically successful in all embolized ureters. All patients experienced prompt resolution of symptoms as indicated by complete or near complete perineal dryness within 72 hours. Complications were limited to coil migration into the renal pelvis in two patients and nephrostomy catheter occlusion requiring replacement in another three patients. Conclusion Ureteral occlusion with Gianturco coils and Gelatin Sponge is a safe and reliable method of achieving permanent supravesical urinary diversion in the management of chronic lower urinary tract fistulas.
Taku Okamoto - One of the best experts on this subject based on the ideXlab platform.
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regeneration of canine tracheal cartilage by slow release of basic fibroblast growth factor from Gelatin Sponge
Asaio Journal, 2006Co-Authors: Hitoshi Igai, Taku Okamoto, Yasumichi Yamamoto, Masashi Gotoh, Yasuhiko Tabata, Sung Soo Chang, Noriyuki Misaki, Masaya Yamamoto, Hiroyasu YokomiseAbstract:: We investigated the efficiency of basic fibroblast growth factor (b-FGF) released from a Gelatin Sponge in the regeneration of tracheal cartilage. A 1-cm gap was made in the midventral portion of each of 10 consecutive cervical tracheal cartilages (rings 4 to 13) in 15 experimental dogs. In the control group (n = 5), the resulting gap was left blank. In the Gelatin group (n = 5), a Gelatin Sponge alone was implanted in the gap. In the b-FGF group (n = 5), a Gelatin Sponge containing 100 mug b-FGF solution was implanted in the gap. We euthanatized one of the five dogs in each group at 1 month after implantation and one at 3 months and examined the implant sites macroscopically and microscopically. In the control and Gelatin groups, no regenerated cartilage was observed in the tracheal cartilage gap at 1 or 3 months. The distances between the cartilage stumps had shrunk. In the b-FGF group, fibrous cartilage had started to regenerate from both host cartilage stumps at 1 month. At 3 months, regenerated fibrous cartilage filled the gap and had connected each of the stumps. The regenerated cartilage was covered with regenerated perichondrium originating from the host perichondrium. Shrinkage of the distance between the host cartilage stumps was not observed in the b-FGF group. We succeeded in inducing cartilage regeneration in the gaps in canine tracheal cartilage rings by using the slow release of b-FGF from a Gelatin Sponge. The regenerated cartilage induced by b-FGF was fibrous cartilage.
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slow release of bone morphogenetic protein 2 from a Gelatin Sponge to promote regeneration of tracheal cartilage in a canine model
The Journal of Thoracic and Cardiovascular Surgery, 2004Co-Authors: Taku Okamoto, Yasumichi Yamamoto, Masashi Gotoh, Chenglong Huang, Tatsuo Nakamura, Yasuhiko Shimizu, Yasuhiko Tabata, Hiroyasu YokomiseAbstract:Abstract Objectives We investigated whether bone morphogenetic protein 2, released slowly from a Gelatin Sponge, could induce cartilage regeneration in a canine model of tracheomalacia and evaluated the long-term results. Methods A 1 × 5-cm gap was made in the anterior cervical trachea by removing 5-cm long strips of 10 sequential cartilagines. In the control group (n = 5), the gaps were left untreated. In the Gelatin Sponge group (n = 5), a Gelatin Sponge soaked in a buffer solution was implanted in each defect. In the bone morphogenetic protein group (n = 5), a Gelatin Sponge soaked in a buffer solution containing 12 μg bone morphogenetic protein 2 was implanted in each defect. Results Tracheomalacia was observed in the control and Gelatin Sponge groups but not in the bone morphogenetic protein group. No regenerated cartilage was detected in the control or Gelatin Sponge groups, even 6 months after surgery. In contrast, regenerated cartilage, which had developed from the host perichondrium, was observed around the stumps of the resected cartilagines in the bone morphogenetic protein group. This regenerated cartilage maintained the integrity of the internal lumen for longer than 6 months. A compressive fracture test revealed that the tracheal cartilage in the bone morphogenetic protein group was significantly more stable than that in the Gelatin Sponge and control groups ( P = .0015 and P = .0001, respectively). Conclusions In this canine model of tracheomalacia, cartilage regeneration was induced around the stumps of tracheal cartilagines by bone morphogenetic protein 2 released slowly from a Gelatin Sponge. This regenerated cartilage was not reabsorbed for longer than 6 months and was strong enough to maintain the integrity of the internal lumen of the trachea.
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cartilage regeneration using slow release of bone morphogenetic protein 2 from a Gelatin Sponge to treat experimental canine tracheomalacia a preliminary report
Asaio Journal, 2003Co-Authors: Taku Okamoto, Yasumichi Yamamoto, Masashi Gotoh, Chenglong Huang, Minoru Kihara, Kotaro Kameyama, Eiichi Hayashi, Kenji Nakamura, Akira Yamauchi, Hiroyasu YokomiseAbstract:: We investigated whether saber sheath-type tracheomalacia could be treated by the slow release of bone morphogenetic protein (BMP)-2 from a Gelatin Sponge. A 1 cm gap was made in the middle portion of each of 10 consecutive tracheal cartilage rings in the canine cervix (control group, n = 3), then a Gelatin Sponge containing 12 microg of BMP-2 solution was implanted in the gap (12 microg group, n = 3). In another group (120 microg + P group, n = 3), the implanted Gelatin Sponge contained 120 microg of BMP-2 solution, and the gap was covered with periosteum. All of the control dogs developed saber sheath-type tracheomalacia, whereas tracheomalacia was not observed in the 12 microg and 120 microg + P groups. In the 12 microg group, fibrous cartilage was observed at the ends of the cartilage stumps. In the 120 microg + P group, newly formed bone and cartilage were observed to form a bridge between the cartilage stumps. The regeneration of cartilage or bone induced by the slow release of BMP-2 from a Gelatin Sponge might be useful for treatment of tracheomalacia.