The Experts below are selected from a list of 315 Experts worldwide ranked by ideXlab platform

C. Bouchard - One of the best experts on this subject based on the ideXlab platform.

  • The human Gene Map for performance and health-related fitness phenotypes: the 2006-2007 update.
    Medicine and science in sports and exercise, 2009
    Co-Authors: Molly S. Bray, Louis Pérusse, Tuomo Rankinen, Bernd Wolfarth, J M. Hagberg, Stephen M. Roth, C. Bouchard
    Abstract:

    This update of the human Gene Map for physical performance and health-related fitness phenotypes covers the research advances reported in 2006 and 2007. The Genes and markers with evidence of association or linkage with a performance or a fitness phenotype in sedentary or active people, in responses to acute exercise, or for training-induced adaptations are positioned on the Map of all autosomes and sex chromosomes. Negative studies are reviewed, but a Gene or a locus must be supported by at least one positive study before being inserted on the Map. A brief discussion on the nature of the evidence and on what to look for in assessing human Genetic studies of relevance to fitness and performance is offered in the introduction, followed by a review of all studies published in 2006 and 2007. The findings from these new studies are added to the appropriate tables that are designed to serve as the cumulative summary of all publications with positive Genetic associations available to date for a given phenotype and study design. The fitness and performance Map now includes 214 autosomal Gene entries and quantitative trait loci plus seven others on the X chromosome. Moreover, there are 18 mitochondrial Genes that have been shown to influence fitness and performance phenotypes. Thus,the Map is growing in complexity. Although the Map is exhaustive for currently published accounts of Genes and exercise associations and linkages, there are undoubtedly many more Gene-exercise interaction effects that have not even been considered thus far. Finally, it should be appreciated that most studies reported to date are based on small sample sizes and cannot therefore provide definitive evidence that DNA sequence variants in a given Gene are reliably associated with human variation in fitness and performance traits.

  • The human obesity Gene Map: The 2005 update
    Obesity, 2006
    Co-Authors: Tuomo Rankinen, George Argyropoulos, Brandon Walts, Yvon C. Chagnon, Louis Pérusse, S. John Weisnagel, Aamir Zuberi, C. Bouchard
    Abstract:

    This paper presents the 12th update of the human obesity Gene Map, which incorporates published results up to the end of October 2005. Evidence from single-Gene mutation obesity cases, Mendelian disorders exhibiting obesity as a clinical feature, transgenic and knockout murine models relevant to obesity, quantitative trait loci (QTL) from animal cross-breeding experiments, association studies with candidate Genes, and linkages from genome scans is reviewed. As of October 2005, 176 human obesity cases due to single-Gene mutations in 11 different Genes have been reported, 50 loci related to Mendelian syndromes relevant to human obesity have been Mapped to a genomic region, and causal Genes or strong candidates have been identified for most of these syndromes. There are 244 Genes that, when mutated or expressed as transGenes in the mouse, result in phenotypes that affect body weight and adiposity. The number of QTLs reported from animal models currently reaches 408. The number of human obesity QTLs derived from genome scans continues to grow, and we now have 253 QTLs for obesity-related phenotypes from 61 genome-wide scans. A total of 52 genomic regions harbor QTLs supported by two or more studies. The number of studies reporting associations between DNA sequence variation in specific Genes and obesity phenotypes has also increased considerably, with 426 findings of positive associations with 127 candidate Genes. A promising observation is that 22 Genes are each supported by at least five positive studies. The obesity Gene Map shows putative loci on all chromosomes except Y. The electronic version of the Map with links to useful publications and relevant sites can be found at http://obesityGene.pbrc.edu.

  • The human Gene Map for performance and health-related fitness phenotypes: the 2005 update.
    Medicine and science in sports and exercise, 2006
    Co-Authors: Molly S. Bray, Louis Pérusse, Tuomo Rankinen, Bernd Wolfarth, J M. Hagberg, Stephen M. Roth, C. Bouchard
    Abstract:

    The current review presents the 2005 update of the human Gene Map for physical performance and health-related fitness phenotypes. It is based on peer-reviewed papers published by the end of 2005. The Genes and markers with evidence of association or linkage with a performance or fitness phenotype in sedentary or active people, in adaptation to acute exercise, or for training-induced changes are positioned on the Genetic Map of all autosomes and the X chromosome. Negative studies are reviewed, but a Gene or locus must be supported by at least one positive study before being inserted on the Map. By the end of 2000, in the early version of the Gene Map, 29 loci were depicted. In contrast, the 2005 human Gene Map for physical performance and health-related phenotypes includes 165 autosomal Gene entries and QTL, plus five others on the X chromosome. Moreover, there are 17 mitochondrial Genes in which sequence variants have been shown to influence relevant fitness and performance phenotypes. Thus, the Map is growing in complexity. Unfortunately, progress is slow in the field of Genetics of fitness and performance, primarily because the number of laboratories and scientists focused on the role of Genes and sequence variations in exercise-related traits continues to be quite limited.

  • The human Gene Map for performance and health-related fitness phenotypes: the 2004 update.
    Medicine and science in sports and exercise, 2005
    Co-Authors: Bernd Wolfarth, Louis Pérusse, Tuomo Rankinen, Rainer Rauramaa, Miguel A. Rivera, Molly S. Bray, J M. Hagberg, Stephen M. Roth, C. Bouchard
    Abstract:

    We began this series in 2000 with the aim of making available in an easily accessible format all the advances on the Genetic basis of a large family of exercise-related traits. The current review presents the 2004 update of the human Gene Map for physical performance and health-related fitness phenotypes. It is based on peer-reviewed papers published by the end of 2004. The Genes and markers with evidence of association or linkage with a performance or fitness phenotype in sedentary or active people, in adaptation to acute exercise, or for training-induced changes are positioned on the Genetic Map of all autosomes and the X chromosome. Negative studies are reviewed but a Gene or locus must be supported by at least one positive study before being inserted on the Map. One new feature is that we have incorporated the Genes whose sequence variants have been associated with either the level of physical activity or indicators of sedentarism. By the end of 2000, in the early version of the Gene Map, 29 loci were depicted. In contrast, the 2004 human Gene Map for physical performance and health-related phenotypes includes 140 autosomal Gene entries and quantitative trait loci, plus four on the X chromosome. Moreover, there are 16 mitochondrial Genes in which sequence variants have been shown to influence relevant fitness and performance phenotypes. Thus, the Map is growing in complexity and progress is being made. The number of laboratories and scientists concerned by the role of Genes and sequence variations in exercise-related traits is rising. But exercise science and sports medicine is Generally lagging behind in terms of utilizing the advances in Genetic and genomic technologies.

  • The human obesity Gene Map: the 2004 update.
    Obesity research, 2005
    Co-Authors: Louis Pérusse, George Argyropoulos, Brandon Walts, Yvon C. Chagnon, Tuomo Rankinen, S. John Weisnagel, Aamir Zuberi, Eric E. Snyder, C. Bouchard
    Abstract:

    This paper presents the eleventh update of the human obesity Gene Map, which incorporates published results up to the end of October 2004. Evidence from single-Gene mutation obesity cases, Mendelian disorders exhibiting obesity as a clinical feature, transgenic and knockout murine models relevant to obesity, quantitative trait loci (QTLs) from animal cross-breeding experiments, association studies with candidate Genes, and linkages from genome scans is reviewed. As of October 2004, 173 human obesity cases due to single-Gene mutations in 10 different Genes have been reported, and 49 loci related to Mendelian syndromes relevant to human obesity have been Mapped to a genomic region, and causal Genes or strong candidates have been identified for most of these syndromes. There are 166 Genes which, when mutated or expressed as transGenes in the mouse, result in phenotypes that affect body weight and adiposity. The number of QTLs reported from animal models currently reaches 221. The number of human obesity QTLs derived from genome scans continues to grow, and we have now 204 QTLs for obesity-related phenotypes from 50 genome-wide scans. A total of 38 genomic regions harbor QTLs replicated among two to four studies. The number of studies reporting associations between DNA sequence variation in specific Genes and obesity phenotypes has also increased considerably with 358 findings of positive associations with 113 candidate Genes. Among them, 18 Genes are supported by at least five positive studies. The obesity Gene Map shows putative loci on all chromosomes except Y. Overall, >600 Genes, markers, and chromosomal regions have been associated or linked with human obesity phenotypes. The electronic version of the Map with links to useful publications and genomic and other relevant sites can be found at http://obesityGene.pbrc.edu.

Tuomo Rankinen - One of the best experts on this subject based on the ideXlab platform.

  • The human Gene Map for performance and health-related fitness phenotypes: the 2006-2007 update.
    Medicine and science in sports and exercise, 2009
    Co-Authors: Molly S. Bray, Louis Pérusse, Tuomo Rankinen, Bernd Wolfarth, J M. Hagberg, Stephen M. Roth, C. Bouchard
    Abstract:

    This update of the human Gene Map for physical performance and health-related fitness phenotypes covers the research advances reported in 2006 and 2007. The Genes and markers with evidence of association or linkage with a performance or a fitness phenotype in sedentary or active people, in responses to acute exercise, or for training-induced adaptations are positioned on the Map of all autosomes and sex chromosomes. Negative studies are reviewed, but a Gene or a locus must be supported by at least one positive study before being inserted on the Map. A brief discussion on the nature of the evidence and on what to look for in assessing human Genetic studies of relevance to fitness and performance is offered in the introduction, followed by a review of all studies published in 2006 and 2007. The findings from these new studies are added to the appropriate tables that are designed to serve as the cumulative summary of all publications with positive Genetic associations available to date for a given phenotype and study design. The fitness and performance Map now includes 214 autosomal Gene entries and quantitative trait loci plus seven others on the X chromosome. Moreover, there are 18 mitochondrial Genes that have been shown to influence fitness and performance phenotypes. Thus,the Map is growing in complexity. Although the Map is exhaustive for currently published accounts of Genes and exercise associations and linkages, there are undoubtedly many more Gene-exercise interaction effects that have not even been considered thus far. Finally, it should be appreciated that most studies reported to date are based on small sample sizes and cannot therefore provide definitive evidence that DNA sequence variants in a given Gene are reliably associated with human variation in fitness and performance traits.

  • The human obesity Gene Map: The 2005 update
    Obesity, 2006
    Co-Authors: Tuomo Rankinen, George Argyropoulos, Brandon Walts, Yvon C. Chagnon, Louis Pérusse, S. John Weisnagel, Aamir Zuberi, C. Bouchard
    Abstract:

    This paper presents the 12th update of the human obesity Gene Map, which incorporates published results up to the end of October 2005. Evidence from single-Gene mutation obesity cases, Mendelian disorders exhibiting obesity as a clinical feature, transgenic and knockout murine models relevant to obesity, quantitative trait loci (QTL) from animal cross-breeding experiments, association studies with candidate Genes, and linkages from genome scans is reviewed. As of October 2005, 176 human obesity cases due to single-Gene mutations in 11 different Genes have been reported, 50 loci related to Mendelian syndromes relevant to human obesity have been Mapped to a genomic region, and causal Genes or strong candidates have been identified for most of these syndromes. There are 244 Genes that, when mutated or expressed as transGenes in the mouse, result in phenotypes that affect body weight and adiposity. The number of QTLs reported from animal models currently reaches 408. The number of human obesity QTLs derived from genome scans continues to grow, and we now have 253 QTLs for obesity-related phenotypes from 61 genome-wide scans. A total of 52 genomic regions harbor QTLs supported by two or more studies. The number of studies reporting associations between DNA sequence variation in specific Genes and obesity phenotypes has also increased considerably, with 426 findings of positive associations with 127 candidate Genes. A promising observation is that 22 Genes are each supported by at least five positive studies. The obesity Gene Map shows putative loci on all chromosomes except Y. The electronic version of the Map with links to useful publications and relevant sites can be found at http://obesityGene.pbrc.edu.

  • The human Gene Map for performance and health-related fitness phenotypes: the 2005 update.
    Medicine and science in sports and exercise, 2006
    Co-Authors: Molly S. Bray, Louis Pérusse, Tuomo Rankinen, Bernd Wolfarth, J M. Hagberg, Stephen M. Roth, C. Bouchard
    Abstract:

    The current review presents the 2005 update of the human Gene Map for physical performance and health-related fitness phenotypes. It is based on peer-reviewed papers published by the end of 2005. The Genes and markers with evidence of association or linkage with a performance or fitness phenotype in sedentary or active people, in adaptation to acute exercise, or for training-induced changes are positioned on the Genetic Map of all autosomes and the X chromosome. Negative studies are reviewed, but a Gene or locus must be supported by at least one positive study before being inserted on the Map. By the end of 2000, in the early version of the Gene Map, 29 loci were depicted. In contrast, the 2005 human Gene Map for physical performance and health-related phenotypes includes 165 autosomal Gene entries and QTL, plus five others on the X chromosome. Moreover, there are 17 mitochondrial Genes in which sequence variants have been shown to influence relevant fitness and performance phenotypes. Thus, the Map is growing in complexity. Unfortunately, progress is slow in the field of Genetics of fitness and performance, primarily because the number of laboratories and scientists focused on the role of Genes and sequence variations in exercise-related traits continues to be quite limited.

  • The human obesity Gene Map: the 2004 update.
    Obesity research, 2005
    Co-Authors: Louis Pérusse, George Argyropoulos, Brandon Walts, Yvon C. Chagnon, Tuomo Rankinen, S. John Weisnagel, Aamir Zuberi, Eric E. Snyder, C. Bouchard
    Abstract:

    This paper presents the eleventh update of the human obesity Gene Map, which incorporates published results up to the end of October 2004. Evidence from single-Gene mutation obesity cases, Mendelian disorders exhibiting obesity as a clinical feature, transgenic and knockout murine models relevant to obesity, quantitative trait loci (QTLs) from animal cross-breeding experiments, association studies with candidate Genes, and linkages from genome scans is reviewed. As of October 2004, 173 human obesity cases due to single-Gene mutations in 10 different Genes have been reported, and 49 loci related to Mendelian syndromes relevant to human obesity have been Mapped to a genomic region, and causal Genes or strong candidates have been identified for most of these syndromes. There are 166 Genes which, when mutated or expressed as transGenes in the mouse, result in phenotypes that affect body weight and adiposity. The number of QTLs reported from animal models currently reaches 221. The number of human obesity QTLs derived from genome scans continues to grow, and we have now 204 QTLs for obesity-related phenotypes from 50 genome-wide scans. A total of 38 genomic regions harbor QTLs replicated among two to four studies. The number of studies reporting associations between DNA sequence variation in specific Genes and obesity phenotypes has also increased considerably with 358 findings of positive associations with 113 candidate Genes. Among them, 18 Genes are supported by at least five positive studies. The obesity Gene Map shows putative loci on all chromosomes except Y. Overall, >600 Genes, markers, and chromosomal regions have been associated or linked with human obesity phenotypes. The electronic version of the Map with links to useful publications and genomic and other relevant sites can be found at http://obesityGene.pbrc.edu.

  • The human Gene Map for performance and health-related fitness phenotypes: the 2004 update.
    Medicine and science in sports and exercise, 2005
    Co-Authors: Bernd Wolfarth, Louis Pérusse, Tuomo Rankinen, Rainer Rauramaa, Miguel A. Rivera, Molly S. Bray, J M. Hagberg, Stephen M. Roth, C. Bouchard
    Abstract:

    We began this series in 2000 with the aim of making available in an easily accessible format all the advances on the Genetic basis of a large family of exercise-related traits. The current review presents the 2004 update of the human Gene Map for physical performance and health-related fitness phenotypes. It is based on peer-reviewed papers published by the end of 2004. The Genes and markers with evidence of association or linkage with a performance or fitness phenotype in sedentary or active people, in adaptation to acute exercise, or for training-induced changes are positioned on the Genetic Map of all autosomes and the X chromosome. Negative studies are reviewed but a Gene or locus must be supported by at least one positive study before being inserted on the Map. One new feature is that we have incorporated the Genes whose sequence variants have been associated with either the level of physical activity or indicators of sedentarism. By the end of 2000, in the early version of the Gene Map, 29 loci were depicted. In contrast, the 2004 human Gene Map for physical performance and health-related phenotypes includes 140 autosomal Gene entries and quantitative trait loci, plus four on the X chromosome. Moreover, there are 16 mitochondrial Genes in which sequence variants have been shown to influence relevant fitness and performance phenotypes. Thus, the Map is growing in complexity and progress is being made. The number of laboratories and scientists concerned by the role of Genes and sequence variations in exercise-related traits is rising. But exercise science and sports medicine is Generally lagging behind in terms of utilizing the advances in Genetic and genomic technologies.

Louis Pérusse - One of the best experts on this subject based on the ideXlab platform.

  • The human Gene Map for performance and health-related fitness phenotypes: the 2006-2007 update.
    Medicine and science in sports and exercise, 2009
    Co-Authors: Molly S. Bray, Louis Pérusse, Tuomo Rankinen, Bernd Wolfarth, J M. Hagberg, Stephen M. Roth, C. Bouchard
    Abstract:

    This update of the human Gene Map for physical performance and health-related fitness phenotypes covers the research advances reported in 2006 and 2007. The Genes and markers with evidence of association or linkage with a performance or a fitness phenotype in sedentary or active people, in responses to acute exercise, or for training-induced adaptations are positioned on the Map of all autosomes and sex chromosomes. Negative studies are reviewed, but a Gene or a locus must be supported by at least one positive study before being inserted on the Map. A brief discussion on the nature of the evidence and on what to look for in assessing human Genetic studies of relevance to fitness and performance is offered in the introduction, followed by a review of all studies published in 2006 and 2007. The findings from these new studies are added to the appropriate tables that are designed to serve as the cumulative summary of all publications with positive Genetic associations available to date for a given phenotype and study design. The fitness and performance Map now includes 214 autosomal Gene entries and quantitative trait loci plus seven others on the X chromosome. Moreover, there are 18 mitochondrial Genes that have been shown to influence fitness and performance phenotypes. Thus,the Map is growing in complexity. Although the Map is exhaustive for currently published accounts of Genes and exercise associations and linkages, there are undoubtedly many more Gene-exercise interaction effects that have not even been considered thus far. Finally, it should be appreciated that most studies reported to date are based on small sample sizes and cannot therefore provide definitive evidence that DNA sequence variants in a given Gene are reliably associated with human variation in fitness and performance traits.

  • The human obesity Gene Map: The 2005 update
    Obesity, 2006
    Co-Authors: Tuomo Rankinen, George Argyropoulos, Brandon Walts, Yvon C. Chagnon, Louis Pérusse, S. John Weisnagel, Aamir Zuberi, C. Bouchard
    Abstract:

    This paper presents the 12th update of the human obesity Gene Map, which incorporates published results up to the end of October 2005. Evidence from single-Gene mutation obesity cases, Mendelian disorders exhibiting obesity as a clinical feature, transgenic and knockout murine models relevant to obesity, quantitative trait loci (QTL) from animal cross-breeding experiments, association studies with candidate Genes, and linkages from genome scans is reviewed. As of October 2005, 176 human obesity cases due to single-Gene mutations in 11 different Genes have been reported, 50 loci related to Mendelian syndromes relevant to human obesity have been Mapped to a genomic region, and causal Genes or strong candidates have been identified for most of these syndromes. There are 244 Genes that, when mutated or expressed as transGenes in the mouse, result in phenotypes that affect body weight and adiposity. The number of QTLs reported from animal models currently reaches 408. The number of human obesity QTLs derived from genome scans continues to grow, and we now have 253 QTLs for obesity-related phenotypes from 61 genome-wide scans. A total of 52 genomic regions harbor QTLs supported by two or more studies. The number of studies reporting associations between DNA sequence variation in specific Genes and obesity phenotypes has also increased considerably, with 426 findings of positive associations with 127 candidate Genes. A promising observation is that 22 Genes are each supported by at least five positive studies. The obesity Gene Map shows putative loci on all chromosomes except Y. The electronic version of the Map with links to useful publications and relevant sites can be found at http://obesityGene.pbrc.edu.

  • The human Gene Map for performance and health-related fitness phenotypes: the 2005 update.
    Medicine and science in sports and exercise, 2006
    Co-Authors: Molly S. Bray, Louis Pérusse, Tuomo Rankinen, Bernd Wolfarth, J M. Hagberg, Stephen M. Roth, C. Bouchard
    Abstract:

    The current review presents the 2005 update of the human Gene Map for physical performance and health-related fitness phenotypes. It is based on peer-reviewed papers published by the end of 2005. The Genes and markers with evidence of association or linkage with a performance or fitness phenotype in sedentary or active people, in adaptation to acute exercise, or for training-induced changes are positioned on the Genetic Map of all autosomes and the X chromosome. Negative studies are reviewed, but a Gene or locus must be supported by at least one positive study before being inserted on the Map. By the end of 2000, in the early version of the Gene Map, 29 loci were depicted. In contrast, the 2005 human Gene Map for physical performance and health-related phenotypes includes 165 autosomal Gene entries and QTL, plus five others on the X chromosome. Moreover, there are 17 mitochondrial Genes in which sequence variants have been shown to influence relevant fitness and performance phenotypes. Thus, the Map is growing in complexity. Unfortunately, progress is slow in the field of Genetics of fitness and performance, primarily because the number of laboratories and scientists focused on the role of Genes and sequence variations in exercise-related traits continues to be quite limited.

  • The human Gene Map for performance and health-related fitness phenotypes: the 2004 update.
    Medicine and science in sports and exercise, 2005
    Co-Authors: Bernd Wolfarth, Louis Pérusse, Tuomo Rankinen, Rainer Rauramaa, Miguel A. Rivera, Molly S. Bray, J M. Hagberg, Stephen M. Roth, C. Bouchard
    Abstract:

    We began this series in 2000 with the aim of making available in an easily accessible format all the advances on the Genetic basis of a large family of exercise-related traits. The current review presents the 2004 update of the human Gene Map for physical performance and health-related fitness phenotypes. It is based on peer-reviewed papers published by the end of 2004. The Genes and markers with evidence of association or linkage with a performance or fitness phenotype in sedentary or active people, in adaptation to acute exercise, or for training-induced changes are positioned on the Genetic Map of all autosomes and the X chromosome. Negative studies are reviewed but a Gene or locus must be supported by at least one positive study before being inserted on the Map. One new feature is that we have incorporated the Genes whose sequence variants have been associated with either the level of physical activity or indicators of sedentarism. By the end of 2000, in the early version of the Gene Map, 29 loci were depicted. In contrast, the 2004 human Gene Map for physical performance and health-related phenotypes includes 140 autosomal Gene entries and quantitative trait loci, plus four on the X chromosome. Moreover, there are 16 mitochondrial Genes in which sequence variants have been shown to influence relevant fitness and performance phenotypes. Thus, the Map is growing in complexity and progress is being made. The number of laboratories and scientists concerned by the role of Genes and sequence variations in exercise-related traits is rising. But exercise science and sports medicine is Generally lagging behind in terms of utilizing the advances in Genetic and genomic technologies.

  • The human obesity Gene Map: the 2004 update.
    Obesity research, 2005
    Co-Authors: Louis Pérusse, George Argyropoulos, Brandon Walts, Yvon C. Chagnon, Tuomo Rankinen, S. John Weisnagel, Aamir Zuberi, Eric E. Snyder, C. Bouchard
    Abstract:

    This paper presents the eleventh update of the human obesity Gene Map, which incorporates published results up to the end of October 2004. Evidence from single-Gene mutation obesity cases, Mendelian disorders exhibiting obesity as a clinical feature, transgenic and knockout murine models relevant to obesity, quantitative trait loci (QTLs) from animal cross-breeding experiments, association studies with candidate Genes, and linkages from genome scans is reviewed. As of October 2004, 173 human obesity cases due to single-Gene mutations in 10 different Genes have been reported, and 49 loci related to Mendelian syndromes relevant to human obesity have been Mapped to a genomic region, and causal Genes or strong candidates have been identified for most of these syndromes. There are 166 Genes which, when mutated or expressed as transGenes in the mouse, result in phenotypes that affect body weight and adiposity. The number of QTLs reported from animal models currently reaches 221. The number of human obesity QTLs derived from genome scans continues to grow, and we have now 204 QTLs for obesity-related phenotypes from 50 genome-wide scans. A total of 38 genomic regions harbor QTLs replicated among two to four studies. The number of studies reporting associations between DNA sequence variation in specific Genes and obesity phenotypes has also increased considerably with 358 findings of positive associations with 113 candidate Genes. Among them, 18 Genes are supported by at least five positive studies. The obesity Gene Map shows putative loci on all chromosomes except Y. Overall, >600 Genes, markers, and chromosomal regions have been associated or linked with human obesity phenotypes. The electronic version of the Map with links to useful publications and genomic and other relevant sites can be found at http://obesityGene.pbrc.edu.

Bernd Wolfarth - One of the best experts on this subject based on the ideXlab platform.

  • The human Gene Map for performance and health-related fitness phenotypes: the 2006-2007 update.
    Medicine and science in sports and exercise, 2009
    Co-Authors: Molly S. Bray, Louis Pérusse, Tuomo Rankinen, Bernd Wolfarth, J M. Hagberg, Stephen M. Roth, C. Bouchard
    Abstract:

    This update of the human Gene Map for physical performance and health-related fitness phenotypes covers the research advances reported in 2006 and 2007. The Genes and markers with evidence of association or linkage with a performance or a fitness phenotype in sedentary or active people, in responses to acute exercise, or for training-induced adaptations are positioned on the Map of all autosomes and sex chromosomes. Negative studies are reviewed, but a Gene or a locus must be supported by at least one positive study before being inserted on the Map. A brief discussion on the nature of the evidence and on what to look for in assessing human Genetic studies of relevance to fitness and performance is offered in the introduction, followed by a review of all studies published in 2006 and 2007. The findings from these new studies are added to the appropriate tables that are designed to serve as the cumulative summary of all publications with positive Genetic associations available to date for a given phenotype and study design. The fitness and performance Map now includes 214 autosomal Gene entries and quantitative trait loci plus seven others on the X chromosome. Moreover, there are 18 mitochondrial Genes that have been shown to influence fitness and performance phenotypes. Thus,the Map is growing in complexity. Although the Map is exhaustive for currently published accounts of Genes and exercise associations and linkages, there are undoubtedly many more Gene-exercise interaction effects that have not even been considered thus far. Finally, it should be appreciated that most studies reported to date are based on small sample sizes and cannot therefore provide definitive evidence that DNA sequence variants in a given Gene are reliably associated with human variation in fitness and performance traits.

  • The human Gene Map for performance and health-related fitness phenotypes: the 2005 update.
    Medicine and science in sports and exercise, 2006
    Co-Authors: Molly S. Bray, Louis Pérusse, Tuomo Rankinen, Bernd Wolfarth, J M. Hagberg, Stephen M. Roth, C. Bouchard
    Abstract:

    The current review presents the 2005 update of the human Gene Map for physical performance and health-related fitness phenotypes. It is based on peer-reviewed papers published by the end of 2005. The Genes and markers with evidence of association or linkage with a performance or fitness phenotype in sedentary or active people, in adaptation to acute exercise, or for training-induced changes are positioned on the Genetic Map of all autosomes and the X chromosome. Negative studies are reviewed, but a Gene or locus must be supported by at least one positive study before being inserted on the Map. By the end of 2000, in the early version of the Gene Map, 29 loci were depicted. In contrast, the 2005 human Gene Map for physical performance and health-related phenotypes includes 165 autosomal Gene entries and QTL, plus five others on the X chromosome. Moreover, there are 17 mitochondrial Genes in which sequence variants have been shown to influence relevant fitness and performance phenotypes. Thus, the Map is growing in complexity. Unfortunately, progress is slow in the field of Genetics of fitness and performance, primarily because the number of laboratories and scientists focused on the role of Genes and sequence variations in exercise-related traits continues to be quite limited.

  • The human Gene Map for performance and health-related fitness phenotypes: the 2004 update.
    Medicine and science in sports and exercise, 2005
    Co-Authors: Bernd Wolfarth, Louis Pérusse, Tuomo Rankinen, Rainer Rauramaa, Miguel A. Rivera, Molly S. Bray, J M. Hagberg, Stephen M. Roth, C. Bouchard
    Abstract:

    We began this series in 2000 with the aim of making available in an easily accessible format all the advances on the Genetic basis of a large family of exercise-related traits. The current review presents the 2004 update of the human Gene Map for physical performance and health-related fitness phenotypes. It is based on peer-reviewed papers published by the end of 2004. The Genes and markers with evidence of association or linkage with a performance or fitness phenotype in sedentary or active people, in adaptation to acute exercise, or for training-induced changes are positioned on the Genetic Map of all autosomes and the X chromosome. Negative studies are reviewed but a Gene or locus must be supported by at least one positive study before being inserted on the Map. One new feature is that we have incorporated the Genes whose sequence variants have been associated with either the level of physical activity or indicators of sedentarism. By the end of 2000, in the early version of the Gene Map, 29 loci were depicted. In contrast, the 2004 human Gene Map for physical performance and health-related phenotypes includes 140 autosomal Gene entries and quantitative trait loci, plus four on the X chromosome. Moreover, there are 16 mitochondrial Genes in which sequence variants have been shown to influence relevant fitness and performance phenotypes. Thus, the Map is growing in complexity and progress is being made. The number of laboratories and scientists concerned by the role of Genes and sequence variations in exercise-related traits is rising. But exercise science and sports medicine is Generally lagging behind in terms of utilizing the advances in Genetic and genomic technologies.

  • The human Gene Map for performance and health-related fitness phenotypes: the 2003 update.
    Medicine and science in sports and exercise, 2004
    Co-Authors: Tuomo Rankinen, Louis Pérusse, Rainer Rauramaa, Miguel A. Rivera, Bernd Wolfarth, C. Bouchard
    Abstract:

    This review presents the 2003 update of the human Gene Map for physical performance and health-related fitness phenotypes. It is based on peer-reviewed papers published by the end of 2003 and includes association studies with candidate Genes, genome-wide scans with polymorphic markers, and single-Gene defects causing exercise intolerance to variable degrees. The Genes and markers with evidence of association or linkage with a performance or fitness phenotype in sedentary or active people, in adaptation to acute exercise, or for training-induced changes are positioned on the Genetic Map of all autosomes and the X chromosome. Negative studies are reviewed but a Gene or locus must be supported by at least one positive study before being inserted on the Map. By the end of 2000, 29 loci were depicted on the first edition of the Map. In contrast, the 2003 human Gene Map for physical performance and health-related phenotypes includes 109 autosomal Gene entries and QTL, plus two on the X chromosome. Moreover, there are 15 mitochondrial Genes in which sequence variants have been shown to influence relevant fitness and performance phenotypes.

  • The human Gene Map for performance and health-related fitness phenotypes: the 2002 update.
    Medicine and science in sports and exercise, 2003
    Co-Authors: Louis Pérusse, Tuomo Rankinen, Rainer Rauramaa, Miguel A. Rivera, Bernd Wolfarth, C. Bouchard
    Abstract:

    This review presents the 2002 update of the human Gene Map for physical performance and health-related phenotypes. It is based on peer-reviewed papers published by the end of 2002 and includes association studies with candidate Genes, genome-wide scans with polymorphic markers, and single Gene defects causing exercise intolerance to variable degrees. The Genes and markers with evidence of association or linkage with a performance or fitness phenotype in sedentary or active people, in adaptation to acute exercise, or for training-induced changes are positioned on the Genetic Map of all autosomes and the X chromosome. Negative studies are reviewed, but a Gene or locus must be supported by at least one positive study before being inserted on the Map. By the end of 2000, 29 loci were depicted on the Map. The 2001 Map includes 71 loci on the autosomes and two on the X chromosome. In contrast, the 2002 human Gene Map for physical performance and health-related phenotypes includes 90 Gene entries and QTL, plus two on the X chromosome. To all these loci, one must add 14 mitochondrial Genes in which sequence variants have been shown to influence relevant fitness and performance phenotypes.

Miguel A. Rivera - One of the best experts on this subject based on the ideXlab platform.

  • The human Gene Map for performance and health-related fitness phenotypes: the 2004 update.
    Medicine and science in sports and exercise, 2005
    Co-Authors: Bernd Wolfarth, Louis Pérusse, Tuomo Rankinen, Rainer Rauramaa, Miguel A. Rivera, Molly S. Bray, J M. Hagberg, Stephen M. Roth, C. Bouchard
    Abstract:

    We began this series in 2000 with the aim of making available in an easily accessible format all the advances on the Genetic basis of a large family of exercise-related traits. The current review presents the 2004 update of the human Gene Map for physical performance and health-related fitness phenotypes. It is based on peer-reviewed papers published by the end of 2004. The Genes and markers with evidence of association or linkage with a performance or fitness phenotype in sedentary or active people, in adaptation to acute exercise, or for training-induced changes are positioned on the Genetic Map of all autosomes and the X chromosome. Negative studies are reviewed but a Gene or locus must be supported by at least one positive study before being inserted on the Map. One new feature is that we have incorporated the Genes whose sequence variants have been associated with either the level of physical activity or indicators of sedentarism. By the end of 2000, in the early version of the Gene Map, 29 loci were depicted. In contrast, the 2004 human Gene Map for physical performance and health-related phenotypes includes 140 autosomal Gene entries and quantitative trait loci, plus four on the X chromosome. Moreover, there are 16 mitochondrial Genes in which sequence variants have been shown to influence relevant fitness and performance phenotypes. Thus, the Map is growing in complexity and progress is being made. The number of laboratories and scientists concerned by the role of Genes and sequence variations in exercise-related traits is rising. But exercise science and sports medicine is Generally lagging behind in terms of utilizing the advances in Genetic and genomic technologies.

  • The human Gene Map for performance and health-related fitness phenotypes: the 2003 update.
    Medicine and science in sports and exercise, 2004
    Co-Authors: Tuomo Rankinen, Louis Pérusse, Rainer Rauramaa, Miguel A. Rivera, Bernd Wolfarth, C. Bouchard
    Abstract:

    This review presents the 2003 update of the human Gene Map for physical performance and health-related fitness phenotypes. It is based on peer-reviewed papers published by the end of 2003 and includes association studies with candidate Genes, genome-wide scans with polymorphic markers, and single-Gene defects causing exercise intolerance to variable degrees. The Genes and markers with evidence of association or linkage with a performance or fitness phenotype in sedentary or active people, in adaptation to acute exercise, or for training-induced changes are positioned on the Genetic Map of all autosomes and the X chromosome. Negative studies are reviewed but a Gene or locus must be supported by at least one positive study before being inserted on the Map. By the end of 2000, 29 loci were depicted on the first edition of the Map. In contrast, the 2003 human Gene Map for physical performance and health-related phenotypes includes 109 autosomal Gene entries and QTL, plus two on the X chromosome. Moreover, there are 15 mitochondrial Genes in which sequence variants have been shown to influence relevant fitness and performance phenotypes.

  • The human Gene Map for performance and health-related fitness phenotypes: the 2002 update.
    Medicine and science in sports and exercise, 2003
    Co-Authors: Louis Pérusse, Tuomo Rankinen, Rainer Rauramaa, Miguel A. Rivera, Bernd Wolfarth, C. Bouchard
    Abstract:

    This review presents the 2002 update of the human Gene Map for physical performance and health-related phenotypes. It is based on peer-reviewed papers published by the end of 2002 and includes association studies with candidate Genes, genome-wide scans with polymorphic markers, and single Gene defects causing exercise intolerance to variable degrees. The Genes and markers with evidence of association or linkage with a performance or fitness phenotype in sedentary or active people, in adaptation to acute exercise, or for training-induced changes are positioned on the Genetic Map of all autosomes and the X chromosome. Negative studies are reviewed, but a Gene or locus must be supported by at least one positive study before being inserted on the Map. By the end of 2000, 29 loci were depicted on the Map. The 2001 Map includes 71 loci on the autosomes and two on the X chromosome. In contrast, the 2002 human Gene Map for physical performance and health-related phenotypes includes 90 Gene entries and QTL, plus two on the X chromosome. To all these loci, one must add 14 mitochondrial Genes in which sequence variants have been shown to influence relevant fitness and performance phenotypes.

  • The human Gene Map for performance and health-related fitness phenotypes: the 2001 update.
    Medicine and science in sports and exercise, 2002
    Co-Authors: Tuomo Rankinen, Louis Pérusse, Rainer Rauramaa, Miguel A. Rivera, Bernd Wolfarth, C. Bouchard
    Abstract:

    This review presents the 2001 update of the human Gene Map for physical performance and health-related phenotypes. It is based on scientific papers published by the end of 2001. Association studies with candidate Genes, genome-wide scans with polymorphic markers, and single Gene defects causing exercise intolerance to variable degrees are included. The Genes and markers with evidence of association or linkage with a performance or fitness phenotype in sedentary or active people, in adaptation to acute exercise or for training-induced changes are positioned on the Genetic Map of all autosomes and the X chromosome. Negative studies are reviewed, but a Gene or locus must be supported by at least one positive study before being inserted on the Map. By the end of 2000, there were 29 loci depicted on the Map. The 2001 Map includes 71 loci on the autosomes and two on the X chromosome. Among these Genes or markers, 24 are from prior publications on exercise intolerance and four relate to other pathologies. Finally, 13 sequence variants in mitochondrial DNA have been shown to influence relevant fitness and performance phenotypes.

  • The human Gene Map for performance and health-related fitness phenotypes.
    Medicine and science in sports and exercise, 2001
    Co-Authors: Tuomo Rankinen, Louis Pérusse, Rainer Rauramaa, Miguel A. Rivera, Bernd Wolfarth, C. Bouchard
    Abstract:

    The human Gene Map for performance and health-related fitness phenotypes. Med. Sci. Sports Exerc., Vol. 33, No. 6, 2001, pp. 855–867. The aim of this paper is to describe the first human Gene Map for physical performance and health-related fitness traits based on the papers published until the end of 2000. Studies of candidate Genes using case-control and other designs are reviewed. Quantitative trait loci from the limited evidence reported to date in genomic scans are also incorporated. Performance and fitness phenotypes in the sedentary state as well as their changes during exercise, if applicable, or in response to exercise training are considered. Physical performance traits include cardiorespiratory endurance indicators and muscular strength or muscular performance variables. Health-related fitness phenotypes are grouped under the following categories: hemodynamic traits; anthropometry and body composition; insulin and glucose metabolism; and lipids, lipoproteins, and hemostatic factors. A yearly update of this human Gene Map will be published.