The Experts below are selected from a list of 213021 Experts worldwide ranked by ideXlab platform
Tian-biao Zhou - One of the best experts on this subject based on the ideXlab platform.
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Role of toll-like receptors Gene Polymorphism in renal transplantation.
Journal of receptor and signal transduction research, 2013Co-Authors: Tian-biao ZhouAbstract:Toll-like receptors (TLRs), evolutionarily conserved innate, are expressed in a wide variety of tissues and cell types, and they play key role in the innate immune system. Gene mutation is an important factor associated with some diseases risk and Gene Polymorphism of TLRs can influence their function to take part in the physiological process in the body. Chronic kidney disease causes high morbidity and mortality, and renal transplantation provides the optimal treatment for people with end-stage renal disease. Innate immune takes a most important role in renal transplantation. There are some studies reporting that TLRs Gene Polymorphism takes an important role in the renal transplantation. However, no review summed up the role of TLRs Gene Polymorphism in renal transplantation. The literatures were searched extensively and this review was performed to review the role of TLRs Gene Polymorphism in renal transplantation.
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Relationship between the prohibitin 3' untranslated region C > T Gene Polymorphism and cancer susceptibility--results of a meta-analysis.
Asian Pacific Journal of Cancer Prevention, 2012Co-Authors: Tian-biao Zhou, Jian-jian Huang, Chao OuAbstract:Objective: The results from the published studies on the association between prohibitin 3’ untranslated region C > T Gene Polymorphism and cancer risk are conflicting. This meta-analysis was performed to evaluate the relationship with cancer susceptibility overall, and to explore whether the T allele or TT genotype could become a predictive marker for cancer risk. Methods: Association studies were identified from the databases of PubMed, Embase, and Cochrane Library as of March 1, 2012, and eligible investigations were synthesized using the meta-analysis method. Results were expressed with odds ratios (OR) for dichotomous data, and 95% confidence intervals (CI) were also calculated. Results: Six investigations were identified for the analysis of association between the prohibitin 3’ untranslated region C > T Gene Polymorphism and cancer risk, covering of 1,461 patients with cancer and 1,197 controls. There was a positive association between the T allele and cancer susceptibility (OR=1.20, 95% CI: 1.03-1.39, P=0.02), and CC homozygous might play a protective role (OR=0.80, 95% CI: 0.68-6.11, P=0.95). In the sub-group analysis, prohibitin 3’ untranslated region C > T Gene Polymorphism and cancer risk appeared associated with the risk of breast cancer, but not ovarian cancer. Conclusions: Our results indicate that T allele is a significant Genetic molecular marker to predict cancer susceptibility and CC genotype is protective, especially for breast cancer. However, more investigations are required to further clarify the association of the prohibitin 3’ untranslated region C > T Gene Polymorphism with cancer susceptibility.
Takao Saruta - One of the best experts on this subject based on the ideXlab platform.
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Stromal Cell‐Derived Factor‐1 Chemokine Gene Polymorphism Is Not Associated with Onset Age of Japanese Type 1 Diabetes
Annals of the New York Academy of Sciences, 2003Co-Authors: Toshikatsu Shigihara, Akira Shimada, Satoru Yamada, Taro Maruyama, Hiroshi Hirose, Takao SarutaAbstract:Type 1 diabetes is characterized by cell-mediated autoimmune destruction of pancreatic beta cells. Although the disease shows a strong association with HLA class II alleles, other Genes may influence the initiation or the rate of progression of the autoimmune process. Recently, it was reported that a Polymorphism of the stromal cell-derived factor-1 (SDF-1) (a kind of chemokine) Gene was associated with early onset of type 1 diabetes in Caucasians. Therefore, we examined SDF-1 Gene Polymorphism in Japanese type 1 diabetes in this study. We examined the SDF-1 Gene Polymorphism (801G-->A) in 298 unrelated Japanese type 1 diabetic patients and 270 healthy subjects by the TaqMan PCR method. Allelic and genotypic frequencies of the SDF-1 A variants were similar in overall type 1 diabetic patients and healthy subjects. We then stratified the patients by their onset pattern (acute vs. slow onset) and islet-associated autoantibody positivity. However, no significant difference was found among each group of type 1 diabetes. Furthermore, unlike the previous report in "Caucasian" type 1 diabetics, the SDF-1 A variant was not associated with early onset of the disease in Japanese type 1 diabetics. The SDF-1 Gene Polymorphism was not associated with onset age (or onset pattern) of type 1 diabetes in Japanese. Further study is necessary to conclude whether SDF-1 Gene Polymorphism affects the onset age in type 1 diabetes in General.
Toshikatsu Shigihara - One of the best experts on this subject based on the ideXlab platform.
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Stromal Cell‐Derived Factor‐1 Chemokine Gene Polymorphism Is Not Associated with Onset Age of Japanese Type 1 Diabetes
Annals of the New York Academy of Sciences, 2003Co-Authors: Toshikatsu Shigihara, Akira Shimada, Satoru Yamada, Taro Maruyama, Hiroshi Hirose, Takao SarutaAbstract:Type 1 diabetes is characterized by cell-mediated autoimmune destruction of pancreatic beta cells. Although the disease shows a strong association with HLA class II alleles, other Genes may influence the initiation or the rate of progression of the autoimmune process. Recently, it was reported that a Polymorphism of the stromal cell-derived factor-1 (SDF-1) (a kind of chemokine) Gene was associated with early onset of type 1 diabetes in Caucasians. Therefore, we examined SDF-1 Gene Polymorphism in Japanese type 1 diabetes in this study. We examined the SDF-1 Gene Polymorphism (801G-->A) in 298 unrelated Japanese type 1 diabetic patients and 270 healthy subjects by the TaqMan PCR method. Allelic and genotypic frequencies of the SDF-1 A variants were similar in overall type 1 diabetic patients and healthy subjects. We then stratified the patients by their onset pattern (acute vs. slow onset) and islet-associated autoantibody positivity. However, no significant difference was found among each group of type 1 diabetes. Furthermore, unlike the previous report in "Caucasian" type 1 diabetics, the SDF-1 A variant was not associated with early onset of the disease in Japanese type 1 diabetics. The SDF-1 Gene Polymorphism was not associated with onset age (or onset pattern) of type 1 diabetes in Japanese. Further study is necessary to conclude whether SDF-1 Gene Polymorphism affects the onset age in type 1 diabetes in General.
Yun Qian - One of the best experts on this subject based on the ideXlab platform.
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p22phox C242T Gene Polymorphism and overt diabetic nephropathy: a meta-analysis of 1,452 participants.
The Korean journal of internal medicine, 2016Co-Authors: Ge Gong, Hong-yu Geng, Yun QianAbstract:BACKGROUND/AIMS The p22phox C242T Gene Polymorphism (rs4673) may be linked to an increased susceptibility for overt diabetic nephropathy (ODN), but the study results are still inconclusive. METHODS To explore the relationship between p22phox C242T Gene Polymorphism and ODN, the current meta-analysis of 707 ODN patients and 745 controls from five individual studies was conducted. The pooled odds ratio (OR) and its corresponding 95% confidence interval (CI) were evaluated by either a random or fixed effect model. RESULTS In our meta-analysis, a significant relationship between the p22phox C242T Gene Polymorphism and ODN was found under allelic (OR, 2.760; 95% CI, 1.400 to 5.450; p = 0.004), recessive (OR, 5.080; 95% CI, 1.020 to 25.430; p = 0.05), dominant (OR, 1.700; 95% CI, 1.167 to 2.477; p = 0.006), homozygous (OR, 3.900; 95% CI, 1.022 to 14.889; p = 0.046), heterozygous (OR, 1.523; 95% CI, 1.167 to 1.986; p = 0.002), and additive Genetic models (OR, 2.019; 95% CI, 1.232 to 3.309; p = 0.005). CONCLUSIONS A positive correlation between p22phox C242T Gene Polymorphism and ODN risk was found. The T allele carriers of p22phox C242T Gene Polymorphism might be predisposed to ODN.
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TAP1 I333V Gene Polymorphism and type 1 diabetes mellitus: a meta-analysis of 2248 cases
Journal of cellular and molecular medicine, 2014Co-Authors: Wei Gao, Sisi Pang, Xiaoyan Min, Zhijian Yang, Hui Wang, Lian-sheng Wang, Xiangming Wang, Yun QianAbstract:Transporter associated with antigen processing 1 (TAP1) I333V Gene Polymorphism has been suggested to be associated with type 1 diabetes mellitus (T1DM) susceptibility. However, the results from individual studies are inconsistent. To explore the association of TAP1 I333V Gene Polymorphisms with T1DM, a meta-analysis involving 2246 cases from 13 individual studies was conducted. The pooled odd ratios (ORs) and their corresponding 95% confidence intervals (95% CIs) were evaluated by a fixed-effect model. A significant relationship was observed between TAP1 I333V Gene Polymorphism and T1DM in allelic (OR: 1.35, 95% CI: 1.08–1.68, P = 0.007), dominant (OR: 1.462, 95% CI: 1.094–1.955, P = 0.010), homozygous (OR: 1.725, 95% CI: 1.082–2.752, P = 0.022), heterozygous (OR: 1.430, 95% CI: 1.048–1.951, P = 0.024) and additive (OR: 1.348, 95% CI: 1.084–1.676, P = 0.007) Genetic models. No significant association between TAP1 I333V Gene Polymorphism and T1DM was detected in a recessive Genetic model (OR: 1.384, 95% CI: 0.743–2.579, P = 0.306) in the entire population, especially among Caucasians. No significant association between them was found in an Asian or African population. TAP1 I333V Gene Polymorphism was significantly associated with increased T1DM risk. V allele carriers might be predisposed to T1DM susceptibility.
Xiaojing Kuang - One of the best experts on this subject based on the ideXlab platform.
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glypican 4 Gene Polymorphism rs1048369 and susceptibility to epstein barr virus associated and negative gastric carcinoma
Virus Research, 2016Co-Authors: Danrui Zhao, Zhenzhen Zhao, Xiaojing KuangAbstract:Abstract Background/aims Gastric cancer (GC) is one of the most common malignant tumors in China and single nucleotide Polymorphisms (SNPs) have been found to be highly related to GC carcinoGenesis. Glypican-4 (GPC4), a member of the heparan sulphate proteoglycan family, plays an important role in the regulation of cell growth and differentiation. However, little is known about Polymorphisms of GPC4 Gene and their associated susceptibility to GC, especially to Epstein-Barr virus-associated GC (EBVaGC). Here we studied the GPC4 Polymorphism (rs1048369) in GC individuals, especially those with EBVaGC, and we explored an association between the GPC4 Gene Polymorphism (rs1048369) and susceptibility to EBVaGC and Epstein-Barr virus-negative GC (EBVnGC) in a population from Northern China. Patients and methods The GPC4 Gene Polymorphism (rs1048369) was detected in 54 cases of EBVaGC and 73 cases of EBVnGC using polymerase chain reaction (PCR). One hundred and seven peripheral blood samples from healthy individuals were also measured as a control group. Results There were significant differences in both the genotype and allelic frequency of GPC4 Gene (rs1048369) between the EBVaGC and EBVnGC patients. Meanwhile, the distribution of genotype and allelic frequency of GPC4 (rs1048369) differed between EBVaGC and control groups. Distribution of the GPC4 genotype also revealed differences between EBVnGC and control groups, no significant differences in the allelic frequency of the GPC4 Gene (rs1048369) were observed. The frequency of the T allele in EBVaGC group was significantly higher than that in control and EBVnGC groups. Conclusions The GPC4 Gene Polymorphism and the allele of GPC4 are both associated with susceptibility to EBVaGC. The T allele of GPC4 may represent a risk factor for EBVaGC.