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Andrew L Gundlach - One of the best experts on this subject based on the ideXlab platform.
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Modulation of forebrain Function by nucleus incertus and relaxin-3/RXFP3 signaling.
CNS neuroscience & therapeutics, 2018Co-Authors: Francisco E. Olucha-bordonau, Ana María Sánchez-pérez, Héctor Albert-gascó, Francisco Ros-bernal, Valeria Rytova, Emma K E Ong-pålsson, Andrew L GundlachAbstract:The nucleus incertus (NI) in the pontine tegmentum sends ascending projections to the midbrain, hypothalamus, amygdala, basal forebrain, hippocampus, and prefrontal cortex, and has a postulated role in modulating several forebrain Functions. A substantial population of GABAergic NI neurons expresses the neuropeptide, relaxin-3, which acts via the Gi/o -protein-coupled receptor, RXFP3, present throughout the forebrain target regions. Broad and specific manipulations of these systems by activation or inhibition of the NI or modulating RXFP3 signaling have revealed key insights into the likely influence of the NI/relaxin-3/RXFP3 system on modalities including arousal, feeding, stress responses, anxiety and addiction, and attention and memory. This range of actions corresponds to a likely impact of NI/(relaxin-3) projections on multiple integrated circuits, but makes it difficult to draw conclusions about a Generalized Function for this network. This review will focus on the key physiological process of oscillatory theta rhythm and the neural circuits that promote it during behavioral activation, highlighting the ability of NI and relaxin-3/RXFP3 signaling systems to modulate these circuits. A better understanding of these mechanisms may provide a way to therapeutically adjust malFunction of forebrain activity present in several pathological conditions.
Francisco E. Olucha-bordonau - One of the best experts on this subject based on the ideXlab platform.
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Modulation of forebrain Function by nucleus incertus and relaxin-3/RXFP3 signaling.
CNS neuroscience & therapeutics, 2018Co-Authors: Francisco E. Olucha-bordonau, Ana María Sánchez-pérez, Héctor Albert-gascó, Francisco Ros-bernal, Valeria Rytova, Emma K E Ong-pålsson, Andrew L GundlachAbstract:The nucleus incertus (NI) in the pontine tegmentum sends ascending projections to the midbrain, hypothalamus, amygdala, basal forebrain, hippocampus, and prefrontal cortex, and has a postulated role in modulating several forebrain Functions. A substantial population of GABAergic NI neurons expresses the neuropeptide, relaxin-3, which acts via the Gi/o -protein-coupled receptor, RXFP3, present throughout the forebrain target regions. Broad and specific manipulations of these systems by activation or inhibition of the NI or modulating RXFP3 signaling have revealed key insights into the likely influence of the NI/relaxin-3/RXFP3 system on modalities including arousal, feeding, stress responses, anxiety and addiction, and attention and memory. This range of actions corresponds to a likely impact of NI/(relaxin-3) projections on multiple integrated circuits, but makes it difficult to draw conclusions about a Generalized Function for this network. This review will focus on the key physiological process of oscillatory theta rhythm and the neural circuits that promote it during behavioral activation, highlighting the ability of NI and relaxin-3/RXFP3 signaling systems to modulate these circuits. A better understanding of these mechanisms may provide a way to therapeutically adjust malFunction of forebrain activity present in several pathological conditions.
Hui Wang - One of the best experts on this subject based on the ideXlab platform.
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hyperchaotic secure communication via Generalized Function projective synchronization
Nonlinear Analysis-real World Applications, 2011Co-Authors: Hui WangAbstract:Abstract This paper presents two different hyperchaotic secure communication schemes by using Generalized Function projective synchronization (GFPS), where the drive and response systems could be synchronized up to a desired scaling Function matrix. The unpredictability of the scaling Functions can additionally enhance the security of communication. First, a hyperchaotic secure communication scheme applying GFPS of the uncertain Chen hyperchaotic system is proposed. The transmitted information signal is modulated into the parameter of the Chen hyperchaotic system in the transmitter and it is assumed that the parameter of the receiver system is unknown. Based on the Lyapunov stability theory and the adaptive control technique, the controllers are designed to make two identical Chen hyperchaotic systems with unknown parameter asymptotically synchronized; thus, the uncertain parameter of the receiver system is identified. The information signal can be recovered accurately by the estimated parameter. Secondly, another secure communication scheme by the coupled GFPS of the Chen hyperchaotic system is introduced. The information signal transmitted can be extracted exactly through simple operation in the receiver. The corresponding theoretical proofs and numerical simulations demonstrate the validity and feasibility of the proposed hyperchaotic secure communication schemes.
Francisco Ros-bernal - One of the best experts on this subject based on the ideXlab platform.
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Modulation of forebrain Function by nucleus incertus and relaxin-3/RXFP3 signaling.
CNS neuroscience & therapeutics, 2018Co-Authors: Francisco E. Olucha-bordonau, Ana María Sánchez-pérez, Héctor Albert-gascó, Francisco Ros-bernal, Valeria Rytova, Emma K E Ong-pålsson, Andrew L GundlachAbstract:The nucleus incertus (NI) in the pontine tegmentum sends ascending projections to the midbrain, hypothalamus, amygdala, basal forebrain, hippocampus, and prefrontal cortex, and has a postulated role in modulating several forebrain Functions. A substantial population of GABAergic NI neurons expresses the neuropeptide, relaxin-3, which acts via the Gi/o -protein-coupled receptor, RXFP3, present throughout the forebrain target regions. Broad and specific manipulations of these systems by activation or inhibition of the NI or modulating RXFP3 signaling have revealed key insights into the likely influence of the NI/relaxin-3/RXFP3 system on modalities including arousal, feeding, stress responses, anxiety and addiction, and attention and memory. This range of actions corresponds to a likely impact of NI/(relaxin-3) projections on multiple integrated circuits, but makes it difficult to draw conclusions about a Generalized Function for this network. This review will focus on the key physiological process of oscillatory theta rhythm and the neural circuits that promote it during behavioral activation, highlighting the ability of NI and relaxin-3/RXFP3 signaling systems to modulate these circuits. A better understanding of these mechanisms may provide a way to therapeutically adjust malFunction of forebrain activity present in several pathological conditions.
Ana María Sánchez-pérez - One of the best experts on this subject based on the ideXlab platform.
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Modulation of forebrain Function by nucleus incertus and relaxin-3/RXFP3 signaling.
CNS neuroscience & therapeutics, 2018Co-Authors: Francisco E. Olucha-bordonau, Ana María Sánchez-pérez, Héctor Albert-gascó, Francisco Ros-bernal, Valeria Rytova, Emma K E Ong-pålsson, Andrew L GundlachAbstract:The nucleus incertus (NI) in the pontine tegmentum sends ascending projections to the midbrain, hypothalamus, amygdala, basal forebrain, hippocampus, and prefrontal cortex, and has a postulated role in modulating several forebrain Functions. A substantial population of GABAergic NI neurons expresses the neuropeptide, relaxin-3, which acts via the Gi/o -protein-coupled receptor, RXFP3, present throughout the forebrain target regions. Broad and specific manipulations of these systems by activation or inhibition of the NI or modulating RXFP3 signaling have revealed key insights into the likely influence of the NI/relaxin-3/RXFP3 system on modalities including arousal, feeding, stress responses, anxiety and addiction, and attention and memory. This range of actions corresponds to a likely impact of NI/(relaxin-3) projections on multiple integrated circuits, but makes it difficult to draw conclusions about a Generalized Function for this network. This review will focus on the key physiological process of oscillatory theta rhythm and the neural circuits that promote it during behavioral activation, highlighting the ability of NI and relaxin-3/RXFP3 signaling systems to modulate these circuits. A better understanding of these mechanisms may provide a way to therapeutically adjust malFunction of forebrain activity present in several pathological conditions.