The Experts below are selected from a list of 174135 Experts worldwide ranked by ideXlab platform
Clare Turnbull - One of the best experts on this subject based on the ideXlab platform.
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a genome wide Association Study identifies susceptibility loci for wilms tumor
Nature Genetics, 2012Co-Authors: Clare Turnbull, David Pernet, Anthony Renwick, Sheila Seal, Elizabeth R Perdeaux, Arlene Naranjo, Rosa Maria Munozxicola, Sandra Hanks, Ingrid Slade, Anna ZachariouAbstract:Nazneen Rahman and colleagues report the results of a Genome-Wide Association Study of Wilms tumor. They show that common variants at 2p24 and 11q14 influence susceptibility to this rare pediatric kidney tumor.
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genome wide Association Study identifies five new breast cancer susceptibility loci
Nature Genetics, 2010Co-Authors: Clare Turnbull, Melanie Maranian, Maya Ghoussaini, Shahana Ahmed, Jonathan J Morrison, David Pernet, Anthony Renwick, Sheila Seal, Sarah Hines, Catherine S HealeyAbstract:Breast cancer is the most common cancer in women in developed countries. To identify common breast cancer susceptibility alleles, we conducted a Genome-Wide Association Study in which 582,886 SNPs were genotyped in 3,659 cases with a family history of the disease and 4,897 controls. Promising Associations were evaluated in a second stage, comprising 12,576 cases and 12,223 controls. We identified five new susceptibility loci, on chromosomes 9, 10 and 11 (P = 4.6 x 10(-7) to P = 3.2 x 10(-15)). We also identified SNPs in the 6q25.1 (rs3757318, P = 2.9 x 10(-6)), 8q24 (rs1562430, P = 5.8 x 10(-7)) and LSP1 (rs909116, P = 7.3 x 10(-7)) regions that showed more significant Association with risk than those reported previously. Previously identified breast cancer susceptibility loci were also found to show larger effect sizes in this Study of familial breast cancer cases than in previous population-based studies, consistent with polygenic susceptibility to the disease.
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a genome wide Association Study of testicular germ cell tumor
Nature Genetics, 2009Co-Authors: Elizabeth A Rapley, Clare Turnbull, Anthony Renwick, Sarah Hines, Ali Amin Al Olama, Emmanouil T Dermitzakis, Rachel Linger, Robert Huddart, D H Hughes, Sheila SealAbstract:We conducted a Genome-Wide Association Study for testicular germ cell tumor (TGCT), genotyping 307,666 SNPs in 730 cases and 1,435 controls from the UK and replicating Associations in a further 571 cases and 1,806 controls. We found strong evidence for susceptibility loci on chromosome 5 (per allele OR = 1.37 (95% CI = 1.19-1.58), P = 3 x 10(-13)), chromosome 6 (OR = 1.50 (95% CI = 1.28-1.75), P = 10(-13)) and chromosome 12 (OR = 2.55 (95% CI = 2.05-3.19), P = 10(-31)). KITLG, encoding the ligand for the receptor tyrosine kinase KIT, which has previously been implicated in the pathogenesis of TGCT and the biology of germ cells, may explain the Association on chromosome 12.
Marketa Zvelebil - One of the best experts on this subject based on the ideXlab platform.
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genome wide Association Study identifies a common variant in rad51b associated with male breast cancer risk
Nature Genetics, 2012Co-Authors: Nick Orr, Alina Lemnrau, Rosie Cooke, Olivia Fletcher, Katarzyna Tomczyk, Michael E Jones, Nichola Johnson, Christopher J Lord, Costas Mitsopoulos, Marketa ZvelebilAbstract:We conducted a Genome-Wide Association Study of male breast cancer comprising 823 cases and 2,795 controls of European ancestry, with validation in independent sample sets totaling 438 cases and 474 controls. A SNP in RAD51B at 14q24.1 was significantly associated with male breast cancer risk (P = 3.02 x 10(-13); odds ratio (OR) = 1.57). We also refine Association at 16q12.1 to a SNP within TOX3 (P = 3.87 x 10(-15); OR = 1.50).
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genome wide Association Study identifies a common variant in rad51b associated with male breast cancer risk
Nature Genetics, 2012Co-Authors: Alina Lemnrau, Rosie Cooke, Olivia Fletcher, Katarzyna Tomczyk, Michael E Jones, Nichola Johnson, Christopher J Lord, Costas Mitsopoulos, Marketa Zvelebil, Simon S McdadeAbstract:We conducted a Genome-Wide Association Study of male breast cancer comprising 823 cases and 2,795 controls of European ancestry, with validation in independent sample sets totaling 438 cases and 474 controls. A SNP in RAD51B at 14q24.1 was significantly associated with male breast cancer risk (P = 3.02 x 10(-13); odds ratio (OR) = 1.57). We also refine Association at 16q12.1 to a SNP within TOX3 (P = 3.87 x 10(-15); OR = 1.50).
Yongyong Shi - One of the best experts on this subject based on the ideXlab platform.
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a genome wide Association Study identifies two new lung cancer susceptibility loci at 13q12 12 and 22q12 2 in han chinese
Nature Genetics, 2011Co-Authors: Yongyong Shi, Juncheng Dai, Huan Guo, Xueying Zhao, Zhihua Yin, Lei Yang, Wen Tan, Qifei Deng, Jiucun Wang, Guangfu JinAbstract:Hongbing Shen and colleagues report a Genome-Wide Association Study for lung cancer in individuals of Han Chinese ancestry. The authors identify two new lung cancer susceptibility loci.
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genome wide Association Study identifies susceptibility loci for polycystic ovary syndrome on chromosome 2p16 3 2p21 and 9q33 3
Nature Genetics, 2011Co-Authors: Zijiang Chen, Jiayin Liu, Han Zhao, Yuhua Shi, Yingying Qin, Yongyong Shi, Li You, Junli Zhao, Xiaoyan Liang, Xiaoming ZhaoAbstract:Zi-Jiang Chen and Yongyong Shi report a Genome-Wide Association Study for polycystic ovary syndrome, a common metabolic and endocrine disorder in women. They identified three susceptibility loci associated with this condition.
Peter Kraft - One of the best experts on this subject based on the ideXlab platform.
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genome wide Association Study identifies 14 novel risk alleles associated with basal cell carcinoma
Nature Communications, 2016Co-Authors: Harvind S Chahal, Abrar A Qureshi, Katherine J Ransohoff, Lingyao Yang, Haley Hedlin, Manisha Desai, Yuan Lin, Hongji Dai, Peter KraftAbstract:Basal cell carcinoma is a common skin lesion and the risk loci for this cancer are beginning to be understood. In this Study, the authors conduct a two-stage Genome-Wide Association Study and confirm known risk loci and identify an additional 14 loci.
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genome wide Association Study identifies multiple susceptibility loci for pancreatic cancer
Nature Genetics, 2014Co-Authors: Brian M Wolpin, Peter Kraft, Cosmeri Rizzato, Charles Kooperberg, Gloria M Petersen, Zhaoming Wang, Alan A Arslan, Laura Beanefreeman, Paige M Bracci, Julie E BuringAbstract:We performed a multistage Genome-Wide Association Study including 7,683 individuals with pancreatic cancer and 14,397 controls of European descent. Four new loci reached Genome-Wide significance: rs6971499 at 7q32.3 (LINC-PINT, per-allele odds ratio (OR) = 0.79, 95% confidence interval (CI) 0.74-0.84, P = 3.0 × 10(-12)), rs7190458 at 16q23.1 (BCAR1/CTRB1/CTRB2, OR = 1.46, 95% CI 1.30-1.65, P = 1.1 × 10(-10)), rs9581943 at 13q12.2 (PDX1, OR = 1.15, 95% CI 1.10-1.20, P = 2.4 × 10(-9)) and rs16986825 at 22q12.1 (ZNRF3, OR = 1.18, 95% CI 1.12-1.25, P = 1.2 × 10(-8)). We identified an independent signal in exon 2 of TERT at the established region 5p15.33 (rs2736098, OR = 0.80, 95% CI 0.76-0.85, P = 9.8 × 10(-14)). We also identified a locus at 8q24.21 (rs1561927, P = 1.3 × 10(-7)) that approached Genome-Wide significance located 455 kb telomeric of PVT1. Our Study identified multiple new susceptibility alleles for pancreatic cancer that are worthy of follow-up studies.
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a new statistic and its power to infer membership in a genome wide Association Study using genotype frequencies
Nature Genetics, 2009Co-Authors: David J Hunter, Peter Kraft, Kevin B Jacobs, Meredith Yeager, Sholom Wacholder, David Craig, Justin Paschal, Teri A ManolioAbstract:Kevin Jacobs and colleagues report a new test statistic for detection of membership of an individual within a Genome-Wide Association Study, based on reporting of Study genotype frequencies.
Catherine S Healey - One of the best experts on this subject based on the ideXlab platform.
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genome wide Association Study identifies five new breast cancer susceptibility loci
Nature Genetics, 2010Co-Authors: Clare Turnbull, Melanie Maranian, Maya Ghoussaini, Shahana Ahmed, Jonathan J Morrison, David Pernet, Anthony Renwick, Sheila Seal, Sarah Hines, Catherine S HealeyAbstract:Breast cancer is the most common cancer in women in developed countries. To identify common breast cancer susceptibility alleles, we conducted a Genome-Wide Association Study in which 582,886 SNPs were genotyped in 3,659 cases with a family history of the disease and 4,897 controls. Promising Associations were evaluated in a second stage, comprising 12,576 cases and 12,223 controls. We identified five new susceptibility loci, on chromosomes 9, 10 and 11 (P = 4.6 x 10(-7) to P = 3.2 x 10(-15)). We also identified SNPs in the 6q25.1 (rs3757318, P = 2.9 x 10(-6)), 8q24 (rs1562430, P = 5.8 x 10(-7)) and LSP1 (rs909116, P = 7.3 x 10(-7)) regions that showed more significant Association with risk than those reported previously. Previously identified breast cancer susceptibility loci were also found to show larger effect sizes in this Study of familial breast cancer cases than in previous population-based studies, consistent with polygenic susceptibility to the disease.