The Experts below are selected from a list of 37194 Experts worldwide ranked by ideXlab platform

S Ciccarese - One of the best experts on this subject based on the ideXlab platform.

  • Genomic Organization of sheep TRDJ segments and their expression in the delta-chain repertoire in thymus.
    Immunogenetics, 2000
    Co-Authors: S Massari, R Antonacci, C Lanave, S Ciccarese
    Abstract:

    cDNA sequences obtained from polymerase chain reaction products of reverse-transcribed RNA from sheep thymus showed the presence of a large number of members of the TRDV1 gene family. Some are TRDV1 genes also found in peripheral blood lymphocytes, while four genes had not been described so far. The cDNA sequences also showed extensive junctional diversity and a preferential usage of the three TRDJ elements. We characterized the Genomic Organization of the sheep TRDJ locus and detected a correlation between the nonrandom usage of TRDJ elements during development and their chromosomal order.

  • Genomic Organization of sheep TRDJ segments and their expression in the δ-chain repertoire in thymus
    Immunogenetics, 2000
    Co-Authors: S Massari, R Antonacci, C Lanave, S Ciccarese
    Abstract:

    cDNA sequences obtained from polymerase chain reaction products of reverse-transcribed RNA from sheep thymus showed the presence of a large number of members of the TRDV1 gene family. Some are TRDV1 genes also found in peripheral blood lymphocytes, while four genes had not been described so far. The cDNA sequences also showed extensive junctional diversity and a preferential usage of the three TRDJ elements. We characterized the Genomic Organization of the sheep TRDJ locus and detected a correlation between the nonrandom usage of TRDJ elements during development and their chromosomal order.

S Massari - One of the best experts on this subject based on the ideXlab platform.

  • Genomic Organization of sheep TRDJ segments and their expression in the delta-chain repertoire in thymus.
    Immunogenetics, 2000
    Co-Authors: S Massari, R Antonacci, C Lanave, S Ciccarese
    Abstract:

    cDNA sequences obtained from polymerase chain reaction products of reverse-transcribed RNA from sheep thymus showed the presence of a large number of members of the TRDV1 gene family. Some are TRDV1 genes also found in peripheral blood lymphocytes, while four genes had not been described so far. The cDNA sequences also showed extensive junctional diversity and a preferential usage of the three TRDJ elements. We characterized the Genomic Organization of the sheep TRDJ locus and detected a correlation between the nonrandom usage of TRDJ elements during development and their chromosomal order.

  • Genomic Organization of sheep TRDJ segments and their expression in the δ-chain repertoire in thymus
    Immunogenetics, 2000
    Co-Authors: S Massari, R Antonacci, C Lanave, S Ciccarese
    Abstract:

    cDNA sequences obtained from polymerase chain reaction products of reverse-transcribed RNA from sheep thymus showed the presence of a large number of members of the TRDV1 gene family. Some are TRDV1 genes also found in peripheral blood lymphocytes, while four genes had not been described so far. The cDNA sequences also showed extensive junctional diversity and a preferential usage of the three TRDJ elements. We characterized the Genomic Organization of the sheep TRDJ locus and detected a correlation between the nonrandom usage of TRDJ elements during development and their chromosomal order.

C Lanave - One of the best experts on this subject based on the ideXlab platform.

  • Genomic Organization of sheep TRDJ segments and their expression in the delta-chain repertoire in thymus.
    Immunogenetics, 2000
    Co-Authors: S Massari, R Antonacci, C Lanave, S Ciccarese
    Abstract:

    cDNA sequences obtained from polymerase chain reaction products of reverse-transcribed RNA from sheep thymus showed the presence of a large number of members of the TRDV1 gene family. Some are TRDV1 genes also found in peripheral blood lymphocytes, while four genes had not been described so far. The cDNA sequences also showed extensive junctional diversity and a preferential usage of the three TRDJ elements. We characterized the Genomic Organization of the sheep TRDJ locus and detected a correlation between the nonrandom usage of TRDJ elements during development and their chromosomal order.

  • Genomic Organization of sheep TRDJ segments and their expression in the δ-chain repertoire in thymus
    Immunogenetics, 2000
    Co-Authors: S Massari, R Antonacci, C Lanave, S Ciccarese
    Abstract:

    cDNA sequences obtained from polymerase chain reaction products of reverse-transcribed RNA from sheep thymus showed the presence of a large number of members of the TRDV1 gene family. Some are TRDV1 genes also found in peripheral blood lymphocytes, while four genes had not been described so far. The cDNA sequences also showed extensive junctional diversity and a preferential usage of the three TRDJ elements. We characterized the Genomic Organization of the sheep TRDJ locus and detected a correlation between the nonrandom usage of TRDJ elements during development and their chromosomal order.

R Antonacci - One of the best experts on this subject based on the ideXlab platform.

  • Genomic Organization of sheep TRDJ segments and their expression in the delta-chain repertoire in thymus.
    Immunogenetics, 2000
    Co-Authors: S Massari, R Antonacci, C Lanave, S Ciccarese
    Abstract:

    cDNA sequences obtained from polymerase chain reaction products of reverse-transcribed RNA from sheep thymus showed the presence of a large number of members of the TRDV1 gene family. Some are TRDV1 genes also found in peripheral blood lymphocytes, while four genes had not been described so far. The cDNA sequences also showed extensive junctional diversity and a preferential usage of the three TRDJ elements. We characterized the Genomic Organization of the sheep TRDJ locus and detected a correlation between the nonrandom usage of TRDJ elements during development and their chromosomal order.

  • Genomic Organization of sheep TRDJ segments and their expression in the δ-chain repertoire in thymus
    Immunogenetics, 2000
    Co-Authors: S Massari, R Antonacci, C Lanave, S Ciccarese
    Abstract:

    cDNA sequences obtained from polymerase chain reaction products of reverse-transcribed RNA from sheep thymus showed the presence of a large number of members of the TRDV1 gene family. Some are TRDV1 genes also found in peripheral blood lymphocytes, while four genes had not been described so far. The cDNA sequences also showed extensive junctional diversity and a preferential usage of the three TRDJ elements. We characterized the Genomic Organization of the sheep TRDJ locus and detected a correlation between the nonrandom usage of TRDJ elements during development and their chromosomal order.

Meng Zhou - One of the best experts on this subject based on the ideXlab platform.

  • Systematic analysis of Genomic Organization and structure of long non-coding RNAs in the human genome.
    FEBS letters, 2013
    Co-Authors: Jie Sun, Meng Zhou, Zhi-tao Mao, Dapeng Hao, Zhenzhen Wang
    Abstract:

    The Genomic architecture of several functional elements in animals and plants, such as microRNAs and tRNA, has been better characterized. As yet, there is very little known about Genomic Organization and structure of lncRNA in animals and plants. Here, we conducted a genome-wide systematic computational analysis of Genomic architecture of lncRNAs, and further provided a more comprehensive comparative view of Genomic Organization between lncRNAs and several other functional elements in the human genome. Our study not only provides comprehensive knowledge for further studies into the correlations between the Genomic architecture of lncRNAs and their important functional roles in diverse cellular processes and in disease, but also will be valuable for understanding the origin and evolution of lncRNAs.

  • Systematic analysis of Genomic Organization and heterogeneities of miRNA cluster in vertebrates.
    Molecular biology reports, 2011
    Co-Authors: Jie Sun, Hai-ping Liu, Jia-en Deng, Meng Zhou
    Abstract:

    The clustering propensity of microRNA genes is a common biological phenomenon in various animal and plant species. To gain novel insight into Genomic Organization and potential functional heterogeneities of miRNA clusters in vertebrates from a genome scale, we used large scale data and presented a comprehensive analysis to examine various features of Genomic Organization of miRNA clusters across seven vertebrates by a combination of comparative Genomics and bioinformatics approaches. The results of pair-wise distance analysis of same-strand consecutive miRNAs suggested that the fractions of the miRNA gene pairs are higher at relatively short pair-wise distances than those of protein-coding genes and other non-coding RNA genes. Especially relatively small number of miRNAs is more clustered at very short pair-wise distances than expected at random. We further observed significant difference between real miRNA clusters and randomly organized clusters for different aspects, including higher overlap of target genes, fewer seed types and significant enrichment in diseases. However, the extent of these features of clustered miRNAs has a different tendency and largely depends on inter-miRNA distances because of diverse clustering propensity of miRNAs in vertebrates, suggesting that this cooperated function or cooperative effects between miRNAs in clusters perhaps be affected by inter-miRNA distances.