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Amal Dafar - One of the best experts on this subject based on the ideXlab platform.
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Increased levels of calprotectin in the saliva of patients with Geographic Tongue.
Oral Diseases, 2020Co-Authors: Vegard Garsjö, Amal Dafar, Mats Jontell, Hülya Çevik-aras, John BratelAbstract:OBJECTIVE We investigated whether patients with Geographic Tongue have increased salivary levels of calprotectin and whether there is a correlation between the salivary levels of calprotectin and interleukin 8 (IL-8), which is another marker of inflammation. METHODS Twenty-three patients diagnosed with Geographic Tongue and 32 control subjects without oral mucosal lesions were included in the study. The patients with Geographic Tongue were classified based on clinical appearance and number of oral lesions. ELISAs were used to determine the levels of calprotectin and IL-8 in whole saliva samples. RESULTS There was a statistically significant increase in the salivary output of calprotectin in patients with Geographic Tongue compared with the healthy controls (62 ± 9,1 vs. 37,5 ± 4,7 µg/min; p = .0134). Furthermore, the levels of calprotectin correlated positively with the number of oral lesions in patients with Geographic Tongue. There was also a significant and positive correlation between the salivary levels of calprotectin and IL-8, both for the patients with Geographic Tongue and the controls. CONCLUSION This study supports the notion that GT is an inflammatory disease, in which the activation of neutrophils and production of calprotectin in the saliva may play roles in its pathogenesis.
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Salivary levels of interleukin-8 and growth factors are modulated in patients with Geographic Tongue.
Oral Diseases, 2017Co-Authors: Amal Dafar, Mats Jontell, Vegard Garsjö, Maria Bankvall, Hülya Çevik-arasAbstract:Objectives The aim of the study was to determine the levels of salivary epidermal growth factor (EGF) and vascular endothelial growth factor (VEGF) as well as interleukin-8 (IL-8) in patients with Geographic Tongue (GT), as compared to control subjects. Methodology An enzyme-linked immunosorbent assay was used to measure the levels of IL-8, EGF and VEGF in whole saliva samples collected from 34 patients with GT and 38 control subjects. The patients and controls were grouped and matched according to age, gender and the presence of systemic diseases, which are factors that may influence the levels of salivary biomarkers. Results All patients with GT displayed significantly higher levels of IL-8 than the controls (P
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salivary levels of interleukin 8 and growth factors are modulated in patients with Geographic Tongue
Oral Diseases, 2017Co-Authors: Amal Dafar, Mats Jontell, Maria Bankvall, V Garsjo, Hulya CevikarasAbstract:Objectives The aim of the study was to determine the levels of salivary epidermal growth factor (EGF) and vascular endothelial growth factor (VEGF) as well as interleukin-8 (IL-8) in patients with Geographic Tongue (GT), as compared to control subjects. Methodology An enzyme-linked immunosorbent assay was used to measure the levels of IL-8, EGF and VEGF in whole saliva samples collected from 34 patients with GT and 38 control subjects. The patients and controls were grouped and matched according to age, gender and the presence of systemic diseases, which are factors that may influence the levels of salivary biomarkers. Results All patients with GT displayed significantly higher levels of IL-8 than the controls (P < 0.001). The young female patients also showed reduced levels of EGF (P < 0.05) and VEGF (P < 0.05), as compared to the young male patients where no such differences were observed. Interestingly, high levels of IL-8 (P < 0.001) and VEGF (P < 0.05) were detected in the patients with GT who also suffered from hypertension. Conclusion We consider IL-8 an inflammatory mediator, which contributes to the acute inflammatory response found in GT. EGF and VEGF also seem to be involved in the pathophysiology of GT.
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Lingual microbiota profiles of patients with Geographic Tongue.
Journal of Oral Microbiology, 2017Co-Authors: Amal Dafar, Mats Jontell, Hülya Çevik-aras, Maria Bankvall, Fei SjöbergAbstract:Geographic Tongue (GT) is an oral mucosal lesion that affects the Tongue. The association between GT and the bacterial colonization profiles of the Tongue is not clear. Lingual swabs were collected from lesion sites and healthy sites of 35 patients with GT (19 males and 16 females; Mage = 54.3 ± 16.1 years) and 22 controls (12 males and 10 females; Mage = 56.3 ± 15.8 years). Bacterial DNA was extracted and sequenced by next-generation sequencing. At the phylum level, Fusobacteria were significantly less abundant, while Spirochaetes were significantly more abundant in GT patients compared to controls. At the operational taxonomic units level, multivariate analysis revealed distinct clusters for the three groups based on the lingual microbiota composition. Acinetobacter and Delftia were significantly associated with GT lesion and healthy sites. However, Microbacterium, Leptospira, Methylotenera, and Lactococcus were significantly associated with GT lesion sites. Additionally, Mogibacterium and Simonsiella were significantly associated with GT healthy sites and controls. The changes in the lingual microbiota profiles of patients with GT imply a shift in the lingual bacterial ecology. However, it remains unknown if this shift is a consequence of the lesions or of factors associated with the initiation and progression of the disease.
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factors associated with Geographic Tongue and fissured Tongue
Acta Odontologica Scandinavica, 2016Co-Authors: Amal Dafar, Ulf Mattsson, Hulya Cevikaras, Jairo Robledosierra, Mats JontellAbstract:AbstractObjectives: The primary objective of this study was to investigate the association of systemic diseases, use of medications, allergies and tobacco habits with Geographic Tongue (GT) and fissured Tongue (FT) lesions. The secondary objectives were to evaluate the clinical characteristics of Tongue lesions and to compare the overall results for referred and non-referred patients.Methodology: Non-referred patients with GT (GTgp; n = 130) and FT (FTgp; n = 62) were examined by general practitioners (gp) and compared to a control group without oral mucosal lesions (C; n = 1029). Referred patients with GT (GTs; n = 166) and FT (FTs; n = 15) were examined by oral medicine specialists (s) and compared to GTgp and FTgp. Statistical analyses were performed using unpaired t-test or Fisher’s exact test. A multiple logistic regression model was developed to control for age and gender as confounders.Results: Compared to the C group, GTgp patients used more anti-hypertensive medications and Swedish snus (p < 0.01...
Hulya Cevikaras - One of the best experts on this subject based on the ideXlab platform.
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salivary levels of interleukin 8 and growth factors are modulated in patients with Geographic Tongue
Oral Diseases, 2017Co-Authors: Amal Dafar, Mats Jontell, Maria Bankvall, V Garsjo, Hulya CevikarasAbstract:Objectives The aim of the study was to determine the levels of salivary epidermal growth factor (EGF) and vascular endothelial growth factor (VEGF) as well as interleukin-8 (IL-8) in patients with Geographic Tongue (GT), as compared to control subjects. Methodology An enzyme-linked immunosorbent assay was used to measure the levels of IL-8, EGF and VEGF in whole saliva samples collected from 34 patients with GT and 38 control subjects. The patients and controls were grouped and matched according to age, gender and the presence of systemic diseases, which are factors that may influence the levels of salivary biomarkers. Results All patients with GT displayed significantly higher levels of IL-8 than the controls (P < 0.001). The young female patients also showed reduced levels of EGF (P < 0.05) and VEGF (P < 0.05), as compared to the young male patients where no such differences were observed. Interestingly, high levels of IL-8 (P < 0.001) and VEGF (P < 0.05) were detected in the patients with GT who also suffered from hypertension. Conclusion We consider IL-8 an inflammatory mediator, which contributes to the acute inflammatory response found in GT. EGF and VEGF also seem to be involved in the pathophysiology of GT.
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factors associated with Geographic Tongue and fissured Tongue
Acta Odontologica Scandinavica, 2016Co-Authors: Amal Dafar, Ulf Mattsson, Hulya Cevikaras, Jairo Robledosierra, Mats JontellAbstract:AbstractObjectives: The primary objective of this study was to investigate the association of systemic diseases, use of medications, allergies and tobacco habits with Geographic Tongue (GT) and fissured Tongue (FT) lesions. The secondary objectives were to evaluate the clinical characteristics of Tongue lesions and to compare the overall results for referred and non-referred patients.Methodology: Non-referred patients with GT (GTgp; n = 130) and FT (FTgp; n = 62) were examined by general practitioners (gp) and compared to a control group without oral mucosal lesions (C; n = 1029). Referred patients with GT (GTs; n = 166) and FT (FTs; n = 15) were examined by oral medicine specialists (s) and compared to GTgp and FTgp. Statistical analyses were performed using unpaired t-test or Fisher’s exact test. A multiple logistic regression model was developed to control for age and gender as confounders.Results: Compared to the C group, GTgp patients used more anti-hypertensive medications and Swedish snus (p < 0.01...
Mats Jontell - One of the best experts on this subject based on the ideXlab platform.
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Increased levels of calprotectin in the saliva of patients with Geographic Tongue.
Oral Diseases, 2020Co-Authors: Vegard Garsjö, Amal Dafar, Mats Jontell, Hülya Çevik-aras, John BratelAbstract:OBJECTIVE We investigated whether patients with Geographic Tongue have increased salivary levels of calprotectin and whether there is a correlation between the salivary levels of calprotectin and interleukin 8 (IL-8), which is another marker of inflammation. METHODS Twenty-three patients diagnosed with Geographic Tongue and 32 control subjects without oral mucosal lesions were included in the study. The patients with Geographic Tongue were classified based on clinical appearance and number of oral lesions. ELISAs were used to determine the levels of calprotectin and IL-8 in whole saliva samples. RESULTS There was a statistically significant increase in the salivary output of calprotectin in patients with Geographic Tongue compared with the healthy controls (62 ± 9,1 vs. 37,5 ± 4,7 µg/min; p = .0134). Furthermore, the levels of calprotectin correlated positively with the number of oral lesions in patients with Geographic Tongue. There was also a significant and positive correlation between the salivary levels of calprotectin and IL-8, both for the patients with Geographic Tongue and the controls. CONCLUSION This study supports the notion that GT is an inflammatory disease, in which the activation of neutrophils and production of calprotectin in the saliva may play roles in its pathogenesis.
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Salivary levels of interleukin-8 and growth factors are modulated in patients with Geographic Tongue.
Oral Diseases, 2017Co-Authors: Amal Dafar, Mats Jontell, Vegard Garsjö, Maria Bankvall, Hülya Çevik-arasAbstract:Objectives The aim of the study was to determine the levels of salivary epidermal growth factor (EGF) and vascular endothelial growth factor (VEGF) as well as interleukin-8 (IL-8) in patients with Geographic Tongue (GT), as compared to control subjects. Methodology An enzyme-linked immunosorbent assay was used to measure the levels of IL-8, EGF and VEGF in whole saliva samples collected from 34 patients with GT and 38 control subjects. The patients and controls were grouped and matched according to age, gender and the presence of systemic diseases, which are factors that may influence the levels of salivary biomarkers. Results All patients with GT displayed significantly higher levels of IL-8 than the controls (P
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salivary levels of interleukin 8 and growth factors are modulated in patients with Geographic Tongue
Oral Diseases, 2017Co-Authors: Amal Dafar, Mats Jontell, Maria Bankvall, V Garsjo, Hulya CevikarasAbstract:Objectives The aim of the study was to determine the levels of salivary epidermal growth factor (EGF) and vascular endothelial growth factor (VEGF) as well as interleukin-8 (IL-8) in patients with Geographic Tongue (GT), as compared to control subjects. Methodology An enzyme-linked immunosorbent assay was used to measure the levels of IL-8, EGF and VEGF in whole saliva samples collected from 34 patients with GT and 38 control subjects. The patients and controls were grouped and matched according to age, gender and the presence of systemic diseases, which are factors that may influence the levels of salivary biomarkers. Results All patients with GT displayed significantly higher levels of IL-8 than the controls (P < 0.001). The young female patients also showed reduced levels of EGF (P < 0.05) and VEGF (P < 0.05), as compared to the young male patients where no such differences were observed. Interestingly, high levels of IL-8 (P < 0.001) and VEGF (P < 0.05) were detected in the patients with GT who also suffered from hypertension. Conclusion We consider IL-8 an inflammatory mediator, which contributes to the acute inflammatory response found in GT. EGF and VEGF also seem to be involved in the pathophysiology of GT.
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Lingual microbiota profiles of patients with Geographic Tongue.
Journal of Oral Microbiology, 2017Co-Authors: Amal Dafar, Mats Jontell, Hülya Çevik-aras, Maria Bankvall, Fei SjöbergAbstract:Geographic Tongue (GT) is an oral mucosal lesion that affects the Tongue. The association between GT and the bacterial colonization profiles of the Tongue is not clear. Lingual swabs were collected from lesion sites and healthy sites of 35 patients with GT (19 males and 16 females; Mage = 54.3 ± 16.1 years) and 22 controls (12 males and 10 females; Mage = 56.3 ± 15.8 years). Bacterial DNA was extracted and sequenced by next-generation sequencing. At the phylum level, Fusobacteria were significantly less abundant, while Spirochaetes were significantly more abundant in GT patients compared to controls. At the operational taxonomic units level, multivariate analysis revealed distinct clusters for the three groups based on the lingual microbiota composition. Acinetobacter and Delftia were significantly associated with GT lesion and healthy sites. However, Microbacterium, Leptospira, Methylotenera, and Lactococcus were significantly associated with GT lesion sites. Additionally, Mogibacterium and Simonsiella were significantly associated with GT healthy sites and controls. The changes in the lingual microbiota profiles of patients with GT imply a shift in the lingual bacterial ecology. However, it remains unknown if this shift is a consequence of the lesions or of factors associated with the initiation and progression of the disease.
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factors associated with Geographic Tongue and fissured Tongue
Acta Odontologica Scandinavica, 2016Co-Authors: Amal Dafar, Ulf Mattsson, Hulya Cevikaras, Jairo Robledosierra, Mats JontellAbstract:AbstractObjectives: The primary objective of this study was to investigate the association of systemic diseases, use of medications, allergies and tobacco habits with Geographic Tongue (GT) and fissured Tongue (FT) lesions. The secondary objectives were to evaluate the clinical characteristics of Tongue lesions and to compare the overall results for referred and non-referred patients.Methodology: Non-referred patients with GT (GTgp; n = 130) and FT (FTgp; n = 62) were examined by general practitioners (gp) and compared to a control group without oral mucosal lesions (C; n = 1029). Referred patients with GT (GTs; n = 166) and FT (FTs; n = 15) were examined by oral medicine specialists (s) and compared to GTgp and FTgp. Statistical analyses were performed using unpaired t-test or Fisher’s exact test. A multiple logistic regression model was developed to control for age and gender as confounders.Results: Compared to the C group, GTgp patients used more anti-hypertensive medications and Swedish snus (p < 0.01...
Maria Jose Garciapola - One of the best experts on this subject based on the ideXlab platform.
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association between Geographic Tongue and psoriasis a systematic review and meta analyses
Journal of Oral Pathology & Medicine, 2019Co-Authors: Laura Gonzalezalvarez, Jose M Garciamartin, Maria Jose GarciapolaAbstract:Geographic Tongue (GT) has been described as a predictor of psoriasis. The objective of this study was to analyse the prevalence of GT in psoriatic and non-psoriatic patients. For this purpose, we conducted a systematic review and meta-analysis. A literature search was performed on PubMed, Embase, Web of Science and the Cochrane Database of Systematic Reviews. The search and selection process was performed according to the PRISMA (Preferred Reporting Items for Systematic Reviews and Meta-Analyses) criteria. Only case-control studies were selected, and the prevalence of GT in both groups was compared. Eleven articles met the inclusion criteria, and the frequency of GT was statistically associated with psoriasis in ten studies. The pooled odds ratio (OR) was 3.53 (95% confidence interval [CI] 2.56-4.86). There were no significant differences between the presence of GT and the clinical form. However, the Psoriasis Area and Severity Index (PASI) score was statistically higher in patients affected by GT in three of four studies. Psoriatic patients with GT also exhibited less improvement in the PASI score after treatment. One study found an association between GT and a negative impact on patients' quality of life. Nevertheless, age, gender, toxic habits, psoriasis onset and duration of the disease were not clearly associated. The results support the concept of GT as a manifestation of psoriasis. Future research should focus on the repercussions of GT in psoriatic patients, due to the negative consequences on severity and treatment response.
Laura Gonzalezalvarez - One of the best experts on this subject based on the ideXlab platform.
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association between Geographic Tongue and psoriasis a systematic review and meta analyses
Journal of Oral Pathology & Medicine, 2019Co-Authors: Laura Gonzalezalvarez, Jose M Garciamartin, Maria Jose GarciapolaAbstract:Geographic Tongue (GT) has been described as a predictor of psoriasis. The objective of this study was to analyse the prevalence of GT in psoriatic and non-psoriatic patients. For this purpose, we conducted a systematic review and meta-analysis. A literature search was performed on PubMed, Embase, Web of Science and the Cochrane Database of Systematic Reviews. The search and selection process was performed according to the PRISMA (Preferred Reporting Items for Systematic Reviews and Meta-Analyses) criteria. Only case-control studies were selected, and the prevalence of GT in both groups was compared. Eleven articles met the inclusion criteria, and the frequency of GT was statistically associated with psoriasis in ten studies. The pooled odds ratio (OR) was 3.53 (95% confidence interval [CI] 2.56-4.86). There were no significant differences between the presence of GT and the clinical form. However, the Psoriasis Area and Severity Index (PASI) score was statistically higher in patients affected by GT in three of four studies. Psoriatic patients with GT also exhibited less improvement in the PASI score after treatment. One study found an association between GT and a negative impact on patients' quality of life. Nevertheless, age, gender, toxic habits, psoriasis onset and duration of the disease were not clearly associated. The results support the concept of GT as a manifestation of psoriasis. Future research should focus on the repercussions of GT in psoriatic patients, due to the negative consequences on severity and treatment response.