The Experts below are selected from a list of 6411 Experts worldwide ranked by ideXlab platform
Hachiro Sugimoto - One of the best experts on this subject based on the ideXlab platform.
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Highly water pressurized brown rice improves cognitive dysfunction in senescence-accelerated mouse prone 8 and reduces amyloid beta in the brain
BMC Complementary and Alternative Medicine, 2018Co-Authors: Michiaki Okuda, Michio Hashimoto, Takuya Katsube, Hiromasa Tabata, Yuki Fujita, Katsumi Yoshino, Hachiro SugimotoAbstract:Alzheimer’s disease (AD) is the most common form of dementia and the number of AD patients continues to increase worldwide. Components of the Germ Layer and bran of Brown rice (BR) help maintain good health and prevent AD. Because the Germ Layer and bran absorb little water and are very hard and difficult to cook, they are often removed during processing. To solve these problems, in this study, we tried to use a high-pressure (HP) technique. We produced the highly water pressurized brown rice (HPBR) by pressurizing BR at 600 MPa, and then we fed it to an AD mouse model, senescence-accelerated mouse prone 8, to investigate the therapeutic effects of HPBR on cognitive dysfunction by Y-maze spatial memory test. HP treatment increased the water absorbency of BR without nutrient loss. HPBR ameliorated cognitive dysfunction and reduced the levels of amyloid-β, which is a major protein responsible for AD, in the brain. These results suggest that HPBR is effective for preventing AD.
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Highly water pressurized brown rice improves cognitive dysfunction in senescence-accelerated mouse prone 8 and reduces amyloid beta in the brain
BMC Complementary and Alternative Medicine, 2018Co-Authors: Michiaki Okuda, Michio Hashimoto, Takuya Katsube, Hiromasa Tabata, Yuki Fujita, Katsumi Yoshino, Hachiro SugimotoAbstract:Background Alzheimer’s disease (AD) is the most common form of dementia and the number of AD patients continues to increase worldwide. Components of the Germ Layer and bran of Brown rice (BR) help maintain good health and prevent AD. Because the Germ Layer and bran absorb little water and are very hard and difficult to cook, they are often removed during processing. To solve these problems, in this study, we tried to use a high-pressure (HP) technique. Methods We produced the highly water pressurized brown rice (HPBR) by pressurizing BR at 600 MPa, and then we fed it to an AD mouse model, senescence-accelerated mouse prone 8, to investigate the therapeutic effects of HPBR on cognitive dysfunction by Y-maze spatial memory test. Results HP treatment increased the water absorbency of BR without nutrient loss. HPBR ameliorated cognitive dysfunction and reduced the levels of amyloid-β, which is a major protein responsible for AD, in the brain. Conclusions These results suggest that HPBR is effective for preventing AD.
Michiaki Okuda - One of the best experts on this subject based on the ideXlab platform.
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Highly water pressurized brown rice improves cognitive dysfunction in senescence-accelerated mouse prone 8 and reduces amyloid beta in the brain
BMC Complementary and Alternative Medicine, 2018Co-Authors: Michiaki Okuda, Michio Hashimoto, Takuya Katsube, Hiromasa Tabata, Yuki Fujita, Katsumi Yoshino, Hachiro SugimotoAbstract:Alzheimer’s disease (AD) is the most common form of dementia and the number of AD patients continues to increase worldwide. Components of the Germ Layer and bran of Brown rice (BR) help maintain good health and prevent AD. Because the Germ Layer and bran absorb little water and are very hard and difficult to cook, they are often removed during processing. To solve these problems, in this study, we tried to use a high-pressure (HP) technique. We produced the highly water pressurized brown rice (HPBR) by pressurizing BR at 600 MPa, and then we fed it to an AD mouse model, senescence-accelerated mouse prone 8, to investigate the therapeutic effects of HPBR on cognitive dysfunction by Y-maze spatial memory test. HP treatment increased the water absorbency of BR without nutrient loss. HPBR ameliorated cognitive dysfunction and reduced the levels of amyloid-β, which is a major protein responsible for AD, in the brain. These results suggest that HPBR is effective for preventing AD.
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Highly water pressurized brown rice improves cognitive dysfunction in senescence-accelerated mouse prone 8 and reduces amyloid beta in the brain
BMC Complementary and Alternative Medicine, 2018Co-Authors: Michiaki Okuda, Michio Hashimoto, Takuya Katsube, Hiromasa Tabata, Yuki Fujita, Katsumi Yoshino, Hachiro SugimotoAbstract:Background Alzheimer’s disease (AD) is the most common form of dementia and the number of AD patients continues to increase worldwide. Components of the Germ Layer and bran of Brown rice (BR) help maintain good health and prevent AD. Because the Germ Layer and bran absorb little water and are very hard and difficult to cook, they are often removed during processing. To solve these problems, in this study, we tried to use a high-pressure (HP) technique. Methods We produced the highly water pressurized brown rice (HPBR) by pressurizing BR at 600 MPa, and then we fed it to an AD mouse model, senescence-accelerated mouse prone 8, to investigate the therapeutic effects of HPBR on cognitive dysfunction by Y-maze spatial memory test. Results HP treatment increased the water absorbency of BR without nutrient loss. HPBR ameliorated cognitive dysfunction and reduced the levels of amyloid-β, which is a major protein responsible for AD, in the brain. Conclusions These results suggest that HPBR is effective for preventing AD.
Ulrich Technau - One of the best experts on this subject based on the ideXlab platform.
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gastrulation and Germ Layer formation in the sea anemone nematostella vectensis and other cnidarians
Mechanisms of Development, 2020Co-Authors: Ulrich TechnauAbstract:Abstract Among the basally branching metazoans, cnidarians display well-defined gastrulation processes leading to a diploblastic body plan, consisting of an endodermal and an ectodermal cell Layer. As the outgroup to all Bilateria, cnidarians are an interesting group to investigate ancestral developmental mechanisms. Interestingly, all known gastrulation mechanisms known in Bilateria are already found in different species of Cnidaria. Here I review the morphogenetic processes found in different Cnidaria and focus on the investigation of the cellular and molecular mechanisms in the sea anemone Nematostella vectensis, which has been a major model organism among cnidarians for evolutionary developmental biology. Many of the genes involved in Germ Layer specification and morphogenetic processes in Bilateria are also found active during gastrulation of Nematostella and other cnidarians, suggesting an ancestral role of this process. The molecular analyses indicate a tight link between gastrulation and axis patterning processes by Wnt and FGF signaling. Interestingly, the endodermal Layer displays many features of the mesodermal Layer in Bilateria, while the pharyngeal ectoderm has an endodermal expression profile. Comparative analyses as well as experimental studies using embryonic aggregates suggest that minor differences in the gene regulatory networks allow the embryo to transition relatively easily from one mode of gastrulation to another.
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A cadherin switch marks Germ Layer formation in the diploblastic sea anemone Nematostella vectensis.
Development, 2019Co-Authors: Ekaterina Pukhlyakova, A. O. Kirillova, Yulia Kraus, Bob Zimmermann, Ulrich TechnauAbstract:Morphogenesis is a shape-building process during development of multicellular organisms. During this process the establishment and modulation of cell-cell contacts play an important role. Cadherins, the major cell adhesion molecules, form adherens junctions connecting epithelial cells. Numerous studies in Bilateria have shown that cadherins are associated with the regulation of cell differentiation, cell shape changes, cell migration and tissue morphogenesis. To date, the role of Cadherins in non-bilaterians is unknown. Here, we study the expression and the function of two paralogous classical cadherins, cadherin1 and cadherin3, in the diploblastic animal, the sea anemone Nematostella vectensis. We show that a cadherin switch is accompanying the formation of Germ Layers. Using specific antibodies, we show that both cadherins are localized to adherens junctions at apical and basal positions in ectoderm and endoderm. During gastrulation, partial EMT of endodermal cells is marked by a step-wise down-regulation of cadherin3 and up-regulation of cadherin1. Knockdown experiments show that both cadherins are required for maintenance of tissue integrity and tissue morphogenesis. Thus, both sea anemones and bilaterians use independently duplicated cadherins combinatorially for tissue morphogenesis and Germ Layer differentiation.
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a cadherin switch marks Germ Layer formation in the diploblastic sea anemone nematostella vectensis
Development, 2019Co-Authors: Ekaterina Pukhlyakova, Yulia Kraus, Bob Zimmermann, Anastasia Kirillova, Ulrich TechnauAbstract:Morphogenesis is a shape-building process during development of multicellular organisms. During this process, the establishment and modulation of cell-cell contacts play an important role. Cadherins, the major cell adhesion molecules, form adherens junctions connecting epithelial cells. Numerous studies of Bilateria have shown that cadherins are associated with the regulation of cell differentiation, cell shape changes, cell migration and tissue morphogenesis. To date, the role of cadherins in non-bilaterians is unknown. Here, we study the expression and function of two paralogous classical cadherins, Cadherin 1 and Cadherin 3, in a diploblastic animal, the sea anemone Nematostella vectensis We show that a cadherin switch accompanies the formation of Germ Layers. Using specific antibodies, we show that both cadherins are localized to adherens junctions at apical and basal positions in ectoderm and endoderm. During gastrulation, partial epithelial-to-mesenchymal transition of endodermal cells is marked by stepwise downregulation of Cadherin 3 and upregulation of Cadherin 1. Knockdown experiments show that both cadherins are required for maintenance of tissue integrity and tissue morphogenesis. Thus, both sea anemones and bilaterians use independently duplicated cadherins combinatorially for tissue morphogenesis and Germ Layer differentiation.
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Gut-like ectodermal tissue in a sea anemone challenges Germ Layer homology.
Nature Ecology & Evolution, 2017Co-Authors: Patrick R. H. Steinmetz, Andy Aman, Johanna E. M. Kraus, Ulrich TechnauAbstract:Cnidarians (for example, sea anemones and jellyfish) develop from an outer ectodermal and inner endodermal Germ Layer, whereas bilaterians (for example, vertebrates and flies) additionally have a mesodermal Layer as intermediate Germ Layer. Currently, cnidarian endoderm (that is, ‘mesendoderm’) is considered homologous to both bilaterian endoderm and mesoderm. Here we test this hypothesis by studying the fate of Germ Layers, the localization of gut cell types, and the expression of numerous ‘endodermal’ and ‘mesodermal’ transcription factor orthologues in the anthozoan sea anemone Nematostella vectensis. Surprisingly, we find that the developing pharyngeal ectoderm and its derivatives display a transcription-factor expression profile (foxA, hhex, islet, soxB1, hlxB9, tbx2/3, nkx6 and nkx2.2) and cell-type combination (exocrine and insulinergic) reminiscent of the developing bilaterian midgut, and, in particular, vertebrate pancreatic tissue. Endodermal derivatives, instead, display cell functions and transcription-factor profiles similar to bilaterian mesoderm derivatives (for example, somatic gonad and heart). Thus, our data supports an alternative model of Germ Layer homologies, where cnidarian pharyngeal ectoderm corresponds to bilaterian endoderm, and the cnidarian endoderm is homologous to bilaterian mesoderm. The cnidarian endoderm has been considered homologous to the bilaterian endoderm and mesoderm. Here, a gut-like ectoderm is revealed in a sea anemone, corresponding to the bilaterian endoderm, supporting an alternative model of Germ Layer homology.
Katsumi Yoshino - One of the best experts on this subject based on the ideXlab platform.
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Highly water pressurized brown rice improves cognitive dysfunction in senescence-accelerated mouse prone 8 and reduces amyloid beta in the brain
BMC Complementary and Alternative Medicine, 2018Co-Authors: Michiaki Okuda, Michio Hashimoto, Takuya Katsube, Hiromasa Tabata, Yuki Fujita, Katsumi Yoshino, Hachiro SugimotoAbstract:Alzheimer’s disease (AD) is the most common form of dementia and the number of AD patients continues to increase worldwide. Components of the Germ Layer and bran of Brown rice (BR) help maintain good health and prevent AD. Because the Germ Layer and bran absorb little water and are very hard and difficult to cook, they are often removed during processing. To solve these problems, in this study, we tried to use a high-pressure (HP) technique. We produced the highly water pressurized brown rice (HPBR) by pressurizing BR at 600 MPa, and then we fed it to an AD mouse model, senescence-accelerated mouse prone 8, to investigate the therapeutic effects of HPBR on cognitive dysfunction by Y-maze spatial memory test. HP treatment increased the water absorbency of BR without nutrient loss. HPBR ameliorated cognitive dysfunction and reduced the levels of amyloid-β, which is a major protein responsible for AD, in the brain. These results suggest that HPBR is effective for preventing AD.
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Highly water pressurized brown rice improves cognitive dysfunction in senescence-accelerated mouse prone 8 and reduces amyloid beta in the brain
BMC Complementary and Alternative Medicine, 2018Co-Authors: Michiaki Okuda, Michio Hashimoto, Takuya Katsube, Hiromasa Tabata, Yuki Fujita, Katsumi Yoshino, Hachiro SugimotoAbstract:Background Alzheimer’s disease (AD) is the most common form of dementia and the number of AD patients continues to increase worldwide. Components of the Germ Layer and bran of Brown rice (BR) help maintain good health and prevent AD. Because the Germ Layer and bran absorb little water and are very hard and difficult to cook, they are often removed during processing. To solve these problems, in this study, we tried to use a high-pressure (HP) technique. Methods We produced the highly water pressurized brown rice (HPBR) by pressurizing BR at 600 MPa, and then we fed it to an AD mouse model, senescence-accelerated mouse prone 8, to investigate the therapeutic effects of HPBR on cognitive dysfunction by Y-maze spatial memory test. Results HP treatment increased the water absorbency of BR without nutrient loss. HPBR ameliorated cognitive dysfunction and reduced the levels of amyloid-β, which is a major protein responsible for AD, in the brain. Conclusions These results suggest that HPBR is effective for preventing AD.
Michio Hashimoto - One of the best experts on this subject based on the ideXlab platform.
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Highly water pressurized brown rice improves cognitive dysfunction in senescence-accelerated mouse prone 8 and reduces amyloid beta in the brain
BMC Complementary and Alternative Medicine, 2018Co-Authors: Michiaki Okuda, Michio Hashimoto, Takuya Katsube, Hiromasa Tabata, Yuki Fujita, Katsumi Yoshino, Hachiro SugimotoAbstract:Alzheimer’s disease (AD) is the most common form of dementia and the number of AD patients continues to increase worldwide. Components of the Germ Layer and bran of Brown rice (BR) help maintain good health and prevent AD. Because the Germ Layer and bran absorb little water and are very hard and difficult to cook, they are often removed during processing. To solve these problems, in this study, we tried to use a high-pressure (HP) technique. We produced the highly water pressurized brown rice (HPBR) by pressurizing BR at 600 MPa, and then we fed it to an AD mouse model, senescence-accelerated mouse prone 8, to investigate the therapeutic effects of HPBR on cognitive dysfunction by Y-maze spatial memory test. HP treatment increased the water absorbency of BR without nutrient loss. HPBR ameliorated cognitive dysfunction and reduced the levels of amyloid-β, which is a major protein responsible for AD, in the brain. These results suggest that HPBR is effective for preventing AD.
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Highly water pressurized brown rice improves cognitive dysfunction in senescence-accelerated mouse prone 8 and reduces amyloid beta in the brain
BMC Complementary and Alternative Medicine, 2018Co-Authors: Michiaki Okuda, Michio Hashimoto, Takuya Katsube, Hiromasa Tabata, Yuki Fujita, Katsumi Yoshino, Hachiro SugimotoAbstract:Background Alzheimer’s disease (AD) is the most common form of dementia and the number of AD patients continues to increase worldwide. Components of the Germ Layer and bran of Brown rice (BR) help maintain good health and prevent AD. Because the Germ Layer and bran absorb little water and are very hard and difficult to cook, they are often removed during processing. To solve these problems, in this study, we tried to use a high-pressure (HP) technique. Methods We produced the highly water pressurized brown rice (HPBR) by pressurizing BR at 600 MPa, and then we fed it to an AD mouse model, senescence-accelerated mouse prone 8, to investigate the therapeutic effects of HPBR on cognitive dysfunction by Y-maze spatial memory test. Results HP treatment increased the water absorbency of BR without nutrient loss. HPBR ameliorated cognitive dysfunction and reduced the levels of amyloid-β, which is a major protein responsible for AD, in the brain. Conclusions These results suggest that HPBR is effective for preventing AD.