The Experts below are selected from a list of 81 Experts worldwide ranked by ideXlab platform

Viatcheslav Jouikov - One of the best experts on this subject based on the ideXlab platform.

  • Novel R3M (M = Si, Ge) substituted furan and thiophene-derived aldimines: Synthesis, electrochemistry, and biological activity
    Comptes Rendus Chimie, 2019
    Co-Authors: Jana Spura, Amel Farhati, Vitalijs Romanovs, Artyom Borodulin, Sergejs Belakovs, Juris Popelis, I. Shestakova, Mohamed Dammak, Viatcheslav Jouikov
    Abstract:

    Abstract New furan and thiophene derivatives of aldimines o-HO-C6H4N CHC4H4X(R) (X = O, S; R = H, SiMe3, SiEt3, GeMe3, GeEt3) were synthesized by condensation of o-aminophenol with the substituted aldehyde precursor. Their structure, electrochemical reduction/oxidation (in CH3CN/0.1 M Bu4NPF6), frontier orbital energies, and cytotoxicity have been studied. Their electrochemical redox potentials Ep show good correlation with the corresponding orbital energies and the difference Epox – Epred corresponds well to their orbital hardness. These new compounds have a pronounced cytotoxicity toward cancer cells of human fibrosarcoma HT-1080 and mouse hepatoma MG-22A (IC50 ≅ 1–8 μg ml−1) that can be modulated by introducing a Me3M substituent into the fifth position of the heterocycle (e.g., IC50(Me3Si)/IC50(H) ≥ 50). R3M-substitution reduces the orbital hardness of the aldimines studied and facilitates oxidation, promoting their oxidative metabolism. The neighboring Group effect in the α-Me3Si-substituted thiophene derivative favors S-oxidation, which supposedly makes its metabolic mechanism different compared to R3M-substituted furan series (or for M = Ge in the thiophene series). Interestingly, SiMe3 and GeMe3 Groups in both heterocyclic series (furan and thiophene) cause opposite trends in cytotoxicity, while the silyl Group increases it, the Germyl Group decreases it.

  • Novel R3M (M = Si, Ge) substituted furan and thiophene-derived aldimines Synthesis, electrochemistry, and biological activity [Nouvelles aldimines dérivées du furanne et du thiophène substituées par R3M (M = Si, Ge) Synthèse, électrochimie et activit
    Comptes Rendus Chimie, 2019
    Co-Authors: Jana Spura, Amel Farhati, Vitalijs Romanovs, Artyom Borodulin, Sergejs Belakovs, Juris Popelis, I. Shestakova, Mohamed Dammak, Viatcheslav Jouikov
    Abstract:

    New furan and thiophene derivatives of aldimines o-HO-C6H4N[dbnd]CHC4H4X(R) (X = O, S; R = H, SiMe3, SiEt3, GeMe3, GeEt3) were synthesized by condensation of o-aminophenol with the substituted aldehyde precursor. Their structure, electrochemical reduction/oxidation (in CH3CN/0.1 M Bu4NPF6), frontier orbital energies, and cytotoxicity have been studied. Their electrochemical redox potentials Ep show good correlation with the corresponding orbital energies and the difference Ep ox – Ep red corresponds well to their orbital hardness. These new compounds have a pronounced cytotoxicity toward cancer cells of human fibrosarcoma HT-1080 and mouse hepatoma MG-22A (IC50 ≅ 1–8 μg ml−1) that can be modulated by introducing a Me3M substituent into the fifth position of the heterocycle (e.g., IC50(Me3Si)/IC50(H) ≥ 50). R3M-substitution reduces the orbital hardness of the aldimines studied and facilitates oxidation, promoting their oxidative metabolism. The neighboring Group effect in the α-Me3Si-substituted thiophene derivative favors S-oxidation, which supposedly makes its metabolic mechanism different compared to R3M-substituted furan series (or for M = Ge in the thiophene series). Interestingly, SiMe3 and GeMe3 Groups in both heterocyclic series (furan and thiophene) cause opposite trends in cytotoxicity, while the silyl Group increases it, the Germyl Group decreases it. © 2019 Académie des sciences

Jana Spura - One of the best experts on this subject based on the ideXlab platform.

  • Novel R3M (M = Si, Ge) substituted furan and thiophene-derived aldimines: Synthesis, electrochemistry, and biological activity
    Comptes Rendus Chimie, 2019
    Co-Authors: Jana Spura, Amel Farhati, Vitalijs Romanovs, Artyom Borodulin, Sergejs Belakovs, Juris Popelis, I. Shestakova, Mohamed Dammak, Viatcheslav Jouikov
    Abstract:

    Abstract New furan and thiophene derivatives of aldimines o-HO-C6H4N CHC4H4X(R) (X = O, S; R = H, SiMe3, SiEt3, GeMe3, GeEt3) were synthesized by condensation of o-aminophenol with the substituted aldehyde precursor. Their structure, electrochemical reduction/oxidation (in CH3CN/0.1 M Bu4NPF6), frontier orbital energies, and cytotoxicity have been studied. Their electrochemical redox potentials Ep show good correlation with the corresponding orbital energies and the difference Epox – Epred corresponds well to their orbital hardness. These new compounds have a pronounced cytotoxicity toward cancer cells of human fibrosarcoma HT-1080 and mouse hepatoma MG-22A (IC50 ≅ 1–8 μg ml−1) that can be modulated by introducing a Me3M substituent into the fifth position of the heterocycle (e.g., IC50(Me3Si)/IC50(H) ≥ 50). R3M-substitution reduces the orbital hardness of the aldimines studied and facilitates oxidation, promoting their oxidative metabolism. The neighboring Group effect in the α-Me3Si-substituted thiophene derivative favors S-oxidation, which supposedly makes its metabolic mechanism different compared to R3M-substituted furan series (or for M = Ge in the thiophene series). Interestingly, SiMe3 and GeMe3 Groups in both heterocyclic series (furan and thiophene) cause opposite trends in cytotoxicity, while the silyl Group increases it, the Germyl Group decreases it.

  • Novel R3M (M = Si, Ge) substituted furan and thiophene-derived aldimines Synthesis, electrochemistry, and biological activity [Nouvelles aldimines dérivées du furanne et du thiophène substituées par R3M (M = Si, Ge) Synthèse, électrochimie et activit
    Comptes Rendus Chimie, 2019
    Co-Authors: Jana Spura, Amel Farhati, Vitalijs Romanovs, Artyom Borodulin, Sergejs Belakovs, Juris Popelis, I. Shestakova, Mohamed Dammak, Viatcheslav Jouikov
    Abstract:

    New furan and thiophene derivatives of aldimines o-HO-C6H4N[dbnd]CHC4H4X(R) (X = O, S; R = H, SiMe3, SiEt3, GeMe3, GeEt3) were synthesized by condensation of o-aminophenol with the substituted aldehyde precursor. Their structure, electrochemical reduction/oxidation (in CH3CN/0.1 M Bu4NPF6), frontier orbital energies, and cytotoxicity have been studied. Their electrochemical redox potentials Ep show good correlation with the corresponding orbital energies and the difference Ep ox – Ep red corresponds well to their orbital hardness. These new compounds have a pronounced cytotoxicity toward cancer cells of human fibrosarcoma HT-1080 and mouse hepatoma MG-22A (IC50 ≅ 1–8 μg ml−1) that can be modulated by introducing a Me3M substituent into the fifth position of the heterocycle (e.g., IC50(Me3Si)/IC50(H) ≥ 50). R3M-substitution reduces the orbital hardness of the aldimines studied and facilitates oxidation, promoting their oxidative metabolism. The neighboring Group effect in the α-Me3Si-substituted thiophene derivative favors S-oxidation, which supposedly makes its metabolic mechanism different compared to R3M-substituted furan series (or for M = Ge in the thiophene series). Interestingly, SiMe3 and GeMe3 Groups in both heterocyclic series (furan and thiophene) cause opposite trends in cytotoxicity, while the silyl Group increases it, the Germyl Group decreases it. © 2019 Académie des sciences

Horst Borrmann - One of the best experts on this subject based on the ideXlab platform.

  • MULTINUCLEAR MAGNETIC RESONANCE STUDY OF Group 14-SUBSTITUTED SULFUR DIIMIDES, AND THE MOLECULAR STRUCTURES OF DI-tert-BUTYL-, BIS(TRIPHENYLSILYL)- AND N-TRIMETHYLSILYL-N′-TRIPHENYLSILYL SULFUR DIIMIDE
    Phosphorus Sulfur and Silicon and the Related Elements, 1996
    Co-Authors: Max Herberhold, Silke Gerstmann, Wolfgang Milius, Bernd Wrackmeyer, Horst Borrmann
    Abstract:

    Abstract Sulfur diimides of the type R(NSN)R′ (1–19, 2a–9a, 12a–17a, 20a, 3b–16b, 20b) were investigated by 15N, 29Si and 119Sn NMR at variable temperature in order to determine their preferred configuration (E/Z, Z/E, E/E or Z/Z) in solution. All sulfur diimides studied are highly fluxional at room temperature. In some cases with N′Bu Groups, the presence of two isomers could be demonstrated. In solution, the E position is preferred for a silyl Group, as shown, e.g., for N-tert-butyl-N′-trimethylsilyl sulfur diimide (2a). In the case of one Germyl Group, there is little preference of either E or Z position, whereas stannyl Groups prefer to be in Z position. The situation in solution may differ considerably from the configurations determined in the solid state. Single crystal X-ray analyses were carried out for di-tert-butyl- (1), bis(triphenylsilyl)- (7) and N-trimethylsilyl-N′-triphenylsilylsulfur diimide (7b). All three molecules adopt the Z/E configuration in the crystal. Solid-state 29Si CP/MAS NMR s...

Dammak M. - One of the best experts on this subject based on the ideXlab platform.

  • Novel R3M (M = Si, Ge) substituted furan and thiophene-derived aldimines Synthesis, electrochemistry, and biological activity [Nouvelles aldimines dérivées du furanne et du thiophène substituées par R3M (M = Si, Ge) Synthèse, électrochimie et activit
    'Elsevier BV', 2019
    Co-Authors: Spura J., Farhati A., Borodulin A., Belakovs S., Popelis J., Dammak M.
    Abstract:

    National audienceNew furan and thiophene derivatives of aldimines o-HO-C6H4N[dbnd]CHC4H4X(R) (X = O, S; R = H, SiMe3, SiEt3, GeMe3, GeEt3) were synthesized by condensation of o-aminophenol with the substituted aldehyde precursor. Their structure, electrochemical reduction/oxidation (in CH3CN/0.1 M Bu4NPF6), frontier orbital energies, and cytotoxicity have been studied. Their electrochemical redox potentials Ep show good correlation with the corresponding orbital energies and the difference Ep ox – Ep red corresponds well to their orbital hardness. These new compounds have a pronounced cytotoxicity toward cancer cells of human fibrosarcoma HT-1080 and mouse hepatoma MG-22A (IC50 ≅ 1–8 μg ml−1) that can be modulated by introducing a Me3M substituent into the fifth position of the heterocycle (e.g., IC50(Me3Si)/IC50(H) ≥ 50). R3M-substitution reduces the orbital hardness of the aldimines studied and facilitates oxidation, promoting their oxidative metabolism. The neighboring Group effect in the α-Me3Si-substituted thiophene derivative favors S-oxidation, which supposedly makes its metabolic mechanism different compared to R3M-substituted furan series (or for M = Ge in the thiophene series). Interestingly, SiMe3 and GeMe3 Groups in both heterocyclic series (furan and thiophene) cause opposite trends in cytotoxicity, while the silyl Group increases it, the Germyl Group decreases it. © 2019 Académie des science

Mohamed Dammak - One of the best experts on this subject based on the ideXlab platform.

  • Novel R3M (M = Si, Ge) substituted furan and thiophene-derived aldimines: Synthesis, electrochemistry, and biological activity
    Comptes Rendus Chimie, 2019
    Co-Authors: Jana Spura, Amel Farhati, Vitalijs Romanovs, Artyom Borodulin, Sergejs Belakovs, Juris Popelis, I. Shestakova, Mohamed Dammak, Viatcheslav Jouikov
    Abstract:

    Abstract New furan and thiophene derivatives of aldimines o-HO-C6H4N CHC4H4X(R) (X = O, S; R = H, SiMe3, SiEt3, GeMe3, GeEt3) were synthesized by condensation of o-aminophenol with the substituted aldehyde precursor. Their structure, electrochemical reduction/oxidation (in CH3CN/0.1 M Bu4NPF6), frontier orbital energies, and cytotoxicity have been studied. Their electrochemical redox potentials Ep show good correlation with the corresponding orbital energies and the difference Epox – Epred corresponds well to their orbital hardness. These new compounds have a pronounced cytotoxicity toward cancer cells of human fibrosarcoma HT-1080 and mouse hepatoma MG-22A (IC50 ≅ 1–8 μg ml−1) that can be modulated by introducing a Me3M substituent into the fifth position of the heterocycle (e.g., IC50(Me3Si)/IC50(H) ≥ 50). R3M-substitution reduces the orbital hardness of the aldimines studied and facilitates oxidation, promoting their oxidative metabolism. The neighboring Group effect in the α-Me3Si-substituted thiophene derivative favors S-oxidation, which supposedly makes its metabolic mechanism different compared to R3M-substituted furan series (or for M = Ge in the thiophene series). Interestingly, SiMe3 and GeMe3 Groups in both heterocyclic series (furan and thiophene) cause opposite trends in cytotoxicity, while the silyl Group increases it, the Germyl Group decreases it.

  • Novel R3M (M = Si, Ge) substituted furan and thiophene-derived aldimines Synthesis, electrochemistry, and biological activity [Nouvelles aldimines dérivées du furanne et du thiophène substituées par R3M (M = Si, Ge) Synthèse, électrochimie et activit
    Comptes Rendus Chimie, 2019
    Co-Authors: Jana Spura, Amel Farhati, Vitalijs Romanovs, Artyom Borodulin, Sergejs Belakovs, Juris Popelis, I. Shestakova, Mohamed Dammak, Viatcheslav Jouikov
    Abstract:

    New furan and thiophene derivatives of aldimines o-HO-C6H4N[dbnd]CHC4H4X(R) (X = O, S; R = H, SiMe3, SiEt3, GeMe3, GeEt3) were synthesized by condensation of o-aminophenol with the substituted aldehyde precursor. Their structure, electrochemical reduction/oxidation (in CH3CN/0.1 M Bu4NPF6), frontier orbital energies, and cytotoxicity have been studied. Their electrochemical redox potentials Ep show good correlation with the corresponding orbital energies and the difference Ep ox – Ep red corresponds well to their orbital hardness. These new compounds have a pronounced cytotoxicity toward cancer cells of human fibrosarcoma HT-1080 and mouse hepatoma MG-22A (IC50 ≅ 1–8 μg ml−1) that can be modulated by introducing a Me3M substituent into the fifth position of the heterocycle (e.g., IC50(Me3Si)/IC50(H) ≥ 50). R3M-substitution reduces the orbital hardness of the aldimines studied and facilitates oxidation, promoting their oxidative metabolism. The neighboring Group effect in the α-Me3Si-substituted thiophene derivative favors S-oxidation, which supposedly makes its metabolic mechanism different compared to R3M-substituted furan series (or for M = Ge in the thiophene series). Interestingly, SiMe3 and GeMe3 Groups in both heterocyclic series (furan and thiophene) cause opposite trends in cytotoxicity, while the silyl Group increases it, the Germyl Group decreases it. © 2019 Académie des sciences