Gianotti-Crosti Syndrome

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M G Righini - One of the best experts on this subject based on the ideXlab platform.

Antonio Chuh - One of the best experts on this subject based on the ideXlab platform.

  • pityriasis rosea gianotti crosti Syndrome asymmetric periflexural exanthem papular purpuric gloves and socks Syndrome eruptive pseudoangiomatosis and eruptive hypomelanosis do their epidemiological data substantiate infectious etiologies
    Infectious Disease Reports, 2016
    Co-Authors: Antonio Chuh, Vijay Zawar, Gabriel F Sciallis, Werner Kempf, Albert Lee
    Abstract:

    Many clinical and laboratory-based studies have been reported for skin rashes which may be due to viral infections, namely pityriasis rosea (PR), Gianotti-Crosti Syndrome (GCS), asymmetric periflexural exanthem/unilateral laterothoracic exanthem (APE/ULE), papular-purpuric gloves and socks Syndrome (PPGSS), and eruptive pseudo-angiomatosis (EP). Eruptive hypomelanosis (EH) is a newly discovered paraviral rash. Novel tools are now available to investigate the epidemiology of these rashes. To retrieve epidemiological data of these exanthema and analyze whether such substantiates or refutes infectious etiologies. We searched for articles published over the last 60 years and indexed by PubMed database. We then analyzed them for universality, demography, concurrent patients, temporal and spatial-temporal clustering, mini-epidemics, epidemics, and other clinical and geographical associations. Based on our criteria, we selected 55, 60, 29, 36, 20, and 4 articles for PR, GCS, APE/ULE, PPGSS, EP, and EH respectively. Universality or multiple-continental reports are found for all exanthema except EH. The ages of patients are compatible with infectious causes for PR, GCS, APE/ULE, and EH. Concurrent patients are reported for all. Significant patient clustering is demonstrated for PR and GCS. Mini-epidemics and epidemics have been reported for GCS, EP, and EH. The current epidemiological data supports, to a moderate extent, that PR, GCS, and APE could be caused by infectious agents. Support for PPGSS is marginal. Epidemiological evidences for infectious origins for EP and EH are inadequate. There might be growing epidemiological evidence to substantiate or to refute our findings in the future.

  • the impacts of gianotti crosti Syndrome papular acrodermatitis of childhood on the quality of life of children
    International Journal of Tropical Disease & Health, 2016
    Co-Authors: Antonio Chuh
    Abstract:

    Background : Gianotti-Crosti Syndrome (GCS) is a self-remitting eruption related to viral infections. Ribavirin has been reported to be effective in treating severe GCS. Before clinical trials on antiviral agents, the magnitude of GCS affecting the quality of life in children should be ascertained. Aim: To investigate the impact of GCS on the QOL of children. Methods: Our setting was a teaching clinic. We validly translated the Children Dermatology Life Quality Index into Chinese. We recruited all children aged five to 16 years diagnosed with GCS over two years. For each child with GCS, we recruited the next age-and-sex pair-matched child consulting us for atopic dermatitis (AD), and the next age-and-sex pair-matched child brought to consult us for problems unrelated to the skin as controls. All study and control subjects completed the CDLQI. Results: 23 children were GCS and 46 children as controls were recruited. The impacts of GCS on children were significantly higher than children brought to consult us for problems unrelated to the skin ( P < 0.05), with the parameters symptoms and feelings , leisure , school or holidays , and treatment mostly affected. However, the scores were low. Four (17%) study subjects and none (0%) in the second control had total CDLQI higher than 30%. The difference is insignificant (RR: inapplicable; P = 0.11).

  • the diagnostic criteria of pityriasis rosea and gianotti crosti Syndrome a protocol to establish diagnostic criteria of skin diseases
    Journal of the Royal College of Physicians of Edinburgh, 2015
    Co-Authors: Antonio Chuh, Vijay Zawar, Gabriel F Sciallis, Albert Lee
    Abstract:

    We established and validated diagnostic criteria for pityriasis rosea and Gianotti-Crosti Syndrome. In this paper, we compare and contrast both diagnostic criteria to formulate a protocol in establishing diagnostic criteria for other dermatological diseases. The diagnostic criteria are similar in employing clear dividing lines and conjunctions ('and/or') to assure high reliability. Both sets of criteria should be applicable for all ethnic groups. Spontaneous remission is not included, so diagnosis is not delayed while waiting for disease remission. Laboratory investigations are not enlisted, so that the criteria can be used in medical care systems in different parts of the world. The diagnostic criteria are different in that pathognomonic clinical manifestations exist for pityriasis rosea, such as the herald patch and the orientation of lesions along the lines of skin cleavages. These features, however, score low for sensitivity. These specific manifestations are not seen in Gianotti-Crosti Syndrome. Such differences led to different categorisation of clinical features. Atypical variants are more common for pityriasis rosea. The diagnostic criteria for pityriasis rosea therefore do not include a list of differential diagnoses, while diagnostic criteria for Gianotti-Crosti Syndrome do. Using this comparison, we constructed a protocol to establish diagnostic criteria for other skin diseases. We advocate the need to justify the establishment of diagnostic criteria, that multiple diagnostic criteria for the same disease should be avoided, that diagnostic criteria should be compatible with the disease classification if applicable, and that the scope should be well-delineated with regard to clinical variants. We outline the need for validation studies to assess the criteria-related validity, test-retest intra-clinician reliability, and inter-clinician reliability. We emphasise that the establishment of diagnostic criteria should not be a generic process. We also highlight limitations of diagnostic criteria, and emphasise that no diagnostic criteria can replace the bedside experience of clinicians.

Albert Lee - One of the best experts on this subject based on the ideXlab platform.

  • pityriasis rosea gianotti crosti Syndrome asymmetric periflexural exanthem papular purpuric gloves and socks Syndrome eruptive pseudoangiomatosis and eruptive hypomelanosis do their epidemiological data substantiate infectious etiologies
    Infectious Disease Reports, 2016
    Co-Authors: Antonio Chuh, Vijay Zawar, Gabriel F Sciallis, Werner Kempf, Albert Lee
    Abstract:

    Many clinical and laboratory-based studies have been reported for skin rashes which may be due to viral infections, namely pityriasis rosea (PR), Gianotti-Crosti Syndrome (GCS), asymmetric periflexural exanthem/unilateral laterothoracic exanthem (APE/ULE), papular-purpuric gloves and socks Syndrome (PPGSS), and eruptive pseudo-angiomatosis (EP). Eruptive hypomelanosis (EH) is a newly discovered paraviral rash. Novel tools are now available to investigate the epidemiology of these rashes. To retrieve epidemiological data of these exanthema and analyze whether such substantiates or refutes infectious etiologies. We searched for articles published over the last 60 years and indexed by PubMed database. We then analyzed them for universality, demography, concurrent patients, temporal and spatial-temporal clustering, mini-epidemics, epidemics, and other clinical and geographical associations. Based on our criteria, we selected 55, 60, 29, 36, 20, and 4 articles for PR, GCS, APE/ULE, PPGSS, EP, and EH respectively. Universality or multiple-continental reports are found for all exanthema except EH. The ages of patients are compatible with infectious causes for PR, GCS, APE/ULE, and EH. Concurrent patients are reported for all. Significant patient clustering is demonstrated for PR and GCS. Mini-epidemics and epidemics have been reported for GCS, EP, and EH. The current epidemiological data supports, to a moderate extent, that PR, GCS, and APE could be caused by infectious agents. Support for PPGSS is marginal. Epidemiological evidences for infectious origins for EP and EH are inadequate. There might be growing epidemiological evidence to substantiate or to refute our findings in the future.

  • the diagnostic criteria of pityriasis rosea and gianotti crosti Syndrome a protocol to establish diagnostic criteria of skin diseases
    Journal of the Royal College of Physicians of Edinburgh, 2015
    Co-Authors: Antonio Chuh, Vijay Zawar, Gabriel F Sciallis, Albert Lee
    Abstract:

    We established and validated diagnostic criteria for pityriasis rosea and Gianotti-Crosti Syndrome. In this paper, we compare and contrast both diagnostic criteria to formulate a protocol in establishing diagnostic criteria for other dermatological diseases. The diagnostic criteria are similar in employing clear dividing lines and conjunctions ('and/or') to assure high reliability. Both sets of criteria should be applicable for all ethnic groups. Spontaneous remission is not included, so diagnosis is not delayed while waiting for disease remission. Laboratory investigations are not enlisted, so that the criteria can be used in medical care systems in different parts of the world. The diagnostic criteria are different in that pathognomonic clinical manifestations exist for pityriasis rosea, such as the herald patch and the orientation of lesions along the lines of skin cleavages. These features, however, score low for sensitivity. These specific manifestations are not seen in Gianotti-Crosti Syndrome. Such differences led to different categorisation of clinical features. Atypical variants are more common for pityriasis rosea. The diagnostic criteria for pityriasis rosea therefore do not include a list of differential diagnoses, while diagnostic criteria for Gianotti-Crosti Syndrome do. Using this comparison, we constructed a protocol to establish diagnostic criteria for other skin diseases. We advocate the need to justify the establishment of diagnostic criteria, that multiple diagnostic criteria for the same disease should be avoided, that diagnostic criteria should be compatible with the disease classification if applicable, and that the scope should be well-delineated with regard to clinical variants. We outline the need for validation studies to assess the criteria-related validity, test-retest intra-clinician reliability, and inter-clinician reliability. We emphasise that the establishment of diagnostic criteria should not be a generic process. We also highlight limitations of diagnostic criteria, and emphasise that no diagnostic criteria can replace the bedside experience of clinicians.

Urbano Baldari - One of the best experts on this subject based on the ideXlab platform.

A. Monti - One of the best experts on this subject based on the ideXlab platform.

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