The Experts below are selected from a list of 327 Experts worldwide ranked by ideXlab platform

Staffan G Svard - One of the best experts on this subject based on the ideXlab platform.

Showgy Y Maayeh - One of the best experts on this subject based on the ideXlab platform.

Bjorn Andersson - One of the best experts on this subject based on the ideXlab platform.

  • comparative genomic analyses of freshly isolated Giardia intestinalis assemblage a isolates
    BMC Genomics, 2015
    Co-Authors: Johan Ankarklev, Jon Jerlstromhultqvist, Oscar Franzen, Jan Andersson, Bjorn Andersson, Dimitra Peirasmaki, Marianne Lebbad, Staffan G Svard
    Abstract:

    Background: The diarrhea-causing protozoan Giardia intestinalis makes up a species complex of eight different assemblages (A-H), where assemblage A and B infect humans. Comparative whole-genome ana ...

  • genome analysis and comparative genomics of a Giardia intestinalis assemblage e isolate
    BMC Genomics, 2010
    Co-Authors: Jon Jerlstromhultqvist, Johan Ankarklev, Oscar Franzen, Feifei Xu, Eva Nohýnkova, Jan Andersson, Staffan G Svard, Bjorn Andersson
    Abstract:

    Giardia intestinalis is a protozoan parasite that causes diarrhea in a wide range of mammalian species. To further understand the genetic diversity between the Giardia intestinalis species, we have performed genome sequencing and analysis of a wild-type Giardia intestinalis sample from the assemblage E group, isolated from a pig. We identified 5012 protein coding genes, the majority of which are conserved compared to the previously sequenced genomes of the WB and GS strains in terms of microsynteny and sequence identity. Despite this, there is an unexpectedly large number of chromosomal rearrangements and several smaller structural changes that are present in all chromosomes. Novel members of the VSP, NEK Kinase and HCMP gene families were identified, which may reveal possible mechanisms for host specificity and new avenues for antigenic variation. We used comparative genomics of the three diverse Giardia intestinalis isolates P15, GS and WB to define a core proteome for this species complex and to identify lineage-specific genes. Extensive analyses of polymorphisms in the core proteome of Giardia revealed differential rates of divergence among cellular processes. Our results indicate that despite a well conserved core of genes there is significant genome variation between Giardia isolates, both in terms of gene content, gene polymorphisms, structural chromosomal variations and surface molecule repertoires. This study improves the annotation of the Giardia genomes and enables the identification of functionally important variation.

Edith Brotlaroche - One of the best experts on this subject based on the ideXlab platform.

  • asymptomatic Giardia intestinalis infection and roux en y gastric bypass
    Surgery for Obesity and Related Diseases, 2015
    Co-Authors: Laurent Genser, Christine Poitoubernert, Edith Brotlaroche
    Abstract:

    Giardiasis is one of the most common parasitic infections of the human intestine worldwide, and ranges from 3-7% in western countries to 100% in some populations [1]. Giardia intestinalis (i.e Duodenalis or Lamblia) is a flagellated, binucleated protozoan parasite that infects the upper intestinal tract in many mammalian hosts. Giardiasis can present with a broad range of clinical manifestations, from being asymptomatic to acute or chronic nonspecific gastro-intestinal symptoms associated with malnutrition [2]. However little is known regarding Giardiasis in human obesity. [...]

Johan Ankarklev - One of the best experts on this subject based on the ideXlab platform.

  • Genomic variation within Giardia intestinalis assemblage A isolates
    2020
    Co-Authors: Johan Ankarklev
    Abstract:

    Background: The diarrhea-causing protozoan Giardia intestinalis makes up a species complex of eight different assemblages (A-H), where assemblage A and B infect humans. We have performed whole geno ...

  • Inter and Intra-Assemblage Characterizations of Giardia intestinalis: from clinic to genome
    2020
    Co-Authors: Johan Ankarklev
    Abstract:

    The protozoan parasite Giardia intestinalis (syn. G. lamblia, G. duodenalis) is one of the most common causes of diarrheal disease throughout the world, where an estimated 500 million people are in ...

  • comparative genomic analyses of freshly isolated Giardia intestinalis assemblage a isolates
    BMC Genomics, 2015
    Co-Authors: Johan Ankarklev, Jon Jerlstromhultqvist, Oscar Franzen, Jan Andersson, Bjorn Andersson, Dimitra Peirasmaki, Marianne Lebbad, Staffan G Svard
    Abstract:

    Background: The diarrhea-causing protozoan Giardia intestinalis makes up a species complex of eight different assemblages (A-H), where assemblage A and B infect humans. Comparative whole-genome ana ...

  • common coinfections of Giardia intestinalis and helicobacter pylori in non symptomatic ugandan children
    PLOS Neglected Tropical Diseases, 2012
    Co-Authors: Johan Ankarklev, Jan Andersson, Marianne Lebbad, Elin Hestvik, Johan Lindh, Deogratias H Kaddumulindwa, Thorkild Tylleskar, James K Tumwine, Staffan G Svard
    Abstract:

    Background The protozoan parasite Giardia intestinalis and the pathogenic bacterium Helicobacter pylori are well known for their high prevalences in human hosts worldwide. The prevalence of both organisms is known to peak in densely populated, low resource settings and children are infected early in life. Different Giardia genotypes/assemblages have been associated with different symptoms and H. pylori with induction of cancer. Despite this, not much data are available from sub-Saharan Africa with regards to the prevalence of different G. intestinalis assemblages and their potential association with H. pylori infections.

  • genome analysis and comparative genomics of a Giardia intestinalis assemblage e isolate
    BMC Genomics, 2010
    Co-Authors: Jon Jerlstromhultqvist, Johan Ankarklev, Oscar Franzen, Feifei Xu, Eva Nohýnkova, Jan Andersson, Staffan G Svard, Bjorn Andersson
    Abstract:

    Giardia intestinalis is a protozoan parasite that causes diarrhea in a wide range of mammalian species. To further understand the genetic diversity between the Giardia intestinalis species, we have performed genome sequencing and analysis of a wild-type Giardia intestinalis sample from the assemblage E group, isolated from a pig. We identified 5012 protein coding genes, the majority of which are conserved compared to the previously sequenced genomes of the WB and GS strains in terms of microsynteny and sequence identity. Despite this, there is an unexpectedly large number of chromosomal rearrangements and several smaller structural changes that are present in all chromosomes. Novel members of the VSP, NEK Kinase and HCMP gene families were identified, which may reveal possible mechanisms for host specificity and new avenues for antigenic variation. We used comparative genomics of the three diverse Giardia intestinalis isolates P15, GS and WB to define a core proteome for this species complex and to identify lineage-specific genes. Extensive analyses of polymorphisms in the core proteome of Giardia revealed differential rates of divergence among cellular processes. Our results indicate that despite a well conserved core of genes there is significant genome variation between Giardia isolates, both in terms of gene content, gene polymorphisms, structural chromosomal variations and surface molecule repertoires. This study improves the annotation of the Giardia genomes and enables the identification of functionally important variation.