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Man Hee Rhee - One of the best experts on this subject based on the ideXlab platform.

  • Alleviation of diabetic complications by ginsenoside Rg3-enriched red Ginseng Extract in western diet-fed LDL–/– mice
    Elsevier, 2018
    Co-Authors: Evelyn Saba, Seung-hyung Kim, Sung Dae Kim, Sang-joon Park, Dongmi Kwak, Chae Kyu Park, Man Hee Rhee
    Abstract:

    In this study, we precisely showed how the Rg3-enriched red Ginseng Extract (Rg3-RGE) lowers glucose, triglyceride, and low-density lipoprotein (LDL) levels in LDL–/– mice. Aspartate aminotransferase/serum glutamic-oxaloacetic transaminase), alanine aminotransferase /serum glutamate-pyruvate transaminase, and steatohepatitis were found to be reduced, and atheroma formation was inhibited by Rg3-enriched red Ginseng Extract. Keywords: antiatheromatic, antidiabetic, antihypercholesterolemic, Rg3-enriched Korean Red Ginseng extrac

  • ginsenoside rg3 enriched red Ginseng Extract inhibits platelet activation and in vivo thrombus formation
    Journal of Ginseng Research, 2017
    Co-Authors: Dahye Jeong, Sung Dae Kim, Chae Kyu Park, Muhammad Irfan, Suk Kim, Hyunkyoung Kim, Man Hee Rhee
    Abstract:

    Background Korean Red Ginseng has been used for several decades to treat many diseases, enhancing both immunity and physical strength. Previous studies have documented the therapeutic effects of Ginseng, including its anticancer, antiaging, and anti-inflammatory activities. These activities are mediated by ginsenosides present in the Ginseng plant. Ginsenoside Rg3, an effective compound from red Ginseng, has been shown to have antiplatelet activity in addition to its anticancer and anti-inflammatory activities. Platelets are important for both primary hemostasis and the repair of the vessels after injury; however, they also play a crucial role in the development of acute coronary diseases. We prepared ginsenoside Rg3-enriched red Ginseng Extract (Rg3-RGE) to examine its role in platelet physiology.

  • Alleviation of diabetic complications by ginsenoside Rg3-enriched red Ginseng Extract in western diet-fed LDL-/- mice.
    Journal of ginseng research, 2017
    Co-Authors: Evelyn Saba, Seung-hyung Kim, Sung Dae Kim, Sang-joon Park, Dongmi Kwak, Chae Kyu Park, Man Hee Rhee
    Abstract:

    In this study, we precisely showed how the Rg3-enriched red Ginseng Extract (Rg3-RGE) lowers glucose, triglyceride, and low-density lipoprotein (LDL) levels in LDL-/- mice. Aspartate aminotransferase/serum glutamic-oxaloacetic transaminase), alanine aminotransferase /serum glutamate-pyruvate transaminase, and steatohepatitis were found to be reduced, and atheroma formation was inhibited by Rg3-enriched red Ginseng Extract.

Jane C J Chao - One of the best experts on this subject based on the ideXlab platform.

  • Ginseng Extract and ginsenoside rb1 attenuate carbon tetrachloride induced liver fibrosis in rats
    BMC Complementary and Alternative Medicine, 2014
    Co-Authors: Ya Hui Tsai, Jane C J Chao
    Abstract:

    Ginsenosides, the major bioactive compounds in Ginseng root, have been found to have antioxidant, immunomodulatory and anti-inflammatory activities. This study investigated the effects of ginsenosides on carbon tetrachloride (CCl4)-induced hepatitis and liver fibrosis in rats. Male Sprague–Dawley rats were randomly divided into four groups: control, CCl4, CCl4 + 0.5 g/kg Panax Ginseng Extract and CCl4 + 0.05 g/kg ginsenoside Rb1 groups. The treated groups were orally given Panax Ginseng Extract or ginsenoside Rb1 two weeks before the induction of liver injury for successive 9 weeks. Liver injury was induced by intraperitoneally injected with 400 ml/l CCl4 at a dose of 0.75 ml/kg body weight weekly for 7 weeks. The control group was intraperitoneally injected with olive oil. The pathological results showed that ginsenoside Rb1 decreased hepatic fat deposition (2.65 ± 0.82 vs 3.50 ± 0.75, p <0.05) and Panax Ginseng Extract lowered hepatic reticular fiber accumulation (1.05 ± 0.44 vs 1.60 ± 0.39, p <0.01) increased by CCl4. Plasma alanine aminotransferase and aspartate aminotransferase activities were increased by CCl4 (p <0.01), and aspartate aminotransferase activity was decreased by Panax Ginseng Extract at week 9 (p <0.05). Exposure to CCl4 for 7 weeks, the levels of plasma and hepatic triglycerides (p <0.01), hepatic cholesterol (p <0.01), interleukin-1β (p <0.01), prostaglandin E2 (p <0.05), soluble intercellular adhesion molecule-1 (p <0.05), hydroxyproline (p <0.05), matrix metalloproteinase-2 (p <0.05) and tissue inhibitor of metalloproteinase-1 (TIMP-1) (p <0.01) were elevated, however, hepatic interleukin-10 level was lowered (p <0.05). Both Panax Ginseng Extract and ginsenoside Rb1 decreased plasma and hepatic triglyceride, hepatic prostaglandin E2, hydroxyproline and TIMP-1 levels, and Panax Ginseng Extract further inhibited interleukin-1β concentrations (p <0.05). Panax Ginseng Extract and ginsenoside Rb1 attenuate plasma aminotransferase activities and liver inflammation to inhibit CCl4-induced liver fibrosis through down-regulation of hepatic prostaglandin E2 and TIMP-1.

  • Ginseng Extract and ginsenoside Rb1 attenuate carbon tetrachloride-induced liver fibrosis in rats
    BMC complementary and alternative medicine, 2014
    Co-Authors: Ya Ling Hou, Ya Hui Tsai, Yun Ho Lin, Jane C J Chao
    Abstract:

    Ginsenosides, the major bioactive compounds in Ginseng root, have been found to have antioxidant, immunomodulatory and anti-inflammatory activities. This study investigated the effects of ginsenosides on carbon tetrachloride (CCl4)-induced hepatitis and liver fibrosis in rats. Male Sprague–Dawley rats were randomly divided into four groups: control, CCl4, CCl4 + 0.5 g/kg Panax Ginseng Extract and CCl4 + 0.05 g/kg ginsenoside Rb1 groups. The treated groups were orally given Panax Ginseng Extract or ginsenoside Rb1 two weeks before the induction of liver injury for successive 9 weeks. Liver injury was induced by intraperitoneally injected with 400 ml/l CCl4 at a dose of 0.75 ml/kg body weight weekly for 7 weeks. The control group was intraperitoneally injected with olive oil. The pathological results showed that ginsenoside Rb1 decreased hepatic fat deposition (2.65 ± 0.82 vs 3.50 ± 0.75, p

Chae Kyu Park - One of the best experts on this subject based on the ideXlab platform.

  • Alleviation of diabetic complications by ginsenoside Rg3-enriched red Ginseng Extract in western diet-fed LDL–/– mice
    Elsevier, 2018
    Co-Authors: Evelyn Saba, Seung-hyung Kim, Sung Dae Kim, Sang-joon Park, Dongmi Kwak, Chae Kyu Park, Man Hee Rhee
    Abstract:

    In this study, we precisely showed how the Rg3-enriched red Ginseng Extract (Rg3-RGE) lowers glucose, triglyceride, and low-density lipoprotein (LDL) levels in LDL–/– mice. Aspartate aminotransferase/serum glutamic-oxaloacetic transaminase), alanine aminotransferase /serum glutamate-pyruvate transaminase, and steatohepatitis were found to be reduced, and atheroma formation was inhibited by Rg3-enriched red Ginseng Extract. Keywords: antiatheromatic, antidiabetic, antihypercholesterolemic, Rg3-enriched Korean Red Ginseng extrac

  • ginsenoside rg3 enriched red Ginseng Extract inhibits platelet activation and in vivo thrombus formation
    Journal of Ginseng Research, 2017
    Co-Authors: Dahye Jeong, Sung Dae Kim, Chae Kyu Park, Muhammad Irfan, Suk Kim, Hyunkyoung Kim, Man Hee Rhee
    Abstract:

    Background Korean Red Ginseng has been used for several decades to treat many diseases, enhancing both immunity and physical strength. Previous studies have documented the therapeutic effects of Ginseng, including its anticancer, antiaging, and anti-inflammatory activities. These activities are mediated by ginsenosides present in the Ginseng plant. Ginsenoside Rg3, an effective compound from red Ginseng, has been shown to have antiplatelet activity in addition to its anticancer and anti-inflammatory activities. Platelets are important for both primary hemostasis and the repair of the vessels after injury; however, they also play a crucial role in the development of acute coronary diseases. We prepared ginsenoside Rg3-enriched red Ginseng Extract (Rg3-RGE) to examine its role in platelet physiology.

  • Alleviation of diabetic complications by ginsenoside Rg3-enriched red Ginseng Extract in western diet-fed LDL-/- mice.
    Journal of ginseng research, 2017
    Co-Authors: Evelyn Saba, Seung-hyung Kim, Sung Dae Kim, Sang-joon Park, Dongmi Kwak, Chae Kyu Park, Man Hee Rhee
    Abstract:

    In this study, we precisely showed how the Rg3-enriched red Ginseng Extract (Rg3-RGE) lowers glucose, triglyceride, and low-density lipoprotein (LDL) levels in LDL-/- mice. Aspartate aminotransferase/serum glutamic-oxaloacetic transaminase), alanine aminotransferase /serum glutamate-pyruvate transaminase, and steatohepatitis were found to be reduced, and atheroma formation was inhibited by Rg3-enriched red Ginseng Extract.

Sung Dae Kim - One of the best experts on this subject based on the ideXlab platform.

  • Alleviation of diabetic complications by ginsenoside Rg3-enriched red Ginseng Extract in western diet-fed LDL–/– mice
    Elsevier, 2018
    Co-Authors: Evelyn Saba, Seung-hyung Kim, Sung Dae Kim, Sang-joon Park, Dongmi Kwak, Chae Kyu Park, Man Hee Rhee
    Abstract:

    In this study, we precisely showed how the Rg3-enriched red Ginseng Extract (Rg3-RGE) lowers glucose, triglyceride, and low-density lipoprotein (LDL) levels in LDL–/– mice. Aspartate aminotransferase/serum glutamic-oxaloacetic transaminase), alanine aminotransferase /serum glutamate-pyruvate transaminase, and steatohepatitis were found to be reduced, and atheroma formation was inhibited by Rg3-enriched red Ginseng Extract. Keywords: antiatheromatic, antidiabetic, antihypercholesterolemic, Rg3-enriched Korean Red Ginseng extrac

  • ginsenoside rg3 enriched red Ginseng Extract inhibits platelet activation and in vivo thrombus formation
    Journal of Ginseng Research, 2017
    Co-Authors: Dahye Jeong, Sung Dae Kim, Chae Kyu Park, Muhammad Irfan, Suk Kim, Hyunkyoung Kim, Man Hee Rhee
    Abstract:

    Background Korean Red Ginseng has been used for several decades to treat many diseases, enhancing both immunity and physical strength. Previous studies have documented the therapeutic effects of Ginseng, including its anticancer, antiaging, and anti-inflammatory activities. These activities are mediated by ginsenosides present in the Ginseng plant. Ginsenoside Rg3, an effective compound from red Ginseng, has been shown to have antiplatelet activity in addition to its anticancer and anti-inflammatory activities. Platelets are important for both primary hemostasis and the repair of the vessels after injury; however, they also play a crucial role in the development of acute coronary diseases. We prepared ginsenoside Rg3-enriched red Ginseng Extract (Rg3-RGE) to examine its role in platelet physiology.

  • Alleviation of diabetic complications by ginsenoside Rg3-enriched red Ginseng Extract in western diet-fed LDL-/- mice.
    Journal of ginseng research, 2017
    Co-Authors: Evelyn Saba, Seung-hyung Kim, Sung Dae Kim, Sang-joon Park, Dongmi Kwak, Chae Kyu Park, Man Hee Rhee
    Abstract:

    In this study, we precisely showed how the Rg3-enriched red Ginseng Extract (Rg3-RGE) lowers glucose, triglyceride, and low-density lipoprotein (LDL) levels in LDL-/- mice. Aspartate aminotransferase/serum glutamic-oxaloacetic transaminase), alanine aminotransferase /serum glutamate-pyruvate transaminase, and steatohepatitis were found to be reduced, and atheroma formation was inhibited by Rg3-enriched red Ginseng Extract.

Evelyn Saba - One of the best experts on this subject based on the ideXlab platform.