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Keun Hong Park - One of the best experts on this subject based on the ideXlab platform.

  • gintonin a novel ginseng derived lysophosphatidic acid receptor ligand stimulates neurotransmitter release
    Neuroscience Letters, 2015
    Co-Authors: Sunghee Hwang, Sunhye Choi, Seokwon Jung, Hochul Shin, Hyun Jin Park, Keun Hong Park
    Abstract:

    Abstract Gintonin is a novel ginseng-derived G protein-coupled lysophosphatidic acid (LPA) receptor ligand. Gintonin elicits an intracellular calcium concentration [Ca 2+ ] i transient via activation of LPA receptors and regulates calcium-dependent ion channels and receptors. [Ca 2+ ] i elevation by neurotransmitters or depolarization is usually coupled to neurotransmitter release in neuronal cells. Little is known about whether gintonin-mediated [Ca 2+ ] i transients are also coupled to neurotransmitter release. The PC12 cell line is derived from a pheochromocytoma of the rat adrenal medulla and is widely used as a model for catecholamine release. In the present study, we examined the effects of gintonin on dopamine release in PC12 cells. Application of gintonin to PC12 cells induced [Ca 2+ ] i transients in concentration-dependent and reversible manners. However, Ginsenoside Rg 3 , another active ingredient of ginseng, induced a lagged and irreversible [Ca 2+ ] i increase. The induction of gintonin-mediated [Ca 2+ ] i transients was attenuated or blocked by the LPA1/3 receptor antagonist Ki16425, a phospholipase C inhibitor, an inositol 1,4,5-triphosphate receptor antagonist, and an intracellular Ca 2+ chelator. Repeated treatment with gintonin induced homologous desensitization of [Ca 2+ ] i transients. Gintonin treatment in PC12 cells increased the release of dopamine in a concentration-dependent manner. Intraperitoneal administration of gintonin to mice also increased serum dopamine concentrations. The present study shows that gintonin-mediated [Ca 2+ ] i transients are coupled to dopamine release via LPA receptor activation. Finally, gintonin-mediated [Ca 2+ ] i transients and dopamine release via LPA receptor activation might explain one mechanism of gintonin-mediated inter-neuronal modulation in the nervous system.

Sunghee Hwang - One of the best experts on this subject based on the ideXlab platform.

  • gintonin a novel ginseng derived lysophosphatidic acid receptor ligand stimulates neurotransmitter release
    Neuroscience Letters, 2015
    Co-Authors: Sunghee Hwang, Sunhye Choi, Seokwon Jung, Hochul Shin, Hyun Jin Park, Keun Hong Park
    Abstract:

    Abstract Gintonin is a novel ginseng-derived G protein-coupled lysophosphatidic acid (LPA) receptor ligand. Gintonin elicits an intracellular calcium concentration [Ca 2+ ] i transient via activation of LPA receptors and regulates calcium-dependent ion channels and receptors. [Ca 2+ ] i elevation by neurotransmitters or depolarization is usually coupled to neurotransmitter release in neuronal cells. Little is known about whether gintonin-mediated [Ca 2+ ] i transients are also coupled to neurotransmitter release. The PC12 cell line is derived from a pheochromocytoma of the rat adrenal medulla and is widely used as a model for catecholamine release. In the present study, we examined the effects of gintonin on dopamine release in PC12 cells. Application of gintonin to PC12 cells induced [Ca 2+ ] i transients in concentration-dependent and reversible manners. However, Ginsenoside Rg 3 , another active ingredient of ginseng, induced a lagged and irreversible [Ca 2+ ] i increase. The induction of gintonin-mediated [Ca 2+ ] i transients was attenuated or blocked by the LPA1/3 receptor antagonist Ki16425, a phospholipase C inhibitor, an inositol 1,4,5-triphosphate receptor antagonist, and an intracellular Ca 2+ chelator. Repeated treatment with gintonin induced homologous desensitization of [Ca 2+ ] i transients. Gintonin treatment in PC12 cells increased the release of dopamine in a concentration-dependent manner. Intraperitoneal administration of gintonin to mice also increased serum dopamine concentrations. The present study shows that gintonin-mediated [Ca 2+ ] i transients are coupled to dopamine release via LPA receptor activation. Finally, gintonin-mediated [Ca 2+ ] i transients and dopamine release via LPA receptor activation might explain one mechanism of gintonin-mediated inter-neuronal modulation in the nervous system.

Sunhye Choi - One of the best experts on this subject based on the ideXlab platform.

  • gintonin a novel ginseng derived lysophosphatidic acid receptor ligand stimulates neurotransmitter release
    Neuroscience Letters, 2015
    Co-Authors: Sunghee Hwang, Sunhye Choi, Seokwon Jung, Hochul Shin, Hyun Jin Park, Keun Hong Park
    Abstract:

    Abstract Gintonin is a novel ginseng-derived G protein-coupled lysophosphatidic acid (LPA) receptor ligand. Gintonin elicits an intracellular calcium concentration [Ca 2+ ] i transient via activation of LPA receptors and regulates calcium-dependent ion channels and receptors. [Ca 2+ ] i elevation by neurotransmitters or depolarization is usually coupled to neurotransmitter release in neuronal cells. Little is known about whether gintonin-mediated [Ca 2+ ] i transients are also coupled to neurotransmitter release. The PC12 cell line is derived from a pheochromocytoma of the rat adrenal medulla and is widely used as a model for catecholamine release. In the present study, we examined the effects of gintonin on dopamine release in PC12 cells. Application of gintonin to PC12 cells induced [Ca 2+ ] i transients in concentration-dependent and reversible manners. However, Ginsenoside Rg 3 , another active ingredient of ginseng, induced a lagged and irreversible [Ca 2+ ] i increase. The induction of gintonin-mediated [Ca 2+ ] i transients was attenuated or blocked by the LPA1/3 receptor antagonist Ki16425, a phospholipase C inhibitor, an inositol 1,4,5-triphosphate receptor antagonist, and an intracellular Ca 2+ chelator. Repeated treatment with gintonin induced homologous desensitization of [Ca 2+ ] i transients. Gintonin treatment in PC12 cells increased the release of dopamine in a concentration-dependent manner. Intraperitoneal administration of gintonin to mice also increased serum dopamine concentrations. The present study shows that gintonin-mediated [Ca 2+ ] i transients are coupled to dopamine release via LPA receptor activation. Finally, gintonin-mediated [Ca 2+ ] i transients and dopamine release via LPA receptor activation might explain one mechanism of gintonin-mediated inter-neuronal modulation in the nervous system.

Seokwon Jung - One of the best experts on this subject based on the ideXlab platform.

  • gintonin a novel ginseng derived lysophosphatidic acid receptor ligand stimulates neurotransmitter release
    Neuroscience Letters, 2015
    Co-Authors: Sunghee Hwang, Sunhye Choi, Seokwon Jung, Hochul Shin, Hyun Jin Park, Keun Hong Park
    Abstract:

    Abstract Gintonin is a novel ginseng-derived G protein-coupled lysophosphatidic acid (LPA) receptor ligand. Gintonin elicits an intracellular calcium concentration [Ca 2+ ] i transient via activation of LPA receptors and regulates calcium-dependent ion channels and receptors. [Ca 2+ ] i elevation by neurotransmitters or depolarization is usually coupled to neurotransmitter release in neuronal cells. Little is known about whether gintonin-mediated [Ca 2+ ] i transients are also coupled to neurotransmitter release. The PC12 cell line is derived from a pheochromocytoma of the rat adrenal medulla and is widely used as a model for catecholamine release. In the present study, we examined the effects of gintonin on dopamine release in PC12 cells. Application of gintonin to PC12 cells induced [Ca 2+ ] i transients in concentration-dependent and reversible manners. However, Ginsenoside Rg 3 , another active ingredient of ginseng, induced a lagged and irreversible [Ca 2+ ] i increase. The induction of gintonin-mediated [Ca 2+ ] i transients was attenuated or blocked by the LPA1/3 receptor antagonist Ki16425, a phospholipase C inhibitor, an inositol 1,4,5-triphosphate receptor antagonist, and an intracellular Ca 2+ chelator. Repeated treatment with gintonin induced homologous desensitization of [Ca 2+ ] i transients. Gintonin treatment in PC12 cells increased the release of dopamine in a concentration-dependent manner. Intraperitoneal administration of gintonin to mice also increased serum dopamine concentrations. The present study shows that gintonin-mediated [Ca 2+ ] i transients are coupled to dopamine release via LPA receptor activation. Finally, gintonin-mediated [Ca 2+ ] i transients and dopamine release via LPA receptor activation might explain one mechanism of gintonin-mediated inter-neuronal modulation in the nervous system.

Hochul Shin - One of the best experts on this subject based on the ideXlab platform.

  • gintonin a novel ginseng derived lysophosphatidic acid receptor ligand stimulates neurotransmitter release
    Neuroscience Letters, 2015
    Co-Authors: Sunghee Hwang, Sunhye Choi, Seokwon Jung, Hochul Shin, Hyun Jin Park, Keun Hong Park
    Abstract:

    Abstract Gintonin is a novel ginseng-derived G protein-coupled lysophosphatidic acid (LPA) receptor ligand. Gintonin elicits an intracellular calcium concentration [Ca 2+ ] i transient via activation of LPA receptors and regulates calcium-dependent ion channels and receptors. [Ca 2+ ] i elevation by neurotransmitters or depolarization is usually coupled to neurotransmitter release in neuronal cells. Little is known about whether gintonin-mediated [Ca 2+ ] i transients are also coupled to neurotransmitter release. The PC12 cell line is derived from a pheochromocytoma of the rat adrenal medulla and is widely used as a model for catecholamine release. In the present study, we examined the effects of gintonin on dopamine release in PC12 cells. Application of gintonin to PC12 cells induced [Ca 2+ ] i transients in concentration-dependent and reversible manners. However, Ginsenoside Rg 3 , another active ingredient of ginseng, induced a lagged and irreversible [Ca 2+ ] i increase. The induction of gintonin-mediated [Ca 2+ ] i transients was attenuated or blocked by the LPA1/3 receptor antagonist Ki16425, a phospholipase C inhibitor, an inositol 1,4,5-triphosphate receptor antagonist, and an intracellular Ca 2+ chelator. Repeated treatment with gintonin induced homologous desensitization of [Ca 2+ ] i transients. Gintonin treatment in PC12 cells increased the release of dopamine in a concentration-dependent manner. Intraperitoneal administration of gintonin to mice also increased serum dopamine concentrations. The present study shows that gintonin-mediated [Ca 2+ ] i transients are coupled to dopamine release via LPA receptor activation. Finally, gintonin-mediated [Ca 2+ ] i transients and dopamine release via LPA receptor activation might explain one mechanism of gintonin-mediated inter-neuronal modulation in the nervous system.