The Experts below are selected from a list of 255 Experts worldwide ranked by ideXlab platform

David B. Sacks - One of the best experts on this subject based on the ideXlab platform.

  • Global Standardization of glycated hemoglobin measurement: The position of the IFCC Working Group
    Clinical Chemistry and Laboratory Medicine, 2007
    Co-Authors: Andrea Mosca, Tadao Hoshino, Kor Miedema, Gary L. Myers, Randie R Little, Jan-olof Jeppsson, Hans Reinauer, W. Garry John, Ian Goodall, David B. Sacks
    Abstract:

    The measurement of glycated hemoglobin is central in the monitoring of glycemic control in patients with diabetes. There are at least 30 different laboratory assays commercially available to measure the proportion of HbA1c in blood. In 1995 the IFCC established a Working Group (IFCC WG-HbA1c) to achieve international Standardization of HbA1c measurement. The main achievements can be summarized as follows: a) a reference measurement procedure has been established with purified primary calibrators; b) a network of reference laboratories has been developed worldwide; and c) work has begun on implementation of traceability to the IFCC reference system. The IFCC WG-HbA1c recognizes the recommendation of the IFCC-IUPAC Committee on Nomenclature, Properties and Units that the analyte measured by the IFCC reference measurement procedure has been defined as betaN1-deoxyfructosyl-hemoglobin and that the recommended measurement units are mmol/mol. The IFCC WG-HbA1c recommends maintaining the use of the name HbA1c in clinical practice.

  • Global Standardization of glycated hemoglobin measurement the position of the ifcc working group
    Clinical Chemistry and Laboratory Medicine, 2007
    Co-Authors: Andrea Mosca, Tadao Hoshino, Kor Miedema, Gary L. Myers, Randie R Little, Jan-olof Jeppsson, Hans Reinauer, Ian Goodall, Garry W John, David B. Sacks
    Abstract:

    The measurement of glycated hemoglobin is central in the monitoring of glycemic control in patients with diabetes. There are at least 30 different laboratory assays commercially available to measure the proportion of HbA1c in blood. In 1995 the IFCC established a Working Group (IFCC WG-HbA1c) to achieve international Standardization of HbA1c measurement. The main achievements can be summarized as follows: a) a reference measurement procedure has been established with purified primary calibrators; b) a network of reference laboratories has been developed worldwide; and c) work has begun on implementation of traceability to the IFCC reference system. The IFCC WG-HbA1c recognizes the recommendation of the IFCC-IUPAC Committee on Nomenclature, Properties and Units that the analyte measured by the IFCC reference measurement procedure has been defined as beta N1-deoxyfructosyl-hemoglobin and that the recommended measurement units are mmol/mol. The IFCC WG-HbA1c recommends maintaining the use of the name HbA1c in clinical practice. (Less)

Darin Okeeffe - One of the best experts on this subject based on the ideXlab platform.

  • Standardization of administered activities in pediatric nuclear medicine a report of the first nuclear medicine Global initiative project part 2 current standards and the path toward Global Standardization
    The Journal of Nuclear Medicine, 2016
    Co-Authors: Frederic H Fahey, Henry Heeseung Bom, Arturo Chiti, Yun Young Choi, Gang Huang, Michael Lassmann, Norman Laurin, Fernando Mut, Rodolfo Nunezmiller, Darin Okeeffe
    Abstract:

    The Nuclear Medicine Global Initiative (NMGI) was formed in 2012 and consists of 13 international organizations with direct involvement in nuclear medicine. The underlying objectives of the NMGI are to promote human health by advancing the field of nuclear medicine and molecular imaging, encourage Global collaboration in education, and harmonize procedure guidelines and other policies that ultimately lead to improvements in quality and safety in the field throughout the world. For its first project, the NMGI decided to consider the issues involved in the Standardization of administered activities in pediatric nuclear medicine. It was decided to divide the final report of this project into 2 parts. Part 1 was published in this journal in the spring of 2015. This article presents part 2 of the final report. It discusses current standards for administered activities in children and adolescents that have been developed by various professional organizations. It also presents an evaluation of the current practice of pediatric nuclear medicine specifically with regard to administered activities as determined by an international survey of 313 nuclear medicine clinics and centers from 29 countries. Lastly, it provides recommendations for a path toward Global Standardization of the administration of radiopharmaceuticals in children.

  • Standardization of administered activities in pediatric nuclear medicine a report of the first nuclear medicine Global initiative project part 1 statement of the issue and a review of available resources
    The Journal of Nuclear Medicine, 2015
    Co-Authors: Frederic H Fahey, Arturo Chiti, Yun Young Choi, Gang Huang, Michael Lassmann, Norman Laurin, Fernando Mut, Rodolfo Nunezmiller, Henry Hee Seong Bom, Darin Okeeffe
    Abstract:

    The Nuclear Medicine Global Initiative (NMGI) was formed in 2012 and consists of 13 international organizations with direct involvement in nuclear medicine. The underlying objectives of the NMGI were to promote human health by advancing the field of nuclear medicine and molecular imaging, encourage Global collaboration in education, and harmonize procedure guidelines and other policies that ultimately lead to improvements in quality and safety in the field throughout the world. For its first project, the NMGI decided to consider the issues involved in the Standardization of administered activities in pediatric nuclear medicine. This article presents part 1 of the final report of this initial project of the NMGI. It provides a review of the value of pediatric nuclear medicine, the current understanding of the carcinogenic risk of radiation as it pertains to the administration of radiopharmaceuticals in children, and the application of dosimetric models in children. A listing of pertinent educational and reference resources available in print and online is also provided. The forthcoming part 2 report will discuss current standards for administered activities in children and adolescents that have been developed by various organizations and an evaluation of the current practice of pediatric nuclear medicine specifically with regard to administered activities as determined by an international survey of nuclear medicine clinics and centers. Lastly, the part 2 report will recommend a path forward toward Global Standardization of the administration of radiopharmaceuticals in children.

Andrea Mosca - One of the best experts on this subject based on the ideXlab platform.

  • Global Standardization of glycated hemoglobin measurement: The position of the IFCC Working Group
    Clinical Chemistry and Laboratory Medicine, 2007
    Co-Authors: Andrea Mosca, Tadao Hoshino, Kor Miedema, Gary L. Myers, Randie R Little, Jan-olof Jeppsson, Hans Reinauer, W. Garry John, Ian Goodall, David B. Sacks
    Abstract:

    The measurement of glycated hemoglobin is central in the monitoring of glycemic control in patients with diabetes. There are at least 30 different laboratory assays commercially available to measure the proportion of HbA1c in blood. In 1995 the IFCC established a Working Group (IFCC WG-HbA1c) to achieve international Standardization of HbA1c measurement. The main achievements can be summarized as follows: a) a reference measurement procedure has been established with purified primary calibrators; b) a network of reference laboratories has been developed worldwide; and c) work has begun on implementation of traceability to the IFCC reference system. The IFCC WG-HbA1c recognizes the recommendation of the IFCC-IUPAC Committee on Nomenclature, Properties and Units that the analyte measured by the IFCC reference measurement procedure has been defined as betaN1-deoxyfructosyl-hemoglobin and that the recommended measurement units are mmol/mol. The IFCC WG-HbA1c recommends maintaining the use of the name HbA1c in clinical practice.

  • Global Standardization of glycated hemoglobin measurement the position of the ifcc working group
    Clinical Chemistry and Laboratory Medicine, 2007
    Co-Authors: Andrea Mosca, Tadao Hoshino, Kor Miedema, Gary L. Myers, Randie R Little, Jan-olof Jeppsson, Hans Reinauer, Ian Goodall, Garry W John, David B. Sacks
    Abstract:

    The measurement of glycated hemoglobin is central in the monitoring of glycemic control in patients with diabetes. There are at least 30 different laboratory assays commercially available to measure the proportion of HbA1c in blood. In 1995 the IFCC established a Working Group (IFCC WG-HbA1c) to achieve international Standardization of HbA1c measurement. The main achievements can be summarized as follows: a) a reference measurement procedure has been established with purified primary calibrators; b) a network of reference laboratories has been developed worldwide; and c) work has begun on implementation of traceability to the IFCC reference system. The IFCC WG-HbA1c recognizes the recommendation of the IFCC-IUPAC Committee on Nomenclature, Properties and Units that the analyte measured by the IFCC reference measurement procedure has been defined as beta N1-deoxyfructosyl-hemoglobin and that the recommended measurement units are mmol/mol. The IFCC WG-HbA1c recommends maintaining the use of the name HbA1c in clinical practice. (Less)

Garry John - One of the best experts on this subject based on the ideXlab platform.

  • 2010 consensus statement on the worldwide Standardization of the hemoglobin a1c measurement
    Diabetes Care, 2010
    Co-Authors: Ragnar Hanas, Garry John
    Abstract:

    Glycated hemoglobin concentrations (most commonly hemoglobin A1C; HbA1c) reflect time-averaged blood glucose during the previous 2–3 months and are used as the gold standard for long-term follow-up of glycemic control. Standardization with common calibration was first proposed in 1984 (1). It was only after the publication of the Diabetes Control and Complications Trial (DCCT) study in 1993 (2), however, that the issue of international Standardization of HbA1c measurements became an important objective for scientists and clinicians. At that time, the lack of international Standardization resulted in several countries developing National Standardization programs; most notable of these are: A common feature of these national programs is the absence of primary and secondary reference materials. To overcome this lack of reference materials, achieve Global Standardization, and meet the requirements of the European Union directive on in vitro diagnostic (IVD) medical devices, the International Federation of Clinical Chemistry and Laboratory Medicine (IFCC) established a Working Group on HbA1c Standardization to develop a reference measurement system within the concept of metrological traceability. Such a system has been developed consisting of incubation with the enzyme endoproteinase Glu-C, cleavage of the NH2-terminal hexapeptide of the β-chain, and separation and …

  • 2010 consensus statement on the worldwide Standardization of the hemoglobin a1c measurement
    Clinical Chemistry, 2010
    Co-Authors: Ragnar Hanas, Garry John
    Abstract:

    Glycated hemoglobin concentrations (most commonly hemoglobin A1c; HbA1c) reflect time averaged blood glucose during the previous 2–3 months, and are used as the gold standard for long-term follow-up of glycemic control. Standardization with common calibration was first proposed in 1984 (1). It was only after the publication of the DCCT study in 1993 (2), however, that the issue of international Standardization of HbA1c measurements became an important objective for scientists and clinicians. At that time, the lack of international Standardization resulted in several countries developing National Standardization programs; most notable of these are: A common feature of these national programs is the absence of primary and secondary reference materials. To overcome this lack of reference materials, achieve Global Standardization, and meet the requirements of the European Union directive on in vitro diagnostic medical devices (IVD), the IFCC established a working Group on HbA1c Standardization to develop a reference measurement system within the concept of metrological traceability. Such a system has been developed consisting of incubation with the enzyme endoproteinase Glu-C, cleavage of the N-terminal hexapeptide of the β chain, and separation and quantification of glycated and non-glycated hexapeptides by mass spectrometry or capillary electrophoresis (3). The analyte measured is a hemoglobin molecule having a stable adduct of glucose to the …

Frederic H Fahey - One of the best experts on this subject based on the ideXlab platform.

  • Standardization of administered activities in pediatric nuclear medicine a report of the first nuclear medicine Global initiative project part 2 current standards and the path toward Global Standardization
    The Journal of Nuclear Medicine, 2016
    Co-Authors: Frederic H Fahey, Henry Heeseung Bom, Arturo Chiti, Yun Young Choi, Gang Huang, Michael Lassmann, Norman Laurin, Fernando Mut, Rodolfo Nunezmiller, Darin Okeeffe
    Abstract:

    The Nuclear Medicine Global Initiative (NMGI) was formed in 2012 and consists of 13 international organizations with direct involvement in nuclear medicine. The underlying objectives of the NMGI are to promote human health by advancing the field of nuclear medicine and molecular imaging, encourage Global collaboration in education, and harmonize procedure guidelines and other policies that ultimately lead to improvements in quality and safety in the field throughout the world. For its first project, the NMGI decided to consider the issues involved in the Standardization of administered activities in pediatric nuclear medicine. It was decided to divide the final report of this project into 2 parts. Part 1 was published in this journal in the spring of 2015. This article presents part 2 of the final report. It discusses current standards for administered activities in children and adolescents that have been developed by various professional organizations. It also presents an evaluation of the current practice of pediatric nuclear medicine specifically with regard to administered activities as determined by an international survey of 313 nuclear medicine clinics and centers from 29 countries. Lastly, it provides recommendations for a path toward Global Standardization of the administration of radiopharmaceuticals in children.

  • Standardization of administered activities in pediatric nuclear medicine a report of the first nuclear medicine Global initiative project part 1 statement of the issue and a review of available resources
    The Journal of Nuclear Medicine, 2015
    Co-Authors: Frederic H Fahey, Arturo Chiti, Yun Young Choi, Gang Huang, Michael Lassmann, Norman Laurin, Fernando Mut, Rodolfo Nunezmiller, Henry Hee Seong Bom, Darin Okeeffe
    Abstract:

    The Nuclear Medicine Global Initiative (NMGI) was formed in 2012 and consists of 13 international organizations with direct involvement in nuclear medicine. The underlying objectives of the NMGI were to promote human health by advancing the field of nuclear medicine and molecular imaging, encourage Global collaboration in education, and harmonize procedure guidelines and other policies that ultimately lead to improvements in quality and safety in the field throughout the world. For its first project, the NMGI decided to consider the issues involved in the Standardization of administered activities in pediatric nuclear medicine. This article presents part 1 of the final report of this initial project of the NMGI. It provides a review of the value of pediatric nuclear medicine, the current understanding of the carcinogenic risk of radiation as it pertains to the administration of radiopharmaceuticals in children, and the application of dosimetric models in children. A listing of pertinent educational and reference resources available in print and online is also provided. The forthcoming part 2 report will discuss current standards for administered activities in children and adolescents that have been developed by various organizations and an evaluation of the current practice of pediatric nuclear medicine specifically with regard to administered activities as determined by an international survey of nuclear medicine clinics and centers. Lastly, the part 2 report will recommend a path forward toward Global Standardization of the administration of radiopharmaceuticals in children.