The Experts below are selected from a list of 6 Experts worldwide ranked by ideXlab platform

Xia Suisheng - One of the best experts on this subject based on the ideXlab platform.

  • peritubular capillary c4d deposition in chronic allograft nephropathy
    China Journal of Modern Medicine, 2005
    Co-Authors: Xia Suisheng
    Abstract:

    To investigate the capillary deposition of complement split product C4d in chronic allograft nephropathy (CAN). Biopsy transplanted renal specimens from 28 cases diagnosed as CAN (CAN group) and from 10 cases without CAN (control group) were used to detect C4d deposition by immunohistochemistry and indirec t immunofluorescence method. In control group C4d deposition was not found at peritubular capillary but in Glomerulus Basement Membrane and renal tubular Basement Membrane. Some tunica intima of artery also had C4d deposition. Immunohistochemistry results showed in CAN group C4d linear deposition in peritubular capillary, but little in Glomerulus capillary. And indirect immunofluorescence method showed linear C4d deposition, mainly along endothelia cells of peritubular capillary. [Conclusion] The activation of complement leads to deposition of complement split products, deposition of C4d in chronic rejection renal allograft shows humoral immunity may be a cause which can lead to chronic renal allograft injury.

Lawrence A Yannuzzi - One of the best experts on this subject based on the ideXlab platform.

  • ocular manifestations of monoclonal immunoglobulin light chain deposition disease
    Retinal Cases & Brief Reports, 2016
    Co-Authors: Elona Dhramigavazi, K B Freund, B Z Cohen, Surya V Seshan, Lawrence A Yannuzzi
    Abstract:

    To demonstrate unusual retinal findings in a patient with progressive renal failure due to idiopathic monoclonal immunoglobulin light chain deposition disease, using multimodal imaging. Observational case report of a 43-year-old white man with renal failure due to light chain deposition disease. His course over 6 years was documented with multimodal imaging including fundus photography, fundus autofluorescence, fluorescein angiography, and spectral domain optical coherence tomography. Additional evaluations included ocular ultrasound, electroretinography, positron emission tomography, serum protein electrophoreses, skeletal surveys to detect osteolytic lesions, and renal, liver, and rectal biopsies in search of amyloid. The patient's ocular course mirrored the severity of his renal dysfunction for which he required a renal transplant. Changes observed in the native kidney recurred in the transplant 2 years later, as evidenced by immunohistochemistry, revealing thick linear deposits of kappa chains, with no complement, overlying the glomerular Basement Membrane. The systemic workup was negative for amyloid but showed an overwhelming ratio of kappa to lambda light chains on serum protein electrophoreses and no clinical signs of plasma cell dyscrasias, all consistent with idiopathic light chain deposition disease. The patient presented with a generalized, bilateral "leopard-spot" fundus appearance on fundus autofluorescence, striking globular subretinal deposits on spectral domain optical coherence tomography, and subfoveal subretinal fluid without retinal pigment epithelium detachment or choroidal effusions. The subfoveal fluid did not respond to intravitreal injections of antiangiogenic agents or steroids but resolved after renal transplantation. A temporary posttransplant visual improvement was associated with lessening of the subretinal drusenoid deposits demonstrated by multimodal imaging. The terminal vision deterioration was associated with amorphous, vitelliform-like material deposition and atrophic changes. This case may illustrate a resemblance in the renal Glomerulus Basement Membrane and retinal pigment epithelium-Bruch Membrane complex, because the authors observed deposits of excess monoclonal kappa chains manifesting as extracellular, proteinaceous aggregates on the Basement Membrane of the Glomerulus, and striking, globular subretinal deposits that overlay a thickened retinal pigment epithelium-Bruch Membrane complex. The ocular lesions' refractoriness to intravitreal treatments could be attributed to the fact that they represent proteinaceous aggregates similar to those documented in the glomeruli. This is the first report of generalized, large, subretinal drusenoid deposits and their course, as documented through multimodal imaging, paralleling the chronology of systemic changes in a patient with light chain deposition disease.

Elona Dhramigavazi - One of the best experts on this subject based on the ideXlab platform.

  • ocular manifestations of monoclonal immunoglobulin light chain deposition disease
    Retinal Cases & Brief Reports, 2016
    Co-Authors: Elona Dhramigavazi, K B Freund, B Z Cohen, Surya V Seshan, Lawrence A Yannuzzi
    Abstract:

    To demonstrate unusual retinal findings in a patient with progressive renal failure due to idiopathic monoclonal immunoglobulin light chain deposition disease, using multimodal imaging. Observational case report of a 43-year-old white man with renal failure due to light chain deposition disease. His course over 6 years was documented with multimodal imaging including fundus photography, fundus autofluorescence, fluorescein angiography, and spectral domain optical coherence tomography. Additional evaluations included ocular ultrasound, electroretinography, positron emission tomography, serum protein electrophoreses, skeletal surveys to detect osteolytic lesions, and renal, liver, and rectal biopsies in search of amyloid. The patient's ocular course mirrored the severity of his renal dysfunction for which he required a renal transplant. Changes observed in the native kidney recurred in the transplant 2 years later, as evidenced by immunohistochemistry, revealing thick linear deposits of kappa chains, with no complement, overlying the glomerular Basement Membrane. The systemic workup was negative for amyloid but showed an overwhelming ratio of kappa to lambda light chains on serum protein electrophoreses and no clinical signs of plasma cell dyscrasias, all consistent with idiopathic light chain deposition disease. The patient presented with a generalized, bilateral "leopard-spot" fundus appearance on fundus autofluorescence, striking globular subretinal deposits on spectral domain optical coherence tomography, and subfoveal subretinal fluid without retinal pigment epithelium detachment or choroidal effusions. The subfoveal fluid did not respond to intravitreal injections of antiangiogenic agents or steroids but resolved after renal transplantation. A temporary posttransplant visual improvement was associated with lessening of the subretinal drusenoid deposits demonstrated by multimodal imaging. The terminal vision deterioration was associated with amorphous, vitelliform-like material deposition and atrophic changes. This case may illustrate a resemblance in the renal Glomerulus Basement Membrane and retinal pigment epithelium-Bruch Membrane complex, because the authors observed deposits of excess monoclonal kappa chains manifesting as extracellular, proteinaceous aggregates on the Basement Membrane of the Glomerulus, and striking, globular subretinal deposits that overlay a thickened retinal pigment epithelium-Bruch Membrane complex. The ocular lesions' refractoriness to intravitreal treatments could be attributed to the fact that they represent proteinaceous aggregates similar to those documented in the glomeruli. This is the first report of generalized, large, subretinal drusenoid deposits and their course, as documented through multimodal imaging, paralleling the chronology of systemic changes in a patient with light chain deposition disease.

K B Freund - One of the best experts on this subject based on the ideXlab platform.

  • ocular manifestations of monoclonal immunoglobulin light chain deposition disease
    Retinal Cases & Brief Reports, 2016
    Co-Authors: Elona Dhramigavazi, K B Freund, B Z Cohen, Surya V Seshan, Lawrence A Yannuzzi
    Abstract:

    To demonstrate unusual retinal findings in a patient with progressive renal failure due to idiopathic monoclonal immunoglobulin light chain deposition disease, using multimodal imaging. Observational case report of a 43-year-old white man with renal failure due to light chain deposition disease. His course over 6 years was documented with multimodal imaging including fundus photography, fundus autofluorescence, fluorescein angiography, and spectral domain optical coherence tomography. Additional evaluations included ocular ultrasound, electroretinography, positron emission tomography, serum protein electrophoreses, skeletal surveys to detect osteolytic lesions, and renal, liver, and rectal biopsies in search of amyloid. The patient's ocular course mirrored the severity of his renal dysfunction for which he required a renal transplant. Changes observed in the native kidney recurred in the transplant 2 years later, as evidenced by immunohistochemistry, revealing thick linear deposits of kappa chains, with no complement, overlying the glomerular Basement Membrane. The systemic workup was negative for amyloid but showed an overwhelming ratio of kappa to lambda light chains on serum protein electrophoreses and no clinical signs of plasma cell dyscrasias, all consistent with idiopathic light chain deposition disease. The patient presented with a generalized, bilateral "leopard-spot" fundus appearance on fundus autofluorescence, striking globular subretinal deposits on spectral domain optical coherence tomography, and subfoveal subretinal fluid without retinal pigment epithelium detachment or choroidal effusions. The subfoveal fluid did not respond to intravitreal injections of antiangiogenic agents or steroids but resolved after renal transplantation. A temporary posttransplant visual improvement was associated with lessening of the subretinal drusenoid deposits demonstrated by multimodal imaging. The terminal vision deterioration was associated with amorphous, vitelliform-like material deposition and atrophic changes. This case may illustrate a resemblance in the renal Glomerulus Basement Membrane and retinal pigment epithelium-Bruch Membrane complex, because the authors observed deposits of excess monoclonal kappa chains manifesting as extracellular, proteinaceous aggregates on the Basement Membrane of the Glomerulus, and striking, globular subretinal deposits that overlay a thickened retinal pigment epithelium-Bruch Membrane complex. The ocular lesions' refractoriness to intravitreal treatments could be attributed to the fact that they represent proteinaceous aggregates similar to those documented in the glomeruli. This is the first report of generalized, large, subretinal drusenoid deposits and their course, as documented through multimodal imaging, paralleling the chronology of systemic changes in a patient with light chain deposition disease.

B Z Cohen - One of the best experts on this subject based on the ideXlab platform.

  • ocular manifestations of monoclonal immunoglobulin light chain deposition disease
    Retinal Cases & Brief Reports, 2016
    Co-Authors: Elona Dhramigavazi, K B Freund, B Z Cohen, Surya V Seshan, Lawrence A Yannuzzi
    Abstract:

    To demonstrate unusual retinal findings in a patient with progressive renal failure due to idiopathic monoclonal immunoglobulin light chain deposition disease, using multimodal imaging. Observational case report of a 43-year-old white man with renal failure due to light chain deposition disease. His course over 6 years was documented with multimodal imaging including fundus photography, fundus autofluorescence, fluorescein angiography, and spectral domain optical coherence tomography. Additional evaluations included ocular ultrasound, electroretinography, positron emission tomography, serum protein electrophoreses, skeletal surveys to detect osteolytic lesions, and renal, liver, and rectal biopsies in search of amyloid. The patient's ocular course mirrored the severity of his renal dysfunction for which he required a renal transplant. Changes observed in the native kidney recurred in the transplant 2 years later, as evidenced by immunohistochemistry, revealing thick linear deposits of kappa chains, with no complement, overlying the glomerular Basement Membrane. The systemic workup was negative for amyloid but showed an overwhelming ratio of kappa to lambda light chains on serum protein electrophoreses and no clinical signs of plasma cell dyscrasias, all consistent with idiopathic light chain deposition disease. The patient presented with a generalized, bilateral "leopard-spot" fundus appearance on fundus autofluorescence, striking globular subretinal deposits on spectral domain optical coherence tomography, and subfoveal subretinal fluid without retinal pigment epithelium detachment or choroidal effusions. The subfoveal fluid did not respond to intravitreal injections of antiangiogenic agents or steroids but resolved after renal transplantation. A temporary posttransplant visual improvement was associated with lessening of the subretinal drusenoid deposits demonstrated by multimodal imaging. The terminal vision deterioration was associated with amorphous, vitelliform-like material deposition and atrophic changes. This case may illustrate a resemblance in the renal Glomerulus Basement Membrane and retinal pigment epithelium-Bruch Membrane complex, because the authors observed deposits of excess monoclonal kappa chains manifesting as extracellular, proteinaceous aggregates on the Basement Membrane of the Glomerulus, and striking, globular subretinal deposits that overlay a thickened retinal pigment epithelium-Bruch Membrane complex. The ocular lesions' refractoriness to intravitreal treatments could be attributed to the fact that they represent proteinaceous aggregates similar to those documented in the glomeruli. This is the first report of generalized, large, subretinal drusenoid deposits and their course, as documented through multimodal imaging, paralleling the chronology of systemic changes in a patient with light chain deposition disease.