The Experts below are selected from a list of 1563 Experts worldwide ranked by ideXlab platform
Christiaan Van Vliet - One of the best experts on this subject based on the ideXlab platform.
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infiltrating Glomus Tumor of uncertain malignant potential arising in the kidney
Human Pathology, 2010Co-Authors: Jespal Gill, Christiaan Van VlietAbstract:Glomus Tumors closely resemble the normal Glomus body and have a predilection for skin and subcutaneous tissue. These Tumors rarely present in visceral organs. We report a case involving the kidney. This Glomus Tumor displays typical cytology and immunohistochemical profile of Glomus Tumors elsewhere. However, this Tumor is large, has a deep location and exhibits an infiltrative margin and increased mitotic activity. These features, by current definition, would suggest malignant behavior. However, the rarity of such an entity in the kidney highlights the need for caution and a diagnosis in a continuum between benignity and malignancy. To the best of our knowledge, this report is the first case of infiltrating Glomus Tumor or Glomus Tumor of uncertain malignant potential arising in the kidney.
Anjia Han - One of the best experts on this subject based on the ideXlab platform.
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clinicopathological features of gastric Glomus Tumor
World Journal of Gastroenterology, 2010Co-Authors: Huiqiong Fang, Jing Yang, Fenfen Zhang, Yi Cui, Anjia HanAbstract:AIM: To study the clinicopathological features of gastric Glomus Tumor and review the related Chinese literature published in 1990-2010. METHODS: A case of gastric Glomus Tumor was reported. Clinicopathological findings in 56 cases of gastric Glomus Tumor were analyzed. RESULTS: Gastric Glomus Tumor was far more common in women than in men with a female to male ratio of 1.6:1. The median age of the patients was 45 years (range 28-79 years). The patients often complained of epigastric pain and bloody stool. The Tumor was located in antrum of the stomach. The greatest diameter of the Tumor was 0.8-11cm. Histologically, the Tumor was comprised of nests of Glomus cells surrounding the capillaries. Glomus cells were small, uniform and round. Vimentin, smooth muscle actin and actin were expressed in the Tumor. Other markers, including S-100 protein, CD34, CD117, desmin, CD56, synaptophysin, chromogranin A, neuron specific enolase and cytokeratin were all negative. CONCLUSION: Gastric Glomus Tumor is a rare benign mesenchymal neoplasm. Its diagnosis depends on pathologic examination. Differential diagnosis includes gastrointestinal stromal Tumor, paraganglioma and carcinoid Tumor.
Izumi Komoto - One of the best experts on this subject based on the ideXlab platform.
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primary pancreatic Glomus Tumor invading into the superior mesenteric vein a case report
Surgical Case Reports, 2020Co-Authors: Ichiro Tamaki, Yohei Hosoda, Hironobu Sasano, Yu Sasaki, Hidenori Kiyochi, Yoshiro Taki, Izumi KomotoAbstract:BACKGROUND Glomus Tumors are subcutaneous Tumors arising from Glomus bodies, thermoregulatory components of the skin. These Tumors could occur in visceral organs where Glomus bodies are not normally present. Herein, we report a case of primary pancreatic Glomus Tumor with aggressive direct invasion into the superior mesenteric vein (SMV). To the best of our knowledge, this is the second case report of a Glomus Tumor arising in the pancreas. CASE PRESENTATION A 46-year-old woman was referred to our hospital due to vomiting with epigastric and back pain. Dynamic-CT revealed a well-circumscribed hypervascular mass, measuring 37 mm in its maximal diameter involving the pancreatic head. Both CT and endoscopic ultrasonography (EUS) revealed direct invasion into the SMV and radiologically suspected Tumor thrombus. Biopsy sample obtained by EUS-guided fine needle aspiration revealed proliferation of small cells, round-to-oval Tumor cells with round nuclei and scant cytoplasm. A histological diagnosis of pancreatic neuroendocrine Tumor, G1 was initially considered. Therefore, subtotal stomach-preserving pancreatoduodenectomy using Child-II reconstruction was subsequently performed. Her SMV was resected and reconstructed due to extensive Tumor involvement. Subsequent histopathological analysis revealed solid Tumor cells proliferation that comprised oval-shaped nuclei and scant cytoplasm around disorganized or slit-shaped vessels in hematoxylin-eosin-stained slides. Immunohistochemical analysis then demonstrated positive immunoreactivity for smooth muscle actin, vimentin, and CD34, but negative for chromogranin A, synaptophysin, CD56, and signal transducer and activator of transcription 6. Based on these histological findings of resected specimens, the lesion was subsequently diagnosed as a primary pancreatic Glomus Tumor harboring direct invasion into the SMV. Her postoperative course was uneventful and annual surveys for the following 4 years post-op detected no clinical signs of recurrence. CONCLUSIONS We report a very rare case of Glomus Tumor of the pancreas accompanied by venous invasion. Curative surgical resection is the best treatment option for pancreatic Glomus Tumors. Although pancreatic Glomus Tumor is rare, it should be taken into consideration in the differential diagnosis of a pancreatic solid Tumor with hypervascularity.
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primary pancreatic Glomus Tumor invading into the superior mesenteric vein a case report
Surgical Case Reports, 2020Co-Authors: Ichiro Tamaki, Yohei Hosoda, Hironobu Sasano, Yu Sasaki, Hidenori Kiyochi, Yoshiro Taki, Izumi KomotoAbstract:Glomus Tumors are subcutaneous Tumors arising from Glomus bodies, thermoregulatory components of the skin. These Tumors could occur in visceral organs where Glomus bodies are not normally present. Herein, we report a case of primary pancreatic Glomus Tumor with aggressive direct invasion into the superior mesenteric vein (SMV). To the best of our knowledge, this is the second case report of a Glomus Tumor arising in the pancreas. A 46-year-old woman was referred to our hospital due to vomiting with epigastric and back pain. Dynamic-CT revealed a well-circumscribed hypervascular mass, measuring 37 mm in its maximal diameter involving the pancreatic head. Both CT and endoscopic ultrasonography (EUS) revealed direct invasion into the SMV and radiologically suspected Tumor thrombus. Biopsy sample obtained by EUS-guided fine needle aspiration revealed proliferation of small cells, round-to-oval Tumor cells with round nuclei and scant cytoplasm. A histological diagnosis of pancreatic neuroendocrine Tumor, G1 was initially considered. Therefore, subtotal stomach-preserving pancreatoduodenectomy using Child-II reconstruction was subsequently performed. Her SMV was resected and reconstructed due to extensive Tumor involvement. Subsequent histopathological analysis revealed solid Tumor cells proliferation that comprised oval-shaped nuclei and scant cytoplasm around disorganized or slit-shaped vessels in hematoxylin–eosin-stained slides. Immunohistochemical analysis then demonstrated positive immunoreactivity for smooth muscle actin, vimentin, and CD34, but negative for chromogranin A, synaptophysin, CD56, and signal transducer and activator of transcription 6. Based on these histological findings of resected specimens, the lesion was subsequently diagnosed as a primary pancreatic Glomus Tumor harboring direct invasion into the SMV. Her postoperative course was uneventful and annual surveys for the following 4 years post-op detected no clinical signs of recurrence. We report a very rare case of Glomus Tumor of the pancreas accompanied by venous invasion. Curative surgical resection is the best treatment option for pancreatic Glomus Tumors. Although pancreatic Glomus Tumor is rare, it should be taken into consideration in the differential diagnosis of a pancreatic solid Tumor with hypervascularity.
Jespal Gill - One of the best experts on this subject based on the ideXlab platform.
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infiltrating Glomus Tumor of uncertain malignant potential arising in the kidney
Human Pathology, 2010Co-Authors: Jespal Gill, Christiaan Van VlietAbstract:Glomus Tumors closely resemble the normal Glomus body and have a predilection for skin and subcutaneous tissue. These Tumors rarely present in visceral organs. We report a case involving the kidney. This Glomus Tumor displays typical cytology and immunohistochemical profile of Glomus Tumors elsewhere. However, this Tumor is large, has a deep location and exhibits an infiltrative margin and increased mitotic activity. These features, by current definition, would suggest malignant behavior. However, the rarity of such an entity in the kidney highlights the need for caution and a diagnosis in a continuum between benignity and malignancy. To the best of our knowledge, this report is the first case of infiltrating Glomus Tumor or Glomus Tumor of uncertain malignant potential arising in the kidney.
Yongqing Lai - One of the best experts on this subject based on the ideXlab platform.
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Glomus Tumor of the anterior urethra a rare case report and review of the literature
Current Opinion in Clinical Nutrition and Metabolic Care, 2016Co-Authors: L U Jin, Jiaju Liu, Yi Ding, Lingzhi Tao, Zebo Chen, Shangqi Yang, Xiangming Mao, Yongqing LaiAbstract:Glomus Tumors are rare and benign neoplasms, which normally originate from peripheral soft tissue. To date, reported cases of Glomus Tumor occurring in genitourinary tract, particularly in the urethra, are exceedingly rare. The present study presented a rare case of Glomus Tumor of the anterior urethra in a 42 year-old male, his main complaints were a history of anterior urethra pain for 3 years, and a palpable and tender mass in the urethra for 2 weeks. Urethrocystoscopy examination and the resection of the urethral mass were performed. Pathological and immunohistochemical examination revealed that the mass was a benign Glomus Tumor. The patient remained in good condition by 6 month follow-up, and revealed no problems or recurrence following surgery. This is the first case, to the best of our knowledge, to present a Glomus Tumor occurring in a male's urethra and the present report provided a supplementary review for the previous cases and the literature.