The Experts below are selected from a list of 17061 Experts worldwide ranked by ideXlab platform

Stephen L. Buchwald - One of the best experts on this subject based on the ideXlab platform.

  • Dosage delivery of sensitive reagents enables Glove-Box-free synthesis
    Nature, 2015
    Co-Authors: Aaron C. Sather, Hong Geun Lee, James R. Colombe, Anni Zhang, Stephen L. Buchwald
    Abstract:

    Contemporary organic chemists employ a broad range of catalytic and stoichiometric methods to construct molecules for applications in the material sciences, and as pharmaceuticals, agrochemicals, and sensors. The utility of a synthetic method may be greatly reduced if it relies on a Glove Box to enable the use of air- and moisture-sensitive reagents or catalysts. Furthermore, many synthetic chemistry laboratories have numerous containers of partially used reagents that have been spoiled by exposure to the ambient atmosphere. This is exceptionally wasteful from both an environmental and a cost perspective. Here we report an encapsulation method for stabilizing and storing air- and moisture-sensitive compounds. We demonstrate this approach in three contexts, by describing single-use capsules that contain all of the reagents (catalysts, ligands, and bases) necessary for the Glove-Box-free palladium-catalysed carbon-fluorine, carbon-nitrogen, and carbon-carbon bond-forming reactions. This strategy should reduce the number of error-prone, tedious and time-consuming weighing procedures required for such syntheses and should be applicable to a wide range of reagents, catalysts, and substrate combinations.

Hajime Ito - One of the best experts on this subject based on the ideXlab platform.

  • mechanochemistry allows carrying out sensitive organometallic reactions in air Glove Box and schlenk line free synthesis of oxidative addition complexes from aryl halides and palladium 0
    Chemical Science, 2019
    Co-Authors: Koji Kubota, Rina Takahashi, Hajime Ito
    Abstract:

    Organic reactions that employ moisture- and/or oxygen-sensitive reagents or intermediates usually involve the use of Glove-Box or Schlenk-line techniques as well as dry and degassed solvents. Unfortunately, these requirements may greatly reduce the utility of the targeted organic molecules. Herein, we demonstrate that solvent-free mechanochemical synthetic techniques allow using highly oxygen-sensitive palladium(0) species in air for the stoichiometric oxidative addition of aryl halides. The low diffusion efficiency of gaseous oxygen in crystalline or amorphous solid-state reaction mixtures should be the main reason for the low impact of the presence of atmospheric oxygen on the sensitive oxidative addition reactions under the applied conditions. This study thus illustrates the outstanding potential of mechanochemistry to serve as an operationally simple, Glove-Box-and-Schlenk-line-free synthetic route to organometallic compounds and other valuable synthetic targets, even when sensitive reagents or intermediates are involved.

Mitchell R. M. Bruce - One of the best experts on this subject based on the ideXlab platform.

Aaron C. Sather - One of the best experts on this subject based on the ideXlab platform.

  • Dosage delivery of sensitive reagents enables Glove-Box-free synthesis
    Nature, 2015
    Co-Authors: Aaron C. Sather, Hong Geun Lee, James R. Colombe, Anni Zhang, Stephen L. Buchwald
    Abstract:

    Contemporary organic chemists employ a broad range of catalytic and stoichiometric methods to construct molecules for applications in the material sciences, and as pharmaceuticals, agrochemicals, and sensors. The utility of a synthetic method may be greatly reduced if it relies on a Glove Box to enable the use of air- and moisture-sensitive reagents or catalysts. Furthermore, many synthetic chemistry laboratories have numerous containers of partially used reagents that have been spoiled by exposure to the ambient atmosphere. This is exceptionally wasteful from both an environmental and a cost perspective. Here we report an encapsulation method for stabilizing and storing air- and moisture-sensitive compounds. We demonstrate this approach in three contexts, by describing single-use capsules that contain all of the reagents (catalysts, ligands, and bases) necessary for the Glove-Box-free palladium-catalysed carbon-fluorine, carbon-nitrogen, and carbon-carbon bond-forming reactions. This strategy should reduce the number of error-prone, tedious and time-consuming weighing procedures required for such syntheses and should be applicable to a wide range of reagents, catalysts, and substrate combinations.

Laurent Charlet - One of the best experts on this subject based on the ideXlab platform.