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Antonino Di Benedetto - One of the best experts on this subject based on the ideXlab platform.
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Positive association between a single abnormal Glucose Tolerance test value in pregnancy and subsequent abnormal Glucose Tolerance.
American Journal of Obstetrics and Gynecology, 2007Co-Authors: Francesco Corrado, Rosario D'anna, Maria Letizia Cannata, Desirée Cannizzaro, Francesco Caputo, Emanuela Raffone, Antonino Di BenedettoAbstract:Objective To study the prevalence of abnormal Glucose Tolerance among women with a single abnormal Glucose Tolerance test value in previous pregnancy and identify factors predictive of the later development of abnormal Glucose Tolerance in this group. Study Design In all, 58 women with gestational diabetes, 66 with a single abnormal value in a Glucose Tolerance test, and 56 control women underwent a 75-g oral Glucose Tolerance test at a mean of 6.9 years from the index pregnancy. Results Abnormal Glucose Tolerance was present in 34.5% of women with previous gestational diabetes and in 28.7% of women with 1 previous abnormal value, significantly different from the controls (9.7%). Independent risk factors that distinguished the subjects who later developed an abnormal Glucose Tolerance were prepregnancy BMI, parity > 1, and first-degree relatives affected by diabetes mellitus in the group with gestational diabetes, and prepregnancy BMI, maternal age, (≥ 30 y) and parity > 1 in the group with a single abnormal value. Prepregnancy BMI (≥26.9) proved to be the most predictive factor of abnormal Glucose Tolerance later in life. Conclusion Sicilian women with a single abnormal value at the Glucose Tolerance test in pregnancy have an increased likelihood of developing an abnormal Glucose Tolerance later in life, similar to gestational diabetes. Prepregnancy BMI was confirmed as the strongest predictive factor in both groups.
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Positive association between a single abnormal Glucose Tolerance test value in pregnancy and subsequent abnormal Glucose Tolerance.
American journal of obstetrics and gynecology, 2007Co-Authors: Francesco Corrado, Rosario D'anna, Maria Letizia Cannata, Desirée Cannizzaro, Francesco Caputo, Emanuela Raffone, Antonino Di BenedettoAbstract:To study the prevalence of abnormal Glucose Tolerance among women with a single abnormal Glucose Tolerance test value in previous pregnancy and identify factors predictive of the later development of abnormal Glucose Tolerance in this group. In all, 58 women with gestational diabetes, 66 with a single abnormal value in a Glucose Tolerance test, and 56 control women underwent a 75-g oral Glucose Tolerance test at a mean of 6.9 years from the index pregnancy. Abnormal Glucose Tolerance was present in 34.5% of women with previous gestational diabetes and in 28.7% of women with 1 previous abnormal value, significantly different from the controls (9.7%). Independent risk factors that distinguished the subjects who later developed an abnormal Glucose Tolerance were prepregnancy BMI, parity > 1, and first-degree relatives affected by diabetes mellitus in the group with gestational diabetes, and prepregnancy BMI, maternal age, (> or = 30 y) and parity > 1 in the group with a single abnormal value. Prepregnancy BMI (> or = 26.9) proved to be the most predictive factor of abnormal Glucose Tolerance later in life. Sicilian women with a single abnormal value at the Glucose Tolerance test in pregnancy have an increased likelihood of developing an abnormal Glucose Tolerance later in life, similar to gestational diabetes. Prepregnancy BMI was confirmed as the strongest predictive factor in both groups.
Francesco Corrado - One of the best experts on this subject based on the ideXlab platform.
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Positive association between a single abnormal Glucose Tolerance test value in pregnancy and subsequent abnormal Glucose Tolerance.
American Journal of Obstetrics and Gynecology, 2007Co-Authors: Francesco Corrado, Rosario D'anna, Maria Letizia Cannata, Desirée Cannizzaro, Francesco Caputo, Emanuela Raffone, Antonino Di BenedettoAbstract:Objective To study the prevalence of abnormal Glucose Tolerance among women with a single abnormal Glucose Tolerance test value in previous pregnancy and identify factors predictive of the later development of abnormal Glucose Tolerance in this group. Study Design In all, 58 women with gestational diabetes, 66 with a single abnormal value in a Glucose Tolerance test, and 56 control women underwent a 75-g oral Glucose Tolerance test at a mean of 6.9 years from the index pregnancy. Results Abnormal Glucose Tolerance was present in 34.5% of women with previous gestational diabetes and in 28.7% of women with 1 previous abnormal value, significantly different from the controls (9.7%). Independent risk factors that distinguished the subjects who later developed an abnormal Glucose Tolerance were prepregnancy BMI, parity > 1, and first-degree relatives affected by diabetes mellitus in the group with gestational diabetes, and prepregnancy BMI, maternal age, (≥ 30 y) and parity > 1 in the group with a single abnormal value. Prepregnancy BMI (≥26.9) proved to be the most predictive factor of abnormal Glucose Tolerance later in life. Conclusion Sicilian women with a single abnormal value at the Glucose Tolerance test in pregnancy have an increased likelihood of developing an abnormal Glucose Tolerance later in life, similar to gestational diabetes. Prepregnancy BMI was confirmed as the strongest predictive factor in both groups.
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Positive association between a single abnormal Glucose Tolerance test value in pregnancy and subsequent abnormal Glucose Tolerance.
American journal of obstetrics and gynecology, 2007Co-Authors: Francesco Corrado, Rosario D'anna, Maria Letizia Cannata, Desirée Cannizzaro, Francesco Caputo, Emanuela Raffone, Antonino Di BenedettoAbstract:To study the prevalence of abnormal Glucose Tolerance among women with a single abnormal Glucose Tolerance test value in previous pregnancy and identify factors predictive of the later development of abnormal Glucose Tolerance in this group. In all, 58 women with gestational diabetes, 66 with a single abnormal value in a Glucose Tolerance test, and 56 control women underwent a 75-g oral Glucose Tolerance test at a mean of 6.9 years from the index pregnancy. Abnormal Glucose Tolerance was present in 34.5% of women with previous gestational diabetes and in 28.7% of women with 1 previous abnormal value, significantly different from the controls (9.7%). Independent risk factors that distinguished the subjects who later developed an abnormal Glucose Tolerance were prepregnancy BMI, parity > 1, and first-degree relatives affected by diabetes mellitus in the group with gestational diabetes, and prepregnancy BMI, maternal age, (> or = 30 y) and parity > 1 in the group with a single abnormal value. Prepregnancy BMI (> or = 26.9) proved to be the most predictive factor of abnormal Glucose Tolerance later in life. Sicilian women with a single abnormal value at the Glucose Tolerance test in pregnancy have an increased likelihood of developing an abnormal Glucose Tolerance later in life, similar to gestational diabetes. Prepregnancy BMI was confirmed as the strongest predictive factor in both groups.
Robert Wagner - One of the best experts on this subject based on the ideXlab platform.
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Prediction of Glucose Tolerance without an Oral Glucose Tolerance Test
Frontiers in endocrinology, 2018Co-Authors: Rohit Babbar, Martin Heni, Andreas Peter, Martin Hrabě De Angelis, Hans-ulrich Häring, Andreas Fritsche, Hubert Preissl, Bernhard Schölkopf, Robert WagnerAbstract:Introduction: Impaired Glucose Tolerance (IGT) is diagnosed by a standardized oral Glucose Tolerance test (OGTT). However, the OGTT is laborious and when not performed, Glucose Tolerance cannot be determined from fasting samples retrospectively. We tested if Glucose Tolerance status is reasonably predictable from a combination of demographic, anthropometric and laboratory data assessed at one time point, in a fasting state. Methods: Given a set of 22 variables selected upon clinical feasibility such as sex, age, height, weight, waist circumference, blood pressure, fasting Glucose, HbA1c, hemoglobin, mean corpuscular volume, serum potassium, fasting levels of insulin, C-peptide, triglyceride, non-esterified fatty acids (NEFA), proinsulin, prolactin, cholesterol, LDL, HDL, uric acid, liver transaminases and ferritin, we used supervised machine learning to estimate Glucose Tolerance status in 2337 participants of the TUEF study who were recruited before 2012. We tested the performance of 10 different machine learning classifiers on data from 929 participants in the test set that was recruited after 2012. Additionally, reproducibility of IGT was analyzed in 78 participants who had 2 repeated OGTTs within one year. Results: The most accurate prediction of IGT was reached with the recursive partitioning method (accuracy=0.78). For all classifiers, mean accuracy was 0.73±0.04. The most important model variable was fasting Glucose in all models. Using mean variable importance across all models, fasting Glucose was followed by NEFA, triglycerides, HbA1c and C-peptide. The accuracy of predicting IGT from a previous OGTT was 0.77. Conclusion: Machine learning methods yield moderate accuracy in predicting Glucose Tolerance from a wide set of clinical and laboratory variables. A substitution of OGTT does not currently seem to be feasible. An important constraint could be the limited reproducibility of Glucose Tolerance status during a subsequent OGTT.
Desirée Cannizzaro - One of the best experts on this subject based on the ideXlab platform.
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Positive association between a single abnormal Glucose Tolerance test value in pregnancy and subsequent abnormal Glucose Tolerance.
American Journal of Obstetrics and Gynecology, 2007Co-Authors: Francesco Corrado, Rosario D'anna, Maria Letizia Cannata, Desirée Cannizzaro, Francesco Caputo, Emanuela Raffone, Antonino Di BenedettoAbstract:Objective To study the prevalence of abnormal Glucose Tolerance among women with a single abnormal Glucose Tolerance test value in previous pregnancy and identify factors predictive of the later development of abnormal Glucose Tolerance in this group. Study Design In all, 58 women with gestational diabetes, 66 with a single abnormal value in a Glucose Tolerance test, and 56 control women underwent a 75-g oral Glucose Tolerance test at a mean of 6.9 years from the index pregnancy. Results Abnormal Glucose Tolerance was present in 34.5% of women with previous gestational diabetes and in 28.7% of women with 1 previous abnormal value, significantly different from the controls (9.7%). Independent risk factors that distinguished the subjects who later developed an abnormal Glucose Tolerance were prepregnancy BMI, parity > 1, and first-degree relatives affected by diabetes mellitus in the group with gestational diabetes, and prepregnancy BMI, maternal age, (≥ 30 y) and parity > 1 in the group with a single abnormal value. Prepregnancy BMI (≥26.9) proved to be the most predictive factor of abnormal Glucose Tolerance later in life. Conclusion Sicilian women with a single abnormal value at the Glucose Tolerance test in pregnancy have an increased likelihood of developing an abnormal Glucose Tolerance later in life, similar to gestational diabetes. Prepregnancy BMI was confirmed as the strongest predictive factor in both groups.
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Positive association between a single abnormal Glucose Tolerance test value in pregnancy and subsequent abnormal Glucose Tolerance.
American journal of obstetrics and gynecology, 2007Co-Authors: Francesco Corrado, Rosario D'anna, Maria Letizia Cannata, Desirée Cannizzaro, Francesco Caputo, Emanuela Raffone, Antonino Di BenedettoAbstract:To study the prevalence of abnormal Glucose Tolerance among women with a single abnormal Glucose Tolerance test value in previous pregnancy and identify factors predictive of the later development of abnormal Glucose Tolerance in this group. In all, 58 women with gestational diabetes, 66 with a single abnormal value in a Glucose Tolerance test, and 56 control women underwent a 75-g oral Glucose Tolerance test at a mean of 6.9 years from the index pregnancy. Abnormal Glucose Tolerance was present in 34.5% of women with previous gestational diabetes and in 28.7% of women with 1 previous abnormal value, significantly different from the controls (9.7%). Independent risk factors that distinguished the subjects who later developed an abnormal Glucose Tolerance were prepregnancy BMI, parity > 1, and first-degree relatives affected by diabetes mellitus in the group with gestational diabetes, and prepregnancy BMI, maternal age, (> or = 30 y) and parity > 1 in the group with a single abnormal value. Prepregnancy BMI (> or = 26.9) proved to be the most predictive factor of abnormal Glucose Tolerance later in life. Sicilian women with a single abnormal value at the Glucose Tolerance test in pregnancy have an increased likelihood of developing an abnormal Glucose Tolerance later in life, similar to gestational diabetes. Prepregnancy BMI was confirmed as the strongest predictive factor in both groups.
Emanuela Raffone - One of the best experts on this subject based on the ideXlab platform.
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Positive association between a single abnormal Glucose Tolerance test value in pregnancy and subsequent abnormal Glucose Tolerance.
American Journal of Obstetrics and Gynecology, 2007Co-Authors: Francesco Corrado, Rosario D'anna, Maria Letizia Cannata, Desirée Cannizzaro, Francesco Caputo, Emanuela Raffone, Antonino Di BenedettoAbstract:Objective To study the prevalence of abnormal Glucose Tolerance among women with a single abnormal Glucose Tolerance test value in previous pregnancy and identify factors predictive of the later development of abnormal Glucose Tolerance in this group. Study Design In all, 58 women with gestational diabetes, 66 with a single abnormal value in a Glucose Tolerance test, and 56 control women underwent a 75-g oral Glucose Tolerance test at a mean of 6.9 years from the index pregnancy. Results Abnormal Glucose Tolerance was present in 34.5% of women with previous gestational diabetes and in 28.7% of women with 1 previous abnormal value, significantly different from the controls (9.7%). Independent risk factors that distinguished the subjects who later developed an abnormal Glucose Tolerance were prepregnancy BMI, parity > 1, and first-degree relatives affected by diabetes mellitus in the group with gestational diabetes, and prepregnancy BMI, maternal age, (≥ 30 y) and parity > 1 in the group with a single abnormal value. Prepregnancy BMI (≥26.9) proved to be the most predictive factor of abnormal Glucose Tolerance later in life. Conclusion Sicilian women with a single abnormal value at the Glucose Tolerance test in pregnancy have an increased likelihood of developing an abnormal Glucose Tolerance later in life, similar to gestational diabetes. Prepregnancy BMI was confirmed as the strongest predictive factor in both groups.
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Positive association between a single abnormal Glucose Tolerance test value in pregnancy and subsequent abnormal Glucose Tolerance.
American journal of obstetrics and gynecology, 2007Co-Authors: Francesco Corrado, Rosario D'anna, Maria Letizia Cannata, Desirée Cannizzaro, Francesco Caputo, Emanuela Raffone, Antonino Di BenedettoAbstract:To study the prevalence of abnormal Glucose Tolerance among women with a single abnormal Glucose Tolerance test value in previous pregnancy and identify factors predictive of the later development of abnormal Glucose Tolerance in this group. In all, 58 women with gestational diabetes, 66 with a single abnormal value in a Glucose Tolerance test, and 56 control women underwent a 75-g oral Glucose Tolerance test at a mean of 6.9 years from the index pregnancy. Abnormal Glucose Tolerance was present in 34.5% of women with previous gestational diabetes and in 28.7% of women with 1 previous abnormal value, significantly different from the controls (9.7%). Independent risk factors that distinguished the subjects who later developed an abnormal Glucose Tolerance were prepregnancy BMI, parity > 1, and first-degree relatives affected by diabetes mellitus in the group with gestational diabetes, and prepregnancy BMI, maternal age, (> or = 30 y) and parity > 1 in the group with a single abnormal value. Prepregnancy BMI (> or = 26.9) proved to be the most predictive factor of abnormal Glucose Tolerance later in life. Sicilian women with a single abnormal value at the Glucose Tolerance test in pregnancy have an increased likelihood of developing an abnormal Glucose Tolerance later in life, similar to gestational diabetes. Prepregnancy BMI was confirmed as the strongest predictive factor in both groups.