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Halil Biyik - One of the best experts on this subject based on the ideXlab platform.
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spectroscopic and biological approach of ni ii cu ii and co ii complexes of 4 methoxy ethoxybenzaldehyde thiosemicarbazone Glyoxime
Spectrochimica Acta Part A: Molecular and Biomolecular Spectroscopy, 2014Co-Authors: Ilknur Babahan, Esin Poyrazoğlu Çoban, Fatih Eyduran, Nil Orhan, Didem Kazar, Halil BiyikAbstract:Abstract Two novel vicinal dioxime ligands containing (4-methoxybenzaldehyde thiosemicarbazone Glyoxime ( L 1 H 2 ) or 4-ethoxybenzaldehyde thiosemicarbazone Glyoxime ( L 2 H 2 )) thiosemicarbazone units were synthesized and characterized using 1H NMR, 13C NMR, HMQC, MS, infrared and, UV–VIS. spectroscopy, elemental analysis, and magnetic susceptibility measurements. Mononuclear nickel(II), copper(II) and cobalt(II) complexes with a metal:ligand ratio of 1:2 for L 1 H 2 and L 2 H 2 were also synthesized. The effect of pH and solvent on the absorption spectra of both ligands and complexes was determined. IR spectra show that the ligands act in a bidentate manner and coordinates N4 donor groups of the ligands to NiII, CuII and CoII ions. The detection of H-bonding (O H⋯O) in the [M(LH)2] metal complexes by IR spectra supported the square-planar MN4 coordination of mononuclear complexes. The antimicrobial activities of compounds L 1 H 2 , L 2 H 2 , and their Ni(II), Cu(II) and Co(II) complexes were evaluated using the disc diffusion method against 12 bacteria and 4 yeasts. The minimal inhibitory concentrations (MICs) against 7 bacteria and 3 yeasts were also determined. Among the test compounds attempted, L 1 H 2 , [ Ni ( L 1 H ) 2 ], [ Cu ( L 1 H ) 2 ], L 2 H 2 , [ Ni ( L 2 H ) 2 ] and [ Cu ( L 2 H ) 2 ] showed some activities against certain Gram-positive bacteria and some of the yeasts tested.
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Spectroscopic and biological approach of Ni(II), Cu(II) and Co(II) complexes of 4-methoxy/ethoxybenzaldehyde thiosemicarbazone Glyoxime
Spectrochimica acta. Part A Molecular and biomolecular spectroscopy, 2013Co-Authors: Ilknur Babahan, Esin Poyrazoğlu Çoban, Fatih Eyduran, Nil Orhan, Didem Kazar, Halil BiyikAbstract:Abstract Two novel vicinal dioxime ligands containing (4-methoxybenzaldehyde thiosemicarbazone Glyoxime ( L 1 H 2 ) or 4-ethoxybenzaldehyde thiosemicarbazone Glyoxime ( L 2 H 2 )) thiosemicarbazone units were synthesized and characterized using 1H NMR, 13C NMR, HMQC, MS, infrared and, UV–VIS. spectroscopy, elemental analysis, and magnetic susceptibility measurements. Mononuclear nickel(II), copper(II) and cobalt(II) complexes with a metal:ligand ratio of 1:2 for L 1 H 2 and L 2 H 2 were also synthesized. The effect of pH and solvent on the absorption spectra of both ligands and complexes was determined. IR spectra show that the ligands act in a bidentate manner and coordinates N4 donor groups of the ligands to NiII, CuII and CoII ions. The detection of H-bonding (O H⋯O) in the [M(LH)2] metal complexes by IR spectra supported the square-planar MN4 coordination of mononuclear complexes. The antimicrobial activities of compounds L 1 H 2 , L 2 H 2 , and their Ni(II), Cu(II) and Co(II) complexes were evaluated using the disc diffusion method against 12 bacteria and 4 yeasts. The minimal inhibitory concentrations (MICs) against 7 bacteria and 3 yeasts were also determined. Among the test compounds attempted, L 1 H 2 , [ Ni ( L 1 H ) 2 ], [ Cu ( L 1 H ) 2 ], L 2 H 2 , [ Ni ( L 2 H ) 2 ] and [ Cu ( L 2 H ) 2 ] showed some activities against certain Gram-positive bacteria and some of the yeasts tested.
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Synthesis, characterisation and antimicrobial activities of vic-dioxime derivatives containing heteroaromatic hydrazone groups and their metal complexes
2013Co-Authors: Halil Biyik, Ilknur Babahan, Esin Poyrazoğlu ÇobanAbstract:Three novel heteroaromatic hydrazone derivatives bearing vic-dioxime groups (L 1 H2: 5-methyl-2-furfural hydrazone Glyoxime, L 2 H2: 3-acetylpyridine hydrazone Glyoxime and L 3 H2: 4-acetylpyridine hydrazone Glyoxime) and their Ni(II), Cu(II) and Co(II) complexes were prepared. They were characterised by elemental analysis, gel permeation chromatography (GPC), FT-IR, UV, 1 H NMR and 13 C NMR. The antimicrobial activities of compounds L 1 H2, L 2 H2, L 3 H2 and their Ni(II), Cu(II) and Co(II) complexes were evaluated using the disc diffusion method against 13 bacteria and 5 yeasts. The minimal inhibitory concentrations (MICs) against 3 bacteria and 3 yeasts were also determined. Among the test compounds attempted, L 1 H2, (Co(L 1 H)2(H2O)2), (Ni(L 2 H)2), (Cu(L 2 H)2), L 3 H2, (Ni(L 3 H)2 and (Co(L 3 H)2(H2O)2) showed some activities against certain Gram-positive bacteria and some of the yeasts tested.
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Synthesis, characterization and biological activity of vic-dioxime derivatives containing benzaldehydehydrazone groups and their metal complexes
African Journal of Microbiology Research, 2011Co-Authors: Ilknur Babahan, Halil Biyik, Esin Poyrazolu Ccedil, Oban, Ali Ouml, Zmen, Burcu ImanAbstract:In this study, three new vic-dioxime derivatives containing benzaldehydehydrazone groups (L1H2: 4-methoxybenzaldehydehydrazone Glyoxime, L2H2: 4-methylbenzaldehydehydrazone Glyoxime and L3H2: 3-methylbenzaldehydehydrazone Glyoxime) and their Ni(II), Cu(II) and Co(II) complexes are used. The biological activity of these aromatic hydrazone-oxime derivatives has been determined in both prokaryotic and eukaryotic systems. For evaluating the antimicrobial activity disc diffusion method has been used and for determining the antiproliferative effect on neoplastic cells, HL 60 (Human promyelocytic leukemia cells) cell line was cultured. The antimicrobial activities of compounds (L1H2, L2H2, L3H2 and their Ni(II), Cu(II) and Co(II) complexes) were evaluated against 13 bacteria and 5 yeasts. Besides they were evaluated using the minimal inhibitory concentration (MIC) dilution method against 1 bacterium and 5 yeasts. The obtained results from disc diffusion method are assessed in sideby-side comparison with those of Chloramphenicol, Gentamycin, Tetracycline, Erytromycine, Ampicillin well-known antibacterial agents and Nystatine antifungal agent. The results from dilution procedure are compared with Streptomycine as antibacterial and Nystatine as antifungal. The antifungal activities are reported on five yeast cultures namely, Candida utilis, C. albicans, C. glabata, C. trophicalis and Saccharomyces cerevisiae ATCC 9763 and the results are referenced with Nystatine, a commercial antifungal agent. As a result of this study, among the test compounds attempted 1, 2, 7 and 9 showed slightly higher activities against B. thrungiensis and some of yeasts that are comparatively higher or equipotent to the antibiotic and antifungal agents in the comparison tests. Furthermore Co(II) complexes of these derivatives can be described as potent anti-cancer agents due to their antiproliferative effects with an IpC50 between 5 to 40 µM concentrations. The strongest antiproliferative activity was determined with the Co(II) complex of L3H2 at 5 µM. Key words: Vic-dioximes, hydrazone, transition metal complexes, antimicrobial activity, antiproliferative, leukemia.
Jian-feng Jia - One of the best experts on this subject based on the ideXlab platform.
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Substituent and Solvent Effects on Electronic Structure and Spectral Property of ReCl(CO)3(N∧N) (N∧N = Glyoxime): DFT and TDDFT Theoretical Studies
The journal of physical chemistry. A, 2010Co-Authors: Ting-ting Zhang, Jian-feng JiaAbstract:The ground- and excited-state structures of five Re(I) halide Glyoxime complexes ReCl(CO)3(N∧N) (N∧N = Glyoxime (DHG 1), dimethylGlyoxime (DMG 2), cyclohexane dione Glyoxime (CHDG 3), dibromoGlyoxime (DBG 4), and dimethylformylgloxime (DMFG 5)) have been studied with density functional theory (DFT) and configuration interaction with single excitations (CIS) methods. Time-dependent density functional theory/polarized continuum model (TDDFT/PCM) was carried out to predict the absorption and emission spectra in different media. The effect of substituent and solvent has been researched. It is found that electron-donating groups increase the lowest unoccupied molecular orbital (LUMO) energy resulting in the increased highest occupied molecular orbital (HOMO)−LUMO energy gap. The change leads to their absorption spectra blue shifts in the order 1 > 2 > 3, which arises from the HOMO-1 → LUMO. Just the opposite, electron-withdrawing groups lead to the spectra red shifts (5 > 4 > 1) because of the decreased HOMO−L...
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substituent and solvent effects on electronic structure and spectral property of recl co 3 n n n n Glyoxime dft and tddft theoretical studies
Journal of Physical Chemistry A, 2010Co-Authors: Ting-ting Zhang, Jian-feng JiaAbstract:The ground- and excited-state structures of five Re(I) halide Glyoxime complexes ReCl(CO)3(N∧N) (N∧N = Glyoxime (DHG 1), dimethylGlyoxime (DMG 2), cyclohexane dione Glyoxime (CHDG 3), dibromoGlyoxime (DBG 4), and dimethylformylgloxime (DMFG 5)) have been studied with density functional theory (DFT) and configuration interaction with single excitations (CIS) methods. Time-dependent density functional theory/polarized continuum model (TDDFT/PCM) was carried out to predict the absorption and emission spectra in different media. The effect of substituent and solvent has been researched. It is found that electron-donating groups increase the lowest unoccupied molecular orbital (LUMO) energy resulting in the increased highest occupied molecular orbital (HOMO)−LUMO energy gap. The change leads to their absorption spectra blue shifts in the order 1 > 2 > 3, which arises from the HOMO-1 → LUMO. Just the opposite, electron-withdrawing groups lead to the spectra red shifts (5 > 4 > 1) because of the decreased HOMO−L...
Ahmet Kilic - One of the best experts on this subject based on the ideXlab platform.
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Mono/multinuclear cobaloxime and organocobaloxime-catalyzed conversion of CO2 and epoxides to cyclic organic carbonates: Synthesis and characterization
Journal of Industrial and Engineering Chemistry, 2015Co-Authors: Ahmet Kilic, Mahmut Ulusoy, Emine Aytar, Mustafa DurgunAbstract:Abstract The synthesis and characterization of the mono- and multinuclear cobaloxime and organocobaloxime complexes bearing bidentate dimethyl Glyoxime ligands are presented. All mono- and multinuclear cobaloxime and organocobaloxime complexes are used as catalysts for the cycloaddition of CO2 to various epoxides, especially epichlorohydrin, in the presence of 4-dimethylamino pyridine (DMAP) as a cocatalyst. In the catalytic applications, DMAP was a more active base with higher yield compared to other Lewis bases. Complexes (1) and (3), which have two dimethyl Glyoxime per cobalt center (mononuclear complexes), are better catalytic systems than the corresponding multinuclear cobaloxime and organocobaloxime complexes (2–5) and (7–10) with two dimethyl Glyoxime per cobalt center and one linked ligands per copper center. In addition, the organocobaloxime complex (6) showed the highest activity for the cycloaddition of CO2 with epichlorohydrin in the presence of 4-dimethylamino pyridine (DMAP) as cocatalyst. The used as catalysts mono- and multinuclear cobaloxime and organocobaloxime complexes were characterized by 1H and 13C NMR spectra, FT-IR spectra, UV–vis spectra, LC-MS spectra, molar conductivity measurements, melting point measurements and magnetic susceptibility measurements.
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type-metal complexes of N,N'-(4-amino-1-benzyl piperidine)-Glyoxime
2009Co-Authors: Ahmet Kilic, Esref Tas, Ismail YilmazAbstract:The novel vic-dioxime ligand containing the 4-amino-1-benzyl piperidine group, N,N'-(4- amino-1-benzyl piperidine)-Glyoxime, (LH2) has been prepared from 4-amino-1-benzyl piperidine with anti-dichloroGlyoxime at -15°C in absolute THF. Mononuclear Ni II
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The synthesis, spectroscopic and voltametric studies of new metal complexes containing three different vic-dioximes
Journal of Coordination Chemistry, 2007Co-Authors: Ahmet Kilic, Esref Tas, Bahattin Gümgüm, Ismail YilmazAbstract:The synthesis, spectroscopic, and redox properties of some metal complexes with three novel vic-dioxime ligands, N-(1-(2-aminoethyl)piperazine)-phenylGlyoxime (L1H2), N-(1-(2-aminoethyl)piperazine)-Glyoxime (L2H2), and N,N′-bis(1-(2-aminoethyl)piperazine)-Glyoxime (L3H2)], prepared from different Glyoxime and 1-(2-aminoethyl)piperazine are reported. The structure of these vic-dioximes have been determined as the anti-form according to 1H NMR, 13C NMR, and FT-IR data. The metal to ligand ratios of Co(II), Ni(II), and Cu(II) complexes were found to be 1 : 2. The Cu(II) complexes of these ligands are proposed to be square planar and Ni(II) complexes of these ligands are proposed to be square planar or octahedral, while the Co(II) complexes are proposed to be octahedral with water molecules as axial ligands. Ni(II), Co(II), and Cu(II) metal complexes are non-electrolytes as shown by their molar conductivities (ΛM) in DMF (dimethyl formamide) at 10−3 M. The structure of ligands and their complexes is proposed ...
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Synthesis, Spectral Characterization and Electrochemical Properties of New vic-dioxime Complexes Bearing Carboxylate
Transition Metal Chemistry, 2006Co-Authors: Ahmet Kilic, Esref Tas, Bahattin Gümgüm, Ismail YilmazAbstract:Three new vic -dioxime ligands, [ N -(ethyl-4-amino-1-piperidine carboxylate)-phenylGlyoxime (L^1H_2), N -(ethyl-4-amino-1-piperidine carboxylate)-Glyoxime (L^2H_2), and N , N ′-bis(ethyl-4-amino-1-piperidine carboxylate)-Glyoxime (L^3H_2)], and their Co(II) with Cu(II) metal complexes, were synthesized for the first time. Mononuclear complexes of these ligands with a 1:2 metal-ligand ratio were prepared with Co(II) and Cu(II) salts. The BF _2 ^+ -capped Co(II) and mononuclear complexes of the vic -dioxime were prepared for [Co(L^1·BF_2)_2] and [Co(L^2·BF_2)_2]. The ligands act in a polydentate fashion bonding through nitrogen atoms in the presence of a base, as do most vic -dioximes. The cobalt(II) and copper(II) complexes are non-electrolytes as shown by their molar conductivities (Λ_ M ) in DMF. The structures of the ligands and complexes were determined by elemental analyses, FT-i.r., u.v.–vis., ^1H- and ^13C-n.m.r. spectra, magnetic susceptibility measurements, and molar conductivity. The comparative electrochemical studies show that the stabilities of the reduced or oxidized species and the electrode potentials of the complexes are affected by the substituents attached on the oxime moieties of the complexes.
Ilknur Babahan - One of the best experts on this subject based on the ideXlab platform.
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spectroscopic and biological approach of ni ii cu ii and co ii complexes of 4 methoxy ethoxybenzaldehyde thiosemicarbazone Glyoxime
Spectrochimica Acta Part A: Molecular and Biomolecular Spectroscopy, 2014Co-Authors: Ilknur Babahan, Esin Poyrazoğlu Çoban, Fatih Eyduran, Nil Orhan, Didem Kazar, Halil BiyikAbstract:Abstract Two novel vicinal dioxime ligands containing (4-methoxybenzaldehyde thiosemicarbazone Glyoxime ( L 1 H 2 ) or 4-ethoxybenzaldehyde thiosemicarbazone Glyoxime ( L 2 H 2 )) thiosemicarbazone units were synthesized and characterized using 1H NMR, 13C NMR, HMQC, MS, infrared and, UV–VIS. spectroscopy, elemental analysis, and magnetic susceptibility measurements. Mononuclear nickel(II), copper(II) and cobalt(II) complexes with a metal:ligand ratio of 1:2 for L 1 H 2 and L 2 H 2 were also synthesized. The effect of pH and solvent on the absorption spectra of both ligands and complexes was determined. IR spectra show that the ligands act in a bidentate manner and coordinates N4 donor groups of the ligands to NiII, CuII and CoII ions. The detection of H-bonding (O H⋯O) in the [M(LH)2] metal complexes by IR spectra supported the square-planar MN4 coordination of mononuclear complexes. The antimicrobial activities of compounds L 1 H 2 , L 2 H 2 , and their Ni(II), Cu(II) and Co(II) complexes were evaluated using the disc diffusion method against 12 bacteria and 4 yeasts. The minimal inhibitory concentrations (MICs) against 7 bacteria and 3 yeasts were also determined. Among the test compounds attempted, L 1 H 2 , [ Ni ( L 1 H ) 2 ], [ Cu ( L 1 H ) 2 ], L 2 H 2 , [ Ni ( L 2 H ) 2 ] and [ Cu ( L 2 H ) 2 ] showed some activities against certain Gram-positive bacteria and some of the yeasts tested.
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Spectroscopic and biological approach of Ni(II), Cu(II) and Co(II) complexes of 4-methoxy/ethoxybenzaldehyde thiosemicarbazone Glyoxime
Spectrochimica acta. Part A Molecular and biomolecular spectroscopy, 2013Co-Authors: Ilknur Babahan, Esin Poyrazoğlu Çoban, Fatih Eyduran, Nil Orhan, Didem Kazar, Halil BiyikAbstract:Abstract Two novel vicinal dioxime ligands containing (4-methoxybenzaldehyde thiosemicarbazone Glyoxime ( L 1 H 2 ) or 4-ethoxybenzaldehyde thiosemicarbazone Glyoxime ( L 2 H 2 )) thiosemicarbazone units were synthesized and characterized using 1H NMR, 13C NMR, HMQC, MS, infrared and, UV–VIS. spectroscopy, elemental analysis, and magnetic susceptibility measurements. Mononuclear nickel(II), copper(II) and cobalt(II) complexes with a metal:ligand ratio of 1:2 for L 1 H 2 and L 2 H 2 were also synthesized. The effect of pH and solvent on the absorption spectra of both ligands and complexes was determined. IR spectra show that the ligands act in a bidentate manner and coordinates N4 donor groups of the ligands to NiII, CuII and CoII ions. The detection of H-bonding (O H⋯O) in the [M(LH)2] metal complexes by IR spectra supported the square-planar MN4 coordination of mononuclear complexes. The antimicrobial activities of compounds L 1 H 2 , L 2 H 2 , and their Ni(II), Cu(II) and Co(II) complexes were evaluated using the disc diffusion method against 12 bacteria and 4 yeasts. The minimal inhibitory concentrations (MICs) against 7 bacteria and 3 yeasts were also determined. Among the test compounds attempted, L 1 H 2 , [ Ni ( L 1 H ) 2 ], [ Cu ( L 1 H ) 2 ], L 2 H 2 , [ Ni ( L 2 H ) 2 ] and [ Cu ( L 2 H ) 2 ] showed some activities against certain Gram-positive bacteria and some of the yeasts tested.
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Synthesis, characterisation and antimicrobial activities of vic-dioxime derivatives containing heteroaromatic hydrazone groups and their metal complexes
2013Co-Authors: Halil Biyik, Ilknur Babahan, Esin Poyrazoğlu ÇobanAbstract:Three novel heteroaromatic hydrazone derivatives bearing vic-dioxime groups (L 1 H2: 5-methyl-2-furfural hydrazone Glyoxime, L 2 H2: 3-acetylpyridine hydrazone Glyoxime and L 3 H2: 4-acetylpyridine hydrazone Glyoxime) and their Ni(II), Cu(II) and Co(II) complexes were prepared. They were characterised by elemental analysis, gel permeation chromatography (GPC), FT-IR, UV, 1 H NMR and 13 C NMR. The antimicrobial activities of compounds L 1 H2, L 2 H2, L 3 H2 and their Ni(II), Cu(II) and Co(II) complexes were evaluated using the disc diffusion method against 13 bacteria and 5 yeasts. The minimal inhibitory concentrations (MICs) against 3 bacteria and 3 yeasts were also determined. Among the test compounds attempted, L 1 H2, (Co(L 1 H)2(H2O)2), (Ni(L 2 H)2), (Cu(L 2 H)2), L 3 H2, (Ni(L 3 H)2 and (Co(L 3 H)2(H2O)2) showed some activities against certain Gram-positive bacteria and some of the yeasts tested.
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Synthesis, characterization and biological activity of vic-dioxime derivatives containing benzaldehydehydrazone groups and their metal complexes
African Journal of Microbiology Research, 2011Co-Authors: Ilknur Babahan, Halil Biyik, Esin Poyrazolu Ccedil, Oban, Ali Ouml, Zmen, Burcu ImanAbstract:In this study, three new vic-dioxime derivatives containing benzaldehydehydrazone groups (L1H2: 4-methoxybenzaldehydehydrazone Glyoxime, L2H2: 4-methylbenzaldehydehydrazone Glyoxime and L3H2: 3-methylbenzaldehydehydrazone Glyoxime) and their Ni(II), Cu(II) and Co(II) complexes are used. The biological activity of these aromatic hydrazone-oxime derivatives has been determined in both prokaryotic and eukaryotic systems. For evaluating the antimicrobial activity disc diffusion method has been used and for determining the antiproliferative effect on neoplastic cells, HL 60 (Human promyelocytic leukemia cells) cell line was cultured. The antimicrobial activities of compounds (L1H2, L2H2, L3H2 and their Ni(II), Cu(II) and Co(II) complexes) were evaluated against 13 bacteria and 5 yeasts. Besides they were evaluated using the minimal inhibitory concentration (MIC) dilution method against 1 bacterium and 5 yeasts. The obtained results from disc diffusion method are assessed in sideby-side comparison with those of Chloramphenicol, Gentamycin, Tetracycline, Erytromycine, Ampicillin well-known antibacterial agents and Nystatine antifungal agent. The results from dilution procedure are compared with Streptomycine as antibacterial and Nystatine as antifungal. The antifungal activities are reported on five yeast cultures namely, Candida utilis, C. albicans, C. glabata, C. trophicalis and Saccharomyces cerevisiae ATCC 9763 and the results are referenced with Nystatine, a commercial antifungal agent. As a result of this study, among the test compounds attempted 1, 2, 7 and 9 showed slightly higher activities against B. thrungiensis and some of yeasts that are comparatively higher or equipotent to the antibiotic and antifungal agents in the comparison tests. Furthermore Co(II) complexes of these derivatives can be described as potent anti-cancer agents due to their antiproliferative effects with an IpC50 between 5 to 40 µM concentrations. The strongest antiproliferative activity was determined with the Co(II) complex of L3H2 at 5 µM. Key words: Vic-dioximes, hydrazone, transition metal complexes, antimicrobial activity, antiproliferative, leukemia.
B. D. Gupta - One of the best experts on this subject based on the ideXlab platform.
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Cobaloximes with Bis(thiophenyl)Glyoxime: Synthesis and Structure−Property Relationship Study
Organometallics, 2009Co-Authors: Gargi Dutta, Kamlesh Kumar, B. D. GuptaAbstract:Alkyl and non-alkyl cobaloximes with bis(thiophenyl)Glyoxime, X/RCo(dSPhgH)2Py (X = Cl, R = Me, Et, Pr, Bu, Bn) have been synthesized and characterized for the first time. The X-ray structures of t...
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cobaloximes with bis thiophenyl Glyoxime synthesis and structure property relationship study
Organometallics, 2009Co-Authors: Gargi Dutta, Kamlesh Kumar, B. D. GuptaAbstract:Alkyl and non-alkyl cobaloximes with bis(thiophenyl)Glyoxime, X/RCo(dSPhgH)2Py (X = Cl, R = Me, Et, Pr, Bu, Bn) have been synthesized and characterized for the first time. The X-ray structures of t...