The Experts below are selected from a list of 9 Experts worldwide ranked by ideXlab platform

Qin Hong-bing - One of the best experts on this subject based on the ideXlab platform.

  • Protection of Elk antlers ethanolic fluidextract on Gonad Dysfunction impairment of male mice induced by cyclophosphamide
    Acta Universitatis Medicinalis Nanjing, 2011
    Co-Authors: Qin Hong-bing
    Abstract:

    Objective: To observe the protective effect of Elk antlers ethanolic fluidextract(EAEF) on Gonad function impairment of male mice induced by cyclophosphamide(CP).Methods: The model of Gonad function depression was prepared by repeatedly intraperitoneal injection of CP.Low and high dose of EAEF were given to mice with oral administration to intervene this process,then the level of testosterone and luteinizing hormone in serum were detected;the weight index of sex organ and accessory sex organ were observed;sperm density and sperm activity were detected;the superoxide dismutase(SOD) activity and malonaldehyde(MDA) content were measured.Meanwhile the histopathological changes in testis were observed by light microscopy.Results: EAEF reversed the decline of testosterone and luteinizing hormone level in serum,enhanced the testicle mass index,sperm density and sperm activity,increased SOD activity and decreased content of MDA in testis,as well alleviated the histologic pathological formation in testis in cyclophosphamide-induced model mice.Conclusion: EAEF has protective effect on Gonad Dysfunction impairment of male mice induced by CP,which might be related to its the Gonadotropin hormone-like effect and antioxidation.

Jerzy Starzyk - One of the best experts on this subject based on the ideXlab platform.

  • thyroid gland Dysfunction disorders of somatic and sexual development disturbances of fertility after hematopoietic stem cell transplantation
    Pediatric endocrinology diabetes and metabolism, 2013
    Co-Authors: Anna Wedrychowicz, Jerzy Starzyk
    Abstract:

    Abstract Since the 1980s, hematopoietic stem cell transplantation (HSCT) has been performed for malignant and non-malignant disorders leading to increasing numbers of long-term survivors. Some of them develop long-term posttransplantation complications, among them endocrine complications that arise many years after HSCT and demand to be treated till the end of patients´ life. In the paper "classical", observed several years after HSCT had been used as a treatment procedure, endocrine complications are discussed and the review of literature regarding this problem is presented. Thyroid Dysfunction, disorders of somatic and sexual development are presented in details. Gonad Dysfunction with the problem of fertility disturbances is reported. The paper presents the etiopathogenesis, methods of prevention, as well as treatment and the results of the treatment of these endocrine complications after HSCT. Moreover actual recommendations for screening and prevention of endocrine complications in long-term HCT survivors are presented.

Anna Wedrychowicz - One of the best experts on this subject based on the ideXlab platform.

  • thyroid gland Dysfunction disorders of somatic and sexual development disturbances of fertility after hematopoietic stem cell transplantation
    Pediatric endocrinology diabetes and metabolism, 2013
    Co-Authors: Anna Wedrychowicz, Jerzy Starzyk
    Abstract:

    Abstract Since the 1980s, hematopoietic stem cell transplantation (HSCT) has been performed for malignant and non-malignant disorders leading to increasing numbers of long-term survivors. Some of them develop long-term posttransplantation complications, among them endocrine complications that arise many years after HSCT and demand to be treated till the end of patients´ life. In the paper "classical", observed several years after HSCT had been used as a treatment procedure, endocrine complications are discussed and the review of literature regarding this problem is presented. Thyroid Dysfunction, disorders of somatic and sexual development are presented in details. Gonad Dysfunction with the problem of fertility disturbances is reported. The paper presents the etiopathogenesis, methods of prevention, as well as treatment and the results of the treatment of these endocrine complications after HSCT. Moreover actual recommendations for screening and prevention of endocrine complications in long-term HCT survivors are presented.

Ambros, Victor R. - One of the best experts on this subject based on the ideXlab platform.

  • The embryonic mir-35 family of microRNAs promotes multiple aspects of fecundity in Caenorhabditis elegans
    eScholarship@UMMS, 2014
    Co-Authors: Mcjunkin Katherine, Ambros, Victor R.
    Abstract:

    MicroRNAs guide many aspects of development in all metazoan species. Frequently, microRNAs are expressed during a specific developmental stage to perform a temporally defined function. The C. elegans mir-35-42 microRNAs are expressed abundantly in oocytes and early embryos and are essential for embryonic development. Here, we show that these embryonic microRNAs surprisingly also function to control the number of progeny produced by adult hermaphrodites. Using a temperature-sensitive mir-35-42 family mutant (a deletion of the mir-35-41 cluster), we demonstrate three distinct defects in hermaphrodite fecundity. At permissive temperatures, a mild sperm defect partially reduces hermaphrodite fecundity. At restrictive temperatures, somatic Gonad Dysfunction combined with a severe sperm defect sharply reduces fecundity. Multiple lines of evidence, including a late embryonic temperature-sensitive period, support a role for mir-35-41 early during development to promote subsequent sperm production in later larval stages. We further show that the predicted mir-35 family target sup-26 (suppressor-26) acts downstream of mir-35-41 in this process, suggesting that sup-26 de-repression in mir-35-41 deletion mutants may contribute to temperature-sensitive loss of fecundity. In addition, these microRNAs play a role in male fertility, promoting proper morphogenesis of male-specific mating structures. Overall, our results demonstrate that robust activity of the mir-35-42 family microRNAs not only is essential for embryonic development across a range of temperatures but also enables the worm to subsequently develop full reproductive capacity

Mcjunkin Katherine - One of the best experts on this subject based on the ideXlab platform.

  • The embryonic mir-35 family of microRNAs promotes multiple aspects of fecundity in Caenorhabditis elegans
    eScholarship@UMMS, 2014
    Co-Authors: Mcjunkin Katherine, Ambros, Victor R.
    Abstract:

    MicroRNAs guide many aspects of development in all metazoan species. Frequently, microRNAs are expressed during a specific developmental stage to perform a temporally defined function. The C. elegans mir-35-42 microRNAs are expressed abundantly in oocytes and early embryos and are essential for embryonic development. Here, we show that these embryonic microRNAs surprisingly also function to control the number of progeny produced by adult hermaphrodites. Using a temperature-sensitive mir-35-42 family mutant (a deletion of the mir-35-41 cluster), we demonstrate three distinct defects in hermaphrodite fecundity. At permissive temperatures, a mild sperm defect partially reduces hermaphrodite fecundity. At restrictive temperatures, somatic Gonad Dysfunction combined with a severe sperm defect sharply reduces fecundity. Multiple lines of evidence, including a late embryonic temperature-sensitive period, support a role for mir-35-41 early during development to promote subsequent sperm production in later larval stages. We further show that the predicted mir-35 family target sup-26 (suppressor-26) acts downstream of mir-35-41 in this process, suggesting that sup-26 de-repression in mir-35-41 deletion mutants may contribute to temperature-sensitive loss of fecundity. In addition, these microRNAs play a role in male fertility, promoting proper morphogenesis of male-specific mating structures. Overall, our results demonstrate that robust activity of the mir-35-42 family microRNAs not only is essential for embryonic development across a range of temperatures but also enables the worm to subsequently develop full reproductive capacity