The Experts below are selected from a list of 32832 Experts worldwide ranked by ideXlab platform
Norbert Zimmermann - One of the best experts on this subject based on the ideXlab platform.
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design and synthesis of novel potent and selective integrin αvβ3 antagonists novel synthetic routes to isoquinolinone benzoxazinone and quinazolinone acetates
Bioorganic & Medicinal Chemistry Letters, 2008Co-Authors: Werner Seitz, Hervé Geneste, Gisela Backfisch, Jürgen Delzer, Claudia Isabella Graef, Wilfried Hornberger, Andreas Kling, Thomas Subkowski, Norbert ZimmermannAbstract:Abstract An unexpected ring contraction of benzazepinone based α v β 3 antagonists led to the design of quinolinone-type derivatives. Novel and efficient synthetic routes to isoquinolinone, benzoxazinone, and quinazolinone acetates were established. Nanomolar α v β 3 antagonists based on these new scaffolds were prepared. Moreover, benzoxazinones 15a and 15b exhibited high microsomal stability and Good Permeability.
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Design and synthesis of novel potent and selective integrin αvβ3 antagonists—Novel synthetic routes to isoquinolinone, benzoxazinone, and quinazolinone acetates
Bioorganic & medicinal chemistry letters, 2007Co-Authors: Werner Seitz, Hervé Geneste, Gisela Backfisch, Jürgen Delzer, Claudia Isabella Graef, Wilfried Hornberger, Andreas Kling, Thomas Subkowski, Norbert ZimmermannAbstract:Abstract An unexpected ring contraction of benzazepinone based α v β 3 antagonists led to the design of quinolinone-type derivatives. Novel and efficient synthetic routes to isoquinolinone, benzoxazinone, and quinazolinone acetates were established. Nanomolar α v β 3 antagonists based on these new scaffolds were prepared. Moreover, benzoxazinones 15a and 15b exhibited high microsomal stability and Good Permeability.
Werner Seitz - One of the best experts on this subject based on the ideXlab platform.
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design and synthesis of novel potent and selective integrin αvβ3 antagonists novel synthetic routes to isoquinolinone benzoxazinone and quinazolinone acetates
Bioorganic & Medicinal Chemistry Letters, 2008Co-Authors: Werner Seitz, Hervé Geneste, Gisela Backfisch, Jürgen Delzer, Claudia Isabella Graef, Wilfried Hornberger, Andreas Kling, Thomas Subkowski, Norbert ZimmermannAbstract:Abstract An unexpected ring contraction of benzazepinone based α v β 3 antagonists led to the design of quinolinone-type derivatives. Novel and efficient synthetic routes to isoquinolinone, benzoxazinone, and quinazolinone acetates were established. Nanomolar α v β 3 antagonists based on these new scaffolds were prepared. Moreover, benzoxazinones 15a and 15b exhibited high microsomal stability and Good Permeability.
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Design and synthesis of novel potent and selective integrin αvβ3 antagonists—Novel synthetic routes to isoquinolinone, benzoxazinone, and quinazolinone acetates
Bioorganic & medicinal chemistry letters, 2007Co-Authors: Werner Seitz, Hervé Geneste, Gisela Backfisch, Jürgen Delzer, Claudia Isabella Graef, Wilfried Hornberger, Andreas Kling, Thomas Subkowski, Norbert ZimmermannAbstract:Abstract An unexpected ring contraction of benzazepinone based α v β 3 antagonists led to the design of quinolinone-type derivatives. Novel and efficient synthetic routes to isoquinolinone, benzoxazinone, and quinazolinone acetates were established. Nanomolar α v β 3 antagonists based on these new scaffolds were prepared. Moreover, benzoxazinones 15a and 15b exhibited high microsomal stability and Good Permeability.
Jürgen Delzer - One of the best experts on this subject based on the ideXlab platform.
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design and synthesis of novel potent and selective integrin αvβ3 antagonists novel synthetic routes to isoquinolinone benzoxazinone and quinazolinone acetates
Bioorganic & Medicinal Chemistry Letters, 2008Co-Authors: Werner Seitz, Hervé Geneste, Gisela Backfisch, Jürgen Delzer, Claudia Isabella Graef, Wilfried Hornberger, Andreas Kling, Thomas Subkowski, Norbert ZimmermannAbstract:Abstract An unexpected ring contraction of benzazepinone based α v β 3 antagonists led to the design of quinolinone-type derivatives. Novel and efficient synthetic routes to isoquinolinone, benzoxazinone, and quinazolinone acetates were established. Nanomolar α v β 3 antagonists based on these new scaffolds were prepared. Moreover, benzoxazinones 15a and 15b exhibited high microsomal stability and Good Permeability.
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Design and synthesis of novel potent and selective integrin αvβ3 antagonists—Novel synthetic routes to isoquinolinone, benzoxazinone, and quinazolinone acetates
Bioorganic & medicinal chemistry letters, 2007Co-Authors: Werner Seitz, Hervé Geneste, Gisela Backfisch, Jürgen Delzer, Claudia Isabella Graef, Wilfried Hornberger, Andreas Kling, Thomas Subkowski, Norbert ZimmermannAbstract:Abstract An unexpected ring contraction of benzazepinone based α v β 3 antagonists led to the design of quinolinone-type derivatives. Novel and efficient synthetic routes to isoquinolinone, benzoxazinone, and quinazolinone acetates were established. Nanomolar α v β 3 antagonists based on these new scaffolds were prepared. Moreover, benzoxazinones 15a and 15b exhibited high microsomal stability and Good Permeability.
Hervé Geneste - One of the best experts on this subject based on the ideXlab platform.
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design and synthesis of novel potent and selective integrin αvβ3 antagonists novel synthetic routes to isoquinolinone benzoxazinone and quinazolinone acetates
Bioorganic & Medicinal Chemistry Letters, 2008Co-Authors: Werner Seitz, Hervé Geneste, Gisela Backfisch, Jürgen Delzer, Claudia Isabella Graef, Wilfried Hornberger, Andreas Kling, Thomas Subkowski, Norbert ZimmermannAbstract:Abstract An unexpected ring contraction of benzazepinone based α v β 3 antagonists led to the design of quinolinone-type derivatives. Novel and efficient synthetic routes to isoquinolinone, benzoxazinone, and quinazolinone acetates were established. Nanomolar α v β 3 antagonists based on these new scaffolds were prepared. Moreover, benzoxazinones 15a and 15b exhibited high microsomal stability and Good Permeability.
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Design and synthesis of novel potent and selective integrin αvβ3 antagonists—Novel synthetic routes to isoquinolinone, benzoxazinone, and quinazolinone acetates
Bioorganic & medicinal chemistry letters, 2007Co-Authors: Werner Seitz, Hervé Geneste, Gisela Backfisch, Jürgen Delzer, Claudia Isabella Graef, Wilfried Hornberger, Andreas Kling, Thomas Subkowski, Norbert ZimmermannAbstract:Abstract An unexpected ring contraction of benzazepinone based α v β 3 antagonists led to the design of quinolinone-type derivatives. Novel and efficient synthetic routes to isoquinolinone, benzoxazinone, and quinazolinone acetates were established. Nanomolar α v β 3 antagonists based on these new scaffolds were prepared. Moreover, benzoxazinones 15a and 15b exhibited high microsomal stability and Good Permeability.
Gisela Backfisch - One of the best experts on this subject based on the ideXlab platform.
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design and synthesis of novel potent and selective integrin αvβ3 antagonists novel synthetic routes to isoquinolinone benzoxazinone and quinazolinone acetates
Bioorganic & Medicinal Chemistry Letters, 2008Co-Authors: Werner Seitz, Hervé Geneste, Gisela Backfisch, Jürgen Delzer, Claudia Isabella Graef, Wilfried Hornberger, Andreas Kling, Thomas Subkowski, Norbert ZimmermannAbstract:Abstract An unexpected ring contraction of benzazepinone based α v β 3 antagonists led to the design of quinolinone-type derivatives. Novel and efficient synthetic routes to isoquinolinone, benzoxazinone, and quinazolinone acetates were established. Nanomolar α v β 3 antagonists based on these new scaffolds were prepared. Moreover, benzoxazinones 15a and 15b exhibited high microsomal stability and Good Permeability.
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Design and synthesis of novel potent and selective integrin αvβ3 antagonists—Novel synthetic routes to isoquinolinone, benzoxazinone, and quinazolinone acetates
Bioorganic & medicinal chemistry letters, 2007Co-Authors: Werner Seitz, Hervé Geneste, Gisela Backfisch, Jürgen Delzer, Claudia Isabella Graef, Wilfried Hornberger, Andreas Kling, Thomas Subkowski, Norbert ZimmermannAbstract:Abstract An unexpected ring contraction of benzazepinone based α v β 3 antagonists led to the design of quinolinone-type derivatives. Novel and efficient synthetic routes to isoquinolinone, benzoxazinone, and quinazolinone acetates were established. Nanomolar α v β 3 antagonists based on these new scaffolds were prepared. Moreover, benzoxazinones 15a and 15b exhibited high microsomal stability and Good Permeability.
