The Experts below are selected from a list of 309 Experts worldwide ranked by ideXlab platform
Jorge Zárate - One of the best experts on this subject based on the ideXlab platform.
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brimonidine timolol fixed combination induced Granulomatous Inflammation of the eye
International Ophthalmology, 2013Co-Authors: María Alejandra Carrasco, Bernardo Ariel Schlaen, Jorge ZárateAbstract:We report on two cases of Granulomatous conjunctivitis and uveitis related with the use of a brimonidine–timolol fixed combination. Case report and a review of medical literature. A 64-year-old man was diagnosed with marked Granulomatous uveitis and a 57-year-old woman was diagnosed with Granulomatous conjunctivitis. Both patients were using a topical fixed combination of brimonidine 0.2 %-timolol 0.5 % for open angle glaucoma. Bilateral Granulomatous uveitis and conjunctivitis were diagnosed after 16 months of treatment with a fixed combination of brimonidine–timolol in both cases. Granulomatous Inflammation resolved with the cessation of antiglaucomatous drugs and topical corticosteroid treatment. When the Inflammation had resolved completely, both patients were rechallenged with topical brimonidine in one eye only to determine causality. Conjunctival hyperemia is a common side effect of glaucoma medications and is sometimes overlooked. Hyperemia may be associated with other signs such as iritis and keratic precipitates or conjunctival Inflammation. In such cases, Granulomatous Inflammation may be considered in the differential diagnosis. The fixed-combination of brimonidine–timolol may cause this clinical picture.
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Brimonidine–timolol fixed combination induced Granulomatous Inflammation of the eye
International Ophthalmology, 2012Co-Authors: María Alejandra Carrasco, Bernardo Ariel Schlaen, Jorge ZárateAbstract:We report on two cases of Granulomatous conjunctivitis and uveitis related with the use of a brimonidine–timolol fixed combination. Case report and a review of medical literature. A 64-year-old man was diagnosed with marked Granulomatous uveitis and a 57-year-old woman was diagnosed with Granulomatous conjunctivitis. Both patients were using a topical fixed combination of brimonidine 0.2 %-timolol 0.5 % for open angle glaucoma. Bilateral Granulomatous uveitis and conjunctivitis were diagnosed after 16 months of treatment with a fixed combination of brimonidine–timolol in both cases. Granulomatous Inflammation resolved with the cessation of antiglaucomatous drugs and topical corticosteroid treatment. When the Inflammation had resolved completely, both patients were rechallenged with topical brimonidine in one eye only to determine causality. Conjunctival hyperemia is a common side effect of glaucoma medications and is sometimes overlooked. Hyperemia may be associated with other signs such as iritis and keratic precipitates or conjunctival Inflammation. In such cases, Granulomatous Inflammation may be considered in the differential diagnosis. The fixed-combination of brimonidine–timolol may cause this clinical picture.
María Alejandra Carrasco - One of the best experts on this subject based on the ideXlab platform.
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brimonidine timolol fixed combination induced Granulomatous Inflammation of the eye
International Ophthalmology, 2013Co-Authors: María Alejandra Carrasco, Bernardo Ariel Schlaen, Jorge ZárateAbstract:We report on two cases of Granulomatous conjunctivitis and uveitis related with the use of a brimonidine–timolol fixed combination. Case report and a review of medical literature. A 64-year-old man was diagnosed with marked Granulomatous uveitis and a 57-year-old woman was diagnosed with Granulomatous conjunctivitis. Both patients were using a topical fixed combination of brimonidine 0.2 %-timolol 0.5 % for open angle glaucoma. Bilateral Granulomatous uveitis and conjunctivitis were diagnosed after 16 months of treatment with a fixed combination of brimonidine–timolol in both cases. Granulomatous Inflammation resolved with the cessation of antiglaucomatous drugs and topical corticosteroid treatment. When the Inflammation had resolved completely, both patients were rechallenged with topical brimonidine in one eye only to determine causality. Conjunctival hyperemia is a common side effect of glaucoma medications and is sometimes overlooked. Hyperemia may be associated with other signs such as iritis and keratic precipitates or conjunctival Inflammation. In such cases, Granulomatous Inflammation may be considered in the differential diagnosis. The fixed-combination of brimonidine–timolol may cause this clinical picture.
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Brimonidine–timolol fixed combination induced Granulomatous Inflammation of the eye
International Ophthalmology, 2012Co-Authors: María Alejandra Carrasco, Bernardo Ariel Schlaen, Jorge ZárateAbstract:We report on two cases of Granulomatous conjunctivitis and uveitis related with the use of a brimonidine–timolol fixed combination. Case report and a review of medical literature. A 64-year-old man was diagnosed with marked Granulomatous uveitis and a 57-year-old woman was diagnosed with Granulomatous conjunctivitis. Both patients were using a topical fixed combination of brimonidine 0.2 %-timolol 0.5 % for open angle glaucoma. Bilateral Granulomatous uveitis and conjunctivitis were diagnosed after 16 months of treatment with a fixed combination of brimonidine–timolol in both cases. Granulomatous Inflammation resolved with the cessation of antiglaucomatous drugs and topical corticosteroid treatment. When the Inflammation had resolved completely, both patients were rechallenged with topical brimonidine in one eye only to determine causality. Conjunctival hyperemia is a common side effect of glaucoma medications and is sometimes overlooked. Hyperemia may be associated with other signs such as iritis and keratic precipitates or conjunctival Inflammation. In such cases, Granulomatous Inflammation may be considered in the differential diagnosis. The fixed-combination of brimonidine–timolol may cause this clinical picture.
Bernardo Ariel Schlaen - One of the best experts on this subject based on the ideXlab platform.
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brimonidine timolol fixed combination induced Granulomatous Inflammation of the eye
International Ophthalmology, 2013Co-Authors: María Alejandra Carrasco, Bernardo Ariel Schlaen, Jorge ZárateAbstract:We report on two cases of Granulomatous conjunctivitis and uveitis related with the use of a brimonidine–timolol fixed combination. Case report and a review of medical literature. A 64-year-old man was diagnosed with marked Granulomatous uveitis and a 57-year-old woman was diagnosed with Granulomatous conjunctivitis. Both patients were using a topical fixed combination of brimonidine 0.2 %-timolol 0.5 % for open angle glaucoma. Bilateral Granulomatous uveitis and conjunctivitis were diagnosed after 16 months of treatment with a fixed combination of brimonidine–timolol in both cases. Granulomatous Inflammation resolved with the cessation of antiglaucomatous drugs and topical corticosteroid treatment. When the Inflammation had resolved completely, both patients were rechallenged with topical brimonidine in one eye only to determine causality. Conjunctival hyperemia is a common side effect of glaucoma medications and is sometimes overlooked. Hyperemia may be associated with other signs such as iritis and keratic precipitates or conjunctival Inflammation. In such cases, Granulomatous Inflammation may be considered in the differential diagnosis. The fixed-combination of brimonidine–timolol may cause this clinical picture.
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Brimonidine–timolol fixed combination induced Granulomatous Inflammation of the eye
International Ophthalmology, 2012Co-Authors: María Alejandra Carrasco, Bernardo Ariel Schlaen, Jorge ZárateAbstract:We report on two cases of Granulomatous conjunctivitis and uveitis related with the use of a brimonidine–timolol fixed combination. Case report and a review of medical literature. A 64-year-old man was diagnosed with marked Granulomatous uveitis and a 57-year-old woman was diagnosed with Granulomatous conjunctivitis. Both patients were using a topical fixed combination of brimonidine 0.2 %-timolol 0.5 % for open angle glaucoma. Bilateral Granulomatous uveitis and conjunctivitis were diagnosed after 16 months of treatment with a fixed combination of brimonidine–timolol in both cases. Granulomatous Inflammation resolved with the cessation of antiglaucomatous drugs and topical corticosteroid treatment. When the Inflammation had resolved completely, both patients were rechallenged with topical brimonidine in one eye only to determine causality. Conjunctival hyperemia is a common side effect of glaucoma medications and is sometimes overlooked. Hyperemia may be associated with other signs such as iritis and keratic precipitates or conjunctival Inflammation. In such cases, Granulomatous Inflammation may be considered in the differential diagnosis. The fixed-combination of brimonidine–timolol may cause this clinical picture.
Despina Moshous - One of the best experts on this subject based on the ideXlab platform.
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Granulomatous Inflammation in cartilage hair hypoplasia risks and benefits of anti tnf α mabs
The Journal of Allergy and Clinical Immunology, 2011Co-Authors: Despina Moshous, Isabelle Meyts, Sylvie Fraitag, Carl E.i. Janssen, Marianne Debré, Felipe SuarezAbstract:Background Cartilage-hair hypoplasia (CHH) is a rare autosomal recessive disorder characterized by short-limbed skeletal dysplasia. Some patients also have defects in cell-mediated immunity and antibody production. Granulomatous Inflammation has been described in patients with various forms of primary immunodeficiencies but has not been reported in patients with CHH. Objective We sought to describe Granulomatous Inflammation as a novel feature in patients with CHH, assess associated immunodeficiency, and evaluate treatment options. Methods In a retrospective observational study we collected clinical data on 21 patients with CHH to identify and further characterize patients with Granulomatous Inflammation. Results Four unrelated patients with CHH (with variable degrees of combined immunodeficiency) had epithelioid cell Granulomatous Inflammation in the skin and visceral organs. Anti–TNF-α mAb therapy in 3 of these patients led to significant regression of granulomas. However, 1 treated patient had fatal progressive multifocal leukoencephalopathy caused by the JC polyomavirus. In 2 patients immune reconstitution after allogeneic hematopoietic stem cell transplantation led to the complete disappearance of granulomas. Conclusion To the best of our knowledge, this is the first report of Granulomatous Inflammation in patients with CHH. Although TNF-α antagonists can effectively suppress granulomas, the risk of severe infectious complications limits their use in immunodeficient patients.
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Granulomatous Inflammation in cartilage-hair hypoplasia: Risks and benefits of anti–TNF-α mAbs
The Journal of allergy and clinical immunology, 2011Co-Authors: Despina Moshous, Isabelle Meyts, Sylvie Fraitag, Carl E.i. Janssen, Marianne Debré, Felipe Suarez, Jaan Toelen, K. De Boeck, Tania Roskams, Antoine DeschildreAbstract:Background Cartilage-hair hypoplasia (CHH) is a rare autosomal recessive disorder characterized by short-limbed skeletal dysplasia. Some patients also have defects in cell-mediated immunity and antibody production. Granulomatous Inflammation has been described in patients with various forms of primary immunodeficiencies but has not been reported in patients with CHH. Objective We sought to describe Granulomatous Inflammation as a novel feature in patients with CHH, assess associated immunodeficiency, and evaluate treatment options. Methods In a retrospective observational study we collected clinical data on 21 patients with CHH to identify and further characterize patients with Granulomatous Inflammation. Results Four unrelated patients with CHH (with variable degrees of combined immunodeficiency) had epithelioid cell Granulomatous Inflammation in the skin and visceral organs. Anti–TNF-α mAb therapy in 3 of these patients led to significant regression of granulomas. However, 1 treated patient had fatal progressive multifocal leukoencephalopathy caused by the JC polyomavirus. In 2 patients immune reconstitution after allogeneic hematopoietic stem cell transplantation led to the complete disappearance of granulomas. Conclusion To the best of our knowledge, this is the first report of Granulomatous Inflammation in patients with CHH. Although TNF-α antagonists can effectively suppress granulomas, the risk of severe infectious complications limits their use in immunodeficient patients.
Carlos A. Jimenez - One of the best experts on this subject based on the ideXlab platform.
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Mediastinal Granulomatous Inflammation and Overall Survival in Patients with a History of Malignancy
Annals of the American Thoracic Society, 2015Co-Authors: Horiana B. Grosu, David Ost, Rodolfo C. Morice, George A. Eapen, Juhee Song, Xiudong Lei, Donald R. Lazarus, Roberto F. Casal, Carlos A. JimenezAbstract:Rationale: Investigators have postulated that mediastinal Granulomatous Inflammation is associated with prolonged overall survival in patients with cancer.Objectives: We sought to determine whether mediastinal Granulomatous Inflammation affects overall survival in patients with a history of treated cancer.Methods: Patients with a history of treated cancer who underwent endobronchial ultrasound–transbronchial needle aspiration (EBUS-TBNA) for evaluation of mediastinal or hilar lymphadenopathy were grouped based on whether they had mediastinal Granulomatous Inflammation or benign mediastinal lymphadenopathy without granulomas. Overall survival from the date of EBUS-TBNA to cancer-related death or to last follow-up in patient groups was compared.Measurements and Main Results: We reviewed the records of 106 patients (44 with mediastinal Granulomatous Inflammation and 62 with benign mediastinal lymphadenopathy). The 3-year survival rate was 90% overall and 93 and 88% in patients with mediastinal Granulomatous ...
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clinical implications of Granulomatous Inflammation detected by endobronchial ultrasound transbronchial needle aspiration in patients with suspected cancer recurrence in the mediastinum
Journal of Cardiothoracic Surgery, 2008Co-Authors: Marcus P Kennedy, Rodolfo C. Morice, Carlos A. Jimenez, Ashwini D Mhatre, George A. EapenAbstract:Background Granulomatous Inflammation has been previously reported in association with cancer. Endobronchial ultrasound guided transbronchial needle aspiration (EBUS-TBNA) is a new minimally invasive test for investigating mediastinal lymphadenopathy. The identification of Granulomatous Inflammation by EBUS-TBNA and the clinical implications of such detection in a series of patients with previously treated cancer and new mediastinal lymphadenopathy has not previously been performed.
