The Experts below are selected from a list of 5943 Experts worldwide ranked by ideXlab platform
Glenn W Mccluggage - One of the best experts on this subject based on the ideXlab platform.
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juvenile Granulosa Cell Tumor arising in ovarian adenosarcoma an unusual form of sarcomatous overgrowth
Human Pathology, 2015Co-Authors: Claire Carleton, Oisin P Houghton, Glenn W MccluggageAbstract:Summary We report 2 ovarian neoplasms in women aged 58 and 69 years composed of an admixture of adenosarcoma and a predominant stromal component morphologically and immunohistochemically in keeping with juvenile Granulosa Cell Tumor. As far as we are aware, this association has not been reported previously. We speculate that, in both cases, the juvenile Granulosa Cell Tumor component arose from the adenosarcoma as an unusual form of sarcomatous overgrowth of sex cord elements.
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ovarian Cellular fibromas lack foxl2 mutations a useful diagnostic adjunct in the distinction from diffuse adult Granulosa Cell Tumor
The American Journal of Surgical Pathology, 2013Co-Authors: Glenn W Mccluggage, David G. Huntsman, Naveena Singh, Stefan Kommoss, Blake C GilksAbstract:Ovarian Cellular fibromas are uncommon neoplasms, which may result in considerable diagnostic confusion with diffuse adult Granulosa Cell Tumor. This is an important distinction, as the former usually exhibits benign behavior, whereas the latter is a low-grade malignant neoplasm capable of recurrence and metastasis. FOXL2 mutation (402C→G) has been demonstrated in >95% of ovarian adult Granulosa Cell Tumors, only rarely in other ovarian sex cord-stromal neoplasms, and never in ovarian fibromas. In this study, we evaluated a series of ovarian Cellular fibromas or mitotically active Cellular fibromas (n=22), 3 with minor sex cord elements, for FOXL2 mutation. These were mostly received in consultation, often with a differential diagnosis of diffuse adult Granulosa Cell Tumor. Immunohistochemically, 10 of 10 cases tested exhibited nuclear staining with FOXL2. FOXL2 (402C→G) mutation was not demonstrated in any of the 22 Cellular or mitotically active Cellular fibromas. Three additional neoplasms composed of Cellular nodules of epithelioid Cells in a background fibrous stroma, raising the possibility of adult Granulosa Cell Tumor with a prominent fibrothecomatous component, were also tested; 2 of these were mutation negative, and 1 contained a FOXL2 mutation. FOXL2 mutation analysis is a useful adjunct in distinguishing between diffuse adult Granulosa Cell Tumor (mutation present) and Cellular fibroma (mutation absent). Mutation testing should be considered in problematic cases, as this will provide prognostic information for the patient.
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combined adult Granulosa Cell Tumor and mucinous cystadenoma of the ovary Granulosa Cell Tumor with heterologous mucinous elements
International Journal of Gynecological Pathology, 2005Co-Authors: Michael J Mckenna, Brian Kenny, Gary Dorman, Glenn W MccluggageAbstract:Summary:We describe an unusual ovarian neoplasm in a 57-year-old woman composed of an admixture of mucinous cystadenoma and adult Granulosa Cell Tumor (AGCT). In areas the two components were separate but elsewhere there was intermingling of the two elements. The combination of mucinous cystadenoma
Toshiji Nishi - One of the best experts on this subject based on the ideXlab platform.
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Ovarian juvenile Granulosa Cell Tumor associated with Maffucci's syndrome.
American journal of clinical pathology, 1992Co-Authors: Yukichi Tanaka, Yoshiroh Sasaki, Hirokazu Nishihira, Toshiro Izawa, Toshiji NishiAbstract:A 15-year-old girl developed a juvenile Granulosa Cell Tumor associated with Maffucci’s syndrome (enchondromatosis + hemangiomas). Clinical manifestations of the disease included an abdominal mass and progressive anemia. She underwent the removal of a Stage Ic juvenile Granulosa Cell Tumor and subsequent adjuvant chemotherapy. On follow-up examination 4 years later, no recurrence of the ovarian Tumor was noted. A review of the literature showed 10 previous cases of juvenile Granulosa Cell Tumor associated with enchondromatosis, two associated with Maffucci’s syndrome, and the rest with Ollier’s disease (enchondromatosis). Ovarian juvenile Granulosa Cell Tumor may occur not infrequently in female patients with enchondromatosis in the first or second decades, in contrast to the widely recognized sarcomatous changes of enchondromas that usually occur after the second decade. Data provided from these cases also emphasize the concept of a generalized mesodermal dysplasia.
Hideko Tasaka - One of the best experts on this subject based on the ideXlab platform.
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Juvenile Granulosa Cell Tumor in association with a high serum inhibin level.
Gynecologic oncology, 1991Co-Authors: Makoto Nishida, Shoji Jimi, Masafumi Haji, Itsuro Hayashi, Takeshi Kai, Hideko TasakaAbstract:Inhibin is a glycoprotein hormone produced mainly by ovarian Granulosa Cells. Recently measurement of serum inhibin levels was made possible by radioimmunoassay. We describe a patient with a juvenile Granulosa Cell Tumor, a distinctive and rare form of Granulosa Cell Tumor. This patient's serum inhibin level was extremely high preoperatively and returned to normal after the Tumor was resected. This case suggests that serum inhibin level may be a useful marker of Granulosa Cell Tumors.
Yanan Zhang - One of the best experts on this subject based on the ideXlab platform.
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outcomes of fertility sparing surgery in ovarian juvenile Granulosa Cell Tumor
International Journal of Gynecological Cancer, 2019Co-Authors: Dan Zhao, Yan Song, Yanan ZhangAbstract:Objective To analyze the clinical characteristics, diagnosis, and treatment of ovarian juvenile Granulosa Cell Tumor. Methods The clinical and pathological data of six patients with ovarian juvenile Granulosa Cell Tumor was collected. Results The mean age of disease onset was 20.5 years (range 12 to 33). All six patients had an adnexal mass located laterally in the pelvis, and two developed ascites. All patients had fertility-sparing surgery with complete staging. The mean size of the Tumors was 15.3 cm (range 5 to 35). Ovarian sex cord stromal Tumors were diagnosed or highly suspected from the frozen sections for all patients. Five patients received three to six courses of postoperative adjuvant chemotherapy, with three receiving a bleomycin/etoposide/cisplatin regimen and two receiving a paclitaxel/carboplatin regimen. The five stage I patients had no recurrence with 52 to 155 months of follow-up. The patient with stage IIIB disease had a recurrence 55 months’ later and underwent reoperation and chemotherapy. This patient remained disease-free 30 months after the reoperation. Conclusions Fertility-sparing surgery is the treatment of choice for ovarian juvenile Granulosa Cell Tumor and the overall prognosis is good.
Yukichi Tanaka - One of the best experts on this subject based on the ideXlab platform.
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Ovarian juvenile Granulosa Cell Tumor associated with Maffucci's syndrome.
American journal of clinical pathology, 1992Co-Authors: Yukichi Tanaka, Yoshiroh Sasaki, Hirokazu Nishihira, Toshiro Izawa, Toshiji NishiAbstract:A 15-year-old girl developed a juvenile Granulosa Cell Tumor associated with Maffucci’s syndrome (enchondromatosis + hemangiomas). Clinical manifestations of the disease included an abdominal mass and progressive anemia. She underwent the removal of a Stage Ic juvenile Granulosa Cell Tumor and subsequent adjuvant chemotherapy. On follow-up examination 4 years later, no recurrence of the ovarian Tumor was noted. A review of the literature showed 10 previous cases of juvenile Granulosa Cell Tumor associated with enchondromatosis, two associated with Maffucci’s syndrome, and the rest with Ollier’s disease (enchondromatosis). Ovarian juvenile Granulosa Cell Tumor may occur not infrequently in female patients with enchondromatosis in the first or second decades, in contrast to the widely recognized sarcomatous changes of enchondromas that usually occur after the second decade. Data provided from these cases also emphasize the concept of a generalized mesodermal dysplasia.
