The Experts below are selected from a list of 75654 Experts worldwide ranked by ideXlab platform
K. I. Erickson - One of the best experts on this subject based on the ideXlab platform.
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physical activity fitness and Gray Matter volume
Neurobiology of Aging, 2014Co-Authors: K. I. Erickson, Regina L. Leckie, Andrea M. WeinsteinAbstract:Abstract In this review, we explore the association among physical activity, cardiorespiratory fitness, and exercise on Gray Matter volume in older adults. We conclude that higher cardiorespiratory fitness levels are routinely associated with greater Gray Matter volume in the prefrontal cortex and hippocampus and less consistently in other regions. We also conclude that physical activity is associated with greater Gray Matter volume in the same regions that are associated with cardiorespiratory fitness including the prefrontal cortex and hippocampus. Some heterogeneity in the literature may be explained by effect moderation by age, stress, or other factors. Finally, we report promising results from randomized exercise interventions that suggest that the volume of the hippocampus and prefrontal cortex remain pliable and responsive to moderate intensity exercise for 6 months–1 year. Physical activity appears to be a propitious method for influencing Gray Matter volume in late adulthood, but additional well-controlled studies are necessary to inform public policies about the potential protective or therapeutic effects of exercise on brain volume.
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Physical activity, fitness, and Gray Matter volume
Neurobiology of Aging, 2014Co-Authors: K. I. Erickson, Regina L. Leckie, Andrea M. WeinsteinAbstract:In this review, we explore the association among physical activity, cardiorespiratory fitness, and exercise on Gray Matter volume in older adults. We conclude that higher cardiorespiratory fitness levels are routinely associated with greater Gray Matter volume in the prefrontal cortex and hippocampus and less consistently in other regions. We also conclude that physical activity is associated with greater Gray Matter volume in the same regions that are associated with cardiorespiratory fitness including the prefrontal cortex and hippocampus. Some heterogeneity in the literature may be explained by effect moderation by age, stress, or other factors. Finally, we report promising results from randomized exercise interventions that suggest that the volume of the hippocampus and prefrontal cortex remain pliable and responsive to moderate intensity exercise for 6 months-1 year. Physical activity appears to be a propitious method for influencing Gray Matter volume in late adulthood, but additional well-controlled studies are necessary to inform public policies about the potential protective or therapeutic effects of exercise on brain volume. © 2014 Elsevier Inc.
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physical activity predicts Gray Matter volume in late adulthood the cardiovascular health study
Neurology, 2010Co-Authors: K. I. Erickson, Paul M. Thompson, Cyrus A Raji, Oscar L Lopez, James T Becker, Caterina Rosano, Anne B Newman, H M Gach, April J Ho, L H KullerAbstract:Objectives: Physical activity (PA) has been hypothesized to spare Gray Matter volume in late adulthood, but longitudinal data testing an association has been lacking. Here we tested whether PA would be associated with greater Gray Matter volume after a 9-year follow-up, a threshold could be identified for the amount of walking necessary to spare Gray Matter volume, and greater Gray Matter volume associated with PA would be associated with a reduced risk for cognitive impairment 13 years after the PA evaluation. Methods: In 299 adults (mean age 78 years) from the Cardiovascular Health Cognition Study, we examined the association between Gray Matter volume, PA, and cognitive impairment. Physical activity was quantified as the number of blocks walked over 1 week. High-resolution brain scans were acquired 9 years after the PA assessment on cognitively normal adults. White Matter hyperintensities, ventricular grade, and other health variables at baseline were used as covariates. Clinical adjudication for cognitive impairment occurred 13 years after baseline. Results: Walking amounts ranged from 0 to 300 blocks (mean 56.3; SD 69.7). Greater PA predicted greater volumes of frontal, occipital, entorhinal, and hippocampal regions 9 years later. Walking 72 blocks was necessary to detect increased Gray Matter volume but walking more than 72 blocks did not spare additional volume. Greater Gray Matter volume with PA reduced the risk for cognitive impairment 2-fold. Conclusion: Greater amounts of walking are associated with greater Gray Matter volume, which is in turn associated with a reduced risk of cognitive impairment.
Andrea M. Weinstein - One of the best experts on this subject based on the ideXlab platform.
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physical activity fitness and Gray Matter volume
Neurobiology of Aging, 2014Co-Authors: K. I. Erickson, Regina L. Leckie, Andrea M. WeinsteinAbstract:Abstract In this review, we explore the association among physical activity, cardiorespiratory fitness, and exercise on Gray Matter volume in older adults. We conclude that higher cardiorespiratory fitness levels are routinely associated with greater Gray Matter volume in the prefrontal cortex and hippocampus and less consistently in other regions. We also conclude that physical activity is associated with greater Gray Matter volume in the same regions that are associated with cardiorespiratory fitness including the prefrontal cortex and hippocampus. Some heterogeneity in the literature may be explained by effect moderation by age, stress, or other factors. Finally, we report promising results from randomized exercise interventions that suggest that the volume of the hippocampus and prefrontal cortex remain pliable and responsive to moderate intensity exercise for 6 months–1 year. Physical activity appears to be a propitious method for influencing Gray Matter volume in late adulthood, but additional well-controlled studies are necessary to inform public policies about the potential protective or therapeutic effects of exercise on brain volume.
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Physical activity, fitness, and Gray Matter volume
Neurobiology of Aging, 2014Co-Authors: K. I. Erickson, Regina L. Leckie, Andrea M. WeinsteinAbstract:In this review, we explore the association among physical activity, cardiorespiratory fitness, and exercise on Gray Matter volume in older adults. We conclude that higher cardiorespiratory fitness levels are routinely associated with greater Gray Matter volume in the prefrontal cortex and hippocampus and less consistently in other regions. We also conclude that physical activity is associated with greater Gray Matter volume in the same regions that are associated with cardiorespiratory fitness including the prefrontal cortex and hippocampus. Some heterogeneity in the literature may be explained by effect moderation by age, stress, or other factors. Finally, we report promising results from randomized exercise interventions that suggest that the volume of the hippocampus and prefrontal cortex remain pliable and responsive to moderate intensity exercise for 6 months-1 year. Physical activity appears to be a propitious method for influencing Gray Matter volume in late adulthood, but additional well-controlled studies are necessary to inform public policies about the potential protective or therapeutic effects of exercise on brain volume. © 2014 Elsevier Inc.
Regina L. Leckie - One of the best experts on this subject based on the ideXlab platform.
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physical activity fitness and Gray Matter volume
Neurobiology of Aging, 2014Co-Authors: K. I. Erickson, Regina L. Leckie, Andrea M. WeinsteinAbstract:Abstract In this review, we explore the association among physical activity, cardiorespiratory fitness, and exercise on Gray Matter volume in older adults. We conclude that higher cardiorespiratory fitness levels are routinely associated with greater Gray Matter volume in the prefrontal cortex and hippocampus and less consistently in other regions. We also conclude that physical activity is associated with greater Gray Matter volume in the same regions that are associated with cardiorespiratory fitness including the prefrontal cortex and hippocampus. Some heterogeneity in the literature may be explained by effect moderation by age, stress, or other factors. Finally, we report promising results from randomized exercise interventions that suggest that the volume of the hippocampus and prefrontal cortex remain pliable and responsive to moderate intensity exercise for 6 months–1 year. Physical activity appears to be a propitious method for influencing Gray Matter volume in late adulthood, but additional well-controlled studies are necessary to inform public policies about the potential protective or therapeutic effects of exercise on brain volume.
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Physical activity, fitness, and Gray Matter volume
Neurobiology of Aging, 2014Co-Authors: K. I. Erickson, Regina L. Leckie, Andrea M. WeinsteinAbstract:In this review, we explore the association among physical activity, cardiorespiratory fitness, and exercise on Gray Matter volume in older adults. We conclude that higher cardiorespiratory fitness levels are routinely associated with greater Gray Matter volume in the prefrontal cortex and hippocampus and less consistently in other regions. We also conclude that physical activity is associated with greater Gray Matter volume in the same regions that are associated with cardiorespiratory fitness including the prefrontal cortex and hippocampus. Some heterogeneity in the literature may be explained by effect moderation by age, stress, or other factors. Finally, we report promising results from randomized exercise interventions that suggest that the volume of the hippocampus and prefrontal cortex remain pliable and responsive to moderate intensity exercise for 6 months-1 year. Physical activity appears to be a propitious method for influencing Gray Matter volume in late adulthood, but additional well-controlled studies are necessary to inform public policies about the potential protective or therapeutic effects of exercise on brain volume. © 2014 Elsevier Inc.
Qiyong Gong - One of the best experts on this subject based on the ideXlab platform.
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Data on Gray Matter alterations in anxious depression
Data in Brief, 2019Co-Authors: Wei Peng, Xiaoqi Huang, Weihong Kuang, John A. Sweeney, Qiyong GongAbstract:Abstract This data article provided additional data related to the research article entitled “Brain structural abnormalities in emotional regulation and sensory processing regions associated with anxious depression” Peng et al.,2019. Correlation analyses were conducted for clinical information (HAMD total, anxiety/somatization scores, HAMA total and illness duration) and identified regional Gray Matter volumes in all patients with anxious depression and non-anxious depression. More detailed correlation analysis was applied for each item of anxiety factor and reginal Gray Matter volumes to find which items were more associated with structural alterations in patients. Data showed that mean values of regional Gray Matter volumes in left postcentral gyrus (PCG) were positively associated with HAMD total and anxiety factor scores in anxious depression group. More detailed correlation analysis considering each item of anxiety factor revealed that, item 10 (psychic anxiety) and Item15 (hypochondriasis) were most significantly and positively associated with regional Gray Matter volumes in left PCG in anxious group. While HAMA scores and illness duration showed no significant correlation with any regional Gray Matter volume in both patient groups. Sample size matched groups were selected to explore possible replicability of imaging results. It revealed that different Gray Matter volumes in right inferior frontal gyrus were most robust findings among three groups. And anxious group had larger Gray Matter volumes in left PCG than non-anxious depression, despite of not survived after multiple comparisons corrections.
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voxelwise meta analysis of Gray Matter reduction in major depressive disorder
Progress in Neuro-psychopharmacology & Biological Psychiatry, 2012Co-Authors: Mingying Du, Xiaoqi Huang, Weihong Kuang, Qizhu Wu, Jun Li, Yi Liao, Raymond C K Chan, Andrea Mechelli, Qiyong GongAbstract:Background: Voxel-based morphometry (VBM) has been widely used in studies of major depressive disorder (MDD) and has provided cumulative evidence of Gray Matter abnormalities in patients relative to controls. Thus we performed a meta-analysis to integrate the reported studies to determine the consistent Gray Matter alterations in MDD.
Christos Pantelis - One of the best experts on this subject based on the ideXlab platform.
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voxelwise meta analysis of Gray Matter abnormalities in bipolar disorder
Biological Psychiatry, 2010Co-Authors: Emre Bora, Alex Fornito, Murat Yucel, Christos PantelisAbstract:Background We conducted a meta-analysis of Gray Matter abnormalities in bipolar disorder (BD) using voxel-based morphometry studies to help clarify the structural abnormalities underpinning this condition. Methods A systematic review was conducted for voxel-based morphometry studies of patients with BD. Meta-analyses of Gray Matter differences between BD and control subjects were undertaken using “signed differential mapping,” a novel method that, in contrast to previously used techniques, allows inclusion of negative findings and ensures that single studies do not exert undue influence on the results. Meta-regression and subgroup analyses were used to examine the effect of moderator variables on Gray Matter abnormalities. Results A total of 21 studies comparing Gray Matter volumes of 660 BD patients and 770 healthy control subjects were included. Gray Matter reduction in left rostral anterior cingulate cortex (ACC) and right fronto-insular cortex was associated with BD. Fronto-insular cortex abnormality was not evident in early phases of the illness. In chronic patients, longer duration of illness was associated with increased Gray Matter in a cluster that included basal ganglia, subgenual ACC, and amygdala. Lithium treatment was associated with enlargement of ACC Gray Matter volumes, which overlapped with the region where Gray Matter was reduced in BD. Conclusions The most robust Gray Matter reductions in BD occur in anterior limbic regions, which may be related to the executive control and emotional processing abnormalities seen in this patient population. Clinical factors such as illness duration and lithium treatment also impact on case-control comparisons of Gray Matter volume.
