The Experts below are selected from a list of 21057 Experts worldwide ranked by ideXlab platform

Jaap N Hamburger - One of the best experts on this subject based on the ideXlab platform.

  • total occlusion trial with angioplasty by using laser Guidewire the total trial
    European Heart Journal, 2000
    Co-Authors: Patrick W Serruys, Jaap N Hamburger, Jacques J Koolen, Jean Fajadet, Michael Haude, H Klues, Ricardo Seabragomes, Thierry Corcos, Christian W Hamm, L Pizzuli
    Abstract:

    Aims A randomized trial was performed to assess the safety and efficacy of a laser Guidewire, in the treatment of chronic coronary occlusions. Methods and Results In 18 European centres, 303 patients with a chronic coronary occlusion were randomized to treatment with either the laser Guidewire (n=144) or conventional Guidewires (mechanical Guidewire, n=159). The primary end-point of the study was treatment success, defined as reaching the true lumen distal to the occlusion by the allocated wire within 30min of fluoroscopic time: laser Guidewire vs mechanical Guidewire; 52·8% (n=76) vs 47·2% (n=75), P =0·33. Serious adverse events following the initial Guidewire attempt were 0% (laser Guidewire) and 0·6% (mechanical Guidewire), respectively. Angioplasty (performed following successful Guidewire crossing) was successful in 179 patients (91%, laser Guidewire n=79, mechanical Guidewire n=100), followed by stent implantation in 149 (79%). At the 6-month angiographic follow-up, the difference in binary restenosis rate (laser Guidewire vs mechanical Guidewire; 45·5% vs 38·3 %, P =0·72) or reocclusion rate (25·8% vs 16·1%, P =0·15) did not reach statistical significance. At 1, 6 and 12 months, angina and event-free survival were 69%, 35% and 24% (laser Guidewire) vs 74%, 40% and 31% (mechanical Guidewire). Conclusion Although laser Guidewire technology was safe, the increase in crossing success did not reach statistical significance.

  • recanalization of total coronary occlusions using a laser Guidewire the european total surveillance study
    American Journal of Cardiology, 1997
    Co-Authors: Jaap N Hamburger, Patrick W Serruys, Jacques J Koolen, Rodrigo Scabragomes, R Simon, Eckhard Fleck, D Mathey, Horst Sievert, W Rutsch, A Buchwald
    Abstract:

    The success rates of coronary angioplasty for the treatment of chronic total occlusions are less favorable than for coronary stenosis. Therefore, a new laser Guidewire (LW) was designed to facilitate the crossing of chronic total occlusions. We report on the results of a European multicenter surveillance study, evaluating the laser Guidewire performance. Between May 1994 and July 1996, 345 patients (age 59 ± 10 years, 291 men) with chronic total occlusions were enrolled in 28 European centers. The median age of occlusion was 29 weeks (range 2 to 884), the occlusion length 19 ± 10 mm. LW recanalization was successful in 205 patients (59%). LW perforation occurred in 73 patients (21%), with hemodynamic consequences in 4 (1%). There were no deaths, emergency coronary artery bypass graft surgery, or Q-wave myocardial infarctions. In a multivariate regression analysis an occlusion age of <40 weeks (p = 0.001, RR = 1.34) and an occlusion length <30 mm (p = 0.01, RR = 1.59) were independent predictors of success. Results indicate that the LW is an effective and safe tool in the treatment of chronic total occlusion refractory to conventional Guidewires.

Patrick W Serruys - One of the best experts on this subject based on the ideXlab platform.

  • total occlusion trial with angioplasty by using laser Guidewire the total trial
    European Heart Journal, 2000
    Co-Authors: Patrick W Serruys, Jaap N Hamburger, Jacques J Koolen, Jean Fajadet, Michael Haude, H Klues, Ricardo Seabragomes, Thierry Corcos, Christian W Hamm, L Pizzuli
    Abstract:

    Aims A randomized trial was performed to assess the safety and efficacy of a laser Guidewire, in the treatment of chronic coronary occlusions. Methods and Results In 18 European centres, 303 patients with a chronic coronary occlusion were randomized to treatment with either the laser Guidewire (n=144) or conventional Guidewires (mechanical Guidewire, n=159). The primary end-point of the study was treatment success, defined as reaching the true lumen distal to the occlusion by the allocated wire within 30min of fluoroscopic time: laser Guidewire vs mechanical Guidewire; 52·8% (n=76) vs 47·2% (n=75), P =0·33. Serious adverse events following the initial Guidewire attempt were 0% (laser Guidewire) and 0·6% (mechanical Guidewire), respectively. Angioplasty (performed following successful Guidewire crossing) was successful in 179 patients (91%, laser Guidewire n=79, mechanical Guidewire n=100), followed by stent implantation in 149 (79%). At the 6-month angiographic follow-up, the difference in binary restenosis rate (laser Guidewire vs mechanical Guidewire; 45·5% vs 38·3 %, P =0·72) or reocclusion rate (25·8% vs 16·1%, P =0·15) did not reach statistical significance. At 1, 6 and 12 months, angina and event-free survival were 69%, 35% and 24% (laser Guidewire) vs 74%, 40% and 31% (mechanical Guidewire). Conclusion Although laser Guidewire technology was safe, the increase in crossing success did not reach statistical significance.

  • recanalization of total coronary occlusions using a laser Guidewire the european total surveillance study
    American Journal of Cardiology, 1997
    Co-Authors: Jaap N Hamburger, Patrick W Serruys, Jacques J Koolen, Rodrigo Scabragomes, R Simon, Eckhard Fleck, D Mathey, Horst Sievert, W Rutsch, A Buchwald
    Abstract:

    The success rates of coronary angioplasty for the treatment of chronic total occlusions are less favorable than for coronary stenosis. Therefore, a new laser Guidewire (LW) was designed to facilitate the crossing of chronic total occlusions. We report on the results of a European multicenter surveillance study, evaluating the laser Guidewire performance. Between May 1994 and July 1996, 345 patients (age 59 ± 10 years, 291 men) with chronic total occlusions were enrolled in 28 European centers. The median age of occlusion was 29 weeks (range 2 to 884), the occlusion length 19 ± 10 mm. LW recanalization was successful in 205 patients (59%). LW perforation occurred in 73 patients (21%), with hemodynamic consequences in 4 (1%). There were no deaths, emergency coronary artery bypass graft surgery, or Q-wave myocardial infarctions. In a multivariate regression analysis an occlusion age of <40 weeks (p = 0.001, RR = 1.34) and an occlusion length <30 mm (p = 0.01, RR = 1.59) were independent predictors of success. Results indicate that the LW is an effective and safe tool in the treatment of chronic total occlusion refractory to conventional Guidewires.

Jacques J Koolen - One of the best experts on this subject based on the ideXlab platform.

  • total occlusion trial with angioplasty by using laser Guidewire the total trial
    European Heart Journal, 2000
    Co-Authors: Patrick W Serruys, Jaap N Hamburger, Jacques J Koolen, Jean Fajadet, Michael Haude, H Klues, Ricardo Seabragomes, Thierry Corcos, Christian W Hamm, L Pizzuli
    Abstract:

    Aims A randomized trial was performed to assess the safety and efficacy of a laser Guidewire, in the treatment of chronic coronary occlusions. Methods and Results In 18 European centres, 303 patients with a chronic coronary occlusion were randomized to treatment with either the laser Guidewire (n=144) or conventional Guidewires (mechanical Guidewire, n=159). The primary end-point of the study was treatment success, defined as reaching the true lumen distal to the occlusion by the allocated wire within 30min of fluoroscopic time: laser Guidewire vs mechanical Guidewire; 52·8% (n=76) vs 47·2% (n=75), P =0·33. Serious adverse events following the initial Guidewire attempt were 0% (laser Guidewire) and 0·6% (mechanical Guidewire), respectively. Angioplasty (performed following successful Guidewire crossing) was successful in 179 patients (91%, laser Guidewire n=79, mechanical Guidewire n=100), followed by stent implantation in 149 (79%). At the 6-month angiographic follow-up, the difference in binary restenosis rate (laser Guidewire vs mechanical Guidewire; 45·5% vs 38·3 %, P =0·72) or reocclusion rate (25·8% vs 16·1%, P =0·15) did not reach statistical significance. At 1, 6 and 12 months, angina and event-free survival were 69%, 35% and 24% (laser Guidewire) vs 74%, 40% and 31% (mechanical Guidewire). Conclusion Although laser Guidewire technology was safe, the increase in crossing success did not reach statistical significance.

  • recanalization of total coronary occlusions using a laser Guidewire the european total surveillance study
    American Journal of Cardiology, 1997
    Co-Authors: Jaap N Hamburger, Patrick W Serruys, Jacques J Koolen, Rodrigo Scabragomes, R Simon, Eckhard Fleck, D Mathey, Horst Sievert, W Rutsch, A Buchwald
    Abstract:

    The success rates of coronary angioplasty for the treatment of chronic total occlusions are less favorable than for coronary stenosis. Therefore, a new laser Guidewire (LW) was designed to facilitate the crossing of chronic total occlusions. We report on the results of a European multicenter surveillance study, evaluating the laser Guidewire performance. Between May 1994 and July 1996, 345 patients (age 59 ± 10 years, 291 men) with chronic total occlusions were enrolled in 28 European centers. The median age of occlusion was 29 weeks (range 2 to 884), the occlusion length 19 ± 10 mm. LW recanalization was successful in 205 patients (59%). LW perforation occurred in 73 patients (21%), with hemodynamic consequences in 4 (1%). There were no deaths, emergency coronary artery bypass graft surgery, or Q-wave myocardial infarctions. In a multivariate regression analysis an occlusion age of <40 weeks (p = 0.001, RR = 1.34) and an occlusion length <30 mm (p = 0.01, RR = 1.59) were independent predictors of success. Results indicate that the LW is an effective and safe tool in the treatment of chronic total occlusion refractory to conventional Guidewires.

A Buchwald - One of the best experts on this subject based on the ideXlab platform.

  • recanalization of total coronary occlusions using a laser Guidewire the european total surveillance study
    American Journal of Cardiology, 1997
    Co-Authors: Jaap N Hamburger, Patrick W Serruys, Jacques J Koolen, Rodrigo Scabragomes, R Simon, Eckhard Fleck, D Mathey, Horst Sievert, W Rutsch, A Buchwald
    Abstract:

    The success rates of coronary angioplasty for the treatment of chronic total occlusions are less favorable than for coronary stenosis. Therefore, a new laser Guidewire (LW) was designed to facilitate the crossing of chronic total occlusions. We report on the results of a European multicenter surveillance study, evaluating the laser Guidewire performance. Between May 1994 and July 1996, 345 patients (age 59 ± 10 years, 291 men) with chronic total occlusions were enrolled in 28 European centers. The median age of occlusion was 29 weeks (range 2 to 884), the occlusion length 19 ± 10 mm. LW recanalization was successful in 205 patients (59%). LW perforation occurred in 73 patients (21%), with hemodynamic consequences in 4 (1%). There were no deaths, emergency coronary artery bypass graft surgery, or Q-wave myocardial infarctions. In a multivariate regression analysis an occlusion age of <40 weeks (p = 0.001, RR = 1.34) and an occlusion length <30 mm (p = 0.01, RR = 1.59) were independent predictors of success. Results indicate that the LW is an effective and safe tool in the treatment of chronic total occlusion refractory to conventional Guidewires.

L Pizzuli - One of the best experts on this subject based on the ideXlab platform.

  • total occlusion trial with angioplasty by using laser Guidewire the total trial
    European Heart Journal, 2000
    Co-Authors: Patrick W Serruys, Jaap N Hamburger, Jacques J Koolen, Jean Fajadet, Michael Haude, H Klues, Ricardo Seabragomes, Thierry Corcos, Christian W Hamm, L Pizzuli
    Abstract:

    Aims A randomized trial was performed to assess the safety and efficacy of a laser Guidewire, in the treatment of chronic coronary occlusions. Methods and Results In 18 European centres, 303 patients with a chronic coronary occlusion were randomized to treatment with either the laser Guidewire (n=144) or conventional Guidewires (mechanical Guidewire, n=159). The primary end-point of the study was treatment success, defined as reaching the true lumen distal to the occlusion by the allocated wire within 30min of fluoroscopic time: laser Guidewire vs mechanical Guidewire; 52·8% (n=76) vs 47·2% (n=75), P =0·33. Serious adverse events following the initial Guidewire attempt were 0% (laser Guidewire) and 0·6% (mechanical Guidewire), respectively. Angioplasty (performed following successful Guidewire crossing) was successful in 179 patients (91%, laser Guidewire n=79, mechanical Guidewire n=100), followed by stent implantation in 149 (79%). At the 6-month angiographic follow-up, the difference in binary restenosis rate (laser Guidewire vs mechanical Guidewire; 45·5% vs 38·3 %, P =0·72) or reocclusion rate (25·8% vs 16·1%, P =0·15) did not reach statistical significance. At 1, 6 and 12 months, angina and event-free survival were 69%, 35% and 24% (laser Guidewire) vs 74%, 40% and 31% (mechanical Guidewire). Conclusion Although laser Guidewire technology was safe, the increase in crossing success did not reach statistical significance.