The Experts below are selected from a list of 1053 Experts worldwide ranked by ideXlab platform
Yonghui Zhang - One of the best experts on this subject based on the ideXlab platform.
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mangiterpenes a c and 2 3 seco manginoid c four sesquiterpene monoterpene shikimate conjugated spirocyclic meroterpenoids from Guignardia mangiferae
Phytochemistry, 2019Co-Authors: Keliang Chen, Jing Yang, Chunmei Chen, Jianping Wang, Yonghui ZhangAbstract:Abstract Mangiterpenes A–C and 2′,3′-seco-manginoid C, four undescribed sesquiterpene/monoterpene–shikimate–conjugated meroterpenoids with spiro ring systems, were isolated from Guignardia mangiferae. The structures and absolute configurations of these compounds were established by comprehensive spectroscopic analyses and electronic circular dichroism (ECD) calculations. Mangiterpenes A–C represent the first examples of sesquiterpene–shikimate-conjugated spirocyclic meroterpenoids, and 2′,3′-seco-manginoid C features an unexpected 2′,3′-seco-manginoids skeleton. Mangiterpene C strongly inhibited the production of NO inducted by LPS, with an IC50 value of 5.97 μM. It showed an anti-inflammatory effect by means of blocking in the NF-κB signaling pathway and decreasing the expression of inflammatory mediators.
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manginoids a g seven monoterpene shikimate conjugated meroterpenoids with a spiro ring system from Guignardia mangiferae
Organic Letters, 2017Co-Authors: Keliang Chen, Xuwen Zhang, Jing Yang, Chunmei Chen, Jianping Wang, Hua Li, Yonghui ZhangAbstract:Manginoids A–G (1–7), seven monoterpene–shikimate-conjugated meroterpenoids with a spiro ring system, were isolated from Guignardia mangiferae. Compounds 1–4 are four isomers with epimeric and double-bond isomeric features possessing a 6-oxaspiro[bicyclo[3.2.1]octane-3,5′-indene] ring, which represent the first examples of spiro meroterpenoids bearing a bridged spirocyclohexanedione moiety. Compounds 5 and 6 possess an unexpected 2,4-dioxatricyclo[3.3.1.03,7]nonane motif, which fuses with a 6-oxabicyclo[3.2.1]octane moiety. Compound 1 exhibits inhibitory activities against 11β-hydroxysteroid dehydrogenase type 1 with an IC50 value of 0.84 μM.
Keliang Chen - One of the best experts on this subject based on the ideXlab platform.
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mangiterpenes a c and 2 3 seco manginoid c four sesquiterpene monoterpene shikimate conjugated spirocyclic meroterpenoids from Guignardia mangiferae
Phytochemistry, 2019Co-Authors: Keliang Chen, Jing Yang, Chunmei Chen, Jianping Wang, Yonghui ZhangAbstract:Abstract Mangiterpenes A–C and 2′,3′-seco-manginoid C, four undescribed sesquiterpene/monoterpene–shikimate–conjugated meroterpenoids with spiro ring systems, were isolated from Guignardia mangiferae. The structures and absolute configurations of these compounds were established by comprehensive spectroscopic analyses and electronic circular dichroism (ECD) calculations. Mangiterpenes A–C represent the first examples of sesquiterpene–shikimate-conjugated spirocyclic meroterpenoids, and 2′,3′-seco-manginoid C features an unexpected 2′,3′-seco-manginoids skeleton. Mangiterpene C strongly inhibited the production of NO inducted by LPS, with an IC50 value of 5.97 μM. It showed an anti-inflammatory effect by means of blocking in the NF-κB signaling pathway and decreasing the expression of inflammatory mediators.
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Mangiterpenes A-C and 2',3'-seco-manginoid C, four sesquiterpene/monoterpene-shikimate-conjugated spirocyclic meroterpenoids from Guignardia mangiferae.
Phytochemistry, 2019Co-Authors: Keliang Chen, Jing Yang, Chunmei Chen, Jianping WangAbstract:Abstract Mangiterpenes A–C and 2′,3′-seco-manginoid C, four undescribed sesquiterpene/monoterpene–shikimate–conjugated meroterpenoids with spiro ring systems, were isolated from Guignardia mangiferae. The structures and absolute configurations of these compounds were established by comprehensive spectroscopic analyses and electronic circular dichroism (ECD) calculations. Mangiterpenes A–C represent the first examples of sesquiterpene–shikimate-conjugated spirocyclic meroterpenoids, and 2′,3′-seco-manginoid C features an unexpected 2′,3′-seco-manginoids skeleton. Mangiterpene C strongly inhibited the production of NO inducted by LPS, with an IC50 value of 5.97 μM. It showed an anti-inflammatory effect by means of blocking in the NF-κB signaling pathway and decreasing the expression of inflammatory mediators.
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manginoids a g seven monoterpene shikimate conjugated meroterpenoids with a spiro ring system from Guignardia mangiferae
Organic Letters, 2017Co-Authors: Keliang Chen, Xuwen Zhang, Jing Yang, Chunmei Chen, Jianping Wang, Hua Li, Yonghui ZhangAbstract:Manginoids A–G (1–7), seven monoterpene–shikimate-conjugated meroterpenoids with a spiro ring system, were isolated from Guignardia mangiferae. Compounds 1–4 are four isomers with epimeric and double-bond isomeric features possessing a 6-oxaspiro[bicyclo[3.2.1]octane-3,5′-indene] ring, which represent the first examples of spiro meroterpenoids bearing a bridged spirocyclohexanedione moiety. Compounds 5 and 6 possess an unexpected 2,4-dioxatricyclo[3.3.1.03,7]nonane motif, which fuses with a 6-oxabicyclo[3.2.1]octane moiety. Compound 1 exhibits inhibitory activities against 11β-hydroxysteroid dehydrogenase type 1 with an IC50 value of 0.84 μM.
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Manginoids A–G: Seven Monoterpene–Shikimate-Conjugated Meroterpenoids with a Spiro Ring System from Guignardia mangiferae
Organic Letters, 2017Co-Authors: Keliang Chen, Xuwen Zhang, Jing Yang, Chunmei Chen, Jianping Wang, Hua LiAbstract:Manginoids A–G (1–7), seven monoterpene–shikimate-conjugated meroterpenoids with a spiro ring system, were isolated from Guignardia mangiferae. Compounds 1–4 are four isomers with epimeric and double-bond isomeric features possessing a 6-oxaspiro[bicyclo[3.2.1]octane-3,5′-indene] ring, which represent the first examples of spiro meroterpenoids bearing a bridged spirocyclohexanedione moiety. Compounds 5 and 6 possess an unexpected 2,4-dioxatricyclo[3.3.1.03,7]nonane motif, which fuses with a 6-oxabicyclo[3.2.1]octane moiety. Compound 1 exhibits inhibitory activities against 11β-hydroxysteroid dehydrogenase type 1 with an IC50 value of 0.84 μM.
Jianping Wang - One of the best experts on this subject based on the ideXlab platform.
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mangiterpenes a c and 2 3 seco manginoid c four sesquiterpene monoterpene shikimate conjugated spirocyclic meroterpenoids from Guignardia mangiferae
Phytochemistry, 2019Co-Authors: Keliang Chen, Jing Yang, Chunmei Chen, Jianping Wang, Yonghui ZhangAbstract:Abstract Mangiterpenes A–C and 2′,3′-seco-manginoid C, four undescribed sesquiterpene/monoterpene–shikimate–conjugated meroterpenoids with spiro ring systems, were isolated from Guignardia mangiferae. The structures and absolute configurations of these compounds were established by comprehensive spectroscopic analyses and electronic circular dichroism (ECD) calculations. Mangiterpenes A–C represent the first examples of sesquiterpene–shikimate-conjugated spirocyclic meroterpenoids, and 2′,3′-seco-manginoid C features an unexpected 2′,3′-seco-manginoids skeleton. Mangiterpene C strongly inhibited the production of NO inducted by LPS, with an IC50 value of 5.97 μM. It showed an anti-inflammatory effect by means of blocking in the NF-κB signaling pathway and decreasing the expression of inflammatory mediators.
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Mangiterpenes A-C and 2',3'-seco-manginoid C, four sesquiterpene/monoterpene-shikimate-conjugated spirocyclic meroterpenoids from Guignardia mangiferae.
Phytochemistry, 2019Co-Authors: Keliang Chen, Jing Yang, Chunmei Chen, Jianping WangAbstract:Abstract Mangiterpenes A–C and 2′,3′-seco-manginoid C, four undescribed sesquiterpene/monoterpene–shikimate–conjugated meroterpenoids with spiro ring systems, were isolated from Guignardia mangiferae. The structures and absolute configurations of these compounds were established by comprehensive spectroscopic analyses and electronic circular dichroism (ECD) calculations. Mangiterpenes A–C represent the first examples of sesquiterpene–shikimate-conjugated spirocyclic meroterpenoids, and 2′,3′-seco-manginoid C features an unexpected 2′,3′-seco-manginoids skeleton. Mangiterpene C strongly inhibited the production of NO inducted by LPS, with an IC50 value of 5.97 μM. It showed an anti-inflammatory effect by means of blocking in the NF-κB signaling pathway and decreasing the expression of inflammatory mediators.
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manginoids a g seven monoterpene shikimate conjugated meroterpenoids with a spiro ring system from Guignardia mangiferae
Organic Letters, 2017Co-Authors: Keliang Chen, Xuwen Zhang, Jing Yang, Chunmei Chen, Jianping Wang, Hua Li, Yonghui ZhangAbstract:Manginoids A–G (1–7), seven monoterpene–shikimate-conjugated meroterpenoids with a spiro ring system, were isolated from Guignardia mangiferae. Compounds 1–4 are four isomers with epimeric and double-bond isomeric features possessing a 6-oxaspiro[bicyclo[3.2.1]octane-3,5′-indene] ring, which represent the first examples of spiro meroterpenoids bearing a bridged spirocyclohexanedione moiety. Compounds 5 and 6 possess an unexpected 2,4-dioxatricyclo[3.3.1.03,7]nonane motif, which fuses with a 6-oxabicyclo[3.2.1]octane moiety. Compound 1 exhibits inhibitory activities against 11β-hydroxysteroid dehydrogenase type 1 with an IC50 value of 0.84 μM.
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Manginoids A–G: Seven Monoterpene–Shikimate-Conjugated Meroterpenoids with a Spiro Ring System from Guignardia mangiferae
Organic Letters, 2017Co-Authors: Keliang Chen, Xuwen Zhang, Jing Yang, Chunmei Chen, Jianping Wang, Hua LiAbstract:Manginoids A–G (1–7), seven monoterpene–shikimate-conjugated meroterpenoids with a spiro ring system, were isolated from Guignardia mangiferae. Compounds 1–4 are four isomers with epimeric and double-bond isomeric features possessing a 6-oxaspiro[bicyclo[3.2.1]octane-3,5′-indene] ring, which represent the first examples of spiro meroterpenoids bearing a bridged spirocyclohexanedione moiety. Compounds 5 and 6 possess an unexpected 2,4-dioxatricyclo[3.3.1.03,7]nonane motif, which fuses with a 6-oxabicyclo[3.2.1]octane moiety. Compound 1 exhibits inhibitory activities against 11β-hydroxysteroid dehydrogenase type 1 with an IC50 value of 0.84 μM.
Chunmei Chen - One of the best experts on this subject based on the ideXlab platform.
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mangiterpenes a c and 2 3 seco manginoid c four sesquiterpene monoterpene shikimate conjugated spirocyclic meroterpenoids from Guignardia mangiferae
Phytochemistry, 2019Co-Authors: Keliang Chen, Jing Yang, Chunmei Chen, Jianping Wang, Yonghui ZhangAbstract:Abstract Mangiterpenes A–C and 2′,3′-seco-manginoid C, four undescribed sesquiterpene/monoterpene–shikimate–conjugated meroterpenoids with spiro ring systems, were isolated from Guignardia mangiferae. The structures and absolute configurations of these compounds were established by comprehensive spectroscopic analyses and electronic circular dichroism (ECD) calculations. Mangiterpenes A–C represent the first examples of sesquiterpene–shikimate-conjugated spirocyclic meroterpenoids, and 2′,3′-seco-manginoid C features an unexpected 2′,3′-seco-manginoids skeleton. Mangiterpene C strongly inhibited the production of NO inducted by LPS, with an IC50 value of 5.97 μM. It showed an anti-inflammatory effect by means of blocking in the NF-κB signaling pathway and decreasing the expression of inflammatory mediators.
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Mangiterpenes A-C and 2',3'-seco-manginoid C, four sesquiterpene/monoterpene-shikimate-conjugated spirocyclic meroterpenoids from Guignardia mangiferae.
Phytochemistry, 2019Co-Authors: Keliang Chen, Jing Yang, Chunmei Chen, Jianping WangAbstract:Abstract Mangiterpenes A–C and 2′,3′-seco-manginoid C, four undescribed sesquiterpene/monoterpene–shikimate–conjugated meroterpenoids with spiro ring systems, were isolated from Guignardia mangiferae. The structures and absolute configurations of these compounds were established by comprehensive spectroscopic analyses and electronic circular dichroism (ECD) calculations. Mangiterpenes A–C represent the first examples of sesquiterpene–shikimate-conjugated spirocyclic meroterpenoids, and 2′,3′-seco-manginoid C features an unexpected 2′,3′-seco-manginoids skeleton. Mangiterpene C strongly inhibited the production of NO inducted by LPS, with an IC50 value of 5.97 μM. It showed an anti-inflammatory effect by means of blocking in the NF-κB signaling pathway and decreasing the expression of inflammatory mediators.
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manginoids a g seven monoterpene shikimate conjugated meroterpenoids with a spiro ring system from Guignardia mangiferae
Organic Letters, 2017Co-Authors: Keliang Chen, Xuwen Zhang, Jing Yang, Chunmei Chen, Jianping Wang, Hua Li, Yonghui ZhangAbstract:Manginoids A–G (1–7), seven monoterpene–shikimate-conjugated meroterpenoids with a spiro ring system, were isolated from Guignardia mangiferae. Compounds 1–4 are four isomers with epimeric and double-bond isomeric features possessing a 6-oxaspiro[bicyclo[3.2.1]octane-3,5′-indene] ring, which represent the first examples of spiro meroterpenoids bearing a bridged spirocyclohexanedione moiety. Compounds 5 and 6 possess an unexpected 2,4-dioxatricyclo[3.3.1.03,7]nonane motif, which fuses with a 6-oxabicyclo[3.2.1]octane moiety. Compound 1 exhibits inhibitory activities against 11β-hydroxysteroid dehydrogenase type 1 with an IC50 value of 0.84 μM.
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Manginoids A–G: Seven Monoterpene–Shikimate-Conjugated Meroterpenoids with a Spiro Ring System from Guignardia mangiferae
Organic Letters, 2017Co-Authors: Keliang Chen, Xuwen Zhang, Jing Yang, Chunmei Chen, Jianping Wang, Hua LiAbstract:Manginoids A–G (1–7), seven monoterpene–shikimate-conjugated meroterpenoids with a spiro ring system, were isolated from Guignardia mangiferae. Compounds 1–4 are four isomers with epimeric and double-bond isomeric features possessing a 6-oxaspiro[bicyclo[3.2.1]octane-3,5′-indene] ring, which represent the first examples of spiro meroterpenoids bearing a bridged spirocyclohexanedione moiety. Compounds 5 and 6 possess an unexpected 2,4-dioxatricyclo[3.3.1.03,7]nonane motif, which fuses with a 6-oxabicyclo[3.2.1]octane moiety. Compound 1 exhibits inhibitory activities against 11β-hydroxysteroid dehydrogenase type 1 with an IC50 value of 0.84 μM.
Jing Yang - One of the best experts on this subject based on the ideXlab platform.
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mangiterpenes a c and 2 3 seco manginoid c four sesquiterpene monoterpene shikimate conjugated spirocyclic meroterpenoids from Guignardia mangiferae
Phytochemistry, 2019Co-Authors: Keliang Chen, Jing Yang, Chunmei Chen, Jianping Wang, Yonghui ZhangAbstract:Abstract Mangiterpenes A–C and 2′,3′-seco-manginoid C, four undescribed sesquiterpene/monoterpene–shikimate–conjugated meroterpenoids with spiro ring systems, were isolated from Guignardia mangiferae. The structures and absolute configurations of these compounds were established by comprehensive spectroscopic analyses and electronic circular dichroism (ECD) calculations. Mangiterpenes A–C represent the first examples of sesquiterpene–shikimate-conjugated spirocyclic meroterpenoids, and 2′,3′-seco-manginoid C features an unexpected 2′,3′-seco-manginoids skeleton. Mangiterpene C strongly inhibited the production of NO inducted by LPS, with an IC50 value of 5.97 μM. It showed an anti-inflammatory effect by means of blocking in the NF-κB signaling pathway and decreasing the expression of inflammatory mediators.
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Mangiterpenes A-C and 2',3'-seco-manginoid C, four sesquiterpene/monoterpene-shikimate-conjugated spirocyclic meroterpenoids from Guignardia mangiferae.
Phytochemistry, 2019Co-Authors: Keliang Chen, Jing Yang, Chunmei Chen, Jianping WangAbstract:Abstract Mangiterpenes A–C and 2′,3′-seco-manginoid C, four undescribed sesquiterpene/monoterpene–shikimate–conjugated meroterpenoids with spiro ring systems, were isolated from Guignardia mangiferae. The structures and absolute configurations of these compounds were established by comprehensive spectroscopic analyses and electronic circular dichroism (ECD) calculations. Mangiterpenes A–C represent the first examples of sesquiterpene–shikimate-conjugated spirocyclic meroterpenoids, and 2′,3′-seco-manginoid C features an unexpected 2′,3′-seco-manginoids skeleton. Mangiterpene C strongly inhibited the production of NO inducted by LPS, with an IC50 value of 5.97 μM. It showed an anti-inflammatory effect by means of blocking in the NF-κB signaling pathway and decreasing the expression of inflammatory mediators.
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manginoids a g seven monoterpene shikimate conjugated meroterpenoids with a spiro ring system from Guignardia mangiferae
Organic Letters, 2017Co-Authors: Keliang Chen, Xuwen Zhang, Jing Yang, Chunmei Chen, Jianping Wang, Hua Li, Yonghui ZhangAbstract:Manginoids A–G (1–7), seven monoterpene–shikimate-conjugated meroterpenoids with a spiro ring system, were isolated from Guignardia mangiferae. Compounds 1–4 are four isomers with epimeric and double-bond isomeric features possessing a 6-oxaspiro[bicyclo[3.2.1]octane-3,5′-indene] ring, which represent the first examples of spiro meroterpenoids bearing a bridged spirocyclohexanedione moiety. Compounds 5 and 6 possess an unexpected 2,4-dioxatricyclo[3.3.1.03,7]nonane motif, which fuses with a 6-oxabicyclo[3.2.1]octane moiety. Compound 1 exhibits inhibitory activities against 11β-hydroxysteroid dehydrogenase type 1 with an IC50 value of 0.84 μM.
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Manginoids A–G: Seven Monoterpene–Shikimate-Conjugated Meroterpenoids with a Spiro Ring System from Guignardia mangiferae
Organic Letters, 2017Co-Authors: Keliang Chen, Xuwen Zhang, Jing Yang, Chunmei Chen, Jianping Wang, Hua LiAbstract:Manginoids A–G (1–7), seven monoterpene–shikimate-conjugated meroterpenoids with a spiro ring system, were isolated from Guignardia mangiferae. Compounds 1–4 are four isomers with epimeric and double-bond isomeric features possessing a 6-oxaspiro[bicyclo[3.2.1]octane-3,5′-indene] ring, which represent the first examples of spiro meroterpenoids bearing a bridged spirocyclohexanedione moiety. Compounds 5 and 6 possess an unexpected 2,4-dioxatricyclo[3.3.1.03,7]nonane motif, which fuses with a 6-oxabicyclo[3.2.1]octane moiety. Compound 1 exhibits inhibitory activities against 11β-hydroxysteroid dehydrogenase type 1 with an IC50 value of 0.84 μM.