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Matthew D Barber - One of the best experts on this subject based on the ideXlab platform.

  • Risk of unanticipated abnormal Gynecologic Pathology at the time of hysterectomy for uterovaginal prolapse.
    American journal of obstetrics and gynecology, 2020
    Co-Authors: Anna C Frick, Mark D Walters, Kathleen S Larkin, Matthew D Barber
    Abstract:

    The aim of this study was to assess the risk of unanticipated abnormal Gynecologic Pathology at the time of reconstructive pelvic surgery to better understand risks of uterine conservation in the surgical treatment of uterovaginal prolapse. This was a retrospective analysis of Pathology findings at hysterectomy with reconstructive pelvic surgery over a 3.5-year period. Seventeen of 644 patients had unanticipated premalignant or malignant uterine Pathology (2.6%; 95% confidence interval, 1.7-4.2). Two (0.3%; 95% confidence interval, 0.09-1.1) had endometrial carcinoma. All cases of unanticipated disease were identified in postmenopausal women. Premenopausal women with uterovaginal prolapse and normal bleeding patterns or with negative evaluation for abnormal uterine bleeding have a minimal risk of abnormal Gynecologic Pathology. In postmenopausal women without bleeding, the risk of unanticipated uterine Pathology is 2.6% but may be reduced by preoperative endometrial evaluation. However, in women with a history of postmenopausal bleeding, even with a negative endometrial evaluation, we do not recommend uterine preservation at the time of prolapse surgery. Copyright (c) 2010 Mosby, Inc. All rights reserved.

  • risk of unanticipated abnormal Gynecologic Pathology at the time of hysterectomy for uterovaginal prolapse
    American Journal of Obstetrics and Gynecology, 2010
    Co-Authors: Anna C Frick, Mark D Walters, Kathleen S Larkin, Matthew D Barber
    Abstract:

    Objective The aim of this study was to assess the risk of unanticipated abnormal Gynecologic Pathology at the time of reconstructive pelvic surgery to better understand risks of uterine conservation in the surgical treatment of uterovaginal prolapse. Study Design This was a retrospective analysis of Pathology findings at hysterectomy with reconstructive pelvic surgery over a 3.5-year period. Results Seventeen of 644 patients had unanticipated premalignant or malignant uterine Pathology (2.6%; 95% confidence interval, 1.7–4.2). Two (0.3%; 95% confidence interval, 0.09–1.1) had endometrial carcinoma. All cases of unanticipated disease were identified in postmenopausal women. Conclusion Premenopausal women with uterovaginal prolapse and normal bleeding patterns or with negative evaluation for abnormal uterine bleeding have a minimal risk of abnormal Gynecologic Pathology. In postmenopausal women without bleeding, the risk of unanticipated uterine Pathology is 2.6% but may be reduced by preoperative endometrial evaluation. However, in women with a history of postmenopausal bleeding, even with a negative endometrial evaluation, we do not recommend uterine preservation at the time of prolapse surgery.

Ibrahim Ramzy - One of the best experts on this subject based on the ideXlab platform.

Anna C Frick - One of the best experts on this subject based on the ideXlab platform.

  • Risk of unanticipated abnormal Gynecologic Pathology at the time of hysterectomy for uterovaginal prolapse.
    American journal of obstetrics and gynecology, 2020
    Co-Authors: Anna C Frick, Mark D Walters, Kathleen S Larkin, Matthew D Barber
    Abstract:

    The aim of this study was to assess the risk of unanticipated abnormal Gynecologic Pathology at the time of reconstructive pelvic surgery to better understand risks of uterine conservation in the surgical treatment of uterovaginal prolapse. This was a retrospective analysis of Pathology findings at hysterectomy with reconstructive pelvic surgery over a 3.5-year period. Seventeen of 644 patients had unanticipated premalignant or malignant uterine Pathology (2.6%; 95% confidence interval, 1.7-4.2). Two (0.3%; 95% confidence interval, 0.09-1.1) had endometrial carcinoma. All cases of unanticipated disease were identified in postmenopausal women. Premenopausal women with uterovaginal prolapse and normal bleeding patterns or with negative evaluation for abnormal uterine bleeding have a minimal risk of abnormal Gynecologic Pathology. In postmenopausal women without bleeding, the risk of unanticipated uterine Pathology is 2.6% but may be reduced by preoperative endometrial evaluation. However, in women with a history of postmenopausal bleeding, even with a negative endometrial evaluation, we do not recommend uterine preservation at the time of prolapse surgery. Copyright (c) 2010 Mosby, Inc. All rights reserved.

  • risk of unanticipated abnormal Gynecologic Pathology at the time of hysterectomy for uterovaginal prolapse
    American Journal of Obstetrics and Gynecology, 2010
    Co-Authors: Anna C Frick, Mark D Walters, Kathleen S Larkin, Matthew D Barber
    Abstract:

    Objective The aim of this study was to assess the risk of unanticipated abnormal Gynecologic Pathology at the time of reconstructive pelvic surgery to better understand risks of uterine conservation in the surgical treatment of uterovaginal prolapse. Study Design This was a retrospective analysis of Pathology findings at hysterectomy with reconstructive pelvic surgery over a 3.5-year period. Results Seventeen of 644 patients had unanticipated premalignant or malignant uterine Pathology (2.6%; 95% confidence interval, 1.7–4.2). Two (0.3%; 95% confidence interval, 0.09–1.1) had endometrial carcinoma. All cases of unanticipated disease were identified in postmenopausal women. Conclusion Premenopausal women with uterovaginal prolapse and normal bleeding patterns or with negative evaluation for abnormal uterine bleeding have a minimal risk of abnormal Gynecologic Pathology. In postmenopausal women without bleeding, the risk of unanticipated uterine Pathology is 2.6% but may be reduced by preoperative endometrial evaluation. However, in women with a history of postmenopausal bleeding, even with a negative endometrial evaluation, we do not recommend uterine preservation at the time of prolapse surgery.

Robert Soslow - One of the best experts on this subject based on the ideXlab platform.

W G Mccluggage - One of the best experts on this subject based on the ideXlab platform.

  • application of immunohistochemistry to Gynecologic Pathology
    Archives of Pathology & Laboratory Medicine, 2009
    Co-Authors: Khush Mittal, Robert A Soslow, W G Mccluggage
    Abstract:

    CONTEXT: A large variety of tumors and lesions arise in the female genital tract. Although the majority of these can be correctly recognized on routine hematoxylin-eosin-stained slides, occasional cases present a diagnostic challenge. Immunohistochemical stains are extremely useful in resolving many of these problematic cases. As the knowledge in this area is constantly expanding, it is useful to have this updated information in a review form for easy access. OBJECTIVE: To present our current knowledge of immunohistochemistry of the lesions of the female genital tract in a readily accessible form. DATA SOURCES: The review is based on previously published articles on this topic. CONCLUSIONS: Immunohistochemical stains help in reaching a conclusive diagnosis in a variety of problematic lesions seen in Gynecologic Pathology. As in any other system, immunohistochemical findings need to be interpreted in light of the clinical history and morphologic findings.

  • p16 expression in the female genital tract and its value in diagnosis
    Advances in Anatomic Pathology, 2006
    Co-Authors: Ciaran Oneill, W G Mccluggage
    Abstract:

    p16 is a cyclin-dependent kinase-4 inhibitor that is expressed in a limited range of normal tissues and tumors. In recent years, immunohistochemistry with p16 antibodies has been used as a diagnostic aid in various scenarios in Gynecologic Pathology. Diffuse (as opposed to focal) positivity with p16