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Silvia Stefanini - One of the best experts on this subject based on the ideXlab platform.

  • a double blinded evaluation of propacetamol versus ketorolac in combination with patient controlled analgesia morphine analgesic efficacy and tolerability after Gynecologic Surgery
    Anesthesia & Analgesia, 1999
    Co-Authors: Giustino Varrassi, Franco Marinangeli, Pompilio De Cillis, Aniello De Nicola, Stefano Ischia, Felice Agrò, Maria Ballabio, Luigi Aloe, Francesco Giunta, Silvia Stefanini
    Abstract:

    We assessed the relative morphine consumption in a combined analgesic regimen (on-demand morphine plus the nonopioids propacetamol or ketorolac) after Gynecologic Surgery. Two hundred women randomly received two IV doses of propacetamol 2 g or ketorolac 30 mg in a double-blinded, double-dummy trial.

  • a double blinded evaluation of propacetamol versus ketorolac in combination with patient controlled analgesia morphine analgesic efficacy and tolerability after Gynecologic Surgery
    Anesthesia & Analgesia, 1999
    Co-Authors: Giustino Varrassi, Franco Marinangeli, Pompilio De Cillis, Aniello De Nicola, Stefano Ischia, Felice Agrò, Maria Ballabio, Luigi Aloe, Francesco Giunta, Silvia Stefanini
    Abstract:

    UNLABELLED We assessed the relative morphine consumption in a combined analgesic regimen (on-demand morphine plus the nonopioids propacetamol or ketorolac) after Gynecologic Surgery. Two hundred women randomly received two i.v. doses of propacetamol 2 g or ketorolac 30 mg in a double-blinded, double-dummy trial. Patients were monitored for 12 h, and the following efficacy variables were assessed: total dose of morphine, pain intensity, and global efficacy. Safety and tolerability were evaluated by the occurrence of adverse events, especially the presence and intensity of gastrointestinal symptoms. Hemostatic variables were measured 30 and 60 min after the first infusion; arterial blood pressure, heart and respiratory rates, sedation scores, and renal and hepatic function were also assessed. Total morphine requirements were not significantly different between the propacetamol (10.6 +/- 4.8 mg) and ketorolac (10.2 +/- 4.4 mg) groups. The evolution of pain intensity and the global efficacy also showed similar patterns in the two groups: 70.2% of patients in the propacetamol group rated the efficacy as "good/ excellent" compared with 68.2% in the ketorolac group. There were no clinically significant changes in vital signs or laboratory values and no observed differences between the two groups, although ketorolac slightly, but not significantly, prolonged the bleeding time. Epigastric pain was present in 9% and 15% of patients receiving propacetamol and ketorolac, respectively. There were two adverse events in the propacetamol group and four in the ketorolac group. Propacetamol demonstrates an efficacy similar to that of ketorolac and has an excellent tolerability after Gynecologic Surgery. IMPLICATIONS Propacetamol and ketorolac, combined with patient-controlled analgesia morphine, show similar analgesic efficacy after Gynecologic Surgery. Morphine consumption and pain scores were comparable in the two studied groups. Propacetamol is as effective as ketorolac and has an excellent tolerability after Gynecologic Surgery.

Giustino Varrassi - One of the best experts on this subject based on the ideXlab platform.

  • a double blinded evaluation of propacetamol versus ketorolac in combination with patient controlled analgesia morphine analgesic efficacy and tolerability after Gynecologic Surgery
    Anesthesia & Analgesia, 1999
    Co-Authors: Giustino Varrassi, Franco Marinangeli, Pompilio De Cillis, Aniello De Nicola, Stefano Ischia, Felice Agrò, Maria Ballabio, Luigi Aloe, Francesco Giunta, Silvia Stefanini
    Abstract:

    We assessed the relative morphine consumption in a combined analgesic regimen (on-demand morphine plus the nonopioids propacetamol or ketorolac) after Gynecologic Surgery. Two hundred women randomly received two IV doses of propacetamol 2 g or ketorolac 30 mg in a double-blinded, double-dummy trial.

  • a double blinded evaluation of propacetamol versus ketorolac in combination with patient controlled analgesia morphine analgesic efficacy and tolerability after Gynecologic Surgery
    Anesthesia & Analgesia, 1999
    Co-Authors: Giustino Varrassi, Franco Marinangeli, Pompilio De Cillis, Aniello De Nicola, Stefano Ischia, Felice Agrò, Maria Ballabio, Luigi Aloe, Francesco Giunta, Silvia Stefanini
    Abstract:

    UNLABELLED We assessed the relative morphine consumption in a combined analgesic regimen (on-demand morphine plus the nonopioids propacetamol or ketorolac) after Gynecologic Surgery. Two hundred women randomly received two i.v. doses of propacetamol 2 g or ketorolac 30 mg in a double-blinded, double-dummy trial. Patients were monitored for 12 h, and the following efficacy variables were assessed: total dose of morphine, pain intensity, and global efficacy. Safety and tolerability were evaluated by the occurrence of adverse events, especially the presence and intensity of gastrointestinal symptoms. Hemostatic variables were measured 30 and 60 min after the first infusion; arterial blood pressure, heart and respiratory rates, sedation scores, and renal and hepatic function were also assessed. Total morphine requirements were not significantly different between the propacetamol (10.6 +/- 4.8 mg) and ketorolac (10.2 +/- 4.4 mg) groups. The evolution of pain intensity and the global efficacy also showed similar patterns in the two groups: 70.2% of patients in the propacetamol group rated the efficacy as "good/ excellent" compared with 68.2% in the ketorolac group. There were no clinically significant changes in vital signs or laboratory values and no observed differences between the two groups, although ketorolac slightly, but not significantly, prolonged the bleeding time. Epigastric pain was present in 9% and 15% of patients receiving propacetamol and ketorolac, respectively. There were two adverse events in the propacetamol group and four in the ketorolac group. Propacetamol demonstrates an efficacy similar to that of ketorolac and has an excellent tolerability after Gynecologic Surgery. IMPLICATIONS Propacetamol and ketorolac, combined with patient-controlled analgesia morphine, show similar analgesic efficacy after Gynecologic Surgery. Morphine consumption and pain scores were comparable in the two studied groups. Propacetamol is as effective as ketorolac and has an excellent tolerability after Gynecologic Surgery.

Annekathryn Goodman - One of the best experts on this subject based on the ideXlab platform.

  • Gynecologic oncologist as surgical consultant intraoperative consultations during general Gynecologic Surgery as an important focus of Gynecologic oncology training
    Gynecologic Oncology, 2015
    Co-Authors: Emeline M. Aviki, Rachel M. Clark, Tracilyn Hall, Lori R. Berkowitz, David M. Boruta, Whitfield B. Growdon, John O. Schorge, Alejandro J Rauhhain, Annekathryn Goodman
    Abstract:

    OBJECTIVE: The aim of this study is to explore the previously unexamined role of the Gynecologic Oncologist as an intraoperative consultant during general Gynecologic Surgery. METHODS: Demographic and clinical data were collected on 98 major Gynecologic surgeries that included both a general Gynecologist and a Gynecologic Oncologist between October 2010 and August 2014. Data were analyzed using XLSTAT-Prov2014.2.02. RESULTS: Of 794 major Gynecologic surgeries, 98 (12.3%) cases that involved an intraoperative consultation were identified. There were 36 (37%) planned consults and 62 (63%) unplanned consults. Significantly more planned consults were during laparoscopy (100% v 58%; p<0.01) and significantly more unplanned consults were during laparotomy (42% v 0%; p<0.01). The majority of planned consults were for surgical training (86%) and the most common reasons for unplanned consults were adhesions (40%), bowel injury (19%), inability to identify ureter (19%), and cancer (11%). The most common interventions performed during unplanned consults were identification of anatomy (55%), lysis of adhesions (42%), and retroperitoneal dissection (27%). Average surgeon years in practice were significantly lower for unplanned consults (9 v 15; p<0.01). A total of 25 major adverse events occurred in 15 cases with the majority occurring in cases with unplanned consults (23% v 3%; p<0.01). After controlling for laparotomy, unplanned consultation was not significantly associated with major events (OR=6.67, 95%CI 0.69-64.39; p=0.10). CONCLUSIONS: Gynecologic Oncologists play a pivotal role in the support of generalist colleagues during pelvic Surgery. In this series, Gynecologic Oncologists were consulted frequently for complex major benign surgeries. It is important to incorporate the skills required of an intraoperative consultant into Gynecologic Oncology fellowship training.

  • Gynecologic oncologist as surgical consultant: Intraoperative consultations during general Gynecologic Surgery as an important focus of Gynecologic oncology training
    Gynecologic Oncology, 2015
    Co-Authors: Emeline M. Aviki, J. Alejandro Rauh-hain, Rachel M. Clark, Tracilyn Hall, Lori R. Berkowitz, David M. Boruta, Whitfield B. Growdon, John O. Schorge, Annekathryn Goodman
    Abstract:

    Abstract Objective The aim of this study is to explore the previously unexamined role of the Gynecologic Oncologist as an intraoperative consultant during general Gynecologic Surgery. Methods Demographic and clinical data were collected on 98 major Gynecologic surgeries that included both a general Gynecologist and a Gynecologic Oncologist between October 2010 and August 2014. Data were analyzed using XLSTAT-Prov2014.2.02. Results Of 794 major Gynecologic surgeries, 98 (12.3%) cases that involved an intraoperative consultation were identified. There were 36 (37%) planned consults and 62 (63%) unplanned consults. Significantly more planned consults were during laparoscopy (100% v 58%; p p p p p =0.10). Conclusions Gynecologic Oncologists play a pivotal role in the support of generalist colleagues during pelvic Surgery. In this series, Gynecologic Oncologists were consulted frequently for complex major benign surgeries. It is important to incorporate the skills required of an intraoperative consultant into Gynecologic Oncology fellowship training.

Franco Marinangeli - One of the best experts on this subject based on the ideXlab platform.

  • a double blinded evaluation of propacetamol versus ketorolac in combination with patient controlled analgesia morphine analgesic efficacy and tolerability after Gynecologic Surgery
    Anesthesia & Analgesia, 1999
    Co-Authors: Giustino Varrassi, Franco Marinangeli, Pompilio De Cillis, Aniello De Nicola, Stefano Ischia, Felice Agrò, Maria Ballabio, Luigi Aloe, Francesco Giunta, Silvia Stefanini
    Abstract:

    We assessed the relative morphine consumption in a combined analgesic regimen (on-demand morphine plus the nonopioids propacetamol or ketorolac) after Gynecologic Surgery. Two hundred women randomly received two IV doses of propacetamol 2 g or ketorolac 30 mg in a double-blinded, double-dummy trial.

  • a double blinded evaluation of propacetamol versus ketorolac in combination with patient controlled analgesia morphine analgesic efficacy and tolerability after Gynecologic Surgery
    Anesthesia & Analgesia, 1999
    Co-Authors: Giustino Varrassi, Franco Marinangeli, Pompilio De Cillis, Aniello De Nicola, Stefano Ischia, Felice Agrò, Maria Ballabio, Luigi Aloe, Francesco Giunta, Silvia Stefanini
    Abstract:

    UNLABELLED We assessed the relative morphine consumption in a combined analgesic regimen (on-demand morphine plus the nonopioids propacetamol or ketorolac) after Gynecologic Surgery. Two hundred women randomly received two i.v. doses of propacetamol 2 g or ketorolac 30 mg in a double-blinded, double-dummy trial. Patients were monitored for 12 h, and the following efficacy variables were assessed: total dose of morphine, pain intensity, and global efficacy. Safety and tolerability were evaluated by the occurrence of adverse events, especially the presence and intensity of gastrointestinal symptoms. Hemostatic variables were measured 30 and 60 min after the first infusion; arterial blood pressure, heart and respiratory rates, sedation scores, and renal and hepatic function were also assessed. Total morphine requirements were not significantly different between the propacetamol (10.6 +/- 4.8 mg) and ketorolac (10.2 +/- 4.4 mg) groups. The evolution of pain intensity and the global efficacy also showed similar patterns in the two groups: 70.2% of patients in the propacetamol group rated the efficacy as "good/ excellent" compared with 68.2% in the ketorolac group. There were no clinically significant changes in vital signs or laboratory values and no observed differences between the two groups, although ketorolac slightly, but not significantly, prolonged the bleeding time. Epigastric pain was present in 9% and 15% of patients receiving propacetamol and ketorolac, respectively. There were two adverse events in the propacetamol group and four in the ketorolac group. Propacetamol demonstrates an efficacy similar to that of ketorolac and has an excellent tolerability after Gynecologic Surgery. IMPLICATIONS Propacetamol and ketorolac, combined with patient-controlled analgesia morphine, show similar analgesic efficacy after Gynecologic Surgery. Morphine consumption and pain scores were comparable in the two studied groups. Propacetamol is as effective as ketorolac and has an excellent tolerability after Gynecologic Surgery.

Felice Agrò - One of the best experts on this subject based on the ideXlab platform.

  • a double blinded evaluation of propacetamol versus ketorolac in combination with patient controlled analgesia morphine analgesic efficacy and tolerability after Gynecologic Surgery
    Anesthesia & Analgesia, 1999
    Co-Authors: Giustino Varrassi, Franco Marinangeli, Pompilio De Cillis, Aniello De Nicola, Stefano Ischia, Felice Agrò, Maria Ballabio, Luigi Aloe, Francesco Giunta, Silvia Stefanini
    Abstract:

    We assessed the relative morphine consumption in a combined analgesic regimen (on-demand morphine plus the nonopioids propacetamol or ketorolac) after Gynecologic Surgery. Two hundred women randomly received two IV doses of propacetamol 2 g or ketorolac 30 mg in a double-blinded, double-dummy trial.

  • a double blinded evaluation of propacetamol versus ketorolac in combination with patient controlled analgesia morphine analgesic efficacy and tolerability after Gynecologic Surgery
    Anesthesia & Analgesia, 1999
    Co-Authors: Giustino Varrassi, Franco Marinangeli, Pompilio De Cillis, Aniello De Nicola, Stefano Ischia, Felice Agrò, Maria Ballabio, Luigi Aloe, Francesco Giunta, Silvia Stefanini
    Abstract:

    UNLABELLED We assessed the relative morphine consumption in a combined analgesic regimen (on-demand morphine plus the nonopioids propacetamol or ketorolac) after Gynecologic Surgery. Two hundred women randomly received two i.v. doses of propacetamol 2 g or ketorolac 30 mg in a double-blinded, double-dummy trial. Patients were monitored for 12 h, and the following efficacy variables were assessed: total dose of morphine, pain intensity, and global efficacy. Safety and tolerability were evaluated by the occurrence of adverse events, especially the presence and intensity of gastrointestinal symptoms. Hemostatic variables were measured 30 and 60 min after the first infusion; arterial blood pressure, heart and respiratory rates, sedation scores, and renal and hepatic function were also assessed. Total morphine requirements were not significantly different between the propacetamol (10.6 +/- 4.8 mg) and ketorolac (10.2 +/- 4.4 mg) groups. The evolution of pain intensity and the global efficacy also showed similar patterns in the two groups: 70.2% of patients in the propacetamol group rated the efficacy as "good/ excellent" compared with 68.2% in the ketorolac group. There were no clinically significant changes in vital signs or laboratory values and no observed differences between the two groups, although ketorolac slightly, but not significantly, prolonged the bleeding time. Epigastric pain was present in 9% and 15% of patients receiving propacetamol and ketorolac, respectively. There were two adverse events in the propacetamol group and four in the ketorolac group. Propacetamol demonstrates an efficacy similar to that of ketorolac and has an excellent tolerability after Gynecologic Surgery. IMPLICATIONS Propacetamol and ketorolac, combined with patient-controlled analgesia morphine, show similar analgesic efficacy after Gynecologic Surgery. Morphine consumption and pain scores were comparable in the two studied groups. Propacetamol is as effective as ketorolac and has an excellent tolerability after Gynecologic Surgery.