The Experts below are selected from a list of 164670 Experts worldwide ranked by ideXlab platform
Mi Yang - One of the best experts on this subject based on the ideXlab platform.
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abnormal functional connectivity density in post stroke aphasia
Brain Topography, 2019Co-Authors: Mi Yang, Pu Yang, Bibhuti Bhusan Biswal, Wei Liao, Hesheng ChenAbstract:Post-stroke aphasia (PSA), which refers to the loss or impairment of language, is typically caused by left hemisphere lesions. Previous neuroimaging studies have indicated that the pathology of PSA may be related to abnormalities in functional integration. In this study, we used resting-state functional magnetic resonance imaging (rs-fMRI) to examine functional connectivity density (FCD) in PSA. We compared short- and long-range FCD between individuals with PSA (n = 17) and healthy controls (HC, n = 20). We then performed Pearson’s correlation analysis on the FCD values from the affected brain regions and the speech scores in the PSA group. Compared with HCs, individuals with PSA showed increased short-range FCD in the contralesional temporal Gyrus, the inferior frontal Gyrus, the thalamus, the insula, and the mesial temporal Gyrus [hippocampus/parahippocampus (HIP/ParaHIP)]. PSA demonstrated an increased long-range FCD in the contralesional mesial temporal Gyrus (HIP/ParaHIP). PSA also displayed decreased short-range FCD in the ipsilesional part of the frontal Gyrus, the caudate, the thalamus, the fusiform Gyrus, and the mesial temporal Gyrus (HIP/ParaHIP), and decreased long-range FCD in the ipsilesional superior temporal Gyrus, the fusiform Gyrus, and the mesial temporal Gyrus (HIP/ParaHIP). The decreased long-range FCD in the left superior temporal Gyrus in PSA subjects was positively correlated with the spontaneous speech score. The altered FCD observed due to disrupted functional connectivity after stroke may lead to language production, semantic processing, and cognitive impairments. Our findings expand previous functional studies on stroke and provide new evidence of the intraregional and interregional interactions at the voxel level in the pathophysiology of PSA.
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Altered Structure and Intrinsic Functional Connectivity in Post-stroke Aphasia
Brain Topography, 2018Co-Authors: Mi Yang, Yun-shuang Fan, Dezhong Yao, Pu Yang, Jiao Li, Wei Liao, Huafu ChenAbstract:Previous studies have demonstrated that alterations of gray matter exist in post-stroke aphasia (PSA) patients. However, so far, few studies combined structural alterations of gray matter volume (GMV) and intrinsic functional connectivity (iFC) imbalances of resting-state functional MRI to investigate the mechanism underlying PSA. The present study investigated specific regions with GMV abnormality in patients with PSA (n = 17) and age- and sex- matched healthy controls (HCs, n = 20) using voxel-based morphometry. In addition, we examined whether there is a link between abnormal gray matter and altered iFC. Furthermore, we explored the correlations between abnormal iFC and clinical scores in aphasic patients. We found significantly increased GMV in the right superior temporal Gyrus, right inferior parietal lobule (IPL)/supramarginal Gyrus (SMG), and left middle occipital Gyrus. Decreased GMV was found in the right caudate Gyrus, bilateral thalami in PSA patients. Patients showed increased remote interregional FC between the right IPL/SMG and right precuneus, right angular Gyrus, right superior occipital Gyrus; while reduced FC in the right caudate Gyrus and supplementary motor area, dorsolateral superior frontal Gyrus. Moreover, iFC strength between the left middle occipital Gyrus and the left orbital middle frontal Gyrus was positively correlated with the performance quotient. We suggest that GMV abnormality contributes to interregional FC in PSA. These results may provide useful information to understand the pathogenesis of post-stroke aphasia.
Huafu Chen - One of the best experts on this subject based on the ideXlab platform.
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Altered Structure and Intrinsic Functional Connectivity in Post-stroke Aphasia
Brain Topography, 2018Co-Authors: Mi Yang, Yun-shuang Fan, Dezhong Yao, Pu Yang, Jiao Li, Wei Liao, Huafu ChenAbstract:Previous studies have demonstrated that alterations of gray matter exist in post-stroke aphasia (PSA) patients. However, so far, few studies combined structural alterations of gray matter volume (GMV) and intrinsic functional connectivity (iFC) imbalances of resting-state functional MRI to investigate the mechanism underlying PSA. The present study investigated specific regions with GMV abnormality in patients with PSA (n = 17) and age- and sex- matched healthy controls (HCs, n = 20) using voxel-based morphometry. In addition, we examined whether there is a link between abnormal gray matter and altered iFC. Furthermore, we explored the correlations between abnormal iFC and clinical scores in aphasic patients. We found significantly increased GMV in the right superior temporal Gyrus, right inferior parietal lobule (IPL)/supramarginal Gyrus (SMG), and left middle occipital Gyrus. Decreased GMV was found in the right caudate Gyrus, bilateral thalami in PSA patients. Patients showed increased remote interregional FC between the right IPL/SMG and right precuneus, right angular Gyrus, right superior occipital Gyrus; while reduced FC in the right caudate Gyrus and supplementary motor area, dorsolateral superior frontal Gyrus. Moreover, iFC strength between the left middle occipital Gyrus and the left orbital middle frontal Gyrus was positively correlated with the performance quotient. We suggest that GMV abnormality contributes to interregional FC in PSA. These results may provide useful information to understand the pathogenesis of post-stroke aphasia.
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Reversal alterations of amplitude of low-frequency fluctuations in early and late onset, first-episode, drug-naive depression.
Progress in neuro-psychopharmacology & biological psychiatry, 2012Co-Authors: Wenbin Guo, Huafu Chen, Feng Liu, Changqing Xiao, Guang Lei Xun, Xiao Feng Guo, Sarah C. Wooderson, Jin Dong Chen, Jingping ZhaoAbstract:Abstract Background It is unclear how patients with early onset depression (EOD) and late onset depression (LOD) differ at the neural level. Using amplitude of low-frequency fluctuations (ALFF) approach, we are to test the hypothesis of the different abnormal neural activities between patients with EOD and LOD. Methods Fifteen patients with EOD, 15 patients with LOD, 15 young healthy subjects (HS) and 15 old HS were enrolled in the study. ALFF approach was employed to analyze the images. Results ANOVA analysis revealed widespread differences in ALFF values among the four groups throughout frontal, parietal, temporal, occipital cortex, cerebellum and limbic regions. Compared to LOD group, EOD group had higher ALFF in bilateral precuneus, superior medial frontal Gyrus and superior frontal Gyrus, and lower ALFF in left brainstem and left superior temporal Gyrus. Compared to young HS, lower ALFF in left superior/inferior temporal Gyrus, left lingual Gyrus and right middle occipital Gyrus and higher ALFF in left medial frontal Gyrus and bilateral superior frontal Gyrus were seen in the EOD group; in contrast, in the LOD group, lower ALFF in bilateral superior frontal Gyrus and higher ALFF in left superior temporal Gyrus were observed. Further ROC analysis suggested that the mean ALFF values in the bilateral superior frontal Gyrus and left superior temporal Gyrus could serve as markers to separate patients with EOD from individuals with LOD. Conclusions Patients with EOD and LOD exhibit reversal pattern of abnormal ALFF in bilateral superior frontal Gyrus and left superior temporal Gyrus.
Pu Yang - One of the best experts on this subject based on the ideXlab platform.
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abnormal functional connectivity density in post stroke aphasia
Brain Topography, 2019Co-Authors: Mi Yang, Pu Yang, Bibhuti Bhusan Biswal, Wei Liao, Hesheng ChenAbstract:Post-stroke aphasia (PSA), which refers to the loss or impairment of language, is typically caused by left hemisphere lesions. Previous neuroimaging studies have indicated that the pathology of PSA may be related to abnormalities in functional integration. In this study, we used resting-state functional magnetic resonance imaging (rs-fMRI) to examine functional connectivity density (FCD) in PSA. We compared short- and long-range FCD between individuals with PSA (n = 17) and healthy controls (HC, n = 20). We then performed Pearson’s correlation analysis on the FCD values from the affected brain regions and the speech scores in the PSA group. Compared with HCs, individuals with PSA showed increased short-range FCD in the contralesional temporal Gyrus, the inferior frontal Gyrus, the thalamus, the insula, and the mesial temporal Gyrus [hippocampus/parahippocampus (HIP/ParaHIP)]. PSA demonstrated an increased long-range FCD in the contralesional mesial temporal Gyrus (HIP/ParaHIP). PSA also displayed decreased short-range FCD in the ipsilesional part of the frontal Gyrus, the caudate, the thalamus, the fusiform Gyrus, and the mesial temporal Gyrus (HIP/ParaHIP), and decreased long-range FCD in the ipsilesional superior temporal Gyrus, the fusiform Gyrus, and the mesial temporal Gyrus (HIP/ParaHIP). The decreased long-range FCD in the left superior temporal Gyrus in PSA subjects was positively correlated with the spontaneous speech score. The altered FCD observed due to disrupted functional connectivity after stroke may lead to language production, semantic processing, and cognitive impairments. Our findings expand previous functional studies on stroke and provide new evidence of the intraregional and interregional interactions at the voxel level in the pathophysiology of PSA.
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Altered Structure and Intrinsic Functional Connectivity in Post-stroke Aphasia
Brain Topography, 2018Co-Authors: Mi Yang, Yun-shuang Fan, Dezhong Yao, Pu Yang, Jiao Li, Wei Liao, Huafu ChenAbstract:Previous studies have demonstrated that alterations of gray matter exist in post-stroke aphasia (PSA) patients. However, so far, few studies combined structural alterations of gray matter volume (GMV) and intrinsic functional connectivity (iFC) imbalances of resting-state functional MRI to investigate the mechanism underlying PSA. The present study investigated specific regions with GMV abnormality in patients with PSA (n = 17) and age- and sex- matched healthy controls (HCs, n = 20) using voxel-based morphometry. In addition, we examined whether there is a link between abnormal gray matter and altered iFC. Furthermore, we explored the correlations between abnormal iFC and clinical scores in aphasic patients. We found significantly increased GMV in the right superior temporal Gyrus, right inferior parietal lobule (IPL)/supramarginal Gyrus (SMG), and left middle occipital Gyrus. Decreased GMV was found in the right caudate Gyrus, bilateral thalami in PSA patients. Patients showed increased remote interregional FC between the right IPL/SMG and right precuneus, right angular Gyrus, right superior occipital Gyrus; while reduced FC in the right caudate Gyrus and supplementary motor area, dorsolateral superior frontal Gyrus. Moreover, iFC strength between the left middle occipital Gyrus and the left orbital middle frontal Gyrus was positively correlated with the performance quotient. We suggest that GMV abnormality contributes to interregional FC in PSA. These results may provide useful information to understand the pathogenesis of post-stroke aphasia.
Wei Liao - One of the best experts on this subject based on the ideXlab platform.
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abnormal functional connectivity density in post stroke aphasia
Brain Topography, 2019Co-Authors: Mi Yang, Pu Yang, Bibhuti Bhusan Biswal, Wei Liao, Hesheng ChenAbstract:Post-stroke aphasia (PSA), which refers to the loss or impairment of language, is typically caused by left hemisphere lesions. Previous neuroimaging studies have indicated that the pathology of PSA may be related to abnormalities in functional integration. In this study, we used resting-state functional magnetic resonance imaging (rs-fMRI) to examine functional connectivity density (FCD) in PSA. We compared short- and long-range FCD between individuals with PSA (n = 17) and healthy controls (HC, n = 20). We then performed Pearson’s correlation analysis on the FCD values from the affected brain regions and the speech scores in the PSA group. Compared with HCs, individuals with PSA showed increased short-range FCD in the contralesional temporal Gyrus, the inferior frontal Gyrus, the thalamus, the insula, and the mesial temporal Gyrus [hippocampus/parahippocampus (HIP/ParaHIP)]. PSA demonstrated an increased long-range FCD in the contralesional mesial temporal Gyrus (HIP/ParaHIP). PSA also displayed decreased short-range FCD in the ipsilesional part of the frontal Gyrus, the caudate, the thalamus, the fusiform Gyrus, and the mesial temporal Gyrus (HIP/ParaHIP), and decreased long-range FCD in the ipsilesional superior temporal Gyrus, the fusiform Gyrus, and the mesial temporal Gyrus (HIP/ParaHIP). The decreased long-range FCD in the left superior temporal Gyrus in PSA subjects was positively correlated with the spontaneous speech score. The altered FCD observed due to disrupted functional connectivity after stroke may lead to language production, semantic processing, and cognitive impairments. Our findings expand previous functional studies on stroke and provide new evidence of the intraregional and interregional interactions at the voxel level in the pathophysiology of PSA.
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Altered Structure and Intrinsic Functional Connectivity in Post-stroke Aphasia
Brain Topography, 2018Co-Authors: Mi Yang, Yun-shuang Fan, Dezhong Yao, Pu Yang, Jiao Li, Wei Liao, Huafu ChenAbstract:Previous studies have demonstrated that alterations of gray matter exist in post-stroke aphasia (PSA) patients. However, so far, few studies combined structural alterations of gray matter volume (GMV) and intrinsic functional connectivity (iFC) imbalances of resting-state functional MRI to investigate the mechanism underlying PSA. The present study investigated specific regions with GMV abnormality in patients with PSA (n = 17) and age- and sex- matched healthy controls (HCs, n = 20) using voxel-based morphometry. In addition, we examined whether there is a link between abnormal gray matter and altered iFC. Furthermore, we explored the correlations between abnormal iFC and clinical scores in aphasic patients. We found significantly increased GMV in the right superior temporal Gyrus, right inferior parietal lobule (IPL)/supramarginal Gyrus (SMG), and left middle occipital Gyrus. Decreased GMV was found in the right caudate Gyrus, bilateral thalami in PSA patients. Patients showed increased remote interregional FC between the right IPL/SMG and right precuneus, right angular Gyrus, right superior occipital Gyrus; while reduced FC in the right caudate Gyrus and supplementary motor area, dorsolateral superior frontal Gyrus. Moreover, iFC strength between the left middle occipital Gyrus and the left orbital middle frontal Gyrus was positively correlated with the performance quotient. We suggest that GMV abnormality contributes to interregional FC in PSA. These results may provide useful information to understand the pathogenesis of post-stroke aphasia.
Masayoshi Kurachi - One of the best experts on this subject based on the ideXlab platform.
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temporal lobe gray matter in schizophrenia spectrum a volumetric mri study of the fusiform Gyrus parahippocampal Gyrus and middle and inferior temporal gyri
Schizophrenia Research, 2006Co-Authors: Tsutomu Takahashi, Shi-yu Zhou, Ryoichiro Tanino, Michio Suzuki, Yasuhiro Kawasaki, Hirofumi Hagino, Hikaru Seto, Masayoshi KurachiAbstract:Abstract Although several brain morphologic studies have suggested abnormalities in the temporal regions to be a common indicator of vulnerability for the schizophrenia spectrum, less attention has been paid to temporal lobe structures other than the superior temporal Gyrus or the medial temporal region. In this study, we investigated the volume of gray matter in the fusiform Gyrus, the parahippocampal Gyrus, the middle temporal Gyrus, and the inferior temporal Gyrus using magnetic resonance imaging in 39 schizotypal disorder patients, 65 schizophrenia patients, and 72 age and gender matched healthy control subjects. The anterior fusiform Gyrus was significantly smaller in the schizophrenia patients than the control subjects but not in the schizotypal disorder patients, while the volume reduction of the posterior fusiform Gyrus was common to both disorders. Volumes for the middle and inferior temporal gyri or the parahippocampal Gyrus did not differ between groups. These findings suggest that abnormalities in the posterior region of the fusiform Gyrus are, as have been suggested for the superior temporal Gyrus or the amygdala/hippocampus, prominent among the temporal lobe structures as a common morphologic substrate for the schizophrenia spectrum, whereas more widespread alterations involving the anterior region might be associated with the development of full-blown schizophrenia.
