The Experts below are selected from a list of 360 Experts worldwide ranked by ideXlab platform
Elie Saliba - One of the best experts on this subject based on the ideXlab platform.
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effects on fatty acid metabolism of a new powdered human milk fortifier containing medium chain triacylglycerols and docosahexaenoic acid in preterm infants
Nutrients, 2018Co-Authors: Claude Billeaud, Leslie Couëdelo, Philippe Steenhout, Jonathan Jaeger, Laurent Ameye, Jacques Rigo, Jean-charles Picaud, Carole Bouevaysse, Cristina Cruzhernandez, Elie SalibaAbstract:Preterm infants require fortification of human milk (HM) with essential fatty acids (FA) to ensure adequate post-natal development. As part of a larger randomized controlled study, we investigated FA metabolism in a subset of 47 clinically stable preterm infants (birth weight ≤1500 g or gestational age ≤32 weeks). Infants were randomized to receive HM supplemented with either a new HM fortifier (nHMF; n = 26) containing 12.5 g medium-chain FA (MCFA), 958 mg linoleic acid (LA), 417 mg α-linolenic acid (ALA), and 157 mg docosahexaenoic acid (DHA) per 100 g of powder (in compliance with the latest guidelines) or a fat-free HMF (cHMF; n = 21). Plasma phospholipid (PL) and triacylglycerol (TAG), and red blood cell phosphatidylcholine (RBC-PC) and phosphatidylethanolamine (RBC-PE) FA profiles were assessed before and after 21 days of feeding. In the nHMF group, significantly increased levels of n-9 monounsaturated fatty acids were observed, formed most likely by elongation and desaturation of dietary saturated fatty acids present in HM. ALA fortification increased ALA assimilation into plasma TAG. Similarly, DHA fortification enriched the DHA content in RBC-PE, which, in this compartment, was not associated with lower arachidonic acid levels as observed in plasma TAG and phospholipids. RBC-PE, a reliable indicator of FA metabolism and accretion, was the most sensitive compartment in this study.
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Effects on Fatty Acid Metabolism of a New Powdered Human Milk Fortifier Containing Medium-Chain Triacylglycerols and Docosahexaenoic Acid in Preterm Infants
MDPI AG, 2018Co-Authors: Claude Billeaud, Carole Boué-vaysse, Leslie Couëdelo, Philippe Steenhout, Jonathan Jaeger, Cristina Cruz-hernandez, Laurent Ameye, Jacques Rigo, Jean-charles Picaud, Elie SalibaAbstract:Preterm infants require fortification of human milk (HM) with essential fatty acids (FA) to ensure adequate post-natal development. As part of a larger randomized controlled study, we investigated FA metabolism in a subset of 47 clinically stable preterm infants (birth weight ≤1500 g or gestational age ≤32 weeks). Infants were randomized to receive HM supplemented with either a new HM fortifier (nHMF; n = 26) containing 12.5 g medium-chain FA (MCFA), 958 mg linoleic acid (LA), 417 mg α-linolenic acid (ALA), and 157 mg docosahexaenoic acid (DHA) per 100 g of powder (in compliance with the latest guidelines) or a fat-free HMF (cHMF; n = 21). Plasma phospholipid (PL) and triacylglycerol (TAG), and red blood cell phosphatidylcholine (RBC-PC) and phosphatidylethanolamine (RBC-PE) FA profiles were assessed before and after 21 days of feeding. In the nHMF group, significantly increased levels of n-9 monounsaturated fatty acids were observed, formed most likely by elongation and desaturation of dietary saturated fatty acids present in HM. ALA fortification increased ALA assimilation into plasma TAG. Similarly, DHA fortification enriched the DHA content in RBC-PE, which, in this compartment, was not associated with lower arachidonic acid levels as observed in plasma TAG and phospholipids. RBC-PE, a reliable indicator of FA metabolism and accretion, was the most sensitive compartment in this study
Claude Billeaud - One of the best experts on this subject based on the ideXlab platform.
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effects on fatty acid metabolism of a new powdered human milk fortifier containing medium chain triacylglycerols and docosahexaenoic acid in preterm infants
Nutrients, 2018Co-Authors: Claude Billeaud, Leslie Couëdelo, Philippe Steenhout, Jonathan Jaeger, Laurent Ameye, Jacques Rigo, Jean-charles Picaud, Carole Bouevaysse, Cristina Cruzhernandez, Elie SalibaAbstract:Preterm infants require fortification of human milk (HM) with essential fatty acids (FA) to ensure adequate post-natal development. As part of a larger randomized controlled study, we investigated FA metabolism in a subset of 47 clinically stable preterm infants (birth weight ≤1500 g or gestational age ≤32 weeks). Infants were randomized to receive HM supplemented with either a new HM fortifier (nHMF; n = 26) containing 12.5 g medium-chain FA (MCFA), 958 mg linoleic acid (LA), 417 mg α-linolenic acid (ALA), and 157 mg docosahexaenoic acid (DHA) per 100 g of powder (in compliance with the latest guidelines) or a fat-free HMF (cHMF; n = 21). Plasma phospholipid (PL) and triacylglycerol (TAG), and red blood cell phosphatidylcholine (RBC-PC) and phosphatidylethanolamine (RBC-PE) FA profiles were assessed before and after 21 days of feeding. In the nHMF group, significantly increased levels of n-9 monounsaturated fatty acids were observed, formed most likely by elongation and desaturation of dietary saturated fatty acids present in HM. ALA fortification increased ALA assimilation into plasma TAG. Similarly, DHA fortification enriched the DHA content in RBC-PE, which, in this compartment, was not associated with lower arachidonic acid levels as observed in plasma TAG and phospholipids. RBC-PE, a reliable indicator of FA metabolism and accretion, was the most sensitive compartment in this study.
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Effects on Fatty Acid Metabolism of a New Powdered Human Milk Fortifier Containing Medium-Chain Triacylglycerols and Docosahexaenoic Acid in Preterm Infants
MDPI AG, 2018Co-Authors: Claude Billeaud, Carole Boué-vaysse, Leslie Couëdelo, Philippe Steenhout, Jonathan Jaeger, Cristina Cruz-hernandez, Laurent Ameye, Jacques Rigo, Jean-charles Picaud, Elie SalibaAbstract:Preterm infants require fortification of human milk (HM) with essential fatty acids (FA) to ensure adequate post-natal development. As part of a larger randomized controlled study, we investigated FA metabolism in a subset of 47 clinically stable preterm infants (birth weight ≤1500 g or gestational age ≤32 weeks). Infants were randomized to receive HM supplemented with either a new HM fortifier (nHMF; n = 26) containing 12.5 g medium-chain FA (MCFA), 958 mg linoleic acid (LA), 417 mg α-linolenic acid (ALA), and 157 mg docosahexaenoic acid (DHA) per 100 g of powder (in compliance with the latest guidelines) or a fat-free HMF (cHMF; n = 21). Plasma phospholipid (PL) and triacylglycerol (TAG), and red blood cell phosphatidylcholine (RBC-PC) and phosphatidylethanolamine (RBC-PE) FA profiles were assessed before and after 21 days of feeding. In the nHMF group, significantly increased levels of n-9 monounsaturated fatty acids were observed, formed most likely by elongation and desaturation of dietary saturated fatty acids present in HM. ALA fortification increased ALA assimilation into plasma TAG. Similarly, DHA fortification enriched the DHA content in RBC-PE, which, in this compartment, was not associated with lower arachidonic acid levels as observed in plasma TAG and phospholipids. RBC-PE, a reliable indicator of FA metabolism and accretion, was the most sensitive compartment in this study
H J F Van Valenberg - One of the best experts on this subject based on the ideXlab platform.
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influence of c16 0 and long chain saturated fatty acids on normal variation of bovine milk fat triacylglycerol structure
Journal of Dairy Science, 2014Co-Authors: Daylan A Tzompasosa, G A Van Aken, A C M Van Hooijdonk, H J F Van ValenbergAbstract:Fatty acids (FA) are nonrandomly distributed within milk fat triacylglycerols (TAG). Moreover, the structure of milk fat TAG differs with feeding regimens. So far, nothing is known about the variation of milk fat TAG structure among individual cows. A deep understanding of the normal variation of TAG structures and the relationships between milk fat FA profile and its TAG structure could help to better control functional and compositional differences between milk fats from various sources and to increase the knowledge on milk fat synthesis. The focus of the present study was to determine the regiospecific TAG structure of individual samples of winter milk fat from Dutch Holstein-Friesian cows with a wide variation of FA profiles and with 2 diacylglycerol acyltransferase 1 (DGAT1) genotypes: DGAT1 K232A genotype AA and DGAT1 K232A genotype KK. From an initial set of 1,918 individual milk fat samples, 24 were selected. The selected samples had a wide range of FA composition and had either DGAT1 K232A genotype AA or KK. The structure analysis was done with a regiospecific approach. This analysis is based on the acyl degradation of TAG by a Grignard reagent and further isolation of sn-2 monoacylglycerols by thin-layer chromatography. An intra- and interpositional approach was used to study the structural variation. With the intrapositional approach, the amount of an FA at the secondary (sn-2) and primary (sn-1,3) positions was related to its total amount in the TAG. With the interpositional approach, the proportion of C8:0, C10:0, C14:1 cis-9, C16:1 cis-9, and C18:1 cis-9 at sn-2 was positively correlated with the amount of C16:0 in the triacylglycerol; in contrast, saturated C14:0, C16:0, and long-chain saturated FA (C14:0–C18:0) were negatively correlated. These observations suggest that the amount of long-chain saturated FA in TAG influences the positioning of other FA in the TAG. With an interpositional approach, the DGAT1 polymorphism had a significant effect on the proportional positioning of C16:0 at sn-2. These results provide a new direction to controlling functional and compositional differences between milk fats.
Leslie Couëdelo - One of the best experts on this subject based on the ideXlab platform.
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effects on fatty acid metabolism of a new powdered human milk fortifier containing medium chain triacylglycerols and docosahexaenoic acid in preterm infants
Nutrients, 2018Co-Authors: Claude Billeaud, Leslie Couëdelo, Philippe Steenhout, Jonathan Jaeger, Laurent Ameye, Jacques Rigo, Jean-charles Picaud, Carole Bouevaysse, Cristina Cruzhernandez, Elie SalibaAbstract:Preterm infants require fortification of human milk (HM) with essential fatty acids (FA) to ensure adequate post-natal development. As part of a larger randomized controlled study, we investigated FA metabolism in a subset of 47 clinically stable preterm infants (birth weight ≤1500 g or gestational age ≤32 weeks). Infants were randomized to receive HM supplemented with either a new HM fortifier (nHMF; n = 26) containing 12.5 g medium-chain FA (MCFA), 958 mg linoleic acid (LA), 417 mg α-linolenic acid (ALA), and 157 mg docosahexaenoic acid (DHA) per 100 g of powder (in compliance with the latest guidelines) or a fat-free HMF (cHMF; n = 21). Plasma phospholipid (PL) and triacylglycerol (TAG), and red blood cell phosphatidylcholine (RBC-PC) and phosphatidylethanolamine (RBC-PE) FA profiles were assessed before and after 21 days of feeding. In the nHMF group, significantly increased levels of n-9 monounsaturated fatty acids were observed, formed most likely by elongation and desaturation of dietary saturated fatty acids present in HM. ALA fortification increased ALA assimilation into plasma TAG. Similarly, DHA fortification enriched the DHA content in RBC-PE, which, in this compartment, was not associated with lower arachidonic acid levels as observed in plasma TAG and phospholipids. RBC-PE, a reliable indicator of FA metabolism and accretion, was the most sensitive compartment in this study.
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Effects on Fatty Acid Metabolism of a New Powdered Human Milk Fortifier Containing Medium-Chain Triacylglycerols and Docosahexaenoic Acid in Preterm Infants
MDPI AG, 2018Co-Authors: Claude Billeaud, Carole Boué-vaysse, Leslie Couëdelo, Philippe Steenhout, Jonathan Jaeger, Cristina Cruz-hernandez, Laurent Ameye, Jacques Rigo, Jean-charles Picaud, Elie SalibaAbstract:Preterm infants require fortification of human milk (HM) with essential fatty acids (FA) to ensure adequate post-natal development. As part of a larger randomized controlled study, we investigated FA metabolism in a subset of 47 clinically stable preterm infants (birth weight ≤1500 g or gestational age ≤32 weeks). Infants were randomized to receive HM supplemented with either a new HM fortifier (nHMF; n = 26) containing 12.5 g medium-chain FA (MCFA), 958 mg linoleic acid (LA), 417 mg α-linolenic acid (ALA), and 157 mg docosahexaenoic acid (DHA) per 100 g of powder (in compliance with the latest guidelines) or a fat-free HMF (cHMF; n = 21). Plasma phospholipid (PL) and triacylglycerol (TAG), and red blood cell phosphatidylcholine (RBC-PC) and phosphatidylethanolamine (RBC-PE) FA profiles were assessed before and after 21 days of feeding. In the nHMF group, significantly increased levels of n-9 monounsaturated fatty acids were observed, formed most likely by elongation and desaturation of dietary saturated fatty acids present in HM. ALA fortification increased ALA assimilation into plasma TAG. Similarly, DHA fortification enriched the DHA content in RBC-PE, which, in this compartment, was not associated with lower arachidonic acid levels as observed in plasma TAG and phospholipids. RBC-PE, a reliable indicator of FA metabolism and accretion, was the most sensitive compartment in this study
Philippe Steenhout - One of the best experts on this subject based on the ideXlab platform.
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effects on fatty acid metabolism of a new powdered human milk fortifier containing medium chain triacylglycerols and docosahexaenoic acid in preterm infants
Nutrients, 2018Co-Authors: Claude Billeaud, Leslie Couëdelo, Philippe Steenhout, Jonathan Jaeger, Laurent Ameye, Jacques Rigo, Jean-charles Picaud, Carole Bouevaysse, Cristina Cruzhernandez, Elie SalibaAbstract:Preterm infants require fortification of human milk (HM) with essential fatty acids (FA) to ensure adequate post-natal development. As part of a larger randomized controlled study, we investigated FA metabolism in a subset of 47 clinically stable preterm infants (birth weight ≤1500 g or gestational age ≤32 weeks). Infants were randomized to receive HM supplemented with either a new HM fortifier (nHMF; n = 26) containing 12.5 g medium-chain FA (MCFA), 958 mg linoleic acid (LA), 417 mg α-linolenic acid (ALA), and 157 mg docosahexaenoic acid (DHA) per 100 g of powder (in compliance with the latest guidelines) or a fat-free HMF (cHMF; n = 21). Plasma phospholipid (PL) and triacylglycerol (TAG), and red blood cell phosphatidylcholine (RBC-PC) and phosphatidylethanolamine (RBC-PE) FA profiles were assessed before and after 21 days of feeding. In the nHMF group, significantly increased levels of n-9 monounsaturated fatty acids were observed, formed most likely by elongation and desaturation of dietary saturated fatty acids present in HM. ALA fortification increased ALA assimilation into plasma TAG. Similarly, DHA fortification enriched the DHA content in RBC-PE, which, in this compartment, was not associated with lower arachidonic acid levels as observed in plasma TAG and phospholipids. RBC-PE, a reliable indicator of FA metabolism and accretion, was the most sensitive compartment in this study.
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Effects on Fatty Acid Metabolism of a New Powdered Human Milk Fortifier Containing Medium-Chain Triacylglycerols and Docosahexaenoic Acid in Preterm Infants
MDPI AG, 2018Co-Authors: Claude Billeaud, Carole Boué-vaysse, Leslie Couëdelo, Philippe Steenhout, Jonathan Jaeger, Cristina Cruz-hernandez, Laurent Ameye, Jacques Rigo, Jean-charles Picaud, Elie SalibaAbstract:Preterm infants require fortification of human milk (HM) with essential fatty acids (FA) to ensure adequate post-natal development. As part of a larger randomized controlled study, we investigated FA metabolism in a subset of 47 clinically stable preterm infants (birth weight ≤1500 g or gestational age ≤32 weeks). Infants were randomized to receive HM supplemented with either a new HM fortifier (nHMF; n = 26) containing 12.5 g medium-chain FA (MCFA), 958 mg linoleic acid (LA), 417 mg α-linolenic acid (ALA), and 157 mg docosahexaenoic acid (DHA) per 100 g of powder (in compliance with the latest guidelines) or a fat-free HMF (cHMF; n = 21). Plasma phospholipid (PL) and triacylglycerol (TAG), and red blood cell phosphatidylcholine (RBC-PC) and phosphatidylethanolamine (RBC-PE) FA profiles were assessed before and after 21 days of feeding. In the nHMF group, significantly increased levels of n-9 monounsaturated fatty acids were observed, formed most likely by elongation and desaturation of dietary saturated fatty acids present in HM. ALA fortification increased ALA assimilation into plasma TAG. Similarly, DHA fortification enriched the DHA content in RBC-PE, which, in this compartment, was not associated with lower arachidonic acid levels as observed in plasma TAG and phospholipids. RBC-PE, a reliable indicator of FA metabolism and accretion, was the most sensitive compartment in this study
