The Experts below are selected from a list of 360 Experts worldwide ranked by ideXlab platform
Reinhilde Jacobs - One of the best experts on this subject based on the ideXlab platform.
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local Haemostatic measures after tooth removal in patients on antithrombotic therapy a systematic review
Clinical Oral Investigations, 2019Co-Authors: Anna Ockerman, Isabel Miclotte, Maarten Vanhaverbeke, Peter Verhamme, Lauralien Poortmans, Thomas Vanassche, Constantinus Politis, Reinhilde JacobsAbstract:The interruption of antithrombotics prior to tooth removal because of the fear of bleeding or following postoperative bleeding increases the risk of thromboembolic events. The aim of this systematic review was to investigate which local Haemostatic measures can effectively prevent postoperative bleeding in patients continuing oral antithrombotics. A systematic review was conducted by running a search in PubMed, Embase, Web of Science and Cochrane Library. Clinical randomised trials investigating bleeding and Haemostatics after tooth removal in patients on antithrombotics were identified. In total, 15 articles were included. The investigated Haemostatics included gauze pressure, tranexamic acid-soaked gauze, sponges, glue, calcium sulfate, plant extract Ankaferd Blood Stopper, epsilon-aminocaproic acid and tranexamic acid. In patients treated with vitamin K antagonists, tranexamic acid mouthwash significantly reduced bleeding compared to placebo. Further, histoacryl glue was proven better than gelatin sponges. Other studies failed to show significant differences between Haemostatics, but bleeding events were low. Tranexamic acid seems to effectively reduce bleeding, although its superiority to other Haemostatics was not proven. In view of the rapidly changing landscape of antithrombotics and the lack of standardization of bleeding outcome, adequately powered clinical studies are required to optimise postoperative management in patients on antithrombotics. In order to optimise postoperative management, the best Haemostatics over different patient groups have to be identified and implemented in guidelines.
Christopher H Dalton - One of the best experts on this subject based on the ideXlab platform.
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development of Haemostatic decontaminants for the treatment of wounds contaminated with chemical warfare agents 2 evaluation of in vitro topical decontamination efficacy using undamaged skin
Journal of Applied Toxicology, 2015Co-Authors: Christopher H Dalton, Charlotte A Hall, Helen L Lydon, J K Chipman, John S Graham, John Jenner, Robert P ChilcottAbstract:Previous studies have demonstrated that Haemostatic products with an absorptive mechanism of action retain their clotting efficiency in the presence of toxic materials and are effective in decontaminating chemical warfare (CW) agents when applied to normal, intact skin. The purpose of this in vitro study was to assess three candidate Haemostatic products for effectiveness in the decontamination of superficially damaged porcine skin exposed to the radiolabelled CW agents, soman (GD), VX and sulphur mustard (HD). Controlled physical damage (removal of the upper 100 μm skin layer) resulted in a significant enhancement of the dermal absorption of all three CW agents. Of the Haemostatic products assessed, WoundStat™ was consistently the most effective, being equivalent in performance to a standard military decontaminant (fuller's earth). These data suggest that judicious application of Haemostatic products to wounds contaminated with CW agents may be a viable option for the clinical management of casualties presenting with contaminated, haemorrhaging injuries. Further studies using a relevant animal model are required to confirm the potential clinical efficacy of WoundStat™ for treating wounds contaminated with CW agents. Copyright © 2017 John Wiley & Sons, Ltd.
Robert P Chilcott - One of the best experts on this subject based on the ideXlab platform.
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development of Haemostatic decontaminants for the treatment of wounds contaminated with chemical warfare agents 2 evaluation of in vitro topical decontamination efficacy using undamaged skin
Journal of Applied Toxicology, 2015Co-Authors: Christopher H Dalton, Charlotte A Hall, Helen L Lydon, J K Chipman, John S Graham, John Jenner, Robert P ChilcottAbstract:Previous studies have demonstrated that Haemostatic products with an absorptive mechanism of action retain their clotting efficiency in the presence of toxic materials and are effective in decontaminating chemical warfare (CW) agents when applied to normal, intact skin. The purpose of this in vitro study was to assess three candidate Haemostatic products for effectiveness in the decontamination of superficially damaged porcine skin exposed to the radiolabelled CW agents, soman (GD), VX and sulphur mustard (HD). Controlled physical damage (removal of the upper 100 μm skin layer) resulted in a significant enhancement of the dermal absorption of all three CW agents. Of the Haemostatic products assessed, WoundStat™ was consistently the most effective, being equivalent in performance to a standard military decontaminant (fuller's earth). These data suggest that judicious application of Haemostatic products to wounds contaminated with CW agents may be a viable option for the clinical management of casualties presenting with contaminated, haemorrhaging injuries. Further studies using a relevant animal model are required to confirm the potential clinical efficacy of WoundStat™ for treating wounds contaminated with CW agents. Copyright © 2017 John Wiley & Sons, Ltd.
Charlotte A Hall - One of the best experts on this subject based on the ideXlab platform.
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development of Haemostatic decontaminants for the treatment of wounds contaminated with chemical warfare agents 2 evaluation of in vitro topical decontamination efficacy using undamaged skin
Journal of Applied Toxicology, 2015Co-Authors: Christopher H Dalton, Charlotte A Hall, Helen L Lydon, J K Chipman, John S Graham, John Jenner, Robert P ChilcottAbstract:Previous studies have demonstrated that Haemostatic products with an absorptive mechanism of action retain their clotting efficiency in the presence of toxic materials and are effective in decontaminating chemical warfare (CW) agents when applied to normal, intact skin. The purpose of this in vitro study was to assess three candidate Haemostatic products for effectiveness in the decontamination of superficially damaged porcine skin exposed to the radiolabelled CW agents, soman (GD), VX and sulphur mustard (HD). Controlled physical damage (removal of the upper 100 μm skin layer) resulted in a significant enhancement of the dermal absorption of all three CW agents. Of the Haemostatic products assessed, WoundStat™ was consistently the most effective, being equivalent in performance to a standard military decontaminant (fuller's earth). These data suggest that judicious application of Haemostatic products to wounds contaminated with CW agents may be a viable option for the clinical management of casualties presenting with contaminated, haemorrhaging injuries. Further studies using a relevant animal model are required to confirm the potential clinical efficacy of WoundStat™ for treating wounds contaminated with CW agents. Copyright © 2017 John Wiley & Sons, Ltd.
Helen L Lydon - One of the best experts on this subject based on the ideXlab platform.
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development of Haemostatic decontaminants for the treatment of wounds contaminated with chemical warfare agents 2 evaluation of in vitro topical decontamination efficacy using undamaged skin
Journal of Applied Toxicology, 2015Co-Authors: Christopher H Dalton, Charlotte A Hall, Helen L Lydon, J K Chipman, John S Graham, John Jenner, Robert P ChilcottAbstract:Previous studies have demonstrated that Haemostatic products with an absorptive mechanism of action retain their clotting efficiency in the presence of toxic materials and are effective in decontaminating chemical warfare (CW) agents when applied to normal, intact skin. The purpose of this in vitro study was to assess three candidate Haemostatic products for effectiveness in the decontamination of superficially damaged porcine skin exposed to the radiolabelled CW agents, soman (GD), VX and sulphur mustard (HD). Controlled physical damage (removal of the upper 100 μm skin layer) resulted in a significant enhancement of the dermal absorption of all three CW agents. Of the Haemostatic products assessed, WoundStat™ was consistently the most effective, being equivalent in performance to a standard military decontaminant (fuller's earth). These data suggest that judicious application of Haemostatic products to wounds contaminated with CW agents may be a viable option for the clinical management of casualties presenting with contaminated, haemorrhaging injuries. Further studies using a relevant animal model are required to confirm the potential clinical efficacy of WoundStat™ for treating wounds contaminated with CW agents. Copyright © 2017 John Wiley & Sons, Ltd.
