The Experts below are selected from a list of 273 Experts worldwide ranked by ideXlab platform
Shigeki Matsunaga - One of the best experts on this subject based on the ideXlab platform.
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halicylindrosides antifungal and cytotoxic cerebrosides from the marine sponge Halichondria cylindrata
Tetrahedron, 1995Co-Authors: Shigeki Matsunaga, Nobuhiro FusetaniAbstract:Abstract Ten new glycosphingolipids, halicylindrosides A 1 –A 4 ( 1–4 ) and B 1 –B 6 ( 5–10 ) have been isolated from the Japanese marine sponge Halichondria cylindrata . Their structures were determined by spectroscopic and chemical methods. These cerebrosides were moderately antifungal against Mortierella remanniana , and cytotoxic against P388 murine leukemia cells
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Halicylindramides A-C, antifungal and cytotoxic depsipeptides from the marine sponge Halichondria cylindrata
Journal of medicinal chemistry, 1995Co-Authors: Shigeki Matsunaga, Nobuhiro FusetaniAbstract:Halicylindramides A-C (1-3) have been isolated from the Japanese marine sponge Halichondria cylindrata. They are tetradecapeptides with the N-terminus blocked by a formyl group and the C-terminus lactonized with a threonine residue. Their total structures including absolute stereochemistry were determined by a combination of spectral and chemical methods. Halicylindramides A-C were antifungal against Mortierella ramanniana and cytotoxic against P388 murine leukemia cells.
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cylindramide cytotoxic tetramic acid lactam from the marine sponge Halichondria cylindrata tanita hoshino
Tetrahedron Letters, 1993Co-Authors: Satoshi Kanazawa, Nobuhiro Fusetani, Shigeki MatsunagaAbstract:Abstract A cytotoxic tetramic acid lactam named cylindramide ( 1 ) has been isolated from the marine sponge Halichondria cylindrata . The structure was determined by interpretation of 2D NMR spectra as a macrocyclic lactam including an acyltetramic acid and a trisubstituted bicyclo[3. 3. 0]octene. This lactam was cytotoxic against B16 melanoma cells with an IC 50 of 0.8 μg/mL.
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Cylindramide: Cytotoxic tetramic acid lactam from the marine sponge Halichondria cylindrata Tanita & Hoshino
Tetrahedron Letters, 1993Co-Authors: Satoshi Kanazawa, Nobuhiro Fusetani, Shigeki MatsunagaAbstract:Abstract A cytotoxic tetramic acid lactam named cylindramide ( 1 ) has been isolated from the marine sponge Halichondria cylindrata . The structure was determined by interpretation of 2D NMR spectra as a macrocyclic lactam including an acyltetramic acid and a trisubstituted bicyclo[3. 3. 0]octene. This lactam was cytotoxic against B16 melanoma cells with an IC 50 of 0.8 μg/mL.
Nobuhiro Fusetani - One of the best experts on this subject based on the ideXlab platform.
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halicylindrosides antifungal and cytotoxic cerebrosides from the marine sponge Halichondria cylindrata
Tetrahedron, 1995Co-Authors: Shigeki Matsunaga, Nobuhiro FusetaniAbstract:Abstract Ten new glycosphingolipids, halicylindrosides A 1 –A 4 ( 1–4 ) and B 1 –B 6 ( 5–10 ) have been isolated from the Japanese marine sponge Halichondria cylindrata . Their structures were determined by spectroscopic and chemical methods. These cerebrosides were moderately antifungal against Mortierella remanniana , and cytotoxic against P388 murine leukemia cells
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Halicylindramides A-C, antifungal and cytotoxic depsipeptides from the marine sponge Halichondria cylindrata
Journal of medicinal chemistry, 1995Co-Authors: Shigeki Matsunaga, Nobuhiro FusetaniAbstract:Halicylindramides A-C (1-3) have been isolated from the Japanese marine sponge Halichondria cylindrata. They are tetradecapeptides with the N-terminus blocked by a formyl group and the C-terminus lactonized with a threonine residue. Their total structures including absolute stereochemistry were determined by a combination of spectral and chemical methods. Halicylindramides A-C were antifungal against Mortierella ramanniana and cytotoxic against P388 murine leukemia cells.
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cylindramide cytotoxic tetramic acid lactam from the marine sponge Halichondria cylindrata tanita hoshino
Tetrahedron Letters, 1993Co-Authors: Satoshi Kanazawa, Nobuhiro Fusetani, Shigeki MatsunagaAbstract:Abstract A cytotoxic tetramic acid lactam named cylindramide ( 1 ) has been isolated from the marine sponge Halichondria cylindrata . The structure was determined by interpretation of 2D NMR spectra as a macrocyclic lactam including an acyltetramic acid and a trisubstituted bicyclo[3. 3. 0]octene. This lactam was cytotoxic against B16 melanoma cells with an IC 50 of 0.8 μg/mL.
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Cylindramide: Cytotoxic tetramic acid lactam from the marine sponge Halichondria cylindrata Tanita & Hoshino
Tetrahedron Letters, 1993Co-Authors: Satoshi Kanazawa, Nobuhiro Fusetani, Shigeki MatsunagaAbstract:Abstract A cytotoxic tetramic acid lactam named cylindramide ( 1 ) has been isolated from the marine sponge Halichondria cylindrata . The structure was determined by interpretation of 2D NMR spectra as a macrocyclic lactam including an acyltetramic acid and a trisubstituted bicyclo[3. 3. 0]octene. This lactam was cytotoxic against B16 melanoma cells with an IC 50 of 0.8 μg/mL.
Satoshi Kanazawa - One of the best experts on this subject based on the ideXlab platform.
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cylindramide cytotoxic tetramic acid lactam from the marine sponge Halichondria cylindrata tanita hoshino
Tetrahedron Letters, 1993Co-Authors: Satoshi Kanazawa, Nobuhiro Fusetani, Shigeki MatsunagaAbstract:Abstract A cytotoxic tetramic acid lactam named cylindramide ( 1 ) has been isolated from the marine sponge Halichondria cylindrata . The structure was determined by interpretation of 2D NMR spectra as a macrocyclic lactam including an acyltetramic acid and a trisubstituted bicyclo[3. 3. 0]octene. This lactam was cytotoxic against B16 melanoma cells with an IC 50 of 0.8 μg/mL.
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Cylindramide: Cytotoxic tetramic acid lactam from the marine sponge Halichondria cylindrata Tanita & Hoshino
Tetrahedron Letters, 1993Co-Authors: Satoshi Kanazawa, Nobuhiro Fusetani, Shigeki MatsunagaAbstract:Abstract A cytotoxic tetramic acid lactam named cylindramide ( 1 ) has been isolated from the marine sponge Halichondria cylindrata . The structure was determined by interpretation of 2D NMR spectra as a macrocyclic lactam including an acyltetramic acid and a trisubstituted bicyclo[3. 3. 0]octene. This lactam was cytotoxic against B16 melanoma cells with an IC 50 of 0.8 μg/mL.
Jon Clardy - One of the best experts on this subject based on the ideXlab platform.
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the three dimensional structure of neohalicholactone an unusual fatty acid metabolite from the marine sponge Halichondria okadai kadota
Tetrahedron Letters, 1991Co-Authors: Hideo Kigoshi, Haruki Niwa, Kiyoyuki Yamada, Thomas J Stout, Jon ClardyAbstract:The three-dimensional structure of the unusual fatty acid metabolite neohalicholactone, isolated from the marine sponge Halinchondria okadai Kadota, has been determined by X-ray crystallography.
Akio Murai - One of the best experts on this subject based on the ideXlab platform.
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synthesis of halipanicine a marine sesquiterpene isothiocyanate isolated from an okinawan marine sponge Halichondria panicea
Tetrahedron Letters, 1992Co-Authors: Hideshi Nakamura, Akio MuraiAbstract:Abstract (±)-Halipanicine, 4-isothiocyanato-1-cadinene, isolated from an Okinawan marine sponge Halichondria panicea was synthesized from (±)-cryptone in 21 steps in 7.7% total yield. The regio- and stereospecific synthesis esablished the relative stereochemistry of halipanicine.
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Synthesis of (±)-halipanicine, a marine sesquiterpene isothiocyanate isolated from an Okinawan marine sponge Halichondria panicea
Tetrahedron Letters, 1992Co-Authors: Hideshi Nakamura, Akio MuraiAbstract:Abstract (±)-Halipanicine, 4-isothiocyanato-1-cadinene, isolated from an Okinawan marine sponge Halichondria panicea was synthesized from (±)-cryptone in 21 steps in 7.7% total yield. The regio- and stereospecific synthesis esablished the relative stereochemistry of halipanicine.
