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Iria Neri - One of the best experts on this subject based on the ideXlab platform.
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association of Halo Nevus i and vitiligo in childhood a retrospective observational study
Journal of The European Academy of Dermatology and Venereology, 2013Co-Authors: Annalisa Patrizi, M Bentivogli, Arianna Dondi, Michela Tabanelli, Beatrice Raone, Iria NeriAbstract:Background Although Halo Nevus (HN) is frequently observed, the relationship between vitiligo and HN in children has rarely been investigated. Objectives To investigate the association between HN and vitiligo in children and understand if HN/HNi might be a risk factor for vitiligo. Methods Ninety-eight patients with only HN/HNi and 27 with HN/HNi and vitiligo were investigated for number and localization of HN/HNi, family history for HN/HNi and vitiligo and personal and family history for autoimmune or other diseases. A follow-up telephone interview was performed to investigate the evolution of HN/HNi and the possible onset of vitiligo and/or other diseases. Results In the HN/HNi and vitiligo group, HN/HNi and vitiligo had started almost simultaneously in 11 children; in nine, the onset of HN/HNi was followed by vitiligo after 6 months to 5 years; seven patients presented vitiligo first and HN/HNi after 3–9 years. Patients with associated vitiligo had, significantly more often, multiple HNi and a positive personal and/or family history of autoimmune thyroiditis compared with those with only HN/HNi. Follow-up longer than 5 years was available in 54/98 patients with only HN/HNi; two of them, both with multiple HNi, developed vitiligo. After follow-up, multiple HNi were noticed in 18/52 patients without vitiligo and in 9/11 of those in whom HN/HNi heralded vitiligo (s.s.). Conclusions In patients with multiple HNi, the risk of vitiligo and other autoimmune diseases seems to be higher than in pediatric patients with a single HN; clinicians should pay particular attention to children with multiple HNi and personal or family history of autoimmune diseases.
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Association of Halo Nevus/i and vitiligo in childhood: a retrospective observational study
Journal of the European Academy of Dermatology and Venereology : JEADV, 2012Co-Authors: Annalisa Patrizi, M Bentivogli, Arianna Dondi, Michela Tabanelli, Beatrice Raone, Iria NeriAbstract:Background Although Halo Nevus (HN) is frequently observed, the relationship between vitiligo and HN in children has rarely been investigated. Objectives To investigate the association between HN and vitiligo in children and understand if HN/HNi might be a risk factor for vitiligo. Methods Ninety-eight patients with only HN/HNi and 27 with HN/HNi and vitiligo were investigated for number and localization of HN/HNi, family history for HN/HNi and vitiligo and personal and family history for autoimmune or other diseases. A follow-up telephone interview was performed to investigate the evolution of HN/HNi and the possible onset of vitiligo and/or other diseases. Results In the HN/HNi and vitiligo group, HN/HNi and vitiligo had started almost simultaneously in 11 children; in nine, the onset of HN/HNi was followed by vitiligo after 6 months to 5 years; seven patients presented vitiligo first and HN/HNi after 3–9 years. Patients with associated vitiligo had, significantly more often, multiple HNi and a positive personal and/or family history of autoimmune thyroiditis compared with those with only HN/HNi. Follow-up longer than 5 years was available in 54/98 patients with only HN/HNi; two of them, both with multiple HNi, developed vitiligo. After follow-up, multiple HNi were noticed in 18/52 patients without vitiligo and in 9/11 of those in whom HN/HNi heralded vitiligo (s.s.). Conclusions In patients with multiple HNi, the risk of vitiligo and other autoimmune diseases seems to be higher than in pediatric patients with a single HN; clinicians should pay particular attention to children with multiple HNi and personal or family history of autoimmune diseases.
Annalisa Patrizi - One of the best experts on this subject based on the ideXlab platform.
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association of Halo Nevus i and vitiligo in childhood a retrospective observational study
Journal of The European Academy of Dermatology and Venereology, 2013Co-Authors: Annalisa Patrizi, M Bentivogli, Arianna Dondi, Michela Tabanelli, Beatrice Raone, Iria NeriAbstract:Background Although Halo Nevus (HN) is frequently observed, the relationship between vitiligo and HN in children has rarely been investigated. Objectives To investigate the association between HN and vitiligo in children and understand if HN/HNi might be a risk factor for vitiligo. Methods Ninety-eight patients with only HN/HNi and 27 with HN/HNi and vitiligo were investigated for number and localization of HN/HNi, family history for HN/HNi and vitiligo and personal and family history for autoimmune or other diseases. A follow-up telephone interview was performed to investigate the evolution of HN/HNi and the possible onset of vitiligo and/or other diseases. Results In the HN/HNi and vitiligo group, HN/HNi and vitiligo had started almost simultaneously in 11 children; in nine, the onset of HN/HNi was followed by vitiligo after 6 months to 5 years; seven patients presented vitiligo first and HN/HNi after 3–9 years. Patients with associated vitiligo had, significantly more often, multiple HNi and a positive personal and/or family history of autoimmune thyroiditis compared with those with only HN/HNi. Follow-up longer than 5 years was available in 54/98 patients with only HN/HNi; two of them, both with multiple HNi, developed vitiligo. After follow-up, multiple HNi were noticed in 18/52 patients without vitiligo and in 9/11 of those in whom HN/HNi heralded vitiligo (s.s.). Conclusions In patients with multiple HNi, the risk of vitiligo and other autoimmune diseases seems to be higher than in pediatric patients with a single HN; clinicians should pay particular attention to children with multiple HNi and personal or family history of autoimmune diseases.
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Association of Halo Nevus/i and vitiligo in childhood: a retrospective observational study
Journal of the European Academy of Dermatology and Venereology : JEADV, 2012Co-Authors: Annalisa Patrizi, M Bentivogli, Arianna Dondi, Michela Tabanelli, Beatrice Raone, Iria NeriAbstract:Background Although Halo Nevus (HN) is frequently observed, the relationship between vitiligo and HN in children has rarely been investigated. Objectives To investigate the association between HN and vitiligo in children and understand if HN/HNi might be a risk factor for vitiligo. Methods Ninety-eight patients with only HN/HNi and 27 with HN/HNi and vitiligo were investigated for number and localization of HN/HNi, family history for HN/HNi and vitiligo and personal and family history for autoimmune or other diseases. A follow-up telephone interview was performed to investigate the evolution of HN/HNi and the possible onset of vitiligo and/or other diseases. Results In the HN/HNi and vitiligo group, HN/HNi and vitiligo had started almost simultaneously in 11 children; in nine, the onset of HN/HNi was followed by vitiligo after 6 months to 5 years; seven patients presented vitiligo first and HN/HNi after 3–9 years. Patients with associated vitiligo had, significantly more often, multiple HNi and a positive personal and/or family history of autoimmune thyroiditis compared with those with only HN/HNi. Follow-up longer than 5 years was available in 54/98 patients with only HN/HNi; two of them, both with multiple HNi, developed vitiligo. After follow-up, multiple HNi were noticed in 18/52 patients without vitiligo and in 9/11 of those in whom HN/HNi heralded vitiligo (s.s.). Conclusions In patients with multiple HNi, the risk of vitiligo and other autoimmune diseases seems to be higher than in pediatric patients with a single HN; clinicians should pay particular attention to children with multiple HNi and personal or family history of autoimmune diseases.
Venâncio A. F. Alves - One of the best experts on this subject based on the ideXlab platform.
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Estudo comparativo entre vitiligo, nevo Halo e lúpus eritematoso vitiligóide por meio de métodos imunológicos, histológicos e imuno-histoquímicos Comparative study of vitiligo, Halo Nevus, and vitiligoid variant of lupus erythematosus by immunologica
Sociedade Brasileira de Dermatologia, 2005Co-Authors: Luiz Gonzaga Souza C. Filho, Evandro A. Rivitti, Lucy M. Miyauchi, Mirian N. Sotto, Durvanei A. Maria, Shigueko S. T. Puejo, Venâncio A. F. AlvesAbstract:FUNDAMENTOS: O estudo compara o vitiligo, o nevo Halo (NH) e lúpus eritematoso vitiligóide (LEV) do ponto de vista imunológico, histológico e histoquímico. OBJETIVOS: Avaliar diferenças imuno-histoquímicas entre essas doenças e investigar se a despigmentação do LEV deve-se à destruição pós-inflamatória ou à agressão imunológica aos melanócitos. MÉTODOS: Foram avaliados 20 pacientes com vitiligo, 17 com vitiligo e NH, cinco com NH isolado e 15 com LEV. Detecção de anticorpos: IF direta e indireta com células névicas e de melanoma. Citotoxicidade: atividade NK contra células de melanoma. Estudo anátomo-histoquímico: exame histológico com hematoxilina e eosina, Fontana-Masson, Dopa e Dopa mais prata (D+P) e exame histoquímico com proteína S-100. RESULTADOS: Doentes com vitiligo, NH e LEV apresentaram anticorpos antimelanócitos. Tanto no vitiligo e NH, como no LEV, demonstrou-se a presença de fatores de risco favorecedores da citotoxicidade celular. A coloração com D+P foi superior às colorações tradicionais e à proteína S-100 na detecção de melanócitos e melanina nas lesões de vitiligo, NH e LEV. CONCLUSÕES: Demonstrou-se a existência de anticorpos antimelanócitos no vitiligo e NH. É possível que a despigmentação no LEV se deva a fenômenos imunológicos semelhantes aos do vitiligo e NH. A detecção de melanócitos nas lesões de vitiligo sugere mais inibição funcional do que destruição dessas células.BACKGROUND: There are no records of comparative studies on the immunological, histological and immunohistochemical aspects of vitiligo, Halo Nevus and vitiligoid variant of lupus erythematosus in the literature. The studies available present only descriptive clinical data on leucoderma that accompanies lupus erythematosus in its diverse clinical forms. OBJECTIVES: 1- To evaluate the immunohistochemical differences between vitiligo, Halo Nevus and vitiligoid variant of lupus erythematosus; 2- To verify whether the depigmentation observed in the diverse clinical forms of lupus is due to post-inflammatory destruction or to specific immunological attack on melanocytes. METHODS: 1- Detection of melanocyte antibodies: by direct and indirect immunofluorescence on Nevus and melanoma cells; 2- Cytotoxicity evaluation: study of the activity of NK cells against cultivated melanoma cells; 3- Histopathological study of melanocytes and melanin: histopathology with hematoxylin-eosin, Fontana- Masson, Dopa and Dopa + silver and S-100 protein test by immunoperoxidase. RESULTS: Vitiligo and Halo Nevus patients presented to antimelanocyte antibodies in 25% of cases. Patients with vitiligoid variant of lupus erythematous also presented these antibodies. The presence of risk factors favoring cellular cytotoxicity was demonstrated in vitiligo and/or Halo Nevus, as well as in the vitiligoid variant of lupus erythematous. Staining with Dopa + silver nitrate was superior to traditional staining and to S-100 protein to detect melanocytes and/or melanin in depigmented lesions of vitiligo and/or Halo Nevus and vitiligoid variant of lupus erythematous. CONCLUSION: The results confirm the existence of antimelanocyte antibodies in vitiligo and Halo Nevus. It is not possible to rule out some immunological phenomena similar to those occurring in vitiligo and Halo Nevus in the genesis of vitiligoid lesions in lupus erythematous. The detection of melanocytes in achromic lesions of vitiligo suggests the predominance of a functional inhibitory mechanism rather than cell destruction in the genesis of the disease
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estudo comparativo entre vitiligo nevo Halo e lupus eritematoso vitiligoide por meio de metodos imunologicos histologicos e imuno histoquimicos comparative study of vitiligo Halo Nevus and vitiligoid variant of lupus erythematosus by immunological hi
2005Co-Authors: Luiz Gonzaga, Evandro A. Rivitti, Lucy M. Miyauchi, Mirian N. Sotto, Durvanei A. Maria, Souza C Filho, Venâncio A. F. AlvesAbstract:Abstract : B ACKGROUND : There are no records of comparative studies on the immunological, histological and immunohistochemical aspects ofvitiligo, Halo Nevus and vitiligoid variant of lupus erythematosus in the literature. The studies available present only descriptive clinical dataon leucoderma that accompanies lupus erythematosus in its diverse clinical forms.O BJECTIVES : 1- To evaluate the immunohistochemical differences between vitiligo, Halo Nevus and vitiligoid variant of lupus erythematosus; 2- Toverify whether the depigmentation observed in the diverse clinical forms of lupus is due to post-inflammatory destruction or to specificimmunological attack on melanocytes.M ETHODS : 1- Detection of melanocyte antibodies: by direct and indirect immunofluorescence on Nevus and melanoma cells; 2- Cytotoxicityevaluation: study of the activity of NK cells against cultivated melanoma cells; 3- Histopathological study of melanocytes and melanin:histopathology with hematoxylin-eosin, Fontana- Masson, Dopa and Dopa + silver and S-100 protein test by immunoperoxidase.R
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Estudo comparativo entre vitiligo, nevo Halo e lúpus eritematoso vitiligóide por meio de métodos imunológicos, histológicos e imuno-histoquímicos
Anais Brasileiros de Dermatologia, 2005Co-Authors: Luiz Gonzaga De Castro E Souza Filho, Evandro A. Rivitti, Lucy M. Miyauchi, Mirian N. Sotto, Durvanei A. Maria, Shigueko S. T. Puejo, Venâncio A. F. AlvesAbstract:BACKGROUND: There are no records of comparative studies on the immunological, histological and immunohistochemical aspects of vitiligo, Halo Nevus and vitiligoid variant of lupus erythematosus in the literature. The studies available present only descriptive clinical data on leucoderma that accompanies lupus erythematosus in its diverse clinical forms. OBJECTIVES: 1- To evaluate the immunohistochemical differences between vitiligo, Halo Nevus and vitiligoid variant of lupus erythematosus; 2- To verify whether the depigmentation observed in the diverse clinical forms of lupus is due to post-inflammatory destruction or to specific immunological attack on melanocytes. METHODS: 1- Detection of melanocyte antibodies: by direct and indirect immunofluorescence on Nevus and melanoma cells; 2- Cytotoxicity evaluation: study of the activity of NK cells against cultivated melanoma cells; 3- Histopathological study of melanocytes and melanin: histopathology with hematoxylin-eosin, Fontana- Masson, Dopa and Dopa + silver and S-100 protein test by immunoperoxidase. RESULTS: Vitiligo and Halo Nevus patients presented to antimelanocyte antibodies in 25% of cases. Patients with vitiligoid variant of lupus erythematous also presented these antibodies. The presence of risk factors favoring cellular cytotoxicity was demonstrated in vitiligo and/or Halo Nevus, as well as in the vitiligoid variant of lupus erythematous. Staining with Dopa + silver nitrate was superior to traditional staining and to S-100 protein to detect melanocytes and/or melanin in depigmented lesions of vitiligo and/or Halo Nevus and vitiligoid variant of lupus erythematous. CONCLUSION: The results confirm the existence of antimelanocyte antibodies in vitiligo and Halo Nevus. It is not possible to rule out some immunological phenomena similar to those occurring in vitiligo and Halo Nevus in the genesis of vitiligoid lesions in lupus erythematous. The detection of melanocytes in achromic lesions of vitiligo suggests the predominance of a functional inhibitory mechanism rather than cell destruction in the genesis of the disease.
Samuel Henrique Mandelbaum - One of the best experts on this subject based on the ideXlab platform.
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Association of giant congenital melanocytic Nevus, Halo Nevus and vitiligo in a 75-year-old patient
Anais brasileiros de dermatologia, 2012Co-Authors: Marina Leite Da Silveira, Flávia Regina Ferreira, Marcia Lanzoni De Alvarenga, Samuel Henrique MandelbaumAbstract:A giant congenital melanocytic Nevus represents a rare condition. The Halo phenomenon may be seen in congenital or acquired melanocytic nevi. In the literature, association of Halo Nevus and giant congenital melanocytic Nevus is rare and the association of both with vitiligo even more rare. A 75-yearold woman at first consultation complained of a hyperchromic bluish-brown hairy macula on the lower back, buttocks and thighs present since birth and an achromic Halo of onset three years ago. The histological features were consistent with congenital melanocytic Nevus and Halo Nevus, respectively. After two years the patient developed achromic areas in normal skin, histologically consistent with vitiligo. The authors emphasize the rarity of this triple combination, the patient's age and the absence of malignant degeneration to date.
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association of giant congenital melanocytic Nevus Halo Nevus and vitiligo in a 75 year old patient associacao de nevo melanocitico congenito gigante nevo Halo e vitiligo relato de caso em paciente de 75 anos
2012Co-Authors: Marina Leite Da Silveira, Flávia Regina Ferreira, Marcia Lanzoni De Alvarenga, Samuel Henrique MandelbaumAbstract:4 Abstract: A giant congenital melanocytic Nevus represents a rare condition. The Halo phenomenon may be seen in congenital or acquired melanocytic nevi. In the literature, association of Halo Nevus and giant congenital melanocytic Nevus is rare and the association of both with vitiligo even more rare. A 75-year- old woman at first consultation complained of a hyperchromic bluish-brown hairy macula on the lower back, buttocks and thighs present since birth and an achromic Halo of onset three years ago. The histo- logical features were consistent with congenital melanocytic Nevus and Halo Nevus, respectively. After two years the patient developed achromic areas in normal skin, histologically consistent with vitiligo. The authors emphasize the rarity of this triple combination, the patient's age and the absence of malig- nant degeneration to date. Keywords: Nevus, Halo; Nevus, pigmented; Vitiligo Resumo: Nevo melanocitico congenito gigante constitui uma condicao rara. O fenomeno Halo pode ser observado em nevos melanociticos congenitos ou adquiridos. Na literatura a associacao nevo Halo e nevo melanocitico congenito gigante e rara e a associacao de ambos com vitiligo ainda mais rara. Mulher de 75 anos que a primeira consulta apresentava macula hipercromica castanho-azulada pilosa na regiao lom- bar, nadegas e coxas desde o nascimento e Halo acromico de aparecimento ha 3 anos. Os histologicos foram compativeis com nevo melanocitico congenito e nevo Halo respectivamente. Apos dois anos evo- luiu com areas de acromia a distância, com histologico de vitiligo. Os autores ressaltam a raridade desta tripla associacao; a idade da paciente e a ausencia de degeneracao maligna ate o presente momento. Palavras-chave: Nevo com Halo; Nevo pigmentado; Vitiligo
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Association of giant congenital melanocytic Nevus, Halo Nevus and vitiligo in a 75-year-old patient Associação de nevo melanocítico congênito gigante, nevo Halo e vitiligo. Relato de caso em paciente de 75 anos
Sociedade Brasileira de Dermatologia, 2012Co-Authors: Marina Leite Da Silveira, Flávia Regina Ferreira, Marcia Lanzoni De Alvarenga, Samuel Henrique MandelbaumAbstract:A giant congenital melanocytic Nevus represents a rare condition. The Halo phenomenon may be seen in congenital or acquired melanocytic nevi. In the literature, association of Halo Nevus and giant congenital melanocytic Nevus is rare and the association of both with vitiligo even more rare. A 75-yearold woman at first consultation complained of a hyperchromic bluish-brown hairy macula on the lower back, buttocks and thighs present since birth and an achromic Halo of onset three years ago. The histological features were consistent with congenital melanocytic Nevus and Halo Nevus, respectively. After two years the patient developed achromic areas in normal skin, histologically consistent with vitiligo. The authors emphasize the rarity of this triple combination, the patient's age and the absence of malignant degeneration to date.Nevo melanocitico congênito gigante constitui uma condição rara. O fenômeno Halo pode ser observado em nevos melanocíticos congênitos ou adquiridos. Na literatura a associação nevo Halo e nevo melanocítico congênito gigante é rara e a associação de ambos com vitiligo ainda mais rara. Mulher de 75 anos que à primeira consulta apresentava mácula hipercrômica castanho-azulada pilosa na região lombar, nádegas e coxas desde o nascimento e Halo acrômico de aparecimento há 3 anos. Os histológicos foram compatíveis com nevo melanocítico congênito e nevo Halo respectivamente. Após dois anos evoluiu com áreas de acromia à distância, com histológico de vitiligo. Os autores ressaltam a raridade desta tripla associação; a idade da paciente e a ausência de degeneração maligna até o presente momento
M Bentivogli - One of the best experts on this subject based on the ideXlab platform.
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association of Halo Nevus i and vitiligo in childhood a retrospective observational study
Journal of The European Academy of Dermatology and Venereology, 2013Co-Authors: Annalisa Patrizi, M Bentivogli, Arianna Dondi, Michela Tabanelli, Beatrice Raone, Iria NeriAbstract:Background Although Halo Nevus (HN) is frequently observed, the relationship between vitiligo and HN in children has rarely been investigated. Objectives To investigate the association between HN and vitiligo in children and understand if HN/HNi might be a risk factor for vitiligo. Methods Ninety-eight patients with only HN/HNi and 27 with HN/HNi and vitiligo were investigated for number and localization of HN/HNi, family history for HN/HNi and vitiligo and personal and family history for autoimmune or other diseases. A follow-up telephone interview was performed to investigate the evolution of HN/HNi and the possible onset of vitiligo and/or other diseases. Results In the HN/HNi and vitiligo group, HN/HNi and vitiligo had started almost simultaneously in 11 children; in nine, the onset of HN/HNi was followed by vitiligo after 6 months to 5 years; seven patients presented vitiligo first and HN/HNi after 3–9 years. Patients with associated vitiligo had, significantly more often, multiple HNi and a positive personal and/or family history of autoimmune thyroiditis compared with those with only HN/HNi. Follow-up longer than 5 years was available in 54/98 patients with only HN/HNi; two of them, both with multiple HNi, developed vitiligo. After follow-up, multiple HNi were noticed in 18/52 patients without vitiligo and in 9/11 of those in whom HN/HNi heralded vitiligo (s.s.). Conclusions In patients with multiple HNi, the risk of vitiligo and other autoimmune diseases seems to be higher than in pediatric patients with a single HN; clinicians should pay particular attention to children with multiple HNi and personal or family history of autoimmune diseases.
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Association of Halo Nevus/i and vitiligo in childhood: a retrospective observational study
Journal of the European Academy of Dermatology and Venereology : JEADV, 2012Co-Authors: Annalisa Patrizi, M Bentivogli, Arianna Dondi, Michela Tabanelli, Beatrice Raone, Iria NeriAbstract:Background Although Halo Nevus (HN) is frequently observed, the relationship between vitiligo and HN in children has rarely been investigated. Objectives To investigate the association between HN and vitiligo in children and understand if HN/HNi might be a risk factor for vitiligo. Methods Ninety-eight patients with only HN/HNi and 27 with HN/HNi and vitiligo were investigated for number and localization of HN/HNi, family history for HN/HNi and vitiligo and personal and family history for autoimmune or other diseases. A follow-up telephone interview was performed to investigate the evolution of HN/HNi and the possible onset of vitiligo and/or other diseases. Results In the HN/HNi and vitiligo group, HN/HNi and vitiligo had started almost simultaneously in 11 children; in nine, the onset of HN/HNi was followed by vitiligo after 6 months to 5 years; seven patients presented vitiligo first and HN/HNi after 3–9 years. Patients with associated vitiligo had, significantly more often, multiple HNi and a positive personal and/or family history of autoimmune thyroiditis compared with those with only HN/HNi. Follow-up longer than 5 years was available in 54/98 patients with only HN/HNi; two of them, both with multiple HNi, developed vitiligo. After follow-up, multiple HNi were noticed in 18/52 patients without vitiligo and in 9/11 of those in whom HN/HNi heralded vitiligo (s.s.). Conclusions In patients with multiple HNi, the risk of vitiligo and other autoimmune diseases seems to be higher than in pediatric patients with a single HN; clinicians should pay particular attention to children with multiple HNi and personal or family history of autoimmune diseases.
