The Experts below are selected from a list of 228 Experts worldwide ranked by ideXlab platform
Ca Montecucco - One of the best experts on this subject based on the ideXlab platform.
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ultrasound imaging for the rheumatologist xxiv sonographic evaluation of wrist and Hand Joint and tendon involvement in systemic lupus erythematosus
Clinical and Experimental Rheumatology, 2009Co-Authors: Delle A Sedie, Lucrezia Riente, C A Scire, Annamaria Iagnocco, Emilio Filippucci, G Meenagh, N Possemato, W Grassi, Guido Valesini, Ca MontecuccoAbstract:Systemic lupus erhthematosus (SLE) is an autoimmune multisystem disorder characterised by frequent musculoskeletal manifestations. Joint involvement in SLE is usually not erosive or destructive but some patients develop Hand erosive arthritis or deforming arthropathy of the Hand (respectively "rhupus" Hand and Jaccoud arthritis). To date, few studies, evaluated Joint and tendon involvement in SLE patients by US. We studied wrist and Hand structure, using ultrasound, in 50 patients affected by SLE, detecting inflammatory Joint involvement in 80% of them at the wrist and in 50% at the Hand. Tenosynovitis was visualised in 14 patients, while structural damage was present in 12% of the SLE group. Those results reinforce the importance of including musculoskeletal ultrasound in the patient assessment, especially in those cases in which physical examination is not conclusive.
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ultrasound imaging for the rheumatologist xxiv sonographic evaluation of wrist and Hand Joint and tendon involvement in systemic lupus erythematosus
Clinical and Experimental Rheumatology, 2009Co-Authors: Delle A Sedie, Lucrezia Riente, C A Scire, Annamaria Iagnocco, Emilio Filippucci, G Meenagh, N Possemato, W Grassi, Guido Valesini, Ca MontecuccoAbstract:Systemic lupus erhthematosus (SLE) is an autoimmune multisystem disorder characterised by frequent musculoskeletal manifestations. Joint involvement in SLE is usually not erosive or destructive but some patients develop Hand erosive arthritis or deforming arthropathy of the Hand (respectively "rhupus" Hand and Jaccoud arthritis). To date, few studies, evaluated Joint and tendon involvement in SLE patients by US. We studied wrist and Hand structure, using ultrasound, in 50 patients affected by SLE, detecting inflammatory Joint involvement in 80% of them at the wrist and in 50% at the Hand. Tenosynovitis was visualised in 14 patients, while structural damage was present in 12% of the SLE group. Those results reinforce the importance of including musculoskeletal ultrasound in the patient assessment, especially in those cases in which physical examination is not conclusive.
Delle A Sedie - One of the best experts on this subject based on the ideXlab platform.
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ultrasound imaging for the rheumatologist xxiv sonographic evaluation of wrist and Hand Joint and tendon involvement in systemic lupus erythematosus
Clinical and Experimental Rheumatology, 2009Co-Authors: Delle A Sedie, Lucrezia Riente, C A Scire, Annamaria Iagnocco, Emilio Filippucci, G Meenagh, N Possemato, W Grassi, Guido Valesini, Ca MontecuccoAbstract:Systemic lupus erhthematosus (SLE) is an autoimmune multisystem disorder characterised by frequent musculoskeletal manifestations. Joint involvement in SLE is usually not erosive or destructive but some patients develop Hand erosive arthritis or deforming arthropathy of the Hand (respectively "rhupus" Hand and Jaccoud arthritis). To date, few studies, evaluated Joint and tendon involvement in SLE patients by US. We studied wrist and Hand structure, using ultrasound, in 50 patients affected by SLE, detecting inflammatory Joint involvement in 80% of them at the wrist and in 50% at the Hand. Tenosynovitis was visualised in 14 patients, while structural damage was present in 12% of the SLE group. Those results reinforce the importance of including musculoskeletal ultrasound in the patient assessment, especially in those cases in which physical examination is not conclusive.
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ultrasound imaging for the rheumatologist xxiv sonographic evaluation of wrist and Hand Joint and tendon involvement in systemic lupus erythematosus
Clinical and Experimental Rheumatology, 2009Co-Authors: Delle A Sedie, Lucrezia Riente, C A Scire, Annamaria Iagnocco, Emilio Filippucci, G Meenagh, N Possemato, W Grassi, Guido Valesini, Ca MontecuccoAbstract:Systemic lupus erhthematosus (SLE) is an autoimmune multisystem disorder characterised by frequent musculoskeletal manifestations. Joint involvement in SLE is usually not erosive or destructive but some patients develop Hand erosive arthritis or deforming arthropathy of the Hand (respectively "rhupus" Hand and Jaccoud arthritis). To date, few studies, evaluated Joint and tendon involvement in SLE patients by US. We studied wrist and Hand structure, using ultrasound, in 50 patients affected by SLE, detecting inflammatory Joint involvement in 80% of them at the wrist and in 50% at the Hand. Tenosynovitis was visualised in 14 patients, while structural damage was present in 12% of the SLE group. Those results reinforce the importance of including musculoskeletal ultrasound in the patient assessment, especially in those cases in which physical examination is not conclusive.
David T Felson - One of the best experts on this subject based on the ideXlab platform.
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chopstick arthropathy the beijing osteoarthritis study
Arthritis & Rheumatism, 2004Co-Authors: David J Hunter, Yuqing Zhang, Piran Aliabadi, Michael C Nevitt, Ling Xu, Wei Yu, David T FelsonAbstract:Objective Several investigators have speculated that mechanical stress might play an important role in the development of Hand osteoarthritis (OA). Chopsticks, used universally as eating utensils in China, increase Joint loading in the first through third fingers. We conducted a population-based survey among elderly Chinese individuals living in Beijing, to explore whether chopsticks use is associated with prevalent Hand OA. Methods We recruited a sample of persons ages 60 years and older, using door-to-door enumeration in randomly selected neighborhoods in Beijing. Subjects answered questions about the Hand with which they use chopsticks, Handedness, and pincer grip activities. Bilateral posteroanterior Hand radiographs were obtained, and each Joint was graded according to the Kellgren/Lawrence (K/L) scale. We defined a subject as having radiographic OA if at least 1 of his or her Hand Joints had radiographic OA (K/L score of ≥2). We defined a particular Hand group (i.e., distal interphalangeal [DIP] Joints, proximal interphalangeal [PIP] Joints, or metacarpophalangeal [MCP] Joints) as having OA if at least 1 Joint of the group had radiographic OA. We calculated the prevalence of OA for each Hand Joint and, according to the status of chopsticks use, performed a matched analysis to examine the relationship between chopsticks use and the prevalence of Hand OA. In the analysis, we excluded persons who reported a previous Hand injury. Because most subjects used chopsticks with their dominant Hand (a Hand they would be expected to use more for all manual tasks), we also performed the analysis among subjects who reported that they had no Hand preference when performing other activities and subjects who denied other pincer grip activities. Results A total of 1,008 men and 1,499 women were assessed. The prevalence ratio for OA of the thumb IP Joint in the chopsticks Hand was 1.2 (range 1.1–1.4) in men and 1.6 (range 1.4–1.7) in women; the prevalence ratio for OA of the second and third PIP Joints was 1.5 (range 1.1–2.2) in men and 1.4 (range 1.2–1.7) in women; and the prevalence ratio for OA of the second and third MCP Joints was 1.4 (range 1.2–1.6) in men and 1.4 (range 1.2–1.6) in women. The prevalence ratios in these Joints were greater than the ratios in other MCP, PIP, or DIP Joints from the same Hand that were unlikely to be involved by chopsticks use, especially among women. Similar results were observed when the analyses were limited to ambidextrous subjects and subjects who did not engage in any other pincer grip activities. Thumb IP Joint OA affected 26% of the entire population studied, and chopsticks use accounted for 19% of the risk of OA developing in this Joint in men and 36% of the risk in women. Conclusion This epidemiologic study investigated the relationship of chopsticks use to Hand arthropathy. The results suggest that chopsticks use is associated with an increased prevalence of OA in the IP Joint of the thumb, and in the second and third PIP and MCP Joints.
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lower prevalence of Hand osteoarthritis among chinese subjects in beijing compared with white subjects in the united states the beijing osteoarthritis study
Arthritis & Rheumatism, 2003Co-Authors: Yuqing Zhang, Jingbo Niu, Piran Aliabadi, Michael C Nevitt, Joyce Goggins, Liyung Lui, David T FelsonAbstract:Objective Fewer Chinese subjects in Beijing have hip osteoarthritis (OA) compared with whites in the United States, but as many or more Chinese subjects have knee OA. If these differences are due to a systemic predilection for disease, then the prevalence of Hand OA, the best indicator of generalized disease, should be different in China. The goals of this study were to estimate the prevalence of Hand OA among elderly Chinese in Beijing, and to compare it with that among elderly whites in the United States. Methods We recruited a random sample of Beijing residents ages ≥60 years. Subjects answered questions on Joint symptoms and provided posteroanterior radiographs of the Hand. The protocol was identical to that used in the Framingham, Massachusetts OA Study. The Hand radiographs from the Beijing OA Study were read intermingled with films from the Framingham OA Study. We defined a Hand Joint as having radiographic OA if it had a Kellgren and Lawrence grade ≥2. Symptomatic OA was present when both radiographic OA and self-reported pain were present in the same Joint. We classified a subject as having radiographic or symptomatic Hand OA if at least 1 Hand Joint had radiographic or symptomatic OA. We estimated the prevalence of Hand OA in elderly subjects in Beijing and compared it with the prevalence of Hand OA in elderly subjects from Framingham, using an age-standardized prevalence ratio. Results We obtained both symptom information and Hand radiographs from 2,525 subjects. Despite the older age of the group, only 44.5% of men and 47.0% of women had radiographic Hand OA. Symptomatic Hand OA occurred in 3.0% of men and 5.8% of women. Compared with white men in Framingham, the Beijing Chinese men had a much lower prevalence of radiographic Hand OA (age-adjusted prevalence ratio 0.64, 95% confidence interval [95% CI] 0.58–0.70) and symptomatic Hand OA (age-adjusted prevalence ratio 0.25, 95% CI 0.16–0.34). The proportion of multiple Hand Joints affected by OA in Chinese men was also significantly lower than in white men. A similar magnitude of difference was also observed in the women. However, prevalence of symptomatic OA at the metacarpophalangeal (MCP) Joints in Chinese men and prevalence of radiographic OA at the MCP Joints in Chinese women were similar to those in their white counterparts in Framingham. Conclusion Elderly Chinese subjects in Beijing had a much lower prevalence of Hand OA than did elderly whites in Framingham, Massachusetts. Coupled with the exceedingly low prevalence of hip OA in China, these results may suggest that the overall predilection for OA is less among subjects in China than among whites in the United States.
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prevalence of symptomatic Hand osteoarthritis and its impact on functional status among the elderly the framingham study
American Journal of Epidemiology, 2002Co-Authors: Yuqing Zhang, Jingbo Niu, Margaret Kellyhayes, Christine E Chaisson, Piran Aliabadi, David T FelsonAbstract:Osteoarthritis is one of the most common Joint disorders in the elderly, yet few studies have targeted symptomatic osteoarthritis, especially symptomatic Hand osteoarthritis. The authors conducted a survey in 1992-1993 among an elderly population to estimate the prevalence of symptomatic Hand osteoarthritis and to assess its impact on grip strength and functional activities. Framingham Study subjects received Hand radiographs and answered queries on Joint symptoms. Functional activities were assessed using an interviewer-administered questionnaire. Grip strength and observed functional performance were evaluated using standard procedures. A Hand Joint was defined as having symptomatic osteoarthritis if both symptoms and radiographic evidence of osteoarthritis were present. Of 1,041 subjects aged 71-100 years (36% men), the prevalence of symptomatic Hand osteoarthritis was higher in women (26.2%) than in men (13.4%). Compared with those without symptomatic Hand osteoarthritis, subjects with the disease had 10% reduced maximal grip strength, reported more difficulty writing, Handling, or fingering small objects (odds ratio = 3.4), and showed more self-reported and observed difficulty carrying a 10-pound (4.5-kg) bundle (odds ratio = 1.7 and 1.6, respectively). In conclusion, in the context of a remarkable paucity of data on the epidemiology of symptomatic Hand osteoarthritis, this study suggests that symptomatic Hand osteoarthritis is a common disease among elders and frequently impairs Hand function.
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grip strength and the risk of developing radiographic Hand osteoarthritis results from the framingham study
Arthritis & Rheumatism, 1999Co-Authors: Christine E Chaisson, Yuqing Zhang, Leena Sharma, William B Kannel, David T FelsonAbstract:Objective In knees, quadriceps strength may protect against osteoarthritis (OA). Muscle activity is a major determinant of forces at the Hand Joints, and grip is a common task during which high muscle forces are sustained, especially at the proximal Hand Joints (metacarpophalangeal [MCP] Joints and thumb base). This longitudinal study of radiographic Hand OA examined the association between incident OA at different Hand Joints and maximal grip strength. Methods Four Hand Joint groups were studied: distal interphalangeal (DIP), proximal interphalangeal (PIP), MCP, and the base of the thumb (carpometacarpal and scaphotrapezial combined). Subjects were members of the Framingham OA Study who had a baseline radiograph in 1967–1969 and a followup radiograph in 1992–1993 (mean followup 24 years) and had no prevalent radiographic OA in any Hand Joint at baseline. Incident disease was defined as development of OA defined as a modified Kellgren/Lawrence grade of ≥2. Grip strength was measured in kilograms by dynamometer in 1958–1961 and again in 1960–1963, and the 2 measures were averaged and divided into sex-specific tertiles. Joint-based analysis was performed by adjusting for age, physical activity, and occupational category using the lowest grip strength tertile as the referent. Results Baseline and followup radiographs were obtained from 746 subjects. Of these, 453 subjects with no prevalent OA at baseline were eligible for analysis. In men, higher maximal grip strength was associated with an increased risk of OA in the PIP (highest tertile odds ratio [OR] 2.8 compared with lowest tertile, 95% confidence interval [95% CI] 1.2–6.7), MCP (highest tertile OR 2.9, 95% CI 1.1–7.4), and thumb base Joints (highest tertile OR 2.8, 95% CI 1.1–7.4). In women, there was increased risk of OA in the MCP Joints (highest tertile OR 2.7, 95% CI 1.1–6.4). Conclusion Men with high maximal grip strength are at increased risk for the development of OA in the PIP, MCP, and thumb base Joints, and women, in the MCP Joints. No association was found between maximal grip strength and incident OA in the DIP Joints of men or women.
Jungao Zhu - One of the best experts on this subject based on the ideXlab platform.
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pos1062 ultrasound assessment of sub clinical Hand Joint synovitis a comparative study between psoriatic and rheumatoid arthritis
Annals of the Rheumatic Diseases, 2021Co-Authors: Feng Liu, Y Xin, Jungao ZhuAbstract:Background: Ultrasound (US) detected subclinical synovitis can be present in early psoriatic arthritis (PsA) and rheumatoid arthritis (RA), and also in patients fulfilling clinical remission criteria[1-2]. Numerous evidences support that the persistence of subclinical synovitis detected by US is associated with a high risk of disease progression [2-3]. Objectives: To evaluate sub-clinical synovitis of PsA and RA at the level of small Joints of the Hand and wrist by B-mode and Power Doppler US. Methods: 21 patients of early PsA and 25 patients of early RA (no clinical evidence of Hand Joint involvement, PsA disease duration Results: A total of 25 patients were included in the RA group, including 5 males and 20 females. A total of 21 patients were included in the PsA group, including 7 males and 14 females. There were no significant differences in gender composition, age, and duration of disease between the two groups (P>0.05) (Table 1). 14 (66.67%) PsA patients and 12 (48%) RA patients had sub-clinical Hand Joint synovitis. Among 630 Hand Joints scanned in PsA group, 49 (7.78%) Joints showed evidence of sub-clinical synovitis. Wrist Joint was most commonly involved (24.49%), followed by MCP3 (14.29%), MCP1 (12.24%) and DIP3 (10.20%). Among 750 Hand Joints scanned in RA group, 110 (14.67%) Joints showed evidence of sub-clinical synovitis. Wrist Joint was most commonly involved (60.00%), followed by MCP3 (8.24%), MCP1 (8.24%) and MCP2 (7.06%). No correlation noted between numbers of Joints with subclinical synovitis with DAPSA and DAS28 score. There was no correlation between number of Joints with sub-clinical synovitis and disease activity indices. Conclusion: Almost two-thirds patients with PsA and half patients with RA had US evidence of sub-clinical synovitis in wrist and Hand Joints, most commonly in wrist. There are some similarities in the Joint involvement of sub-clinical synovitis between RA and PsA, physicians should take this into account in clinical work. References: [1]Freeston JE, Coates LC, Nam JL, Moverley AR, Hensor EM, Wakefield RJ, et al. Is there subclinical synovitis in early psoriatic arthritis? A clinical comparison with gray-scale and power Doppler ultrasound. Arthritis care & research 2014, 66:432-439. [2]Kawashiri SY, Suzuki T, Nakashima Y, Horai Y, Okada A, Iwamoto N, et al. Ultrasonographic examination of rheumatoid arthritis patients who are free of physical synovitis: Power doppler subclinical synovitis is associated with bone erosion. Rheumatology (Oxford), 2014, 53:562-569. [3]Vreju FA, Filippucci E, Gutierrez M, Di Geso L, Ciapetti A, Ciurea ME, et al. Subclinical ultrasound synovitis in a particular Joint is associated with ultrasound evidence of bone erosions in that same Joint in rheumatoid patients in clinical remission. Clinical and experimental rheumatology, 2016, 34:673-678. Acknowledgements: This work was supported by National Natural Science Foundation of China (No. 82071930 and 81571684). Disclosure of Interests: None declared.
Yuqing Zhang - One of the best experts on this subject based on the ideXlab platform.
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chopstick arthropathy the beijing osteoarthritis study
Arthritis & Rheumatism, 2004Co-Authors: David J Hunter, Yuqing Zhang, Piran Aliabadi, Michael C Nevitt, Ling Xu, Wei Yu, David T FelsonAbstract:Objective Several investigators have speculated that mechanical stress might play an important role in the development of Hand osteoarthritis (OA). Chopsticks, used universally as eating utensils in China, increase Joint loading in the first through third fingers. We conducted a population-based survey among elderly Chinese individuals living in Beijing, to explore whether chopsticks use is associated with prevalent Hand OA. Methods We recruited a sample of persons ages 60 years and older, using door-to-door enumeration in randomly selected neighborhoods in Beijing. Subjects answered questions about the Hand with which they use chopsticks, Handedness, and pincer grip activities. Bilateral posteroanterior Hand radiographs were obtained, and each Joint was graded according to the Kellgren/Lawrence (K/L) scale. We defined a subject as having radiographic OA if at least 1 of his or her Hand Joints had radiographic OA (K/L score of ≥2). We defined a particular Hand group (i.e., distal interphalangeal [DIP] Joints, proximal interphalangeal [PIP] Joints, or metacarpophalangeal [MCP] Joints) as having OA if at least 1 Joint of the group had radiographic OA. We calculated the prevalence of OA for each Hand Joint and, according to the status of chopsticks use, performed a matched analysis to examine the relationship between chopsticks use and the prevalence of Hand OA. In the analysis, we excluded persons who reported a previous Hand injury. Because most subjects used chopsticks with their dominant Hand (a Hand they would be expected to use more for all manual tasks), we also performed the analysis among subjects who reported that they had no Hand preference when performing other activities and subjects who denied other pincer grip activities. Results A total of 1,008 men and 1,499 women were assessed. The prevalence ratio for OA of the thumb IP Joint in the chopsticks Hand was 1.2 (range 1.1–1.4) in men and 1.6 (range 1.4–1.7) in women; the prevalence ratio for OA of the second and third PIP Joints was 1.5 (range 1.1–2.2) in men and 1.4 (range 1.2–1.7) in women; and the prevalence ratio for OA of the second and third MCP Joints was 1.4 (range 1.2–1.6) in men and 1.4 (range 1.2–1.6) in women. The prevalence ratios in these Joints were greater than the ratios in other MCP, PIP, or DIP Joints from the same Hand that were unlikely to be involved by chopsticks use, especially among women. Similar results were observed when the analyses were limited to ambidextrous subjects and subjects who did not engage in any other pincer grip activities. Thumb IP Joint OA affected 26% of the entire population studied, and chopsticks use accounted for 19% of the risk of OA developing in this Joint in men and 36% of the risk in women. Conclusion This epidemiologic study investigated the relationship of chopsticks use to Hand arthropathy. The results suggest that chopsticks use is associated with an increased prevalence of OA in the IP Joint of the thumb, and in the second and third PIP and MCP Joints.
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lower prevalence of Hand osteoarthritis among chinese subjects in beijing compared with white subjects in the united states the beijing osteoarthritis study
Arthritis & Rheumatism, 2003Co-Authors: Yuqing Zhang, Jingbo Niu, Piran Aliabadi, Michael C Nevitt, Joyce Goggins, Liyung Lui, David T FelsonAbstract:Objective Fewer Chinese subjects in Beijing have hip osteoarthritis (OA) compared with whites in the United States, but as many or more Chinese subjects have knee OA. If these differences are due to a systemic predilection for disease, then the prevalence of Hand OA, the best indicator of generalized disease, should be different in China. The goals of this study were to estimate the prevalence of Hand OA among elderly Chinese in Beijing, and to compare it with that among elderly whites in the United States. Methods We recruited a random sample of Beijing residents ages ≥60 years. Subjects answered questions on Joint symptoms and provided posteroanterior radiographs of the Hand. The protocol was identical to that used in the Framingham, Massachusetts OA Study. The Hand radiographs from the Beijing OA Study were read intermingled with films from the Framingham OA Study. We defined a Hand Joint as having radiographic OA if it had a Kellgren and Lawrence grade ≥2. Symptomatic OA was present when both radiographic OA and self-reported pain were present in the same Joint. We classified a subject as having radiographic or symptomatic Hand OA if at least 1 Hand Joint had radiographic or symptomatic OA. We estimated the prevalence of Hand OA in elderly subjects in Beijing and compared it with the prevalence of Hand OA in elderly subjects from Framingham, using an age-standardized prevalence ratio. Results We obtained both symptom information and Hand radiographs from 2,525 subjects. Despite the older age of the group, only 44.5% of men and 47.0% of women had radiographic Hand OA. Symptomatic Hand OA occurred in 3.0% of men and 5.8% of women. Compared with white men in Framingham, the Beijing Chinese men had a much lower prevalence of radiographic Hand OA (age-adjusted prevalence ratio 0.64, 95% confidence interval [95% CI] 0.58–0.70) and symptomatic Hand OA (age-adjusted prevalence ratio 0.25, 95% CI 0.16–0.34). The proportion of multiple Hand Joints affected by OA in Chinese men was also significantly lower than in white men. A similar magnitude of difference was also observed in the women. However, prevalence of symptomatic OA at the metacarpophalangeal (MCP) Joints in Chinese men and prevalence of radiographic OA at the MCP Joints in Chinese women were similar to those in their white counterparts in Framingham. Conclusion Elderly Chinese subjects in Beijing had a much lower prevalence of Hand OA than did elderly whites in Framingham, Massachusetts. Coupled with the exceedingly low prevalence of hip OA in China, these results may suggest that the overall predilection for OA is less among subjects in China than among whites in the United States.
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prevalence of symptomatic Hand osteoarthritis and its impact on functional status among the elderly the framingham study
American Journal of Epidemiology, 2002Co-Authors: Yuqing Zhang, Jingbo Niu, Margaret Kellyhayes, Christine E Chaisson, Piran Aliabadi, David T FelsonAbstract:Osteoarthritis is one of the most common Joint disorders in the elderly, yet few studies have targeted symptomatic osteoarthritis, especially symptomatic Hand osteoarthritis. The authors conducted a survey in 1992-1993 among an elderly population to estimate the prevalence of symptomatic Hand osteoarthritis and to assess its impact on grip strength and functional activities. Framingham Study subjects received Hand radiographs and answered queries on Joint symptoms. Functional activities were assessed using an interviewer-administered questionnaire. Grip strength and observed functional performance were evaluated using standard procedures. A Hand Joint was defined as having symptomatic osteoarthritis if both symptoms and radiographic evidence of osteoarthritis were present. Of 1,041 subjects aged 71-100 years (36% men), the prevalence of symptomatic Hand osteoarthritis was higher in women (26.2%) than in men (13.4%). Compared with those without symptomatic Hand osteoarthritis, subjects with the disease had 10% reduced maximal grip strength, reported more difficulty writing, Handling, or fingering small objects (odds ratio = 3.4), and showed more self-reported and observed difficulty carrying a 10-pound (4.5-kg) bundle (odds ratio = 1.7 and 1.6, respectively). In conclusion, in the context of a remarkable paucity of data on the epidemiology of symptomatic Hand osteoarthritis, this study suggests that symptomatic Hand osteoarthritis is a common disease among elders and frequently impairs Hand function.
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grip strength and the risk of developing radiographic Hand osteoarthritis results from the framingham study
Arthritis & Rheumatism, 1999Co-Authors: Christine E Chaisson, Yuqing Zhang, Leena Sharma, William B Kannel, David T FelsonAbstract:Objective In knees, quadriceps strength may protect against osteoarthritis (OA). Muscle activity is a major determinant of forces at the Hand Joints, and grip is a common task during which high muscle forces are sustained, especially at the proximal Hand Joints (metacarpophalangeal [MCP] Joints and thumb base). This longitudinal study of radiographic Hand OA examined the association between incident OA at different Hand Joints and maximal grip strength. Methods Four Hand Joint groups were studied: distal interphalangeal (DIP), proximal interphalangeal (PIP), MCP, and the base of the thumb (carpometacarpal and scaphotrapezial combined). Subjects were members of the Framingham OA Study who had a baseline radiograph in 1967–1969 and a followup radiograph in 1992–1993 (mean followup 24 years) and had no prevalent radiographic OA in any Hand Joint at baseline. Incident disease was defined as development of OA defined as a modified Kellgren/Lawrence grade of ≥2. Grip strength was measured in kilograms by dynamometer in 1958–1961 and again in 1960–1963, and the 2 measures were averaged and divided into sex-specific tertiles. Joint-based analysis was performed by adjusting for age, physical activity, and occupational category using the lowest grip strength tertile as the referent. Results Baseline and followup radiographs were obtained from 746 subjects. Of these, 453 subjects with no prevalent OA at baseline were eligible for analysis. In men, higher maximal grip strength was associated with an increased risk of OA in the PIP (highest tertile odds ratio [OR] 2.8 compared with lowest tertile, 95% confidence interval [95% CI] 1.2–6.7), MCP (highest tertile OR 2.9, 95% CI 1.1–7.4), and thumb base Joints (highest tertile OR 2.8, 95% CI 1.1–7.4). In women, there was increased risk of OA in the MCP Joints (highest tertile OR 2.7, 95% CI 1.1–6.4). Conclusion Men with high maximal grip strength are at increased risk for the development of OA in the PIP, MCP, and thumb base Joints, and women, in the MCP Joints. No association was found between maximal grip strength and incident OA in the DIP Joints of men or women.
