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Mali Ram Gupta - One of the best experts on this subject based on the ideXlab platform.
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application of multivariate methods to evaluate the functionality of bovine and vegetable derived magnesium stearate
Journal of Pharmaceutical Sciences, 2014Co-Authors: Rahul V. Haware, Ramya Shivagari, Paul R. Johnson, Scott Staton, William C. Stagner, Mali Ram GuptaAbstract:ABSTRACT This work distinguishes and quantifies the effects of bovine- and vegetable-derived magnesium stearate (MgSt) molecular and macroscopic properties on lubrication efficiency using multivariate analysis. Principal component analysis (PCA) and partial least-square regression (PLS) were used to evaluate and quantify the lubricant effectiveness on a model tablet formulation. PCA score and loading plots showed a sepaRation of model formulations based on the MgSt sources, which indicated different bovine- and vegetable-derived MgSt lubrication potential. PLS quantified the MgSt molecular [enthalpy of dehydRation (ΔHd), enthalpy of melting (ΔHm), percent crystallinity, and moisture content] and macroscopic [particle size ( d 50 ), specific surface area (SSA-MgSt), and MgSt Hausner Ratio (HF-MgSt)] properties, their interactions, and square effects on formulation powder flow and tableting properties relating to MgSt's lubrication effectiveness. For crystalline MgSt, moisture content, HF-MgSt, d 50 , and SSA-MgSt showed a major influence on the lubrication efficiency compared with the other MgSt molecular properties (percent crystallinity, ΔHm, and ΔHd). Amorphous MgSt showed poor lubrication, and none of its molecular or macroscopic properties showed significant effects on lubrication efficiency. © 2014 Wiley Periodicals, Inc. and the American Pharmacists Association.
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Application of Multivariate Methods to Evaluate the Functionality of Bovine‐ and Vegetable‐Derived Magnesium Stearate
Journal of Pharmaceutical Sciences, 2014Co-Authors: Rahul V. Haware, Ramya Shivagari, Paul R. Johnson, Scott Staton, William C. Stagner, Mali Ram GuptaAbstract:ABSTRACT This work distinguishes and quantifies the effects of bovine- and vegetable-derived magnesium stearate (MgSt) molecular and macroscopic properties on lubrication efficiency using multivariate analysis. Principal component analysis (PCA) and partial least-square regression (PLS) were used to evaluate and quantify the lubricant effectiveness on a model tablet formulation. PCA score and loading plots showed a sepaRation of model formulations based on the MgSt sources, which indicated different bovine- and vegetable-derived MgSt lubrication potential. PLS quantified the MgSt molecular [enthalpy of dehydRation (ΔHd), enthalpy of melting (ΔHm), percent crystallinity, and moisture content] and macroscopic [particle size ( d 50 ), specific surface area (SSA-MgSt), and MgSt Hausner Ratio (HF-MgSt)] properties, their interactions, and square effects on formulation powder flow and tableting properties relating to MgSt's lubrication effectiveness. For crystalline MgSt, moisture content, HF-MgSt, d 50 , and SSA-MgSt showed a major influence on the lubrication efficiency compared with the other MgSt molecular properties (percent crystallinity, ΔHm, and ΔHd). Amorphous MgSt showed poor lubrication, and none of its molecular or macroscopic properties showed significant effects on lubrication efficiency. © 2014 Wiley Periodicals, Inc. and the American Pharmacists Association.
Rahul V. Haware - One of the best experts on this subject based on the ideXlab platform.
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application of multivariate methods to evaluate the functionality of bovine and vegetable derived magnesium stearate
Journal of Pharmaceutical Sciences, 2014Co-Authors: Rahul V. Haware, Ramya Shivagari, Paul R. Johnson, Scott Staton, William C. Stagner, Mali Ram GuptaAbstract:ABSTRACT This work distinguishes and quantifies the effects of bovine- and vegetable-derived magnesium stearate (MgSt) molecular and macroscopic properties on lubrication efficiency using multivariate analysis. Principal component analysis (PCA) and partial least-square regression (PLS) were used to evaluate and quantify the lubricant effectiveness on a model tablet formulation. PCA score and loading plots showed a sepaRation of model formulations based on the MgSt sources, which indicated different bovine- and vegetable-derived MgSt lubrication potential. PLS quantified the MgSt molecular [enthalpy of dehydRation (ΔHd), enthalpy of melting (ΔHm), percent crystallinity, and moisture content] and macroscopic [particle size ( d 50 ), specific surface area (SSA-MgSt), and MgSt Hausner Ratio (HF-MgSt)] properties, their interactions, and square effects on formulation powder flow and tableting properties relating to MgSt's lubrication effectiveness. For crystalline MgSt, moisture content, HF-MgSt, d 50 , and SSA-MgSt showed a major influence on the lubrication efficiency compared with the other MgSt molecular properties (percent crystallinity, ΔHm, and ΔHd). Amorphous MgSt showed poor lubrication, and none of its molecular or macroscopic properties showed significant effects on lubrication efficiency. © 2014 Wiley Periodicals, Inc. and the American Pharmacists Association.
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Application of Multivariate Methods to Evaluate the Functionality of Bovine‐ and Vegetable‐Derived Magnesium Stearate
Journal of Pharmaceutical Sciences, 2014Co-Authors: Rahul V. Haware, Ramya Shivagari, Paul R. Johnson, Scott Staton, William C. Stagner, Mali Ram GuptaAbstract:ABSTRACT This work distinguishes and quantifies the effects of bovine- and vegetable-derived magnesium stearate (MgSt) molecular and macroscopic properties on lubrication efficiency using multivariate analysis. Principal component analysis (PCA) and partial least-square regression (PLS) were used to evaluate and quantify the lubricant effectiveness on a model tablet formulation. PCA score and loading plots showed a sepaRation of model formulations based on the MgSt sources, which indicated different bovine- and vegetable-derived MgSt lubrication potential. PLS quantified the MgSt molecular [enthalpy of dehydRation (ΔHd), enthalpy of melting (ΔHm), percent crystallinity, and moisture content] and macroscopic [particle size ( d 50 ), specific surface area (SSA-MgSt), and MgSt Hausner Ratio (HF-MgSt)] properties, their interactions, and square effects on formulation powder flow and tableting properties relating to MgSt's lubrication effectiveness. For crystalline MgSt, moisture content, HF-MgSt, d 50 , and SSA-MgSt showed a major influence on the lubrication efficiency compared with the other MgSt molecular properties (percent crystallinity, ΔHm, and ΔHd). Amorphous MgSt showed poor lubrication, and none of its molecular or macroscopic properties showed significant effects on lubrication efficiency. © 2014 Wiley Periodicals, Inc. and the American Pharmacists Association.
Hadi Valizadeh - One of the best experts on this subject based on the ideXlab platform.
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development of dry powder inhaler formulation loaded with alendronate solid lipid nanoparticles solid state characterization and aerosol dispersion performance
Drug Development and Industrial Pharmacy, 2015Co-Authors: Jafar Ezzati Nazhad Dolatabadi, Hamed Hamishehkar, Hadi ValizadehAbstract:AbstractAlendronate sodium is a bisphosphonate drug used for the treatment of osteoporosis and acts as a specific inhibitor of osteoclast-mediated bone resorption. Inhalable solid lipid nanoparticles (SLNs) of the alendronate were successfully designed and developed by spray-dried and co-spray dried inhalable mannitol from aqueous solution. Emulsification technique using a simple homogenization method was used for prepaRation of SLNs. In vitro deposition of the aerosolized drug was studied using a Next GeneRation Impactor at 60 L/min following the methodology described in the European and United States Pharmacopeias. The Carr’s Index, Hausner Ratio and angle of repose were calculated as suitable criteria for estimation of the flow behavior of solids. Scanning electron microscopy showed spherical particle morphology of the respirable particles. The proposed spray-dried nanoparticulate-on-microparticles dry powders displayed good aerosol dispersion performance as dry powder inhalers with high values in emit...
Paul R. Johnson - One of the best experts on this subject based on the ideXlab platform.
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application of multivariate methods to evaluate the functionality of bovine and vegetable derived magnesium stearate
Journal of Pharmaceutical Sciences, 2014Co-Authors: Rahul V. Haware, Ramya Shivagari, Paul R. Johnson, Scott Staton, William C. Stagner, Mali Ram GuptaAbstract:ABSTRACT This work distinguishes and quantifies the effects of bovine- and vegetable-derived magnesium stearate (MgSt) molecular and macroscopic properties on lubrication efficiency using multivariate analysis. Principal component analysis (PCA) and partial least-square regression (PLS) were used to evaluate and quantify the lubricant effectiveness on a model tablet formulation. PCA score and loading plots showed a sepaRation of model formulations based on the MgSt sources, which indicated different bovine- and vegetable-derived MgSt lubrication potential. PLS quantified the MgSt molecular [enthalpy of dehydRation (ΔHd), enthalpy of melting (ΔHm), percent crystallinity, and moisture content] and macroscopic [particle size ( d 50 ), specific surface area (SSA-MgSt), and MgSt Hausner Ratio (HF-MgSt)] properties, their interactions, and square effects on formulation powder flow and tableting properties relating to MgSt's lubrication effectiveness. For crystalline MgSt, moisture content, HF-MgSt, d 50 , and SSA-MgSt showed a major influence on the lubrication efficiency compared with the other MgSt molecular properties (percent crystallinity, ΔHm, and ΔHd). Amorphous MgSt showed poor lubrication, and none of its molecular or macroscopic properties showed significant effects on lubrication efficiency. © 2014 Wiley Periodicals, Inc. and the American Pharmacists Association.
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Application of Multivariate Methods to Evaluate the Functionality of Bovine‐ and Vegetable‐Derived Magnesium Stearate
Journal of Pharmaceutical Sciences, 2014Co-Authors: Rahul V. Haware, Ramya Shivagari, Paul R. Johnson, Scott Staton, William C. Stagner, Mali Ram GuptaAbstract:ABSTRACT This work distinguishes and quantifies the effects of bovine- and vegetable-derived magnesium stearate (MgSt) molecular and macroscopic properties on lubrication efficiency using multivariate analysis. Principal component analysis (PCA) and partial least-square regression (PLS) were used to evaluate and quantify the lubricant effectiveness on a model tablet formulation. PCA score and loading plots showed a sepaRation of model formulations based on the MgSt sources, which indicated different bovine- and vegetable-derived MgSt lubrication potential. PLS quantified the MgSt molecular [enthalpy of dehydRation (ΔHd), enthalpy of melting (ΔHm), percent crystallinity, and moisture content] and macroscopic [particle size ( d 50 ), specific surface area (SSA-MgSt), and MgSt Hausner Ratio (HF-MgSt)] properties, their interactions, and square effects on formulation powder flow and tableting properties relating to MgSt's lubrication effectiveness. For crystalline MgSt, moisture content, HF-MgSt, d 50 , and SSA-MgSt showed a major influence on the lubrication efficiency compared with the other MgSt molecular properties (percent crystallinity, ΔHm, and ΔHd). Amorphous MgSt showed poor lubrication, and none of its molecular or macroscopic properties showed significant effects on lubrication efficiency. © 2014 Wiley Periodicals, Inc. and the American Pharmacists Association.
Scott Staton - One of the best experts on this subject based on the ideXlab platform.
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application of multivariate methods to evaluate the functionality of bovine and vegetable derived magnesium stearate
Journal of Pharmaceutical Sciences, 2014Co-Authors: Rahul V. Haware, Ramya Shivagari, Paul R. Johnson, Scott Staton, William C. Stagner, Mali Ram GuptaAbstract:ABSTRACT This work distinguishes and quantifies the effects of bovine- and vegetable-derived magnesium stearate (MgSt) molecular and macroscopic properties on lubrication efficiency using multivariate analysis. Principal component analysis (PCA) and partial least-square regression (PLS) were used to evaluate and quantify the lubricant effectiveness on a model tablet formulation. PCA score and loading plots showed a sepaRation of model formulations based on the MgSt sources, which indicated different bovine- and vegetable-derived MgSt lubrication potential. PLS quantified the MgSt molecular [enthalpy of dehydRation (ΔHd), enthalpy of melting (ΔHm), percent crystallinity, and moisture content] and macroscopic [particle size ( d 50 ), specific surface area (SSA-MgSt), and MgSt Hausner Ratio (HF-MgSt)] properties, their interactions, and square effects on formulation powder flow and tableting properties relating to MgSt's lubrication effectiveness. For crystalline MgSt, moisture content, HF-MgSt, d 50 , and SSA-MgSt showed a major influence on the lubrication efficiency compared with the other MgSt molecular properties (percent crystallinity, ΔHm, and ΔHd). Amorphous MgSt showed poor lubrication, and none of its molecular or macroscopic properties showed significant effects on lubrication efficiency. © 2014 Wiley Periodicals, Inc. and the American Pharmacists Association.
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Application of Multivariate Methods to Evaluate the Functionality of Bovine‐ and Vegetable‐Derived Magnesium Stearate
Journal of Pharmaceutical Sciences, 2014Co-Authors: Rahul V. Haware, Ramya Shivagari, Paul R. Johnson, Scott Staton, William C. Stagner, Mali Ram GuptaAbstract:ABSTRACT This work distinguishes and quantifies the effects of bovine- and vegetable-derived magnesium stearate (MgSt) molecular and macroscopic properties on lubrication efficiency using multivariate analysis. Principal component analysis (PCA) and partial least-square regression (PLS) were used to evaluate and quantify the lubricant effectiveness on a model tablet formulation. PCA score and loading plots showed a sepaRation of model formulations based on the MgSt sources, which indicated different bovine- and vegetable-derived MgSt lubrication potential. PLS quantified the MgSt molecular [enthalpy of dehydRation (ΔHd), enthalpy of melting (ΔHm), percent crystallinity, and moisture content] and macroscopic [particle size ( d 50 ), specific surface area (SSA-MgSt), and MgSt Hausner Ratio (HF-MgSt)] properties, their interactions, and square effects on formulation powder flow and tableting properties relating to MgSt's lubrication effectiveness. For crystalline MgSt, moisture content, HF-MgSt, d 50 , and SSA-MgSt showed a major influence on the lubrication efficiency compared with the other MgSt molecular properties (percent crystallinity, ΔHm, and ΔHd). Amorphous MgSt showed poor lubrication, and none of its molecular or macroscopic properties showed significant effects on lubrication efficiency. © 2014 Wiley Periodicals, Inc. and the American Pharmacists Association.
