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Charly Gaul - One of the best experts on this subject based on the ideXlab platform.
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non invasive vagus nerve stimulation for the acute treatment of episodic and chronic cluster headache a randomized double blind sham controlled act2 study
Cephalalgia, 2018Co-Authors: Peter J Goadsby, Hans-christoph Diener, Charly Gaul, Ilse F De Coo, Nicholas Silver, Alok Tyagi, Fayyaz Ahmed, Rigmor Jensen, Kasia Solbach, Andreas StraubeAbstract:BackgroundClinical observations and results from recent studies support the use of non-invasive vagus nerve stimulation (nVNS) for treating cluster headache (CH) attacks. This study compared nVNS with a sham device for acute treatment in patients with episodic or chronic CH (eCH, cCH).MethodsAfter completing a 1-week run-in period, subjects were randomly assigned (1:1) to receive nVNS or sham therapy during a 2-week double-blind period. The primary efficacy endpoint was the proportion of all treated attacks that achieved pain-free status within 15 minutes after treatment initiation, without rescue treatment.ResultsThe Full Analysis Set comprised 48 nVNS-treated (14 eCH, 34 cCH) and 44 sham-treated (13 eCH, 31 cCH) subjects. For the primary endpoint, nVNS (14%) and sham (12%) treatments were not significantly different for the total cohort. In the eCH subgroup, nVNS (48%) was superior to sham (6%; p < 0.01). No significant differences between nVNS (5%) and sham (13%) were seen in the cCH subgroup.Conclusio...
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efficacy and safety of a single occipital nerve blockade in episodic and chronic cluster headache a prospective observational study
Cephalalgia, 2017Co-Authors: Charly Gaul, Hans-christoph Diener, Jana Roguski, Thomas Dresler, Hind Abbas, Andreas Totzeck, Klaus Gorlinger, Ralph WeberAbstract:Background Treatment options for cluster headache (CH) include acute, transitional and prophylactic strategies. We assessed the efficacy and safety of a single occipital nerve block (ONB) in patients with episodic (eCH) and chronic CH (cCH). Methods In this prospective, observational study 101 CH were treated with a single ONB using triamcinolone 10 mg and bupivacaine. Attack frequency, pain intensity and side effects were assessed at days 1 and 7 after ONB and thereafter weekly for 60 days until recurrence of attacks. Results Baseline mean daily attack frequency was 2.9 ± 2.5 (eCH) and 3.3 ± 2.9 (cCH), which was reduced to 0.7 ± 1.2 (eCH) and 1.1 ± 1.4 (cCH) after one day ( p = 0.08 for group difference) and to 1.1 ± 1.6 (eCH) and 1.9 ± 2.3 (cCH) after seven days ( p = 0.01 for group difference). In patients with eCH the pain-free period lasted longer compared to cCH ( p = 0.004). There was no association between the presence of local anesthesia and treatment response ( p = 0.88). No serious adverse events occurred. Conclusion ONB is an easy, safe and effective transitional treatment option in case of insufficient response of CH to treatment both in patients with eCH and cCH. Patients with eCH have a better and more sustainable treatment response.
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differences in clinical characteristics and frequency of accompanying migraine features in episodic and chronic cluster headache
Cephalalgia, 2012Co-Authors: Charly Gaul, Hans-christoph Diener, N Christmann, D Schroder, Rainer Weber, Hind Shanib, Dagny HolleAbstract:Introduction: Data on clinical differences between episodic (eCH) and chronic cluster headache (cCH) and accompanying migraine features are limited.Methods: History and clinical features of 209 consecutive cluster headache patients (144 eCH, 65 cCH; male:female ratio 3.4 : 1) were obtained in a tertiary headache centre by face-to-face interviews. Relationship between occurrence of accompanying symptoms, pain intensity, comorbid migraine, and circannual and circadian rhythmicity was analysed.Results: 99.5% of patients reported a minimum of one ipsilateral cranial autonomic symptom (CAS); 80% showed at least three CAS. A seasonal rhythmicity was observed in both eCH and cCH. A comorbid headache disorder occurred in 25%. No significant difference was detected between patients with comorbid migraine and without regarding occurrence of phonophobia, photophobia or nausea during cluster attacks. Patients with comorbid migraine reported allodynia significantly (p = 0.022) more often during cluster attacks than pa...
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treatment costs and indirect costs of cluster headache a health economics analysis
Cephalalgia, 2011Co-Authors: Charly Gaul, Hans-christoph Diener, Julia Finken, Janine Biermann, Sarah Mostardt, Oliver Muller, Jurgen Wasem, Anja NeumannAbstract:Background: Cluster headache (CH) is the most frequent trigemino-autonomic cephalgia. CH can manifest as episodic (eCH) or chronic cluster headache (cCH) causing significant burden of disease and r...
Hans-christoph Diener - One of the best experts on this subject based on the ideXlab platform.
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non invasive vagus nerve stimulation for the acute treatment of episodic and chronic cluster headache a randomized double blind sham controlled act2 study
Cephalalgia, 2018Co-Authors: Peter J Goadsby, Hans-christoph Diener, Charly Gaul, Ilse F De Coo, Nicholas Silver, Alok Tyagi, Fayyaz Ahmed, Rigmor Jensen, Kasia Solbach, Andreas StraubeAbstract:BackgroundClinical observations and results from recent studies support the use of non-invasive vagus nerve stimulation (nVNS) for treating cluster headache (CH) attacks. This study compared nVNS with a sham device for acute treatment in patients with episodic or chronic CH (eCH, cCH).MethodsAfter completing a 1-week run-in period, subjects were randomly assigned (1:1) to receive nVNS or sham therapy during a 2-week double-blind period. The primary efficacy endpoint was the proportion of all treated attacks that achieved pain-free status within 15 minutes after treatment initiation, without rescue treatment.ResultsThe Full Analysis Set comprised 48 nVNS-treated (14 eCH, 34 cCH) and 44 sham-treated (13 eCH, 31 cCH) subjects. For the primary endpoint, nVNS (14%) and sham (12%) treatments were not significantly different for the total cohort. In the eCH subgroup, nVNS (48%) was superior to sham (6%; p < 0.01). No significant differences between nVNS (5%) and sham (13%) were seen in the cCH subgroup.Conclusio...
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efficacy and safety of a single occipital nerve blockade in episodic and chronic cluster headache a prospective observational study
Cephalalgia, 2017Co-Authors: Charly Gaul, Hans-christoph Diener, Jana Roguski, Thomas Dresler, Hind Abbas, Andreas Totzeck, Klaus Gorlinger, Ralph WeberAbstract:Background Treatment options for cluster headache (CH) include acute, transitional and prophylactic strategies. We assessed the efficacy and safety of a single occipital nerve block (ONB) in patients with episodic (eCH) and chronic CH (cCH). Methods In this prospective, observational study 101 CH were treated with a single ONB using triamcinolone 10 mg and bupivacaine. Attack frequency, pain intensity and side effects were assessed at days 1 and 7 after ONB and thereafter weekly for 60 days until recurrence of attacks. Results Baseline mean daily attack frequency was 2.9 ± 2.5 (eCH) and 3.3 ± 2.9 (cCH), which was reduced to 0.7 ± 1.2 (eCH) and 1.1 ± 1.4 (cCH) after one day ( p = 0.08 for group difference) and to 1.1 ± 1.6 (eCH) and 1.9 ± 2.3 (cCH) after seven days ( p = 0.01 for group difference). In patients with eCH the pain-free period lasted longer compared to cCH ( p = 0.004). There was no association between the presence of local anesthesia and treatment response ( p = 0.88). No serious adverse events occurred. Conclusion ONB is an easy, safe and effective transitional treatment option in case of insufficient response of CH to treatment both in patients with eCH and cCH. Patients with eCH have a better and more sustainable treatment response.
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differences in clinical characteristics and frequency of accompanying migraine features in episodic and chronic cluster headache
Cephalalgia, 2012Co-Authors: Charly Gaul, Hans-christoph Diener, N Christmann, D Schroder, Rainer Weber, Hind Shanib, Dagny HolleAbstract:Introduction: Data on clinical differences between episodic (eCH) and chronic cluster headache (cCH) and accompanying migraine features are limited.Methods: History and clinical features of 209 consecutive cluster headache patients (144 eCH, 65 cCH; male:female ratio 3.4 : 1) were obtained in a tertiary headache centre by face-to-face interviews. Relationship between occurrence of accompanying symptoms, pain intensity, comorbid migraine, and circannual and circadian rhythmicity was analysed.Results: 99.5% of patients reported a minimum of one ipsilateral cranial autonomic symptom (CAS); 80% showed at least three CAS. A seasonal rhythmicity was observed in both eCH and cCH. A comorbid headache disorder occurred in 25%. No significant difference was detected between patients with comorbid migraine and without regarding occurrence of phonophobia, photophobia or nausea during cluster attacks. Patients with comorbid migraine reported allodynia significantly (p = 0.022) more often during cluster attacks than pa...
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treatment costs and indirect costs of cluster headache a health economics analysis
Cephalalgia, 2011Co-Authors: Charly Gaul, Hans-christoph Diener, Julia Finken, Janine Biermann, Sarah Mostardt, Oliver Muller, Jurgen Wasem, Anja NeumannAbstract:Background: Cluster headache (CH) is the most frequent trigemino-autonomic cephalgia. CH can manifest as episodic (eCH) or chronic cluster headache (cCH) causing significant burden of disease and r...
Nandita Singh - One of the best experts on this subject based on the ideXlab platform.
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distribution of hexachlorocyclohexane isomers in soil samples from a small scale industrial area of lucknow north india associated with lindane production
Chemosphere, 2008Co-Authors: P C Abhilash, Nandita SinghAbstract:Concentrations of hexachlorocyclohexane isomers (alpha-HCH, beta-HCH, gamma-HCH, and delta-HCH) were studied in soils samples collected from a small scale industrial unit of Lucknow associated with lindane production. All four isomers were detected from ten sites and the total HCH isomers in the analyzed samples varied from 53 to 99mgkg(-1). Cluster analysis was performed to group the soil sites in terms of their HCH contamination level. Low alpha/gamma HCH ratios were found and they indicate recent input of HCH. There is an urgent need for the on-site remediation of these contaminated sites in order to prevent the long-term environmental pollution.
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distribution of hexachlorocyclohexane isomers in soil samples from a small scale industrial area of lucknow north india associated with lindane production
Chemosphere, 2008Co-Authors: P C Abhilash, Nandita SinghAbstract:Abstract Concentrations of hexachlorocyclohexane isomers (α-HCH, β-HCH, γ-HCH, and δ-HCH) were studied in soils samples collected from a small scale industrial unit of Lucknow associated with lindane production. All four isomers were detected from ten sites and the total HCH isomers in the analyzed samples varied from 53 to 99 mg kg −1 . Cluster analysis was performed to group the soil sites in terms of their HCH contamination level. Low α/γ HCH ratios were found and they indicate recent input of HCH. There is an urgent need for the on-site remediation of these contaminated sites in order to prevent the long-term environmental pollution.
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occurrence and distribution of hexachlorocyclohexane isomers in vegetation samples from a contaminated area
Chemosphere, 2008Co-Authors: P C Abhilash, Nandita Singh, Sarah Jamil, Vandana Singh, Amita Singh, Sweta SrivastavaAbstract:The occurrence and distribution of four major hexachlorocyclohexane (HCH) isomers (alpha-, beta-, gamma- and delta-) were studied in vegetation samples of a highly contaminated area close to a small-scale industrial belt in Lucknow (North India). Eight species of plants were collected at different points of the contaminated area and different parts of the plants were separated in order to study the difference in uptake and accumulation. The samples were extracted by matrix solid-phase dispersion (MSPD) extraction and finally determined by a gas-chromatograph equipped with (63)Ni electron capture detector (ECD). HCH isomers were present in almost all samples and the concentration of total HCH in the plant sample analyzed varied between 13 and 44 mg kg(-1), being the main isomer of beta-HCH (8-22 mg kg(-1)). Lindane (gamma-HCH) was present in all samples (1-9 mg kg(-1)). Solanum torvum Sw., and Erianthus munja shows the highest and lowest capacity for accumulation of HCH, respectively with a significant difference at p<0.01 level. The highest concentration of HCH residue in root samples indicates the most likely mechanism of HCH accumulation in these plants was sorption of soil HCH on roots. Solanum torvum Sw., and Withania somnifera (L.) Dunal could accumulate considerable levels of HCH isomers (44 and 34 mg kg(-1), respectively). The results reflect the importance of plants in monitoring purposes and their potential for phytoremediation of HCH contaminated soils.
F. Vyskočil - One of the best experts on this subject based on the ideXlab platform.
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The effect of carbachol and alpha-bungarotoxin on the frequency of miniature endplate potentials at the frog neuromuscular junction.
Experimental physiology, 2000Co-Authors: E.a. Bukharaeva, E.e. Nikolsky, Tania Ipatova, F. VyskočilAbstract:The effects of an acetylcholine analogue, carbachol (CCh), and a purified irreversible nicotinic antagonist, α-bungarotoxin (BTX), on the frequency of the miniature endplate potentials (mEPPs) at the neuromuscular junction of the frog were tested at 20 and 10°C. CCh (5 ± 10-6 m) reduced the frequency of mEPPs to about 60%; this reduction was not affected by 1 ± 10-7 g ml-1 BTX. BTX also reversibly decreased the mEPP frequency by 40%, but not in the presence of CCh or in Ringer solution with 0 or 8 mM Ca2+. The present data show that BTX, which inhibits a class of nicotinic ACh receptors, does not block the decrease of mEPP frequency evoked by CCh and can itself suppress the frequency of spontaneous quantal release.
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Depression of miniature endplate potential frequency by acetylcholine and its analogues in frog
British journal of pharmacology, 1991Co-Authors: E.e. Nikolsky, E.a. Bukharaeva, E.g. Strunsky, F. VyskočilAbstract:1 Acetylcholine (ACh), 7.5 × 10−5 m, and carbachol, 5 × 10−6m (CCh) depressed the frequency of miniature endplate potentials (m.e.p.ps) in the frog (Rana temporaria) sartorious neuromuscular junction with active acetylcholinesterase to about 50–55% of the controls. 2 A similar depression was produced by the nicotinic agonists, nicotine, suberyldicholine and tetramethylammonium. 3 The muscarinic agonists, oxotremorine, methylfurmethide and methacholine were without effect on m.e.p.p. frequency. The muscarinic antagonist, atropine and the nicotinic antagonist, (+)-tubocurarine, had no effect on the depression of m.e.p.p. frequency evoked by CCh. 4 The ganglionic blockers, benzhexonium and IEM-1119, were also without effect on the CCh-evoked depression of m.e.p.p. frequency. 5 Pretreatment of muscles with anticholinesterases did not prevent the CCh-induced drop in m.e.p.p. frequency. 6 The effect of CCh was proportionally the same as in the controls in preparations where the m.e.p.p. frequency was changed by elevation of K+ and in the presence of theophylline, noradrenaline, dibutyryl adenosine 3′:5′-cyclic monophosphate (db cyclic AMP) and db cyclic GMP. 7 An inhibitor of Na+,K+-ATPase, ouabain, 5 × 10−5 mol l−1, prevented or reversed the depression of m.e.p.p. frequency by CCh. However, the depression was present in a nominally K+-free medium. Insulin and adrenaline, which are considered to be Na+,K+-ATPase activators, were without effect on depression of m.e.p.p. frequency. 8 The depression of m.e.p.p. frequency by 5 × 10−6 m CCh was the same at temperatures between 5 and 30°C with a Q10 near to 1.0. When threshold amounts of CCh were used (6 × 10−7 and 3 × 10−7 m), the depression was less at higher temperatures. 9 The receptive structures responsible for the CCh (or ACh)-evoked depression of m.e.p.p. frequency differ pharmacologically from muscarinic, nicotinic ganglionic and neuromuscular junction ACh-receptors as well as from the synaptic cholinesterase, in contrast to previous reports (Duncan & Publicover, 1979). The low temperature-dependence points to the possibility that physical rather than biochemical processes are limiting in this presynaptic effect of cholinomimetics.;
Lars G M Pettersson - One of the best experts on this subject based on the ideXlab platform.
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half or full core hole in density functional theory x ray absorption spectrum calculations of water
arXiv: Soft Condensed Matter, 2007Co-Authors: Matteo Cavalleri, Michael Odelius, Dennis Nordlund, Anders Nilsson, Lars G M PetterssonAbstract:We analyze the performance of two different core-hole potentials in the theoretical modeling of XAS of ice, liquid and gas phase water; the use of a full core-hole (FCH) in the calculations, as suggested by Hetenyi et al. [J. Chem. Phys. 120 (18), 8632 (2004)], gives poor agreement with experiment in terms of intensity distribution as well as transition energies, while the half core hole (HCH) potential, in the case of water, provides a better compromise between initial and final state effects, leading to good agreement with the experimental data.
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half or full core hole in density functional theory x ray absorption spectrum calculations of water
Physical Chemistry Chemical Physics, 2005Co-Authors: Matteo Cavalleri, Michael Odelius, Dennis Nordlund, Anders Nilsson, Lars G M PetterssonAbstract:We analyze the performance of two different core-hole potentials in the theoretical modeling of XAS of ice, liquid and gas phase water; the use of a full core-hole (FCH) in the calculations, as suggested by Hetenyi et al. [B. Hetenyi, F. De Angelis, P. Giamozzi and R. Car, J. Chem. Phys., 2004, 120(18), 8632], gives poor agreement with experiment in terms of intensity distribution as well as transition energies, while the half core hole (HCH) potential, in the case of water, provides a better compromise between initial and final state effects, leading to good agreement with the experimental data.
