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R M Pilliar - One of the best experts on this subject based on the ideXlab platform.
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osseointegration of sintered porous surfaced and plasma spray coated implants an animal model study of early postimplantation Healing Response and mechanical stability
Journal of Biomedical Materials Research, 1999Co-Authors: Craig A Simmons, Nancy Valiquette, R M PilliarAbstract:The osseointegration and long-term success of bone-interfacing implants are dependent on mechanical stability of the implant relative to host bone during the early Healing period. The geometric design of an implant surface may play an important role in affecting early implant stabilization, possibly by influencing tissue Healing dynamics. In this study, we compared the early tissue Healing Response and resulting implant stability for two surface designs by characterizing the histological and mechanical properties of the Healing tissue around Ti6Al4V sintered porous-surfaced and Ti plasma-sprayed implants. The implants were inserted transversely in rabbit femoral condyles and evaluated at 0, 4, 8, and 16 days postimplantation. At 4 and 8 days after implantation, the early Healing tissue (fibrin and collagenous matrix) was more extensively integrated with the three-dimensional interconnected structure of the sintered porous surface than with the irregular geometry of the plasma-sprayed coating. In addition, histological examination indicated that initial matrix mineralization leading to osseointegration occurred more rapidly with the porous-surfaced implants. The more extensive tissue integration and more rapid matrix mineralization with the porous-surfaced implants were reflected in the mechanical test data, which demonstrated greater attachment strength and interfacial stiffness for the porous-surfaced implants 4 and 8 days postimplantation (p <.05). Sixteen days after implantation, both implant designs were osseointegrated and had comparable attachment characteristics. These data demonstrate that appropriate surface design selection can improve early implant stability and induce an accelerated Healing Response, thereby improving the potential for implant osseointegration.
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Osseointegration of sintered porous-surfaced and plasma spray-coated implants: An animal model study of early postimplantation Healing Response and mechanical stability.
Journal of biomedical materials research, 1999Co-Authors: Craig A Simmons, Nancy Valiquette, R M PilliarAbstract:The osseointegration and long-term success of bone-interfacing implants are dependent on mechanical stability of the implant relative to host bone during the early Healing period. The geometric design of an implant surface may play an important role in affecting early implant stabilization, possibly by influencing tissue Healing dynamics. In this study, we compared the early tissue Healing Response and resulting implant stability for two surface designs by characterizing the histological and mechanical properties of the Healing tissue around Ti6Al4V sintered porous-surfaced and Ti plasma-sprayed implants. The implants were inserted transversely in rabbit femoral condyles and evaluated at 0, 4, 8, and 16 days postimplantation. At 4 and 8 days after implantation, the early Healing tissue (fibrin and collagenous matrix) was more extensively integrated with the three-dimensional interconnected structure of the sintered porous surface than with the irregular geometry of the plasma-sprayed coating. In addition, histological examination indicated that initial matrix mineralization leading to osseointegration occurred more rapidly with the porous-surfaced implants. The more extensive tissue integration and more rapid matrix mineralization with the porous-surfaced implants were reflected in the mechanical test data, which demonstrated greater attachment strength and interfacial stiffness for the porous-surfaced implants 4 and 8 days postimplantation (p
Paul W Ackermann - One of the best experts on this subject based on the ideXlab platform.
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longer duration of operative time enhances Healing metabolites and improves patient outcome after achilles tendon rupture surgery
Knee Surgery Sports Traumatology Arthroscopy, 2018Co-Authors: Simon Svedman, Olof Westin, Susanna Aufwerber, Gunnar Edman, Katarina Nilssonhelander, Michael R Carmont, Jon Karlsson, Paul W AckermannAbstract:Purpose The relationship between the duration of operative time (DOT), Healing Response and patient outcome has not been previously investigated. An enhanced Healing Response related to DOT may potentiate repair processes, especially in hypovascular and sparsely metabolized musculoskeletal tissues such as tendons. This study aimed to investigate the association between DOT and the metabolic Healing Response, patient-reported outcome and the rate of post-operative complications after acute Achilles tendon injury.
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functional weight bearing mobilization after achilles tendon rupture enhances early Healing Response a single blinded randomized controlled trial
Knee Surgery Sports Traumatology Arthroscopy, 2017Co-Authors: Kars P Valkering, Susanna Aufwerber, Gunnar Edman, Paul W Ackermann, Francesco Ranuccio, Enricomaria LuniniAbstract:Functional weight-bearing mobilization may improve repair of Achilles tendon rupture (ATR), but the underlying mechanisms and outcome were unknown. We hypothesized that functional weight-bearing mobilization by means of increased metabolism could improve both early and long-term Healing. In this prospective randomized controlled trial, patients with acute ATR were randomized to either direct post-operative functional weight-bearing mobilization (n = 27) in an orthosis or to non-weight-bearing (n = 29) plaster cast immobilization. During the first two post-operative weeks, 15°–30° of plantar flexion was allowed and encouraged in the functional weight-bearing mobilization group. At 2 weeks, patients in the non-weight-bearing cast immobilization group received a stiff orthosis, while the functional weight-bearing mobilization group continued with increased range of motion. At 6 weeks, all patients discontinued immobilization. At 2 weeks, Healing metabolites and markers of procollagen type I (PINP) and III (PIIINP) were examined using microdialysis. At 6 and 12 months, functional outcome using heel-rise test was assessed. Healing tendons of both groups exhibited increased levels of metabolites glutamate, lactate, pyruvate, and of PIIINP (all p < 0.05). Patients in functional weight-bearing mobilization group demonstrated significantly higher concentrations of glutamate compared to the non-weight-bearing cast immobilization group (p = 0.045).The upregulated glutamate levels were significantly correlated with the concentrations of PINP (r = 0.5, p = 0.002) as well as with improved functional outcome at 6 months (r = 0.4; p = 0.014). Heel-rise tests at 6 and 12 months did not display any differences between the two groups. Functional weight-bearing mobilization enhanced the early Healing Response of ATR. In addition, early ankle range of motion was improved without the risk of Achilles tendon elongation and without altering long-term functional outcome. The relationship between functional weight-bearing mobilization-induced upregulation of glutamate and enhanced Healing suggests novel opportunities to optimize post-operative rehabilitation.
Craig A Simmons - One of the best experts on this subject based on the ideXlab platform.
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osseointegration of sintered porous surfaced and plasma spray coated implants an animal model study of early postimplantation Healing Response and mechanical stability
Journal of Biomedical Materials Research, 1999Co-Authors: Craig A Simmons, Nancy Valiquette, R M PilliarAbstract:The osseointegration and long-term success of bone-interfacing implants are dependent on mechanical stability of the implant relative to host bone during the early Healing period. The geometric design of an implant surface may play an important role in affecting early implant stabilization, possibly by influencing tissue Healing dynamics. In this study, we compared the early tissue Healing Response and resulting implant stability for two surface designs by characterizing the histological and mechanical properties of the Healing tissue around Ti6Al4V sintered porous-surfaced and Ti plasma-sprayed implants. The implants were inserted transversely in rabbit femoral condyles and evaluated at 0, 4, 8, and 16 days postimplantation. At 4 and 8 days after implantation, the early Healing tissue (fibrin and collagenous matrix) was more extensively integrated with the three-dimensional interconnected structure of the sintered porous surface than with the irregular geometry of the plasma-sprayed coating. In addition, histological examination indicated that initial matrix mineralization leading to osseointegration occurred more rapidly with the porous-surfaced implants. The more extensive tissue integration and more rapid matrix mineralization with the porous-surfaced implants were reflected in the mechanical test data, which demonstrated greater attachment strength and interfacial stiffness for the porous-surfaced implants 4 and 8 days postimplantation (p <.05). Sixteen days after implantation, both implant designs were osseointegrated and had comparable attachment characteristics. These data demonstrate that appropriate surface design selection can improve early implant stability and induce an accelerated Healing Response, thereby improving the potential for implant osseointegration.
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Osseointegration of sintered porous-surfaced and plasma spray-coated implants: An animal model study of early postimplantation Healing Response and mechanical stability.
Journal of biomedical materials research, 1999Co-Authors: Craig A Simmons, Nancy Valiquette, R M PilliarAbstract:The osseointegration and long-term success of bone-interfacing implants are dependent on mechanical stability of the implant relative to host bone during the early Healing period. The geometric design of an implant surface may play an important role in affecting early implant stabilization, possibly by influencing tissue Healing dynamics. In this study, we compared the early tissue Healing Response and resulting implant stability for two surface designs by characterizing the histological and mechanical properties of the Healing tissue around Ti6Al4V sintered porous-surfaced and Ti plasma-sprayed implants. The implants were inserted transversely in rabbit femoral condyles and evaluated at 0, 4, 8, and 16 days postimplantation. At 4 and 8 days after implantation, the early Healing tissue (fibrin and collagenous matrix) was more extensively integrated with the three-dimensional interconnected structure of the sintered porous surface than with the irregular geometry of the plasma-sprayed coating. In addition, histological examination indicated that initial matrix mineralization leading to osseointegration occurred more rapidly with the porous-surfaced implants. The more extensive tissue integration and more rapid matrix mineralization with the porous-surfaced implants were reflected in the mechanical test data, which demonstrated greater attachment strength and interfacial stiffness for the porous-surfaced implants 4 and 8 days postimplantation (p
Steven E. Wilson - One of the best experts on this subject based on the ideXlab platform.
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Apoptosis in the Initiation, Modulation and Termination of the Corneal Wound Healing Response
Experimental eye research, 2007Co-Authors: Steven E. Wilson, Shyam S. Chaurasia, Fabricio Witzel De MedeirosAbstract:Stromal keratocyte apoptosis has been well-characterized as an early initiating event of the corneal wound Healing Response, triggering subsequent cellular processes that include bone marrow-derived cell infiltration, proliferation and migration of residual keratocyte cells, and, in some circumstances, generation of myofibroblast cells. Recent studies, however, have suggested a more general role for apoptosis in the overall stromal wound Healing Response that includes modulation and termination functions. This review article highlights, and ties together, recent studies that have demonstrated the important role apoptosis likely plays in weeks to months following an initial insult to the cornea-depending on the type and extent of corneal injury.
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wound Healing in the cornea a review of refractive surgery complications and new prospects for therapy
Cornea, 2005Co-Authors: Marcelo V Netto, Rajiv R Mohan, Renato Ambrosio, Audrey E K Hutcheon, James D Zieske, Steven E. WilsonAbstract:Purpose: The comeal wound Healing Response is of particular relevance for refractive surgical procedures since it is a major determinant of efficacy and safety. The purpose of this review is to provide an overview of the Healing Response in refractive surgery procedures. Methods: Literature review. Results: LASIK and PRK are the most common refractive procedures; however, alternative techniques, including LASEK, PRK with mitomycin C, and Epi-LASIK, have been developed in an attempt to overcome common complications. Clinical outcomes and a number of common complications are directly related to the Healing process and the unpredictable nature of the associated comeal cellular Response. These complications include overcorrection, undercorrection, regression, corneal stroma opacification, and many other side effects that have their roots in the biologic Response to surgery. The corneal epithelium, stroma, nerves, inflammatory cells, and lacrimal glands are the main tissues and organs involved in the wound Healing Response to corneal surgical procedures. Complex cellular interactions mediated by cytokines and growth factors occur among the cells of the cornea, resulting in a highly variable biologic Response. Among the best characterized processes are keratocyte apoptosis, keratocyte necrosis, keratocyte proliferation, migration of inflammatory cells, and myofibroblast generation. These cellular interactions are involved in extracellular matrix reorganization, stromal remodeling, wound contraction, and several other Responses to surgical injury. Conclusions: A better understanding of the complete cascade of events involved in the corneal wound Healing process and anomalies that lead to complications is critical to improve the efficacy and safety of refractive surgical procedures. Recent advances in understanding the biologic and molecular processes that contribute to the Healing Response bring hope that safe and effective pharmacologic modulators of the comeal wound Healing Response may soon be developed.
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the corneal wound Healing Response cytokine mediated interaction of the epithelium stroma and inflammatory cells
Progress in Retinal and Eye Research, 2001Co-Authors: Steven E. Wilson, Rahul R Mohan, Rajiv R Mohan, Renato Ambrosio, Jong Wook HongAbstract:Abstract The corneal wound Healing cascade is complex and involves stromal–epithelial and stromal–epithelial–immune interactions mediated by cytokines. Interleukin-1 appears to be a master modulator of many of the events involved in this cascade. Keratocyte apoptosis is the earliest stromal event noted following epithelial injury and remains a likely target for modulation of the overall wound Healing Response. Other processes such as epithelial mitosis and migration, stromal cell necrosis, keratocyte proliferation, myofibroblast generation, collagen deposition, and inflammatory cell infiltration contribute to the wound Healing cascade and are also likely modulated by cytokines derived from corneal cells, the lacrimal gland, and possibly immune cells. Many questions remain regarding the origin and fate of different cell types that contribute to stromal wound Healing. Over a period of months to years the cornea returns to a state similar to that found in the unwounded normal cornea.
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the wound Healing Response after laser in situ keratomileusis and photorefractive keratectomy elusive control of biological variability and effect on custom laser vision correction
Archives of Ophthalmology, 2001Co-Authors: Steven E. Wilson, Rahul R Mohan, Jong Wook Hong, Jong Soo Lee, Rosan ChoiAbstract:Biological diversity in the wound Healing Response is thought to be a major factor limiting the predictability of the outcome of refractive surgical procedures such as laser in situ keratomileusis and photorefractive keratectomy. Corneal wound Healing is critical to the success of topography-linked or wave front–linked excimer laser ablation to optimize visual performance. This is because of the importance of retaining subtle features of custom ablation and the tendency of epithelial hyperplasia and stromal remodeling to obscure these features following either procedure. The corneal wound Healing Response is exceedingly complex. Keratocyte apoptosis, which occurs in Response to epithelial injury, is the earliest observable event in the wound Healing cascades and is therefore an excellent target for pharmacological intervention. Alterations of surgical technique can be designed to limit keratocyte apoptosis and the subsequent events in corneal wound Healing. Abnormalities of the cascades could contribute to the pathogenesis of corneal diseases. For example, recent data have suggested that perturbation of the keratocyte apoptosis/mitosis balance could underlie the development of keratoconus in a proportion of patients.
Rahul R Mohan - One of the best experts on this subject based on the ideXlab platform.
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the corneal wound Healing Response cytokine mediated interaction of the epithelium stroma and inflammatory cells
Progress in Retinal and Eye Research, 2001Co-Authors: Steven E. Wilson, Rahul R Mohan, Rajiv R Mohan, Renato Ambrosio, Jong Wook HongAbstract:Abstract The corneal wound Healing cascade is complex and involves stromal–epithelial and stromal–epithelial–immune interactions mediated by cytokines. Interleukin-1 appears to be a master modulator of many of the events involved in this cascade. Keratocyte apoptosis is the earliest stromal event noted following epithelial injury and remains a likely target for modulation of the overall wound Healing Response. Other processes such as epithelial mitosis and migration, stromal cell necrosis, keratocyte proliferation, myofibroblast generation, collagen deposition, and inflammatory cell infiltration contribute to the wound Healing cascade and are also likely modulated by cytokines derived from corneal cells, the lacrimal gland, and possibly immune cells. Many questions remain regarding the origin and fate of different cell types that contribute to stromal wound Healing. Over a period of months to years the cornea returns to a state similar to that found in the unwounded normal cornea.
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the wound Healing Response after laser in situ keratomileusis and photorefractive keratectomy elusive control of biological variability and effect on custom laser vision correction
Archives of Ophthalmology, 2001Co-Authors: Steven E. Wilson, Rahul R Mohan, Jong Wook Hong, Jong Soo Lee, Rosan ChoiAbstract:Biological diversity in the wound Healing Response is thought to be a major factor limiting the predictability of the outcome of refractive surgical procedures such as laser in situ keratomileusis and photorefractive keratectomy. Corneal wound Healing is critical to the success of topography-linked or wave front–linked excimer laser ablation to optimize visual performance. This is because of the importance of retaining subtle features of custom ablation and the tendency of epithelial hyperplasia and stromal remodeling to obscure these features following either procedure. The corneal wound Healing Response is exceedingly complex. Keratocyte apoptosis, which occurs in Response to epithelial injury, is the earliest observable event in the wound Healing cascades and is therefore an excellent target for pharmacological intervention. Alterations of surgical technique can be designed to limit keratocyte apoptosis and the subsequent events in corneal wound Healing. Abnormalities of the cascades could contribute to the pathogenesis of corneal diseases. For example, recent data have suggested that perturbation of the keratocyte apoptosis/mitosis balance could underlie the development of keratoconus in a proportion of patients.
