Health Risk Assessment

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Mosaad A Abdelwahhab - One of the best experts on this subject based on the ideXlab platform.

  • mycotoxins and child Health the need for Health Risk Assessment
    International Journal of Hygiene and Environmental Health, 2009
    Co-Authors: Sherif O Sherif, Emad E Salama, Mosaad A Abdelwahhab
    Abstract:

    The occurrences of mycotoxins as food contaminants in different localities particularly in developing countries and the inevitable exposure of populations and children to these toxins with probable adverse outcomes need be scientifically and systematically assessed. Health Risk Assessment developed in the 1980s is separate from Risk management, both with Risk communication form the Risk analysis framework adopted by the World Health Organization. The process contributes increasingly to policy development, public Health decision making, the establishment of mycotoxin regulations and research planning. However, the exercise of the Risk Assessment structured approach is not simple and is faced up to lack of data, capable infrastructure facilities and need for trained personnel and resources. Furthermore, adopted methodologies need be developed focusing on child characteristics and Health concerns.

Sherif O Sherif - One of the best experts on this subject based on the ideXlab platform.

  • mycotoxins and child Health the need for Health Risk Assessment
    International Journal of Hygiene and Environmental Health, 2009
    Co-Authors: Sherif O Sherif, Emad E Salama, Mosaad A Abdelwahhab
    Abstract:

    The occurrences of mycotoxins as food contaminants in different localities particularly in developing countries and the inevitable exposure of populations and children to these toxins with probable adverse outcomes need be scientifically and systematically assessed. Health Risk Assessment developed in the 1980s is separate from Risk management, both with Risk communication form the Risk analysis framework adopted by the World Health Organization. The process contributes increasingly to policy development, public Health decision making, the establishment of mycotoxin regulations and research planning. However, the exercise of the Risk Assessment structured approach is not simple and is faced up to lack of data, capable infrastructure facilities and need for trained personnel and resources. Furthermore, adopted methodologies need be developed focusing on child characteristics and Health concerns.

Fenghua Li - One of the best experts on this subject based on the ideXlab platform.

  • quantitative analysis and Health Risk Assessment of polycyclic aromatic hydrocarbons in edible vegetable oils marketed in shandong of china
    Food and Chemical Toxicology, 2015
    Co-Authors: Dafeng Jiang, Chenglong Xin, Wei Li, Jindong Chen, Fenghua Li
    Abstract:

    Abstract This work studies on the quantitative analysis and Health Risk Assessment of polycyclic aromatic hydrocarbons (PAHs) in edible vegetable oils in Shandong, China. The concentrations of 15 PAHs in 242 samples were determined by high performance liquid chromatography coupled with fluorescence detection. The results indicated that the mean concentration of 15 PAHs in oil samples was 54.37 μg kg −1 . Low molecular weight PAH compounds were the predominant contamination. Especially, the carcinogenic benzo(a)pyrene (BaP) was detected at a mean concentration of 1.28 μg kg −1 , which was lower than the limit of European Union and China. A preliminary evaluation of human Health Risk Assessment for PAHs was accomplished using BaP toxic equivalency factors and the incremental lifetime cancer Risk (ILCR). The ILCR values for children, adolescents, adults, and seniors were all larger than 1 × 10 −6 , indicating a high potential carcinogenic Risk on the dietary exposed populations.

Christian Seigneur - One of the best experts on this subject based on the ideXlab platform.

  • The use of Health Risk Assessment to estimate desirable sampling detection limits.
    Journal of the Air & Waste Management Association, 1995
    Co-Authors: Christian Seigneur, Leonard Levin, Elpida Constantinou, Mary Fend, Lawrence Graft, Chris Whipple
    Abstract:

    Abstract The inclusion of non-detected chemicals in a Health Risk Assessment may lead, in some cases, to estimated Risks that exceed regulatory thresholds, because one must use the detection limit or half of the detection limit. This study presents a methodology which will allow one to estimate appropriate detection limits by conducting a Health Risk Assessment prior to the source sampling program. The advantages and shortcomings of various levels of detail in the Risk Assessment to determine those detection limits are discussed. The application of the methodology is demonstrated with a case study of the potential Health effects of power plant stack emissions.

  • Review of mathematical models for Health Risk Assessment: VI. population exposure
    Environmental Software, 1994
    Co-Authors: Christian Seigneur
    Abstract:

    Abstract The Health Risk Assessment of chemical emissions from industrial facilitiesrequires the mathematical modeling of a variety of processes, including transport and fate of chemicals in and between various environmental media, population exposure to these chemicals, their associated doses, and Health effects. Several models are presently available to address these different components of the Health Risk Assessment. Existing models were reviewed and recommendations are provided for the selection of models suitable for screening and refined Risk Assessments. This article reviews mathematical models for estimating population exposure to chemicals.

  • Review of mathematical models for Health Risk Assessment: II. Atmospheric chemical concentrations
    Environmental Software, 1993
    Co-Authors: Akula Venkatram, Christian Seigneur
    Abstract:

    Abstract The Health Risk Assessment of chemical emissions from industrial facilities requires the mathematical modeling of a variety of processes, including transport and fate of chemicals in and between various environmental media, population exposure to these chemicals, their associated doses, and Health effects. Several models are presently available to address these different components of the Health Risk Assessment. Existing models were reviewed and recommendations are provided for the selection of models suitable for screening and refined Risk Assessments. This article reviews mathematical models for estimating atmospheric chemical concentrations.

  • Review of mathematical models for Health Risk Assessment: I. Overview
    Environmental Software, 1992
    Co-Authors: Christian Seigneur, Akula Venkatram, Don Galya, Paul Anderson, David Liu, Donna Foliart, Rudolph Von Burg, Yoram Cohen, Thomas Permutt, Leonard Levin
    Abstract:

    Abstract The Health Risk Assessment of chemical emissions from industrial facilities requires the mathematical modeling of a variety of processes including transport and fate of chemicals within and between various environmental media, population exposure to those chemicals, their associated doses, and Health effects. Several models are presently available to address these different components of a Health Risk Assessment. Existing models were reviewed and recommendations are provided for the selection of models suitable for screening and refined Risk Assessments. This article presents an overview of a series of seven companion articles that address the various components of Health Risk Assessment.

Angela Mally - One of the best experts on this subject based on the ideXlab platform.

  • A critical evaluation of Health Risk Assessment of modified mycotoxins with a special focus on zearalenone
    Mycotoxin Research, 2019
    Co-Authors: Nicole Lorenz, Sven Dänicke, Lutz Edler, Christoph Gottschalk, Eva Lassek, Doris Marko, Michael Rychlik, Angela Mally
    Abstract:

    A comprehensive definition introducing the term “modified mycotoxins” to encompass all possible forms in which mycotoxins and their modifications can occur was recently proposed and has rapidly gained wide acceptance within the scientific community. It is becoming increasingly evident that exposure to such modified mycotoxins due to their presence in food and feed has the potential to pose a substantial additional Risk to human and animal Health. Zearalenone (ZEN) is a well-characterized Fusarium toxin. Considering the diversity of modified forms of ZEN occurring in food and feed, the toxicologically relevant endocrine activity of many of these metabolites, and the fact that modified forms add to a dietary exposure which approaches the tolerable daily intake by free ZEN alone, modified forms of ZEN present an ideal case study for critical evaluation of modified mycotoxins in food safety. Following a summary of recent scientific opinions of EFSA dealing with Health Risk Assessment of ZEN alone or in combination with its modified forms, uncertainties and data gaps are highlighted. Issues essential for evaluation and prioritization of modified mycotoxins in Health Risk Assessment are identified and discussed, including opportunities to improve exposure Assessment using biomonitoring data. Further issues such as future consideration of combinatory effects of the parent toxin with its modified forms and also other compounds co-occurring in food and feed are addressed. With a particular focus on ZEN, the most pressing challenges associated with Health Risk Assessment of modified mycotoxins are identified and recommendations for further research to fill data gaps and reduce uncertainties are made.