The Experts below are selected from a list of 96 Experts worldwide ranked by ideXlab platform
Alahuhta S - One of the best experts on this subject based on the ideXlab platform.
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Inhaled nitric oxide effectively decreases right Heart Afterload following right Heart infarct in pigs.
Scandinavian cardiovascular journal : SCJ, 2001Co-Authors: M B Spalding, Tero Ala-kokko, Kai Kiviluoma, Alahuhta S, Tatu JuvonenAbstract:Objective - To test the hypothesis that nitric oxide is beneficial in acute right Heart failure after right ventricle infarct. Right ventricle infarct results in a decrease in right Heart function with a subsequent reduction in ejection fraction and cardiac index. The pulmonary circulation is compromised as the right ventricle weakens, and the resulting stasis and further weakening of the ventricle present clinically as an increase in right Heart Afterload. Pulmonary vasodilation should ease these hemodynamic symptoms of right Heart infarct. Design - Ten 3-4-month-old pigs were chosen as experimental animals. All animals were cannulated, a sternotomy was performed and branches of the right main coronary were ligated to cause infarct of the right ventricle. After a 4-h stabilization period, all animals received fluid preload with a dextrose-based solution after which control hemodynamic measurements were recorded. Treatment with inhaled nitric oxide was begun at progressive concentrations and hemodynamic m...
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The hemodynamic effects of adenosine infusion after experimental right Heart infarct in young swine.
Journal of cardiovascular pharmacology, 2000Co-Authors: M B Spalding, Tero Ala-kokko, Kai Kiviluoma, Heikki Ruskoaho, Alahuhta SAbstract:The use of a vasodilator selective to the pulmonary circulation may be beneficial in cases with right-ventricle failure, as it will decrease right-Heart Afterload without concurrent systemic hypotension. Adenosine has recently been advocated as such a drug, although its clinical efficacy in this respect is still in question. We therefore devised an experimental protocol of right-Heart infarct to test the efficacy of adenosine in alleviating symptoms of right-Heart failure. Right-Heart infarct was induced experimentally in 17 young pigs. After hemodynamics had stabilized, preload was optimized with a dextrose-based colloid solution. A continuous infusion of adenosine was then begun at doses of 25, 50, 75, and 100 microg/kg/min in a study group of 10 animals, while the remaining seven were monitored as controls. Hemodynamic parameters were followed throughout the study, with particular attention paid to pulmonary and systemic vascular resistance indices (PVRI and SVRI), right ventricle ejection fraction (REF), cardiac index (CI), and Heart rate (HR). Cardiac index (CI) showed a tendency to increase during the adenosine infusion, as did REF and stroke index (SI), whereas PVRI and mean pulmonary pressure (MPAP) were decreased. There was a marked decrease in SVRI as a result of the adenosine, as there was in mean arterial pressure at the higher infusion rates. HR remained unchanged by the infusion. Discontinuation of the drug resulted in a rapid increase in MAP, SVRI, MPAP, HR, left ventricle stroke work index (LVSWI), and PVRI and in a modest decrease in CI. The continuous infusion of adenosine appears to cause an effective arterial vasodilation, with a consequent unloading of right-Heart Afterload. Its use may be beneficial in the treatment of increased pulmonary vascular resistance after right-Heart failure.
M B Spalding - One of the best experts on this subject based on the ideXlab platform.
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Inhaled nitric oxide effectively decreases right Heart Afterload following right Heart infarct in pigs.
Scandinavian cardiovascular journal : SCJ, 2001Co-Authors: M B Spalding, Tero Ala-kokko, Kai Kiviluoma, Alahuhta S, Tatu JuvonenAbstract:Objective - To test the hypothesis that nitric oxide is beneficial in acute right Heart failure after right ventricle infarct. Right ventricle infarct results in a decrease in right Heart function with a subsequent reduction in ejection fraction and cardiac index. The pulmonary circulation is compromised as the right ventricle weakens, and the resulting stasis and further weakening of the ventricle present clinically as an increase in right Heart Afterload. Pulmonary vasodilation should ease these hemodynamic symptoms of right Heart infarct. Design - Ten 3-4-month-old pigs were chosen as experimental animals. All animals were cannulated, a sternotomy was performed and branches of the right main coronary were ligated to cause infarct of the right ventricle. After a 4-h stabilization period, all animals received fluid preload with a dextrose-based solution after which control hemodynamic measurements were recorded. Treatment with inhaled nitric oxide was begun at progressive concentrations and hemodynamic m...
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The hemodynamic effects of adenosine infusion after experimental right Heart infarct in young swine.
Journal of cardiovascular pharmacology, 2000Co-Authors: M B Spalding, Tero Ala-kokko, Kai Kiviluoma, Heikki Ruskoaho, Alahuhta SAbstract:The use of a vasodilator selective to the pulmonary circulation may be beneficial in cases with right-ventricle failure, as it will decrease right-Heart Afterload without concurrent systemic hypotension. Adenosine has recently been advocated as such a drug, although its clinical efficacy in this respect is still in question. We therefore devised an experimental protocol of right-Heart infarct to test the efficacy of adenosine in alleviating symptoms of right-Heart failure. Right-Heart infarct was induced experimentally in 17 young pigs. After hemodynamics had stabilized, preload was optimized with a dextrose-based colloid solution. A continuous infusion of adenosine was then begun at doses of 25, 50, 75, and 100 microg/kg/min in a study group of 10 animals, while the remaining seven were monitored as controls. Hemodynamic parameters were followed throughout the study, with particular attention paid to pulmonary and systemic vascular resistance indices (PVRI and SVRI), right ventricle ejection fraction (REF), cardiac index (CI), and Heart rate (HR). Cardiac index (CI) showed a tendency to increase during the adenosine infusion, as did REF and stroke index (SI), whereas PVRI and mean pulmonary pressure (MPAP) were decreased. There was a marked decrease in SVRI as a result of the adenosine, as there was in mean arterial pressure at the higher infusion rates. HR remained unchanged by the infusion. Discontinuation of the drug resulted in a rapid increase in MAP, SVRI, MPAP, HR, left ventricle stroke work index (LVSWI), and PVRI and in a modest decrease in CI. The continuous infusion of adenosine appears to cause an effective arterial vasodilation, with a consequent unloading of right-Heart Afterload. Its use may be beneficial in the treatment of increased pulmonary vascular resistance after right-Heart failure.
Kai Kiviluoma - One of the best experts on this subject based on the ideXlab platform.
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Inhaled nitric oxide effectively decreases right Heart Afterload following right Heart infarct in pigs.
Scandinavian cardiovascular journal : SCJ, 2001Co-Authors: M B Spalding, Tero Ala-kokko, Kai Kiviluoma, Alahuhta S, Tatu JuvonenAbstract:Objective - To test the hypothesis that nitric oxide is beneficial in acute right Heart failure after right ventricle infarct. Right ventricle infarct results in a decrease in right Heart function with a subsequent reduction in ejection fraction and cardiac index. The pulmonary circulation is compromised as the right ventricle weakens, and the resulting stasis and further weakening of the ventricle present clinically as an increase in right Heart Afterload. Pulmonary vasodilation should ease these hemodynamic symptoms of right Heart infarct. Design - Ten 3-4-month-old pigs were chosen as experimental animals. All animals were cannulated, a sternotomy was performed and branches of the right main coronary were ligated to cause infarct of the right ventricle. After a 4-h stabilization period, all animals received fluid preload with a dextrose-based solution after which control hemodynamic measurements were recorded. Treatment with inhaled nitric oxide was begun at progressive concentrations and hemodynamic m...
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The hemodynamic effects of adenosine infusion after experimental right Heart infarct in young swine.
Journal of cardiovascular pharmacology, 2000Co-Authors: M B Spalding, Tero Ala-kokko, Kai Kiviluoma, Heikki Ruskoaho, Alahuhta SAbstract:The use of a vasodilator selective to the pulmonary circulation may be beneficial in cases with right-ventricle failure, as it will decrease right-Heart Afterload without concurrent systemic hypotension. Adenosine has recently been advocated as such a drug, although its clinical efficacy in this respect is still in question. We therefore devised an experimental protocol of right-Heart infarct to test the efficacy of adenosine in alleviating symptoms of right-Heart failure. Right-Heart infarct was induced experimentally in 17 young pigs. After hemodynamics had stabilized, preload was optimized with a dextrose-based colloid solution. A continuous infusion of adenosine was then begun at doses of 25, 50, 75, and 100 microg/kg/min in a study group of 10 animals, while the remaining seven were monitored as controls. Hemodynamic parameters were followed throughout the study, with particular attention paid to pulmonary and systemic vascular resistance indices (PVRI and SVRI), right ventricle ejection fraction (REF), cardiac index (CI), and Heart rate (HR). Cardiac index (CI) showed a tendency to increase during the adenosine infusion, as did REF and stroke index (SI), whereas PVRI and mean pulmonary pressure (MPAP) were decreased. There was a marked decrease in SVRI as a result of the adenosine, as there was in mean arterial pressure at the higher infusion rates. HR remained unchanged by the infusion. Discontinuation of the drug resulted in a rapid increase in MAP, SVRI, MPAP, HR, left ventricle stroke work index (LVSWI), and PVRI and in a modest decrease in CI. The continuous infusion of adenosine appears to cause an effective arterial vasodilation, with a consequent unloading of right-Heart Afterload. Its use may be beneficial in the treatment of increased pulmonary vascular resistance after right-Heart failure.
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The effect of aminophylline on right Heart function in young pigs after ligation of the right coronary artery.
Pharmacology & toxicology, 2000Co-Authors: Michael Spalding, Tero Ala-kokko, Kai Kiviluoma, Heikki Ruskoaho, Seppo AlahuhtaAbstract:An experimental model of right Heart failure was developed to determine the effects of fluid loading and aminophylline on right Heart function. We hypothesised that aminophylline would specifically improve right Heart function through a decrease in pulmonary vascular resistance and, possibly, an increase in cardiac contractility. Right Heart infarct was induced in ten experimental pigs and seven control pigs by ligating branches of the right coronary artery. The effect of fluid loading with a colloid solution and subsequent bolus doses of aminophylline on haemodynamics was observed. Fluid loading improved haemodynamics as expected. Aminophylline transiently improved cardiac index and pulmonary vascular resistance, but simultaneously caused an increase in Heart rate and a decrease in stroke volume. Although aminophylline may reduce right Heart Afterload, it did not improve overall cardiac function in this experimental model of right Heart infarction.
Tero Ala-kokko - One of the best experts on this subject based on the ideXlab platform.
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Inhaled nitric oxide effectively decreases right Heart Afterload following right Heart infarct in pigs.
Scandinavian cardiovascular journal : SCJ, 2001Co-Authors: M B Spalding, Tero Ala-kokko, Kai Kiviluoma, Alahuhta S, Tatu JuvonenAbstract:Objective - To test the hypothesis that nitric oxide is beneficial in acute right Heart failure after right ventricle infarct. Right ventricle infarct results in a decrease in right Heart function with a subsequent reduction in ejection fraction and cardiac index. The pulmonary circulation is compromised as the right ventricle weakens, and the resulting stasis and further weakening of the ventricle present clinically as an increase in right Heart Afterload. Pulmonary vasodilation should ease these hemodynamic symptoms of right Heart infarct. Design - Ten 3-4-month-old pigs were chosen as experimental animals. All animals were cannulated, a sternotomy was performed and branches of the right main coronary were ligated to cause infarct of the right ventricle. After a 4-h stabilization period, all animals received fluid preload with a dextrose-based solution after which control hemodynamic measurements were recorded. Treatment with inhaled nitric oxide was begun at progressive concentrations and hemodynamic m...
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The hemodynamic effects of adenosine infusion after experimental right Heart infarct in young swine.
Journal of cardiovascular pharmacology, 2000Co-Authors: M B Spalding, Tero Ala-kokko, Kai Kiviluoma, Heikki Ruskoaho, Alahuhta SAbstract:The use of a vasodilator selective to the pulmonary circulation may be beneficial in cases with right-ventricle failure, as it will decrease right-Heart Afterload without concurrent systemic hypotension. Adenosine has recently been advocated as such a drug, although its clinical efficacy in this respect is still in question. We therefore devised an experimental protocol of right-Heart infarct to test the efficacy of adenosine in alleviating symptoms of right-Heart failure. Right-Heart infarct was induced experimentally in 17 young pigs. After hemodynamics had stabilized, preload was optimized with a dextrose-based colloid solution. A continuous infusion of adenosine was then begun at doses of 25, 50, 75, and 100 microg/kg/min in a study group of 10 animals, while the remaining seven were monitored as controls. Hemodynamic parameters were followed throughout the study, with particular attention paid to pulmonary and systemic vascular resistance indices (PVRI and SVRI), right ventricle ejection fraction (REF), cardiac index (CI), and Heart rate (HR). Cardiac index (CI) showed a tendency to increase during the adenosine infusion, as did REF and stroke index (SI), whereas PVRI and mean pulmonary pressure (MPAP) were decreased. There was a marked decrease in SVRI as a result of the adenosine, as there was in mean arterial pressure at the higher infusion rates. HR remained unchanged by the infusion. Discontinuation of the drug resulted in a rapid increase in MAP, SVRI, MPAP, HR, left ventricle stroke work index (LVSWI), and PVRI and in a modest decrease in CI. The continuous infusion of adenosine appears to cause an effective arterial vasodilation, with a consequent unloading of right-Heart Afterload. Its use may be beneficial in the treatment of increased pulmonary vascular resistance after right-Heart failure.
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The effect of aminophylline on right Heart function in young pigs after ligation of the right coronary artery.
Pharmacology & toxicology, 2000Co-Authors: Michael Spalding, Tero Ala-kokko, Kai Kiviluoma, Heikki Ruskoaho, Seppo AlahuhtaAbstract:An experimental model of right Heart failure was developed to determine the effects of fluid loading and aminophylline on right Heart function. We hypothesised that aminophylline would specifically improve right Heart function through a decrease in pulmonary vascular resistance and, possibly, an increase in cardiac contractility. Right Heart infarct was induced in ten experimental pigs and seven control pigs by ligating branches of the right coronary artery. The effect of fluid loading with a colloid solution and subsequent bolus doses of aminophylline on haemodynamics was observed. Fluid loading improved haemodynamics as expected. Aminophylline transiently improved cardiac index and pulmonary vascular resistance, but simultaneously caused an increase in Heart rate and a decrease in stroke volume. Although aminophylline may reduce right Heart Afterload, it did not improve overall cardiac function in this experimental model of right Heart infarction.
Tomasz Grodzicki - One of the best experts on this subject based on the ideXlab platform.
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Left ventricular geometry and rheological properties of erythrocytes in patients at cardiovascular disease risk.
Clinical hemorheology and microcirculation, 2009Co-Authors: Maria Fornal, Renata A Korbut, Jarosław Królczyk, Tomasz GrodzickiAbstract:The relationship between erythrocyte deformability and aggregability with left ventricular mass index has been examined in patients diagnosed with at least one cardiovascular risk factor but without ongoing coronary Heart disease. The group consisted of 66 individuals, 30 men and 36 women, of the average age 57.7 years. For each patient, deformability and aggregability of red blood cells (RBCs) as well as end-diastolic left ventricle diameter (LVD), interventricular septum thickness (IVST) and posterior wall thickness (PWT) were measured. On the basis of the echocardiographical parameters and anthropometric data, left ventricular mass index (LVMI) was calculated. The analysis revealed statistically significant correlation between the LVMI and erythrocyte deformability and aggregability: the LVMI increases with decreasing deformability and is higher in patients with higher aggregability. This finding indicates that the worsening of RBC rheological properties is one of the main factors contributing to alterations of cardiac geometry through the increase of peripheral resistance which, in turn, significantly augments the Heart Afterload. Given that left ventricular hypertrophy (LVH) is a predictor of cardiovascular morbidity and mortality, the association between hemorheological parameters and left ventricular geometry may be important in clinical practice.
